New Space and Tech

NASA Spaceline Current Awareness List #1,040 10 March 2023 (Space Life Science Research Results)

By Keith Cowing
Status Report
March 10, 2023
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NASA Spaceline Current Awareness List #1,040 10 March 2023 (Space Life Science Research Results)
Astronaut Kjell Lindgren processes samples inside the Life Science Glovebox. (July 26, 2022)

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Wiggs MP, Lee Y, Shimkus KL, O’Reilly CI, Lima F, Macias BR, Shirazi-Fard Y, Greene ES, Hord JM, Braby LA, Carroll CC, Lawler JM, Bloomfield SA, Fluckey JD.

Combined effects of heavy ion exposure and simulated Lunar gravity on skeletal muscle.

Life Sci Space Res. 2023 May;37:39-49.

PIs: B.R. Macias, J.M. Lawler, S.A. Bloomfield

Note: From the abstract: “The limitations to prolonged spaceflight include unloading-induced atrophy of the musculoskeletal system which may be enhanced by exposure to the space radiation environment. Previous results have concluded that partial gravity, comparable to the Lunar surface, may have detrimental effects on skeletal muscle. However, little is known if these outcomes are exacerbated by exposure to low-dose rate, high-energy radiation common to the space environment. Therefore, the present study sought to determine the impact of highly charge, high-energy (HZE) radiation on skeletal muscle when combined with partial weight bearing to simulate Lunar gravity. We hypothesized that partial unloading would compromise skeletal muscle and these effects would be exacerbated by radiation exposure.”

Journal Impact Factor: 2.73

Funding: “These studies were funded through the NASA Cooperative Agreement NCC 9-58 with the National Space Biomedical Research Institute (SAB). Supported was also provided by a National Space Biomedical Research Institute Graduate Training Fellowship (no. NSBRI-RFP-05-02; KLS and BRM).”

“NASA (ROSBio 2018) (80NSSC19K0432) John Lawler (PI), Jim Fluckey (CoI) ‘Upstream Regulation of Nox2 and Skeletal Muscle Atrophy During Spaceflight.’ 2019-2023. NASA HERO (Human Exploration Research) 16-16Flag1_2-0043 (NNX-80NSSC17K0118) JM Lawler (PI), JF Ford (CoI), N Turner (CoI). Attenuation of Space Radiation-induced Pro-oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing. 2017-2022.”


Tyson TL, Flynn-Evans EE, Stone LS.

Differential saccade-pursuit coordination under sleep loss and low-dose alcohol.

Front Neurosci. 2023 Feb 16;16:1067722.

Note: From the abstract: “Ocular tracking of a moving object requires tight coordination between smooth pursuit and saccadic eye movements. Normally, pursuit drives gaze velocity to closely match target velocity, with residual position offsets corrected by catch-up saccades. However, how/if common stressors affect this coordination is largely unknown. This study seeks to elucidate the effects of acute and chronic sleep loss, and low-dose alcohol, on saccade-pursuit coordination, as well as that of caffeine.” This article may be obtained online without charge.

Journal Impact Factor: 5.152

Funding: “This research was supported by the Office of Naval Research (ONR), NASA’s Human Research Program (HRP), and Ames Center Innovation Fund (CIF).”


Allred AR, Clark TK.

Vestibular perceptual thresholds for rotation about the yaw, roll, and pitch axes.

Exp Brain Res. 2023 Mar 4.

Note: From the abstract: “This effort seeks to further assess human perception of self-motion by quantifying and comparing Earth-vertical rotational vestibular perceptual thresholds about the yaw, roll, and pitch axes.”

Journal Impact Factor: 2.064

Funding: “This work was supported by a NASA Space Technology Graduate Research Opportunities Award.”


Fettrow T, Hupfeld K, Hass C, Pasternak O, Seidler R.

Neural correlates of gait adaptation in younger and older adults.

Sci Rep. 2023 Mar 8;13(1):3842.

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.996

Funding: T. Fettrow is affiliated with NASA Langley Research Center.


Other papers of interest:


Bharindwal S, Goswami N, Jha P, Pandey S, Jobby R.

Prospective use of probiotics to maintain astronaut health during spaceflight.

Life. 2023 Mar 8;13(3):727. Review.

Note: This article is part of Special Issue “Gravitational Microbiology Research and Applications” ( The Special Issue also includes articles from previous Current Awareness Lists #984; #1,006 and; #1,011; #1,016; #1,022; and #1,039 Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.


Derobertmasure A, Kably B, Justin J, De Sousa Carvalho C, Billaud EM, Boutouyrie P.

Dried urine spot analysis for assessing cardiovascular drugs exposure applicable in spaceflight conditions.

J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Mar 23;1219:123539.

Note: From the abstract: “Cardiovascular pharmacological countermeasures will be required as a preventive measure of cardiovascular deconditioning and early vascular ageing for long term space travelers. Physiological changes during spaceflight could have severe implications on drug pharmacokinetics and pharmacodynamics (PK/PD). However, limitations exist for the implementation of drug studies due to the requirements and constraints of this extreme environment. Therefore, we developed an easy sampling method on dried urine spot (DUS), for the simultaneous quantification of 5 antihypertensive drugs in human urine: irbesartan, valsartan, olmesartan, metoprolol and furosemide analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), considering spaceflight parameters.”


Liu Y, Xu C, Zhao G, Wang Y, Zhu Y, Yin Y, Wang J, Li Y.

Effect of spaceflight on the phenotype and proteome of Escherichia coli.

Open Life Sci. 2023 Feb 28;18(1):20220576.

Note: From the article: “E. coli K12 strain (CGMCC 1.2389) was purchased from China General Microbiological Culture Collection Center (CGMCC). After cultivating E. colito the exponential phase (OD600

 = 1), 20 µL of bacteria was inoculated into an lysogeny broth (LB) agar slant culture medium. After being incubated at 37°C for 16 hours, samples were cultured in space for 12 days, carried by the Shijian 10 satellite. The orbital height of the satellite is 252 km, the orbital inclination is 42°, and the average daily radiation equivalent dose is 160 µSv. Strains were stored at -20°C after returning.” This article may be obtained online without charge.


Sun Y, Guo S, Yang J, Li Y, Sun Z, Kwok LY, Sun T, Liu W, Liu W.

The space environment activates capsular polysaccharide production in Lacticaseibacillus rhamnosus probio-M9 by mutating the wze (ywqD) gene.

Microbiol Spectr. 2023 Mar 2;e0467722. Online ahead of print.

Note: From the article: “We prepared two parallel sets of cells of two growth conditions (streaking on de Man, Rogosa, and Sharpe [MRS] agar submerged in 20% glycerol). One set of cells was used for the spaceflight mutagenesis experiment (samples were flown into space with a Long March 5B rocket), while the other one served as the ground control (kept at a simulated launch base without space exposure). After the spaceflight, single clones of space mutants and ground control isolates were picked for analysis.” This article may be obtained online without charge.


Banken E, Oeffner J.

Biomimetics for innovative and future-oriented space applications – A review.

Front Space Technol. 2023 Mar 7;3:1000788.

Note: This article is part of Research Topic “Challenges and Solutions for Operating in Extreme Space Environments” ( This article may be obtained online without charge.


Beiranvand H, Ayoobi M, Mortezapour A, Naseh H.

Applying ergonomics for beyond the Earth: Integrating participatory ergonomic design for sending a human to space.

Work. 2023 Feb 27. Online ahead of print.

Note: From the abstract: “The aim of this study was to provide insight into the collaborative ergonomic design process for an astronaut workstation within a small spaceship.”


Le Roy B, Martin-Krumm C, Trousselard M.

Mindfulness for adaptation to analog and new technologies emergence for long-term space missions.

Front Space Technol. 2023 Feb 13;4:1109556.

Note: This article is part of Research Topic “Space Analogs and Habitats” ( This article may be obtained online without charge.


Hu J, Chen H, Wang H, Zheng H, Cai W, Xu P.

A protocol for measuring the response of Arabidopsis roots to gravity and treatment for simulated microgravity.

STAR Protoc. 2023 Mar;4(1):102099.

Note: A 3D clinostat was used in this study.


Murali A, Sarkar RR.

Mechano-immunology in microgravity.

Life Sci Space Res. 2023 Mar 7. Review.

Note: From the abstract: “Life on Earth has evolved to thrive in the Earth’s natural gravitational field; however, as space technology advances, we must revisit and investigate the effects of unnatural conditions on human health, such as gravitational change. Studies have shown that microgravity has a negative impact on various systemic parts of humans, with the effects being more severe in the human immune system. Increasing costs, limited experimental time, and sample handling issues hampered our understanding of this field. To address the existing knowledge gap and provide confidence in modelling the phenomena, in this review, we highlight experimental works in mechano-immunology under microgravity and different computational modelling approaches that can be used to address the existing problems.”

10Sventitskaya МА, Ogneva IV.

Change in the content of cytoskeletal proteins in mouse oocytes after injection of essential phospholipids under simulated microgravity.

Aviakosm Ekolog Med. 2023;57(1):44-8. Russian.

Note: From the abstract: “This paper presents an evaluation of the effect of different doses of essential phospholipids on the cytoskeleton of mouse oocyte microtubes and microfilaments cultivated on a microgravity simulator.”


Gibbs A, Gupta P, Mali B, Poirier Y, Gopalakrishnan M, Newman D, Zodda A, Down JD, Serebrenik AA, Kaytor MD, Jackson IL.

A C57L/J mouse model of the delayed effects of acute radiation exposure in the context of evolving multi-organ dysfunction and failure after total-body irradiation with 2.5% bone marrow sparing.

Radiat Res. 2023 Mar 2. Online ahead of print.


Zhang Z, Wang Z, Luo T, Yan M, Dekker A, De Ruysscher D, Traverso A, Wee L, Zhao L.

Computed tomography and radiation dose images-based deep-learning model for predicting radiation pneumonitis in lung cancer patients after radiation therapy.

Radiother Oncol. 2023 Feb 24;109581. Online ahead of print.

13Deshevaya ЕА, Fialkina SV, Guridov АА, Shashkovsky SG, Kireev SG, Khamidullina NM, Zakharenko DV.

Use of pulse uv technologies to ensure microbiological purity during preparation for missions with planetary protection requirements.

Aviakosm Ekolog Med. 2023;57(1):67-74. Russian.


Grigoriev AI, Orlov OI, Potapov AN.

Role of the native space medicine and physiology in exploration of outer space.

Aviakosm Ekolog Med. 2023;57(1):Russian.


Rodina AV, Zhirnik AS, Vysotskaya OV, Smirnova OD, Semochkina YP, Ratushniak MG, Cheshigin IV, Moskaleva EY.

Cellular and molecular markers of neuroinflammation and state of cognitive functions in a delayed period after prolonged γ-, n-irradiation of mice at low doses.

Aviakosm Ekolog Med. 2023;57(1):34-43. Russian.


Huang Y, Zhang W, Li Q, Wang Z, Yang X.

Identification of m6A/m5C/m1A-associated LncRNAs for prognostic assessment and immunotherapy in pancreatic cancer.

Sci Rep. 2023 Mar 4;13:3661.

Note: This article may be obtained online without charge.


Hou W, Fu R, Zhu M, Zhu H, Ding C.

[Effects of repetitive transcranial magnetic stimulation on neuronal excitability and ion channels in hindlimb unloading mice].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023 Feb 25;40(1):8-19. Chinese.

Note: Hindlimb unloading study.


Krivonogov IA, Solovieva ZO, Skedina MA, Ilyin VK.

Tinctorial and morphological properties of microbial objects for formation of an electronic atlas within an automated analysis system.

Aviakosm Ekolog Med. 2023;57(1):75-81. Russian.

Note: From the abstract: “The authors present the results of automated analysis of gram positive and gram negative cocci and bacilli for a database that facilitates detection of changes in normal microflora and diagnosis of disbiotic conditions of various human biotopes.”


Gornostaeva AN, Buravkova LB.

Immunomodulator sensitivity of innate immunity cells in healthy human subjects during 21-day dry immersion.

Aviakosm Ekolog Med. 2023;57(1):21-8. Russian.


Sheblaeva AS, Solovieva ZO, Rukavishnikov IV, Nosovsky AM, Tsarev VN, Podporin MS, Bystrov aOV, Lovtsevich SM, Ilyin VK.

Comparison of the bacteriological method and mass spectrometry of microbial markers for quantitative estimation of human periodontopathogenic microbiota in a dry immersion study.

Aviakosm Ekolog Med. 2023;57(1):29-33. Russian.


Laosuntisuk K, Elorriaga E, Doherty CJ.

The game of timing: Circadian rhythms intersect with changing environments.

Annu Rev Plant Biol. 2023 May;74(1). Review.


Zibarev EV, Bukhtiyarov IV, Kravchenko OK, Klimov АА, Ivashov SN.

The role of fatigue of civil aviation aircrews in genesis of aviation accidents.

Aviakosm Ekolog Med. 2023;57(1):49-62. Russian.

SpaceRef co-founder, Explorers Club Fellow, ex-NASA, Away Teams, Journalist, Space & Astrobiology, Lapsed climber.