New Space and Tech

NASA Spaceline Current Awareness List #1,041 17 March 2023 (Space Life Science Research Results)

By Keith Cowing
Status Report
March 17, 2023
Filed under , , , , , , , ,
NASA Spaceline Current Awareness List #1,041 17 March 2023 (Space Life Science Research Results)
Space Biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at

Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Freeborn TJ, Critcher S, Hooper G.

Segmental tissue resistance of healthy young adults during four hours of 6-degree head-down-tilt positioning.

Sensors (Basel). 2023 Mar 3;23(5):2793.

Note: Head-down tilt study. This article may be obtained online without charge.

Journal Impact Factor: 3.847

Funding: “This research was supported by funding from the Alabama NASA EPSCoR FY19 Research Infrastructure Development, grant 80NSSC19M0051.”


Lawrence LM, Salary RR, Miller V, Valluri A, Denning KL, Case-Perry S, Abdelgaber K, Smith S, Claudio PP, Day JB.Osteoregenerative potential of 3D-printed poly ε-caprolactone tissue scaffolds in vitro using minimally manipulative expansion of primary human bone marrow stem cells.

Int J Mol Sci. 2023 Mar 3;24(5):4940.

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.208

Funding: “The present studies were partially funded by a Marshall University translational research award (to P.P.C.) In addition, this research work was partially funded by the NASA Established Program to Stimulate Competitive Research (EPSCoR)—Rapid Response Research, Grant #80NSSC22M0249 (to R.S.).”


Flatt AJ, Peleckis AJ, Dalton-Bakes C, Nguyen HL, Ilany S, Matus A, Malone SK, Goel N, Jang S, Weimer J, Lee I, Rickels MR.

Automated insulin delivery for hypoglycemia avoidance and glucose counterregulation in long-standing type 1 diabetes with hypoglycemia unawareness.

Diabetes Technol Ther. 2023 Feb 24. Online ahead of print.

PI: N. Goel

Journal Impact Factor: 7.337

Funding: “This work was supported by Public Health Service research grants R01 DK091331 (to M.R.R.), UL1 TR001878 (University of Pennsylvania Center for Human Phenomic Science), P30 DK19525 (University of Pennsylvania Diabetes Research Center), K99NR017416 (to S.K.M.), and R01 DK11788 (to N.G.); National Aeronautics and Space Administration (NASA) grants NNX14AN49G and 80NSSC20K0243 (to N.G.); Pennsylvania Department of Health grant SAP 4100079750 (to I.L.); the Charles B. Humpton, Jr. Endowed Fellowship in Diabetes Research (to A.J.F.); and the Human Metabolism Resource of the University of Pennsylvania Institute for Diabetes, Obesity & Metabolism. Medtronic supplied discounted 670G insulin pumps and glucose monitoring devices for the study through investigator-initiated grant NERP16-015 (to M.R.R.).”


Mogul R, Miller DR, Ramos B, Lalla SJ.

Metabolomic and cultivation insights into the tolerance of the spacecraft-associated Acinetobacter toward Kleenol 30, a cleanroom floor detergent.

Front Microbiol. 2023 Mar 6;14:1090740.

Note: This article is part of Research Topic “The Impact of the Space Environment on Microbial Growth and Behavior” ( The Research Topic also includes articles from previous Current Awareness List #1,009, and Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

Journal Impact Factor: 6.064

Funding: “This work was supported by a grant (NNH18ZDA001N) from the Planetary Protection Research component of the National Aeronautics and Space Administration (NASA) Research Opportunities in Space and Earth Sciences program.”


Tyson TL, Flynn-Evans EE, Stone LS.

Differential saccade-pursuit coordination under sleep loss and low-dose alcohol.

Front Neurosci. 2023 Feb 16;16:1067722.

Note: This article appeared in last week’s Current Awareness list and it is appearing again to include the write-up of the article from author L.S. Stone: “This study demonstrates that eye-movement-based performance metrics (oculometrics) are sensitive enough to detect small deficits and specific enough to distinguish potential causes. Specifically, low-dose alcohol (< 0.05% BAC) results in impairment of the cortically controlled pursuit system while sleep loss (24 hours awake) impacts cortical, midbrain, and brainstem regions that control both pursuit and the saccadic backup system. Oculometrics also showed that caffeine largely mitigates pursuit deficits from sleep loss but does not restore normal saccades. These findings validate the potential use of oculometrics for the detection/diagnosis of mild neural impairment in operational settings and the assessment of countermeasure efficacy.” This article may be obtained online without charge.

Journal Impact Factor: 5.152

Funding: “This research was supported by the Office of Naval Research (ONR), NASA’s Human Research Program (HRP), and Ames Center Innovation Fund (CIF).”


Other papers of interest:


Kuldavletova O, Navarro Morales DC, Quarck G, Denise P, Clément G.

Spaceflight alters reaction time and duration judgment of astronauts.

Front Physiol. 2023 Mar 17;14:1141078.

Note: ISS results. This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior-Volume II” (—volume-ii#overview). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.


Capri M, Conte M, Ciurca E, Pirazzini C, Garagnani P, Santoro A, Longo F, Salvioli S, Lau P, Moeller R, Jordan J, Illig T, Villanueva MM, Gruber M, Bürkle A, Franceschi C, Rittweger J.

Long-term human spaceflight and inflammaging: Does it promote aging?

Ageing Res Rev. 2023 Mar 12;101909. Review.

Note: From the abstract: “Spaceflight and its associated stressors, such as microgravity, radiation exposure, confinement, circadian derailment, and disruptive workloads represent an unprecedented type of exposome that is entirely novel from an evolutionary stand point. Within this perspective, we aimed to review the effects of prolonged spaceflight on immune-neuroendocrine systems, brain and brain-gut axis, cardiovascular system and musculoskeletal apparatus, highlighting in particular the similarities with an accelerated aging process.”


Ghosh D, Verma E, Gershman S, Anderson T, Kumar Ghosh R, Peter M.

Central nervous system during human spaceflight missions to Mars. A meta-analysis.

Int J Med Sci Clin Invent. 2023 Jan 15;10(01):6411-50.

Note: From the abstract: “The results of more than 50 years of space-related neuroscience studies on people and animals subjected to spaceflight or settings that are similar to spaceflight are reviewed in this article, along with their implications and the future work needed to ensure successful Mars missions.” This article may be obtained online without charge.


Ghosh D, Verma E, Kumar Ghosh R, Gershman S, Anderson T, Peter M.

Challenges and opportunities for neuroscience in the context of spaceflight and the central nervous system.

Int J Med Sci Clin Invent. 2023 Jan 15;10(01):6397-410.

Note: From the article: “We give a summary of what is currently known about the impact of microgravity on the central nervous system (CNS), both in human and cellular models, based on actual spaceflight and parabolic flight investigations as well as ground-based methods appropriate for microgravity-based research. Additionally, we investigate the impact of microgravity on the biology of tumor cells in this review, concentrating on brain tumor cells, in order to provide a fresh perspective on the study of cancer and somewhat novel therapeutic approaches.” This article may be obtained online without charge.


Marfia G, Guarnaccia L, Navone SE, Ampollini A, Balsamo M, Benelli F, Gaudino C, Garzia E, Fratocchi C, Di Murro C, Ligarotti GK, Campanella C, Landolfi A, Perelli P, Locatelli M, Ciniglio Appiani G.

Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine.

Front Physiol. 2023 Mar 14;14:1124991. Review.

Note: From the article: “In the present work, the mechanisms of disc degeneration, the conditions of microgravity, and their association have been discussed in order to identify possible molecular mechanisms underlying disc degeneration and the related clinical manifestations in order to develop a model of prevention to maintain health and performance of air- and space-travelers. The focus on microgravity also allows the development of new proofs of concept with potential therapeutic implications.” This article may be obtained online without charge.


Thoolen SJJ, Kuypers M.

External hemorrhage control techniques for human space exploration: Lessons from the battlefield.

Wilderness Environ Med. 2023 Mar 9. Review. Online ahead of print.


Aventaggiato M, Barreca F, Vitiello L, Vespa S, Valente S, Rotili D, Mai A, Lotti LV, Sansone L, Russo MA, Bizzarri M, Ferretti E, Tafani M.

Role of SIRT3 in microgravity response: A new player in muscle tissue recovery.

Cells. 2023 Feb 22;12(5):691.

Note: A rotary cell culture system was used in this study. This article and the article below (Dubayle et al.) are part of Special Issue “New Insights into Microgravity and Space Biology” ( The Special Issue also includes articles from previous Current Awareness Lists #1,028 #1,032 Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.


Dubayle D, Vanden-Bossche A, Peixoto T, Morel JL.

Hypergravity increases blood-brain barrier permeability to fluorescent dextran and antisense oligonucleotide in mice.

Cells. 2023 Feb 24;12(5).

Note: This article and the article above (Aventaggiato et al.) are part of Special Issue “New Insights into Microgravity and Space Biology” ( This article may be obtained online without charge.


Cui Y, Liu W, Zhao S, Zhao Y, Dai J.

Advances in microgravity directed tissue engineering.

Adv Healthc Mater. 2023 Mar 9;e2202768. Review. Online ahead of print.

Note: From the abstract: “Here, the current status, recent advances, challenges, and prospects of microgravity related to tissue engineering are reviewed.”


Ismaeel A, Van Pelt DW, Hettinger ZR, Fu X, Richards CI, Butterfield TA, Petrocelli JJ, Vechetti IJ, Confides AL, Drummond MJ, Dupont-Versteegden EE.

Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy.

Skelet Muscle. 2023 Mar 10;13:6.

Note: Hindlimb unloading study.


Vilchinskaya N, Lim WF, Belova S, Roberts TC, Wood MJA, Lomonosova Y.

Investigating eEF2k/eEF2 pathway regulation and its role in protein synthesis impairment during disuse-induced skeletal muscle atrophy.

Am J Pathol. 2023 Mar 3;S0002-9440(23)00060-3. Online ahead of print.


Wang Y, Liu H, Wei H, Wu C, Yuan F.

The effect of a knee brace on muscle forces during single-leg landings at two heights.

Int J Environ Res Public Health. 2023 Mar 6;20(5):4652.

Note: From the abstract: “Single-leg landing is one of the maneuvers that has been linked to non-contact anterior cruciate ligament (ACL) injuries, and wearing knee braces has been shown to reduce ACL injury incidence. The purpose of this study was to determine whether wearing a knee brace has an effect on muscle force during single-leg landings at two heights through musculoskeletal simulation.” This article may be obtained online without charge.


Liu CJ, Yang X, Wang SH, Wu XT, Mao Y, Shi JW, Fan YB, Sun LW.

Preventing disused bone loss through inhibition of advanced glycation end products.

Int J Mol Sci. 2023 Mar 3;24(5):4953.

Note: This article is part of Section “Biochemistry” ( and may be obtained online without charge.


Guez-Barber D, Colon LM, Raphael D, Wragan MA, Yun S, Eisch AJ.

Female and male microglia are not different in the dentate gyrus of postnatal day 10 mice.

Neuroscience Letters. 2023 Mar 8;137171.

Note: From the abstract: “Microglia, the resident immune cells of the brain, support normal brain function and the brain’s response to disease and injury. The hippocampal dentate gyrus (DG) is an area of microglial study due to its central role in many behavioral and cognitive functions. Interestingly, microglia and related cells are distinct in female vs. male rodents, even in early life. Indeed, postnatal day (P)-dependent sex differences in number, density, and morphology of microglia have been reported in certain hippocampal subregions at specific ages. However, sex differences in the DG have not yet been assessed at P10, a rodent developmental time point translationally relevant to human term gestation. To address this knowledge gap, Iba1+ cells in the DG (which are enriched in the Hilus and Molecular Layer) in female and male C57BL/6J mice were analyzed for their number (via stereology) and density (via stereology and via sampling).”


Cariati I, Bonanni R, Rinaldi AM, Marini M, Iundusi R, Gasbarra E, Tancredi V, Tarantino U.

Recombinant irisin prevents cell death and mineralization defects induced by random positioning machine exposure in primary cultures of human osteoblasts: A promising strategy for the osteoporosis treatment.

Front Physiol. 2023 Mar 15;14:1107933.

Note: A random positioning machine was used in this study.


Ge YX, Zhuang HJ, Zhang TW, Liang HF, Ding W, Zhou L, Dong ZR, Hu ZC, Chen Q, Dong J, Jiang LB, Yin XF.

Precise manipulation of circadian clock using MnO2

 nanocapsules to amplify photodynamic therapy for osteosarcoma.

Mater Today Bio. 2023 Apr;19:100547.


Zhang P, Yan J, Liu Z, Zhou Q.

Impeded frontal-occipital communications during Go/Nogo tasks in humans owing to mental workload.

Behav Brain Res. 2023 Feb 13;438:114182.

Note: From the abstract: “Human brains rely on oscillatory coupling mechanisms for regulating access to prefrontal cognitive resources, dynamically communicating between the frontal and remote cortex. We worry that communications across cortical regions will be impeded when humans in extreme space environments travel with mental load work, affecting the successful completion of missions. Here, we monitored crews of workers performing a Go/Nogo task in space travel, accompanied by acquisitions of electroencephalography (EEG) signals.”


Cavelli ML, Mao R, Findlay G, Driessen K, Bugnon T, Tononi G, Cirelli C.

Sleep/wake changes in perturbational complexity in rats and mice.

iScience. 2023 Mar 17;26(3):106186.

Note: From the abstract: “In humans, the level of consciousness is assessed by quantifying the spatiotemporal complexity of cortical responses using Perturbational Complexity Index (PCI) and related PCIst

 (st, state transitions). Here, we validate PCIst

 in freely moving rats and mice by showing that it is lower in NREM sleep and slow wave anesthesia than in wake or REM sleep, as in humans.” This article may be obtained online without charge.

SpaceRef co-founder, Explorers Club Fellow, ex-NASA, Away Teams, Journalist, Space & Astrobiology, Lapsed climber.