New Space and Tech

NASA Spaceline Current Awareness List #1,044 7 April 2023 (Space Life Science Research Results)

By Keith Cowing
Status Report
April 7, 2023
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NASA Spaceline Current Awareness List #1,044 7 April 2023 (Space Life Science Research Results)
Space Life Science Research on ISS

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Childress SD, Williams TC, Francisco DR.

NASA Space Flight Human-System Standard: Enabling human spaceflight missions by supporting astronaut health, safety, and performance.

npj Microgravity. 2023 Apr 3;9(1):31.

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.97

Funding: S.D. Childress, T.C. Williams, and D.R. Francisco are affiliated with NASA Headquarters.


Buettmann EG, DeNapoli RC, Abraham LB, Denisco JA, Lorenz MR, Friedman MA, Donahue HJ.

Reambulation following hindlimb unloading attenuates disuse-induced changes in murine fracture healing.

Bone. 2023 Jul;172:116748.

PIs: E.G. Buettmann, M.A. Friedman

Note: Hindlimb unloading study.

Journal Impact Factor: 4.626

Funding: “This work was supported by the Translational Research Institute for Space Health (TRISH) through Cooperative Agreement with NASA (NNX16AO69A).”


Sattgast LH, Wong CP, Branscum AJ, Olson DA, Aguirre-Burk AM, Iwaniec UT, Turner RT.

Small changes in thermoregulation influence cancellous bone turnover balance in distal femur metaphysis in growing female mice.

Bone Rep. 2023 Jun;18:101675.

PI: R.T. Turner

Journal Impact Factor: 3.713

Funding: “This work was supported by NASA (80NSSC19K0430).”


Cochran J, Walsh K.

Clonal hematopoiesis: From macrovascular to microvascular disease.

Arterioscler Thromb Vasc Biol. 2023 Mar 23. Editorial. Online ahead of print.

PI: K. Walsh

Note: This article may be obtained online without charge.

Journal Impact Factor: 10.514

Funding: “This work was supported by the University of Virginia Medical Scientist Training program T32GM007267 to J.C. and the National Institutes of Health (NIH) grants AG073249, AG072095, HL142650, and HL152174 and NASA grant 80NSSC21K0549 to K.W.”


Kloske CM, Barnum CJ, Batista AF, Bradshaw EM, Brickman AM, Bu G, Dennison J, Gearon MD, Goate AM, Haass C, Heneka MT, Hu WT, Huggins LKL, Jones NS, Koldamova R, Lemere CA, Liddelow SA, Marcora E, Marsh SE, Nielsen HM, Petersen KK, Petersen M, Piña-Escudero SD, Qiu WQ, Quiroz YT, Reiman E, Sexton C, Tansey MG, TCW J, Teunissen CE, Tijms BM, van der Kant R, Wallings R, Weninger SC, Wharton W, Wilcock DM, Wishard TJ, Worley SL, Zetterberg H, Carrillo MC.

APOE [apolipoprotein E gene] and immunity: Research highlights.

Alzheimer’s Dement. 2023 Mar 28. Review. Online ahead of print.

PI: C.A. Lemere

Note: This article may be obtained online without charge.

Journal Impact Factor: 16.655

Funding: “…Lemere reports in the past 36 months grants or contracts from NIH/NIA: 1RF1 AG060057 (PI) ‘Novel Inducible Complement C3 Conditional KO Mouse Models to Investigate Neurodegeneration in AD; 1RF1 AG058657 (PI)’ AD Immunotherapy with a Novel CDC-Mutant Anti-Pyroglutatmate-3 Abeta Antibody to Avoid Vascular Side Effects; R01 AB063829 (Co-I) “Role of Mast Cells in AD; NASA: 80NSSC18K0810 (PI) Sex- and APOE-Specific Late CNS and Cardiovascular Effects of Space Radiation. …”


Eller KA, Stamo DF, McCollum CR, Campos JK, Levy M, Nagpal P, Chatterjee A.

Photoactivated antibiotics to treat intracellular infection of bacteria.

Nanoscale Adv. 2023 Mar 28;5(7):1910-8.

PI: A. Chatterjee

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.598

Funding: “We acknowledge financial support from W. M. Keck Foundation and DARPA Young Faculty Award (D17AP00024) to A. C. and National Aeronautics and Space Administration (NASA) Cooperative Agreement Notice – Translational Research Institute (TRISH) award number NNX16AO69A to A. C. and P. N.”


Sharma P, Dwivedi R, Ray P, Shukla J, Pomin VH, Tandon R.

Inhibition of cytomegalovirus by Pentacta pygmaea fucosylated chondroitin sulfate depends on its molecular weight.

Viruses. 2023 Mar 28;15(4):859.

PI: R. Tandon

Note: This article is part of Special Issue “Molecular Biology of Human Cytomegalovirus” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 5.818

Funding: “V.H.P. acknowledges funds from the National Institutes of Health 1P20GM130460-01A1 subproject 7936 and 1R03NS110996-01A1, and the University of Mississippi. R.T. is funded by the National Aeronautics and Space Administration (NASA), grant number 80NSSC19K1603.”


Yadav SK, Gawargi FI, Hasan MH, Tandon R, Upton JW, Mishra PK.

Differential effects of CMV [cytomegalovirus] infection on the viability of cardiac cells.

Cell Death Discov. 2023 Apr 3;9:111.

PI: R. Tandon

Note: This article may be obtained online without charge.

Journal Impact Factor: 7.109

Funding: “This work was supported in part by the National Institutes of Health (NIH) Grant HL113281, 1U54GM115458, P20GM104320, and R56HL156806 and the University of Nebraska Collaboration Initiative Grant to PKM. The work at the University of Mississippi Medical Center was supported by NASA award #80NSSC19K1603 to RT.”


Fischer U, Mosier K, Schmid J, Smithsimmons A, Brougham R.

Braiding–A novel approach to supporting space/ground communication under signal latency.

Acta Astronaut. 2023 Jun;207:411-24.

PI: U. Fischer

Note: From the abstract: “Braiding is a novel, text-based software designed to facilitate communication between crewmembers in space and mission support on Earth under signal latency. Its feasibility and benefits for text-based time-delayed communication were assessed in a Human-in-the loop (HITL) study involving flight surgeons FS/Mission Support personnel and former participants in space exploration analog simulations (Crew). The HITL evaluation was conducted online with pairs of volunteers (one crewmember and one FS/Mission Support personnel as MCC) collaborating under communication delay on operationally relevant task situations, contrasting a texting tool (functionally comparable to the one currently used in NASA analog missions) with braiding. Volunteers received fictional but realistic information for each task to help them perform in their assigned role (MCC or Crew). The study involved two test sessions over two days, each presenting participants with three task events. Data collected included participants’ post-session ratings of their time-delayed communication and a 30-45 min exit interview.”

Journal Impact Factor: 2.954

Funding: “The research was supported by NASA grant 80NSSC21K0444 to the Georgia Institute of Technology. We thank our NASA colleagues Andrew Beitman, James Garrett, Brian Gore, Sarah Huppman, Jessica Marquez, Lauren Landon, Lorrie Primeaux and Alexandra Whitmire for their support throughout the project.”


Vann W, Zhou T, Zhu Q, Du E.

Enabling automated facility maintenance from articulated robot collision-free designs.

Adv Eng Inform. 2023 Jan;55:101820.

PI: E. Du

Note: From the abstract: “Key challenges found in some facilities maintenance (FM) operations include the dependency on placing sophisticated workers in undesirable working conditions that could make them susceptible to accidents. Robot-assisted in-situ facilities maintenance represents new opportunities by assisting human operators when exposed to harsh environments.”

Journal Impact Factor: 7.862

Funding: “This material is supported by the National Aeronautics and Space Administration (NASA) under grant 80NSSC21K0845.”


Other papers of interest:


Malhan D, Yalçin M, Schoenrock B, Blottner D, Relógio A.

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent.

npj Microgravity. 2023 Apr 3;9:30.

Note: From the abstract: “The circadian clock regulates cellular and molecular processes in mammals across all tissues including skeletal muscle, one of the largest organs in the human body. Dysregulated circadian rhythms are characteristic of aging and crewed spaceflight, associated with, for example, musculoskeletal atrophy. Molecular insights into spaceflight-related alterations of circadian regulation in skeletal muscle are still missing. Here, we investigated potential functional consequences of clock disruptions on skeletal muscle using published omics datasets obtained from spaceflights and other clock-altering, external (fasting and exercise), or internal (aging) conditions on Earth.” GeneLab is available at This article may be obtained online without charge.


Olde Engberink RHG, van Oosten PJ, Weber T, Tabury K, Baatout S, Valenti G, Chouker A, Boutouyrie P, Heer M, Jordan J, Goswami N.

The kidney, volume homeostasis and osmoregulation in space: Current perspective and knowledge gaps.

npj Microgravity. 2023 Apr 1;9:29. Review.

Note: This article may be obtained online without charge.


Kokhan VS, Dobynde MI.

The effects of galactic cosmic rays on the central nervous system: From negative to unexpectedly positive effects that astronauts may encounter.

Biology (Basel). 2023 Mar 3;12(3):400. Review.

Note: This article belongs to the Section “Neuroscience” ( and may be obtained online without charge.


Le H, Rai V, Agrawal DK.

Cholesterol: An important determinant of muscle atrophy in astronauts.

J Biotechnol Biomed. 2023 Mar 2;6:67-79.

Note: This article may be obtained online without charge.


Loffredo F, Vardaci E, Bianco D, Di Nitto A, Quarto M.

Radioprotection for astronauts’ missions: Numerical results on the Nomex shielding effectiveness.

Life (Basel). 2023 Mar 15;13(3):790.

Note: This article is part of Special Issue “Ionizing Radiation: Health Effects, Radiological Protection and Medical Applications” ( and may be obtained online without charge.


Lu F, Wang S, Wu X, Yang X, Sun L, Fan Y.

Role of myofascia in the recovery of bone loss after reloading in tail-suspended rats.

Acta Astronaut. 2023 Jul;208:49-54.

Note: Hindlimb unloading study.


Striebel J, Kalinski L, Sturm M, Drouvé N, Peters S, Lichterfeld Y, Habibey R, Hauslage J, El Sheikh S, Busskamp V, Liemersdorf C.

Human neural network activity reacts to gravity changes in vitro.

Front Neurosci. 2023 Mar 8;17:1085282.

Note: This article is part of Research Topic “Mapping Brain Multiscale Dynamics in Health and Disease: Complex Brain Functions Need Scalable Advanced Large-scale Techniques, Modeling, and Theories” ( This article may be obtained online without charge.


Pastushkova LH, Goncharova AG, Rusanov VB, Kashirina DN, Brzhozovskiy AG, Popova OV, Nosovsky AM, Nikolaev EN, Kononikhin AS, Larina IM.

Connection of dried blood spot proteomic composition dynamics and heart rate variability in 3-day female dry immersion.

Microgravity Sci Technol. 2023 Mar 31;35:19.


Zhedyaev RY, Tarasova OS, Sharova AP, Tomilovskaya ES, Vinogradova OL, Borovik AS.

Diverse effects of seven-day dry immersion on hemodynamic responses in head-up tilt and lower body negative pressure tests.

Acta Astronaut. 2023 Apr 4. Online ahead of print.


Lodovichi C, Ratto GM.

Control of circadian rhythm on cortical excitability and synaptic plasticity.

Front Neural Circuits. 2023 Mar 30;17:1099598.

Note: This article is part of Research Topic “Common Tune, Different Players: Emerging Molecular Guiding Factors in Development and Activity Dependent Remodeling of Different Neural Circuits” ( The Research Topic also includes an article from previous Current Awareness List #1,033 This article may be obtained online without charge.


Morgan WH, Khoo J, Vukmirovic A, Abdul-Rahman A, An D, Mehnert A, Obreschkow D, Chowdhury E, Yu DY.

Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change.

npj Microgravity. 2023 Mar 31;9:28.

Note: This article may be obtained online without charge.


Min J, Tu J, Xu C, Lukas H, Shin S, Yang Y, Solomon SA, Mukasa D, Gao W.

Skin-interfaced wearable sweat sensors for precision medicine.

Chem Rev. 2023 Mar 27. Review. Online ahead of print.

Note: From the abstract: “This review provides a comprehensive review of wearable sweat sensors and outlines state-of-the-art technologies and research that strive to bridge these gaps. The physiology of sweat, materials, biosensing mechanisms and advances, and approaches for sweat induction and sampling are introduced.”

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