NASA Spaceline Current Awareness List #1,039 13 March 2023 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm.
Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Su S-H, Levine HG, Masson PH.
Brachypodium distachyon seedlings display accession-specific morphological and transcriptomic responses to the microgravity environment of the International Space Station.
Life. 2023 Feb 23;13(3):626.
https://doi.org/10.3390/life13030626
PI: P.H. Masson
Note: ISS results. This article is part of Special Issue “Plants and Microgravity” (https://www.mdpi.com/journal/life/special_issues/plants_microgravity). The Special Issue also includes articles from previous Current Awareness Lists #1,019 https://doi.org/10.3390/life12101484 and #1,025 https://doi.org/10.3390/life12111809 and https://doi.org/10.3390/life12111782. Additional articles will be forthcoming and may be found in the link to the Special Issue. GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.
Journal Impact Factor: 3.253
Funding: “This research was funded by the NASA Space Biology Program (grant number NNX14AT23G and 80NSSC19K1483) and the National Science Foundation (grant number 1951182-IOS).”
2
Ebnali M, Paladugu P, Miccile C, Park SH, Burian B, Yule S, Dias RD.
Extended reality applications for space health.
Aerosp Med Hum Perform. 2023 Mar 1;94(3):122-30.
https://doi.org/10.3357/AMHP.6131.2023
PI: R.D. Dias
Note: From the abstract: “This study aims to systematically review the scientific literature that has explored the application of extended reality (XR) technologies in the space health field. We also discuss the methodological and design characteristics of the existing studies in this realm, informing future research and development efforts on applying XR technologies to improve space health and enhance crew safety and performance.”
Journal Impact Factor: 0.889
Funding: “This work was funded by the Translational Research Institute for Space Health (TRISH) through NASA Cooperative Agreement NNX16AO69A (Grant # T0506).”
3
Sano S, Thel MC, Walsh K.
Clonal hematopoiesis: The nonhereditary genetics of age-associated cardiovascular disease.
Curr Opin Cardiol. 2023 Feb 22.
https://pubmed.ncbi.nlm.nih.gov/36811645
PI: K. Walsh
Note: From the abstract: “Somatic mutations, described as noninherited changes in DNA that arise and are passed on to descendant cells, are well known to cause cancers; however, it is increasingly appreciated that the propagation of somatic mutations within a tissue may have a role in causing nonneoplastic disorders and abnormalities in elderly individuals. The nonmalignant clonal expansion of somatic mutations in the hematopoietic system is termed clonal hematopoiesis. This review will briefly discuss how this condition has been linked to various age-related diseases outside the hematopoietic system.”
Journal Impact Factor: 2.108
Funding: “This work was supported by the National Institutes of Health (NIH) grants AG073249, AG072095, HL142650, and HL152174 and NASA grant 80NSSC21K0549 to K.W.; Grant-in-Aid for Research Activity Start-up 21K20879 to S.S.; Grant-in-Aid for Scientific Research C 22K08162 to S.S.; and the MSD Life Science Foundation (S.S.); the Cardiovascular Research Fund (S.S.); The Japanese Heart Failure Society (S.S.).”
4
Naruse M, Trappe S, Trappe TA.
Human skeletal muscle-specific atrophy with aging: A comprehensive review.
J Appl Physiol (1985). 2023 Feb 24. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36825643
PI: S. Trappe
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.880
Funding: “This work and our skeletal muscle imaging research has been supported by grants from the NIH (AG-020532, AG-15833, AG-00831, AG-038576, AG-18409, AG-15486) and NASA (NNJ06HF59G, EC400-NCC9-116, NNJ04HF72G).”
5
Crews LA, Ma W, Ladel L, Pham J, Balaian L, Steel SK, Mondala PK, Diep RH, Wu CN, Mason CN, van der Werf I, Oliver I, Reynoso E, Pineda G, Whisenant TC, Wentworth P, La Clair JJ, Jiang Q, Burkart MD, Jamieson CHM.
Reversal of malignant ADAR1 splice isoform switching with Rebecsinib.
Cell Stem Cell. 2023 Feb 14. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36803553
Note: This article may be obtained online without charge.
Journal Impact Factor: 25.269
Funding: “We would like to thank our funding agencies for their vital support, including NIH/NCI R01CA205944, NIH/NIDDK R01DK114468-01, NIH/NCI 2P30CA023100-28, CIRM TRAN1-10540 for Rebecsinib pre-IND studies, the MPN Research Foundation, the Leukemia & Lymphoma Society (LLS) Blood Cancer Discoveries grant that supported in part the biomarker analysis, NASA NRA-NNJ13ZBG001N, and NIH/NCATS UL1TR001442.”
6
Sekel NM, Beckner ME, Conkright WR, LaGoy AD, Proessl F, Lovalekar M, Martin BJ, Jabloner LR, Beck AL, Eagle SR, Dretsch M, Roma PG, Ferrarelli F, Germain A, Flanagan SD, Connaboy C, Haufler AJ, Nindl BC.
Military tactical adaptive decision making during simulated military operational stress is influenced by personality, resilience, aerobic fitness, and neurocognitive function.
Front Psychol. 2023 Feb 8;14:1102425.
https://pubmed.ncbi.nlm.nih.gov/36844343
PI: P.G. Roma
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.232
Funding: “PGR was supported in part by KBR’s Human Health and Performance Contract NNJ15HK11B through the National Aeronautics and Space Administration.”
7
Song JW, Ryu H, Bai W, Xie Z, Vázquez-Guardado A, Nandoliya K, Avila R, Lee G, Song Z, Kim J, Lee MK, Liu Y, Kim M, Wang H, Wu Y, Yoon HJ, Kwak SS, Shin J, Kwon K, Lu W, Chen X, Huang Y, Ameer GA, Rogers JA.
Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites.
Sci Adv. 2023 Feb 22;9(8):eade4687.
https://pubmed.ncbi.nlm.nih.gov/36812305
Note: This article may be obtained online without charge.
Journal Impact Factor: 14.957
Funding: “… Elemental analysis was performed at the Northwestern University Quantitative Bio-element Imaging Center supported by NASA Ames Research Center Grant NNA04CC36G. …”
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Other papers of interest:
1
Ilyin V, Orlov O, Skedina M, Korosteleva A, Molodtsova D, Plotnikov E, Artamonov A.
Mathematical model of antibiotic resistance determinants’ stability under spaceflight conditions.
Astrobiology. 2023 Feb 24. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36827596
Note: ISS results. From the abstract: “Increasing antibiotic resistance (AR) poses dangers of treatment complications and even treatment failure to astronauts. An AR determinant is a gene of resistance carried by bacteria. This article considers the issue of the stability of AR determinants and the influence of manned spaceflight conditions on this characteristic. A phenomenological model has been developed that makes it possible to evaluate the integral value of the stability of determinants of AR in bacteria as a function of time. Based on experimental results obtained during implementation of the SALYUT 7 space program, the stability of determinants of AR in Escherichia coli strains isolated before and after a spaceflight in 16 astronauts was evaluated.” This article may be obtained online without charge.
2
Sakharkar A, Yang J.
Designing a novel monitoring approach for the effects of space travel on astronauts’ health.
Life (Basel). 2023 Feb 18;13(2):576.
https://pubmed.ncbi.nlm.nih.gov/36836933
Note: ISS results. This article is part of Special Issue “Advances in Space Biology” (https://www.mdpi.com/journal/life/special_issues/_space_biology). The Special Issue also includes articles from previous Current Awareness Lists #1,002 https://doi.org/10.3390/life12050610, #1,015 https://doi.org/10.3390/life12081176, #1,019 https://doi.org/10.3390/life12101498, #1,025 https://doi.org/10.3390/life12111838; and #1,034 https://doi.org/10.3390/life13010200. Additional articles will be forthcoming and may be found in the link to the Special Issue. GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.
3
Long MA, Hayes RB.
Evaluation of existing public dose limits applied to recreational spaceflight.
Radiat Prot Dosimetry. 2023 Feb 24;ncad037. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36840519
Note: From the abstract: “Establishing realistic radiation dose limits with a solid scientific basis is a key component of the ‘as low as reasonably achievable’ (ALARA) principle. Although existing occupational dose limits have been established for civil astronauts, with the rise in popularity and technological maturation of the ‘space tourism’ sector, there does not appear to be considerable discussion on the subject of non-occupational astronaut dose limits. The necessity to come to a collective decision on dose limits and radiation safety procedures for recreational spaceflight is urgent and imperative to maintain ALARA goals, as existing federal dose limits to the public cannot be adequately or universally applied to the space tourism sector. Development of an entirely new set of regulations and guidelines should also provide long-term benefits in public perception as evidence of safety commitments from decision makers and the community in protecting passengers from radiological risks balanced with other spaceflight hazards.”
4
Reilly MA, Katz SE, Roberts CJ.
Orbital fat swelling: A biomechanical theory and supporting model for spaceflight-associated neuro-ocular syndrome (SANS).
Front Bioeng Biotechnol. 2023 Feb 9;11:1095948.
https://pubmed.ncbi.nlm.nih.gov/36845176
Note: From the abstract: “Spaceflight-Associated Neuro-ocular Syndrome (SANS) is a descriptor of several ocular and visual signs and symptoms which commonly afflicts those exposed to microgravity. We propose a new theory for the driving force leading to the development of Spaceflight-Associated Neuro-ocular Syndrome which is described via a finite element model of the eye and orbit.” This article is part of Research Topic “Ocular Biomechanics in Health and Pathophysiology” (https://www.frontiersin.org/research-topics/48551/ocular-biomechanics-in-health-and-pathophysiology#overview). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
5
Wazir HU, Narang P, Silvani G, Mehner C, Poole K, Burke C, Chou J.
Bacterial virulence and prevention for human spaceflight.
Life. 2023 Feb 27;13(3):656.
https://doi.org/10.3390/life13030656
Note: A random positioning machine was used in this study. This article is part of Special Issue “Gravitational Microbiology Research and Applications” (https://www.mdpi.com/journal/life/special_issues/gravitational_microbiology). The Special Issue also includes articles from previous Current Awareness Lists #984 https://doi.org/10.3390/life12010047; #1,006 https://doi.org/10.3390/life12060774and https://doi.org/10.3390/life12050660; #1,011 https://doi.org/10.3390/life12081168; #1,016 https://doi.org/10.3390/life12091399, and #1,022 https://doi.org/10.3390/life12101522. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
6
Liang R, Wang L, Li X, Liu X, Chang H, Xu Q, Wang Y, Xu D, Liu D, Yang J, Zheng C, Ming D.
Repetitive transcranial magnetic stimulation rescues simulated space complex environment-induced emotional and social impairments by enhancing neuronal excitability in the medial prefrontal cortex.
Cereb Cortex. 2023 Feb 22;bhad027. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36813305
7
Yan L, Sun C, Zhang Y, Zhang P, Chen Y, Deng Y, Er T, Deng Y, Wang Z, Ma H.
The biological implication of semicarbazide-sensitive amine oxidase (SSAO) upregulation in rat systemic inflammatory response under simulated aerospace environment.
Int J Mol Sci. 2023 Feb 11;24(4):3666.
https://pubmed.ncbi.nlm.nih.gov/36835077
Note: This article is part of Special Issue “Small Molecules, Influence of Molecular Pathways 2.0” (https://www.mdpi.com/journal/ijms/special_issues/smallmolecules_2). This article may be obtained online without charge.
8
Tan S, Tran V, Stretton B, Gupta A, Kovoor J, Bacchi S.
The final frontier: Palliative care in space is an inevitability.
J Palliat Care. 2023 Feb 27;8258597231159839. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36846866
Note: From the abstract: “As space exploration becomes increasingly common, palliative care for astronauts will require greater consideration. All aspects of palliative care need to be specifically adapted for astronauts. For example, addressing additional circumstances such as inability to see loved ones from Earth will be an important part of meeting their psychological and spiritual needs. A different approach to pharmacological management of end-of-life symptoms is also warranted due to changes in human physiology and pharmacokinetics in space.” This article may be obtained online without charge.
9
Beer J, Morse B, Dart T, Adler S, Sherman P.
Lingering altitude effects during piloting and navigation in a synthetic cockpit.
Aerosp Med Hum Perform. 2023 Mar 1;94(3):135-41.
https://doi.org/10.3357/AMHP.6149.2023
Note: From the abstract: “A study was performed to evaluate a cockpit flight simulation suite for measuring moderate altitude effects in a limited subject group. Objectives were to determine whether the apparatus can detect subtle deterioration, record physiological processes throughout hypobaric exposure, and assess recovery.”
10
Burles F, Williams R, Berger L, Pike GB, Lebel C, Iaria G.
The unresolved methodological challenge of detecting neuroplastic changes in astronauts.
Life (Basel). 2023 Feb 11;13(2):500.
https://pubmed.ncbi.nlm.nih.gov/36836857
Note: This article is part of Special Issue “Advances in Space Biomedicine and Disease Pathogenesis” (https://www.mdpi.com/journal/life/special_issues/Space_Biomedicine). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
11
Dehe L, Hohendanner F, Gültekin E, Werth G, Wutzler A, Bender TO.
Hypoxia altitude simulation and reduction of cerebral oxygenation in COPD patients.
Aerosp Med Hum Perform. 2023 Mar 1;94(3):102-6.
https://doi.org/10.3357/AMHP.6102.2023
12
Liu S, Yao Y, Liu Q, Cao W, Ba J.
Development and validation of a novel head-down tilt microgravity simulation device for canines.
Microgravity Sci Technol. 2023 Mar 1;35:15.
https://doi.org/10.1007/s12217-023-10039-y
Note: Head-down tilt study.
13
Chen W, Li C, Jiang X.
Advanced biomaterials with intrinsic immunomodulation effects for cancer immunotherapy.
Small Methods. 2023 Feb 21;e2201404. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36811240
14
Pridham PS, Stirling L.
Ankle exoskeleton torque controllers based on soleus muscle models.
PLoS One. 2023 Feb 27;18(2):e0281944.
https://pubmed.ncbi.nlm.nih.gov/36848340
Note: This article may be obtained online without charge.
15
D’Amora U, Ronca A, Scialla S, Soriente A, Manini P, Phua JW, Ottenheim C, Pezzella A, Calabrese G, Raucci MG, Ambrosio L.
Bioactive composite methacrylated gellan gum for 3D-printed bone tissue-engineered scaffolds.
Nanomaterials (Basel). 2023 Feb 19;13(4):772.
https://pubmed.ncbi.nlm.nih.gov/36839140
Note: This article is part of Special Issue “Micro- and Nanostructured Biomaterials for Biomedical Applications and Regenerative Medicine” (https://www.mdpi.com/journal/nanomaterials/special_issues/H955H1E5IL). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
16
Heggli U, Swanenburg J, Hofstetter L, Häusler M, Schweinhardt P, Bron D.
Typical cockpit ergonomics influence on cervical motor control in healthy young male adults.
Aerosp Med Hum Perform. 2023 Mar 1;94(3):107-12.
https://doi.org/10.3357/AMHP.6096.2023
Note: From the abstract: “Neck pain and injury are common problems in military high-performance aircraft and helicopter aircrews. A contributing factor may be the reclined sitting position in cockpits. This study aimed to determine the effect of typical cockpit ergonomics on cervical proprioception, assessed by using the cervical joint position error (cJPE).”
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