New Space and Tech

NASA Spaceline Current Awareness List #1,043 31 March 2023 (Space Life Science Research Results)

By Keith Cowing

Status Report

NASA

March 31, 2023

Filed under Astrobiology, ISS, Microgravity, NASA, Space Agriculture, space biology, Space Life Science, Space Medicine, space station, Spaceline Current Awareness

NASA Spaceline Current Awareness List #1,043 31 March 2023 (Space Life Science Research Results) — space biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:

Sibony PA, Laurie SS, Ferguson CR, Pardon LP, Young M, Rohlf FJ, Macias BR.

Ocular deformations in spaceflight-associated neuro-ocular syndrome and idiopathic intracranial hypertension.

Invest Ophthalmol Vis Sci. 2023 Mar;64(3):32.

https://pubmed.ncbi.nlm.nih.gov/36988950

Note: From the abstract: “Spaceflight-associated neuro-ocular syndrome (SANS) shares several clinical features with idiopathic intracranial-hypertension (IIH), namely disc edema, globe-flattening, hyperopia, and choroidal folds. Globe-flattening is caused by increased intracranial pressure (ICP) in IIH, but the cause in SANS is uncertain. If increased ICP alone causes SANS, then the ocular deformations should be similar to IIH; if not, alternative mechanisms would be implicated.” This article may be obtained online without charge.

Journal Impact Factor: 4.925

Funding: “Supported by the National Aeronautics and Space Administration (NASA) under the Human Research Program (directed research).”

Sanders LM, Scott RT, Yang JH, Qutub AA, Garcia Martin H, Berrios DC, Hastings JJA, Rask J, Mackintosh G, Hoarfrost AL, Chalk S, Kalantari J, Khezeli K, Antonsen EL, Babdor J, Barker R, Baranzini SE, Beheshti A, Delgado-Aparicio GM, Glicksberg BS, Greene CS, Haendel M, Hamid AA, Heller P, Jamieson D, Jarvis KJ, Komarova SV, Komorowski M, Kothiyal P, Mahabal A, Manor U, Mason CE, Matar M, Mias GI, Miller J, Myers JG, Nelson C, Oribello J, Park S-m, Parsons-Wingerter P, Prabhu RK, Reynolds RJ, Saravia-Butler A, Saria S, Sawyer A, Singh NK, Snyder M, Soboczenski F, Soman K, Theriot CA, Van Valen D, Venkateswaran K, Warren L, Worthey L, Zitnik M, Costes SV.

Biological research and self-driving labs in deep space supported by artificial intelligence.

Nat Mach Intell. 2023 Mar 23;5:208-19. Review.

https://doi.org/10.1038/s42256-023-00618-4

PIs: A. Beheshti, C.E. Mason, G.I. Mias, K. Venkateswaran, S.V. Costes

Note: GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.

Journal Impact Factor: 25.898

Funding: “We thank all June 2021 participants and speakers at the ‘NASA Workshop on Artificial Intelligence and Modeling for Space Biology.’ We thank the NASA Space Biology Program, part of the NASA Biological and Physical Sciences Division within the NASA Science Mission Directorate; as well as the NASA Human Research Program (HRP). We thank the Space Biosciences Division and Space Biology at Ames Research Center (ARC), especially D. Ly, R. Vik, and P. Vaishampayan. We thank the support provided by NASA GeneLab, and the NASA Ames Life Sciences Data Archive. Additional thanks to S. Bhattacharya, NASA Space Biology Program Scientist; K. Martin, ARC Lead of Exploration Medical Capability (an Element of HRP); and L. Lewis, ARC NASA HRP Lead. Funding: S.V.C. is funded by NASA Human Research Program grant NNJ16HP24I. S.E.B holds the Heidrich Family and Friends endowed Chair in Neurology at the University of California, San Francisco (UCSF). S.E.B. also holds the Distinguished Professorship I in Neurology at UCSF. S.E.B is funded by an National Science Foundation Convergence Accelerator award (2033569) and NIH/NCATS Translator award (1OT2TR003450). G.I.M was supported by the Translational Research Institute for Space Health, through NASA NNX16AO69A (Project Number T0412). E.L.A. was supported by the Translational Research Institute for Space Health, through NASA NNX16AO69A. C.E.M. thanks NASA grants NNX14AH50G and NNX17AB26G.”

Scott RT, Sanders LM, Antonsen EL, Hastings JJA, Park S-m, Mackintosh G, Reynolds RJ, Hoarfrost AL, Sawyer A, Greene CS, Glicksberg BS, Theriot CA, Berrios DC, Miller J, Babdor J, Barker R, Baranzini SE, Beheshti A, Chalk S, Delgado-Aparicio GM, Haendel M, Hamid AA, Heller P, Jamieson D, Jarvis KJ, Kalantari J, Khezeli K, Komarova SV, Komorowski M, Kothiyal P, Mahabal A, Manor U, Garcia Martin H, Mason CE, Matar M, Mias GI, Myers JG, Nelson C, Oribello J, Parsons-Wingerter P, Prabhu RK, Qutub AA, Rask J, Saravia-Butler A, Saria S, Singh NK, Snyder M, Soboczenski F, Soman K, Van Valen D, Venkateswaran K, Warren L, Worthey L, Yang JH, Zitnik M, Costes SV.

Biomonitoring and precision health in deep space supported by artificial intelligence.

Nat Mach Intell. 2023 Mar 23;5:196-207. Review.

https://doi.org/10.1038/s42256-023-00617-5

PIs: A. Beheshti, C.E. Mason, G.I. Mias, K. Venkateswaran, S.V. Costes

Note: GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.

Journal Impact Factor: 25.898

Funding: “We thank all June 2021 participants and speakers at the ‘NASA Workshop on Artificial Intelligence & Modeling for Space Biology.’ Thanks go to the NASA Space Biology Program, part of the NASA Biological and Physical Sciences Division within the NASA Science Mission Directorate, as well as the NASA Human Research Program (HRP). We also thank the Space Biosciences Division and Space Biology at Ames Research Center (ARC), especially D. Ly, R. Vik, and P. Vaishampayan. We are grateful for the support provided by NASA GeneLab and the NASA Ames Life Sciences Data Archive. Additional thanks go to S. Bhattacharya (NASA Space Biology Program Scientist), K. Martin (ARC Lead of Exploration Medical Capability (an Element of HRP)), as well as L. Lewis (ARC NASA HRP Lead). S.V.C. is funded by NASA Human Research Program grant NNJ16HP24I. S.E.B. holds the Heidrich Family and Friends Endowed Chair in Neurology at UCSF. S.E.B. also holds the Distinguished Professorship I in Neurology at UCSF. S.E.B. is funded by an NSF Convergence Accelerator award (2033569) and NIH/NCATS Translator award (1OT2TR003450). G.I.M. was supported by the Translational Research Institute for Space Health, through NASA NNX16AO69A (project no. T0412). E.L.A. was supported by the Translational Research Institute for Space Health, through NASA NNX16AO69A. C.E.M. acknowledges NASA grants NNX14AH50G and NNX17AB26G.”

Santomartino R, Averesch NJH, Bhuiyan M, Cockell CS, Colangelo J, Gumulya Y, Lehner B, Lopez-Ayala I, McMahon S, Mohanty A, Santa Maria SR, Urbaniak C, Volger R, Yang J, Zea L.

Toward sustainable space exploration: A roadmap for harnessing the power of microorganisms.

Nat Commun. 2023 Mar 21;14(1):1391. Review.

https://pubmed.ncbi.nlm.nih.gov/36944638

PI: C. Urbaniak

Note: This article may be obtained online without charge.

Journal Impact Factor: 17.69

Funding: PI reports NASA grant related to the MAPS project.

Nemec-Bakk AS, Sridharan V, Seawright JW, Nelson GA, Cao M, Singh P, Cheema AK, Singh B, Li Y, Koturbash I, Miousse IR, Ewing LE, Skinner CM, Landes RD, Lowery JD, Mao X-W, Singh SP, Boerma M.

Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model.

Life Sci Space Res. 2023 Mar 30. Online ahead of print.

https://doi.org/10.1016/j.lssr.2023.03.008

PI: M. Boerma

Journal Impact Factor: 2.73

Funding: “This work supported by the National Space Biomedical Research Institute [RE03701 through NCC 9-58 to MB], National Aeronautics and Space Administration [80NSSC17K0425 to MB], and the National Institutes of General Medical Sciences [P20 GM109005 to MHJ].”

Tays GD, Hupfeld KE, McGregor HR, Beltran NE, Kofman IS, De Dios YE, Mulder ER, Bloomberg JJ, Mulavara AP, Wood SJ, Seidler RD.

Daily artificial gravity is associated with greater neural efficiency during sensorimotor adaptation.

Cereb Cortex. 2023 Mar 23;bhad094. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/36958815

PI: R.D. Seidler

Note: Head-down tilt bedrest study. “From the abstract: Altered vestibular signaling and body unloading in microgravity results in sensory reweighting and adaptation. Microgravity effects are well-replicated in head-down tilt bed rest (HDBR). Artificial gravity (AG) is a potential countermeasure to mitigate the effects of microgravity on human physiology and performance. We examined the effectiveness of daily AG for mitigating brain and/or behavioral changes in 60 days of HDBR.”

Journal Impact Factor: 4.861

Funding: “National Aeronautics and Space Administration (NASA 80NSSC18K0783 to R.S., A.M., S.W., and J.B); University of Florida’s (UF) Graduate Student Funding Award (NIHT32-NS082128toG.T.); National Institute on Aging fellowship (1F99AG068440toK.H.); Natural Sciences and Engineering Research Council of Canada (NSERC) Postdoctoral Fellowship and a NASA Human Research Program Augmentation Grant (to H.R.M.).”

Richmond SB, Rane S, Hanson MR, Albayram M, Iliff JJ, Kernagis D, Rosenberg JT, Seidler RD.

Quantification approaches for magnetic resonance imaging following intravenous gadolinium injection: A window into brain-wide glymphatic function.

Eur J Neurosci. 2023 Mar 25. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/36965006

PI: R.D. Seidler

Journal Impact Factor: Not available for this journal

Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NASA) directed study and the Office of Naval Research [N0014-20- 1-2463] to RDS and DK. During the completion of this work, SBR was also supported by a NASA augmentation grant.”

Zhang Y, Story M, Yeshitla S, Wang X, Scully RR, Theriot C, Wu H, Ryder VE, Lam CW.

Persistent changes in expression of genes involved in inflammation and fibrosis in the lungs of rats exposed to airborne lunar dust.

Inhal Toxicol. 2023 Mar 26;1-18. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/36966416

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.011

Funding: “The lunar dust toxicity studies in rats were funded by the NASA Human Research Program Grant through NASA Johnson Space Center and Wyle Bioastronautics Contract #NAS9-02078. The preparation of the present manuscript was partially supported by NASA Biological and Physical Sciences Division.”

Clark KB.

Neural field continuum limits and the structure-function partitioning of cognitive-emotional brain networks.

Biology (Basel). 2023 Feb 23;12(3):352. Review.

https://pubmed.ncbi.nlm.nih.gov/36979044

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.168

Funding: K.B. Clark is affiliated with NASA Ames Research Center.

Packebush MH, Sanchez-Martinez S, Biswas S, Kc S, Nguyen KH, Ramirez JF, Nicholson V, Boothby TC.

Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state.

Sci Rep. 2023 Mar 20;13:4542.

https://pubmed.ncbi.nlm.nih.gov/36941331

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.996

Funding: “This work was supported by DARPA (W922NF-20-2-0137) to T.C.B. In addition, this work was made possible in part through support from an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (Grant # 2P20GM103432). M.H.P. was supported in part by the Wyoming NASA Space Grant Consortium, NASA Grant #80NSSC20M0113, INBRE undergraduate research grant through the Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Grant #2P20GM103432, and the Wyoming Research Scholars Program. J.F.R. is supported by the USDA National Institute of Food and Agriculture, Hatch project #1012152 and by Wyoming NASA Space Grant Consortium, NASA Grant #80NSSC20M0113. V.N. is supported by the Wyoming NASA Space Grant Consortium, NASA Grant #80NSSC20M0113.”

Maurya AK, Sharma P, Samanta P, Shami AA, Misra SK, Zhang F, Thara R, Kumar D, Shi D, Linhardt RJ, Sharp JS, Doerksen RJ, Tandon R, Pomin VH.

Structure, anti-SARS-CoV-2, and anticoagulant effects of two sulfated galactans from the red alga Botryocladia occidentalis.

Int J Biol Macromol. 2023 May 31;124168. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/36963552

PI: R. Tandon

Journal Impact Factor: 8.025

Funding: “This work was supported by funds from the AACP 2019 New Investigator Award (V. H. P.), the National Institutes of Health [1P20GM130460-01A1-7936 (R. J. D., J. S. S., and V. H. P), 1R03NS110996-01A1 (J. S. S., and V. H. P.), and (1R01DE031928-01A1) (R. Tandon)], NASA #80NSSC19K1603 (R. Tandon) and the University of Mississippi.”

Janko MM, Recalde-Coronel GC, Damasceno CP, Salmón-Mulanovich G, Barbieri AF, Lescano AG, Zaitchik BF, Pan WK.

The impact of sustained malaria control in the Loreto region of Peru: A retrospective, observational, spatially-varying interrupted time series analysis of the PAMAFRO program.

Lancet Reg Health Am. 2023 Apr;20:100477.

https://pubmed.ncbi.nlm.nih.gov/36970494

Journal Impact Factor: Not available for this journal

Funding: “MMJ, WKP, GSM, BFZ and GCR report support from NASA (NNX15AP74G). MMJ, WKP, BFZ, GSM, and AGL report additional support from the National Institutes of Health (R01 AI151056), while AGL is sponsored by a training grant (D43 TW007393) awarded by the Fogarty International Center of the US National Institutes of Health, and GSM received further support from the British Academy (KF400136), Peru’s Consejo Nacional de Ciencia y Tecnologia (CON-CYTEC), and NIH (U01AI151814). MMJ received additional support from the Bill and Melinda Gates Foundation (OPP1132415).”

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Other papers of interest:

Iordachescu A, Eisenstein N, Appleby-Thomas G.

Space habitats for bioengineering and surgical repair: Addressing the requirement for reconstructive and research tissues during deep-space missions.

npj Microgravity. 2023 Mar 25;9:23. Review.

https://pubmed.ncbi.nlm.nih.gov/36966158

Note: This article may be obtained online without charge.

Romanella SM, Mencarelli L, Seyedmadani K, Jillings S, Tomilovskaya E, Rukavishnikov I, Sprugnoli G, Rossi S, Wuyts FL, Santarnecchi E.

Optimizing transcranial magnetic stimulation for spaceflight applications.

npj Microgravity. 2023 Mar 28;9:26.

https://doi.org/10.1038/s41526-023-00249-4

Note: From the abstract: “As space agencies aim to reach and build installations on Mars, the crews will face longer exposure to extreme environments that may compromise their health and performance. Transcranial magnetic stimulation (TMS) is a painless non-invasive brain stimulation technique that could support space exploration in multiple ways. However, changes in brain morphology previously observed after long-term space missions may impact the efficacy of this intervention. We investigated how to optimize TMS for spaceflight-associated brain changes.” This article may be obtained online without charge.

Boschert AL, Gauger P, Bach A, Gerlach D, Johannes B, Jordan J, Li Z, Elmenhorst D, Bauer A, Marshall-Goebel K, Tank J, Zange J, Rittweger J.

External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial.

npj Microgravity. 2023 Mar 28;9:25.

https://doi.org/10.1038/s41526-023-00267-2

Note: Head-down tilt bedrest study. This article may be obtained online without charge.

Eiken O, Elia A, Gottschalk F, Gennser M, Ånell R.

Decompression strain in parachute jumpmasters during simulated high-altitude missions: A special reference to preoxygenation strategies.

Eur J Appl Physiol. 2023 Mar 23.

https://pubmed.ncbi.nlm.nih.gov/36952088

Note: From the abstract: “Military parachute operations are often executed at high altitude, from an unpressurized aircraft compartment. Parachute jumpmasters (JM) are thus regularly exposed to 29,500 ft. for 60 min. The aim was to investigate the decompression strain during a simulated JM mission at high altitude and to compare two strategies of preoxygenation, conducted either at sea-level or below 10,000 ft., during ascent to mission altitude.” This article may be obtained online without charge.

Rajpar I, Kumar G, Fortina P, Tomlinson RE.

Toll-like receptor 4 signaling in osteoblasts is required for load-induced bone formation in mice.

iScience. 2023 Apr 21;26(4):106304.

https://pubmed.ncbi.nlm.nih.gov/36950122

Note: This article may be obtained online without charge.

Gao Z, Zhu Y, Fang Y, Fekete G, Kovács A, Baker JS, Liang M, Gu Y.

Automated recognition of asymmetric gait and fatigue gait using ground reaction force data.

Front Physiol. 2023 Mar 7;14:1159668.

https://pubmed.ncbi.nlm.nih.gov/36960154

Note: This article is part of Research Topic “Biomechanical Performance and Relevant Mechanism of Physical Medicine and Rehabilitation for Neuromusculoskeletal Disorders” (https://www.frontiersin.org/research-topics/46181/biomechanical-performance-and-relevant-mechanism-of-physical-medicine-and-rehabilitation-for-neuromusculoskeletal-disorders#overview). This article may be obtained online without charge.