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NASA Spaceline Current Awareness List #1,042 24 March 2023 (Space Life Science Research Results)

By Keith Cowing
Status Report
March 24, 2023
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NASA Spaceline Current Awareness List #1,042 24 March 2023 (Space Life Science Research Results)
Space Biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, [email protected].

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Barker R, Kruse CPS, Johnson C, Saravia-Butler A, Fogle H, Chang HS, Trane RM, Kinscherf N, Villacampa A, Manzano A, Herranz R, Davin LB, Lewis NG, Perera I, Wolverton C, Gupta P, Jaiswal P, Reinsch SS, Wyatt S, Gilroy S.

Meta-analysis of the spaceflight and microgravity response of the Arabidopsis plant transcriptome.

npj Microgravity. 2023 Mar 20;9(1):21.

PIs: N.G. Lewis, C. Wolverton, S. Wyatt, S. Gilroy

Note: From the abstract: “Spaceflight presents a multifaceted environment for plants, combining the effects on growth of many stressors and factors including altered gravity, the influence of experiment hardware, and increased radiation exposure. To help understand the plant response to this complex suite of factors this study compared transcriptomic analysis of 15 Arabidopsis thaliana spaceflight experiments deposited in the National Aeronautics and Space Administration’s GeneLab data repository.” GeneLab is available at This article may be obtained online without charge.

Journal Impact Factor: 4.97

Funding: “This work was coordinated through the GeneLab Plant Analysis Working Group and was supported by NASA grants 80NSSC19K0126, 80NSSC18K0132 and 80NSSC21K0577 to S.G. and R.B., through NASA 80NSSC19K1481 to S.W., NNX15AG55G to C.W., and NNX15AG56G to L.D. and N.L., from the Spanish Agencia Estatal de Investigació n grant RTI2018-099309-B-I00 and ESA 1340112 4000131202/ 20/NL/PG/pt to R.H. Contributions from P.J. and P.G. were partially supported by funds from the Oregon State University, NSF awards 1127112 a

nd 1340112 and the United States Department of Agriculture, Agriculture Research Service.”


Adkins AM, Colby EM, Boden AF, Gotthold JD, Harris RD, Britten RA, Wellman LL, Sanford LD.

Differential impact of social isolation and space radiation on behavior and motor learning in rats.

Life. 2023 Mar 18;13(3):826.

PI: L.D. Sanford

Note: This article is part of Special Issue “Current Challenges in Space Neuroscience” ( This article may be obtained online without charge.

Journal Impact Factor: 3.235

Funding: “NASA CBS VNSCOR grant 80NSSC19K1582.”


Brojakowska A, Jackson CJ, Bisserier M, Khlgatian MK, Grano C, Blattnig SR, Zhang S, Fish KM, Chepurko V, Chepurko E, Gillespie V, Dai Y, Lee B, Garikipati VNS, Hadri L, Kishore R, Goukassian DA.

Lifetime evaluation of left ventricular structure and function in male C57BL/6J mice after gamma and space-type radiation exposure.

Int J Mol Sci. 2023 Mar 13;24(6):5451.

PI: D.A. Goukassian

Note: This article is part of Special Issue “New Insights into Cardiovascular Diseases in Basic Research” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 6.208

Funding: “This work was funded by the NASA Human Research Program, grant No: 80NSSC19K1079 (formerly, 80NSSC18K0921) to D.A.G, R01HL158998 and R01HL133554 to LH.”


Nemec-Bakk AS, Sridharan V, Desai P, Landes RD, Hart B, Allen AR, Boerma M.

Effects of simulated 5-ion galactic cosmic radiation on function and structure of the mouse heart.

Life. 2023 Mar 15;13(3):795.

PI: A.R. Allen

Note: This article and an article below in the “Other” section (Hart et al.) are part of Special Issue “Advances in Space Biomedicine and Disease Pathogenesis” ( The Special Issue also includes an article from previous Current Awareness List #984 Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 3.253

Funding: “This research was funded by the Translational Research Institute for Space Health (TRISH), grant numbers T0401 and P0702.”


Zhou R, Chuang AZ, Feldman RM, Giancardo L.

MVGL-Net: A generalizable multi-view convolutional network for anterior segment OCT.

Biomed Signal Process Control. 2023 Aug;85:104778.

PI: L. Giancardo

Note: From the abstract: “Correct diagnosis of primary angle-closure disease (PACD) and classification of plateau iris configuration (PIC) existence is essential for appropriate glaucoma treatment. A fast non-contact method that can automatically detect PACD and PIC would be valuable for improving treatment decisions and reducing the misdiagnosis rate.”

Journal Impact Factor: 5.076

Funding: “This work is supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A. LG is also supported in part by NIH grants UL1TR003167 and R01NS121154, and a Cancer Prevention and Research Institute of Texas grant (RP 170668). AZC and RMF are partially supported by NIH/NEI Vision Core Grants P30EY028102.”


Diaz A, Dixit AR, Khodadad CL, Hummerick ME, Justiano-Velez YA, Li W, O’Rourke A.

Biofilm formation is correlated with low nutrient and simulated microgravity conditions in a Burkholderia isolate from the ISS water processor assembly.

Biofilm. 2023 Dec;5:100110.

Note: A high-aspect rotating vessel and rotating wall vessel were used in this study. From the abstract: “The International Space Station (ISS) Water Processor Assembly (WPA) experiences intermittent dormancy in the WPA wastewater tank during water recycling events which promotes biofilm formation within the system. In this work we aimed to gain a deeper understanding of the impact of nutrient limitation on bacterial growth and biofilm formation under microgravity in support of biofilm mitigation efforts in exploration water recovery systems.”

Journal Impact Factor: Not available for this journal

Funding: “This work was supported by a National Aeronautics and Space Administration, Kennedy Space Center, 2021 Space Technology Mission Directorate Center Innovation Fund.”


Nguyen HN, Sharp GM, Stahl-Rommel S, Velez Justiniano YA, Castro CL, Nelman-Gonzalez M, O’Rourke A, Lee MD, Williamson J, McCool C, Crucian B, Clark KW, Jain M, Castro-Wallace SL.

Microbial isolation and characterization from two flex lines from the urine processor assembly onboard the International Space Station.

Biofilm. 2023 Dec;5:100108.

Note: From the abstract: “Urine, humidity condensate, and other sources of non-potable water are processed onboard the International Space Station (ISS) by the Water Recovery System (WRS) yielding potable water. While some means of microbial control are in place, including a phosphoric acid/hexavalent chromium urine pretreatment solution, many areas within the WRS are not available for routine microbial monitoring. Due to refurbishment needs, two flex lines from the Urine Processor Assembly (UPA) within the WRS were removed and returned to Earth. The water from within these lines, as well as flush water, was microbially evaluated.”

Journal Impact Factor: Not available for this journal

Funding: “This work was supported by NASA Exploration Capabilities and the Johnson Space Center’s Office of the Chief Technologist.”


Other papers of interest:


Gan S, Zhang X, Zhuge S, Ning C, Zhong L, Li Y.

A multi-view vision system for astronaut postural reconstruction with self-calibration.

Aerospace. 2023 Mar 17;10(3):298.

Note: From the abstract: “Space exploration missions involve significant participation from astronauts. Therefore, it is of great practical importance to assess the astronauts’ performance via various parameters in the cramped and weightless space station. In this paper, we proposed a calibration-free multi-view vision system for astronaut performance capture, including two modules: (1) an alternating iterative optimization of the camera pose and human pose is implemented to calibrate the extrinsic camera parameters with detected 2D keypoints. (2) Scale factors are restricted by the limb length to recover the real-world scale and the shape parameters are refined for subsequent postural reconstruction.”


Hart DA.

Homo sapiens—A species not designed for spaceflight: Health risks in low Earth orbit and beyond, including potential risks when traveling beyond the geomagnetic field of Earth.

Life. 2023 Mar 10;13(3):757.

Note: This article and an article above in the “NASA” section (Nemec-Bakk et al.) are part of Special Issue “Advances in Space Biomedicine and Disease Pathogenesis” ( This article may be obtained online without charge.


Akhtar MR, Mondal MNI, Rana HK.

Bioinformatics approach to identify the impacts of microgravity on the development of bone and joint diseases.

Inform Med Unlocked. 2023;38:101211.

Note: From the abstract: “Experiencing long-term weightlessness during prolonged spaceflight in microgravity environments causes enormous changes in human physiology. Past space missions have revealed that low gravity in space is a serious threat to the development of several human diseases, especially bone and joint diseases (BJDs), which have been identified as the major obstacle to long-term space missions. Hence, before sending humans to Mars or long duration spaceflight, it is truly essential to investigate the association of microgravity (MG) on the development of BJDs, however, these are not clearly understood.”


Liu H, Liang M, Deng Y, Li Y.

Simulated microgravity alters P-glycoprotein efflux function and expression via the Wnt/β

-catenin signaling pathway in rat intestine and brain.

Int J Mol Sci. 2023 Mar 12;24(6):5438.

Note: From the introduction: “In this study, hindlimb unloading, random 3D rotary cultured human colon adenocarcinoma cell (Caco-2), and human cerebral microvascular endothelial cell (hCMEC/D3) models were used to simulate microgravity.” This article is part of Section “Biochemistry” ( This article may be obtained online without charge.


Karemaker JM.

A Network [Physiology] approach to find poor orthostatic tolerance by simple tilt maneuvers.

Front Netw Physiol. 2023 Feb 6;3:1125023.

Note: From the article: “For the present study of orthostatic tolerance 2 maneuvers from the whole set were chosen: passive head up tilt from supine to 30° and one to 70°. The former gives a load of 0.5 G, the latter of almost 1 G, while still allowing relaxed standing, fully supported by the tilt table. A stable period of 3-5 minutes was chosen and averaged, allowing about 2 min stabilization.” This article is part of Research Topic “Heart and Vessels: Important Nodes in the Network Inside the Human Body” ( and may be obtained online without charge.


Le H, Rai V, Agrawal DK.

Cholesterol: An important determinant of muscle atrophy in astronauts.

Journal of Biotechnology and Biomedicine. 2023 Mar 2;6:67-79.

Note: From the article: “In this critical review, the role of cholesterol is analyzed across the NASA-established parameters of microgravity-induced muscle atrophy with a focus on potential therapeutic targets for research.” This article may be obtained online without charge.


Cameron SJS, Edwards A, Lambert RJ, Stroud M, Mur LAJ.

Participants in the Trans-Antarctic Winter Traverse expedition showed increased bacterial load and diversity in saliva but maintained individual differences within stool microbiota and across metabolite fingerprints.

Int J Mol Sci. 2023 Mar 2;24(5):4850.

Note: This article is part of Collection “Feature Papers in Molecular Microbiology” ( and may be obtained online without charge.


Vidal V, Boyer L, Luciani A.

Bringing interventional radiology to Mars!

Cardiovasc Intervent Radiol. 2023 Mar 14.

Note: From the abstract: “At present, astronauts on space missions can get medical assistant from Earth. In the future, deep space missions such as missions to Mars will delay communication with physicians on Earth, making it impossible to get immediate support in urgent medical situations. On the spaceship, a polyvalent physician-astronaut could mainly perform small surgery and traumatology procedures. Interventional Radiology (IR) allows minimally invasive interventions and requires small devices. In these conditions of space constrains, IR presents significant benefits. To guarantee the technical realization of specific medical interventions during deep space missions, a team composed of interventional radiologists and space engineers, is developing the IR toolbox. The development of the toolbox intents to minimize the volume/weight of medical devices and to ensure the safety requirements for the crew. New scenarios of IR interventions have been developed to adapt the interventions to the spatial context, making possible the treatment of pathologies that are otherwise, on Earth, optimally treated surgically. Interventional radiology has a major role to play in the management of acute medical problems which may occur in the future story of deep space missions to the Moon, and further to Mars.”


Treigyte V, Eimantas N, Venckunas T, Brazaitis M, Chaillou T.

Moderate muscle cooling induced by single and intermittent/prolonged cold-water immersions differently affects muscle contractile function in young males.

Front Physiol. 2023 Mar 21;14:1172817.

Note: This article is part of Research Topic “Cold, Heat, and Hypoxia as a Medical Tool: The Use in a Healthy and Diseased Population” ( and may be obtained online without charge.


Wu Z, Hu L, Ru K, Zhang W, Xu X, Liu S, Liu H, Jia Y, Liang S, Chen Z, Qian A.

Ellagic acid inhibits CDK12 to increase osteoblast differentiation and alleviate osteoporosis in hindlimb-unloaded and ovariectomized mice.

Phytomedicine. 2023 Jun;114:154745.

Note: Hindlimb unloading study.


Yin JCP, Cui E, Hardin PE, Zhou H.

Circadian disruption of memory consolidation in Drosophila.

Front Syst Neurosci. 2023 Mar 22;17:1129152.

Note: This article is part of Research Topic “Sleep and Circadian Rhythms in Plasticity and Memory – Volume II” (—volume-ii#overview) and may be obtained online without charge.

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