New Space and Tech

NASA Spaceline Current Awareness List #1,036 10 February 2023 (Space Life Science Research Results)

By Keith Cowing
Status Report
February 10, 2023
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NASA Spaceline Current Awareness List #1,036 10 February 2023 (Space Life Science Research Results)
NASA astronaut Kayla Barron sets up the Plant Habitat-05 Growth experiment that is studying cotton genetics in microgravity. — NASA

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at

Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:

1 Scott JM, Feiveson AH, English KL, Spector ER, Sibonga JD, Lichar Dillon E, Ploutz-Snyder L, Everett ME.

Effects of exercise countermeasures on multisystem function in long duration spaceflight astronauts.

npj Microgravity. 2023 Feb 3;9:11.

PI: L. Ploutz-Snyder

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.97

Funding: “This study was supported by the Human Research Program of the National Aeronautics and Space Administration (NASA). JMS is supported by the Memorial Sloan Kettering Cancer Center Support Grant/Core Grant (P30 CA008748). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”

2 Fernandez W, Levin D, Steller JG, Kerstman E, Lemery J, Zahner C, Davis HE, Lehnhardt K, Easter B, Kreykes AJ.

Task impairment: A novel approach for assessing impairment during exploration-class spaceflight missions.

J Space Saf Eng. 2023 Jan 11. Online ahead of print.

Note: From the abstract: “Long duration deep space exploration missions require an innovative assessment for medical impairment. Task Impairment is a novel, dynamic, and mission-appropriate impairment paradigm which will replace Functional Impairment, the metric used currently by the NASA Integrated Medical Model for probabilistic risk assessment on the International Space Station. To derive Task Impairment, the Human Exploration of Mars: Preliminary List of Crew Tasks was used as the source of likely exploration mission tasks.”

Journal Impact Factor: Not available for this journal

Funding: D. Levin, J.G. Steller, E. Kerstman, J. Lemery, C. Zahner, K. Lehnhardt, and B. Easter are affiliated with NASA Johnson Space Center.

3 Valencia WE, Mason SS, Brunstetter TJ, Sargsyan AE, Schaefer CM, Tarver WJ, Van Baalen MG, Gibson CR, Lee AG, Danilichev SN, Hinton PV, Makarov IA, Matveev VP, Stern CH, Taniguchi-Shinojima A, Feldon SE.

Evaluation of optic disc edema in long-duration spaceflight crewmembers using retinal photography.

J Neuroophthalmol. 2023 Jan 4. Online ahead of print.

Note: From the abstract: “Long-duration spaceflight crewmembers are at risk for spaceflight-associated neuro-ocular syndrome (SANS). One of the earliest manifestations of SANS is optic disc edema (ODE), which could be missed using the subjective Frisén scale. The primary objective of this study is to determine the inter-rater and intrarater reliability of Frisén grade for SANS-induced ODE among a trained observer cohort. The secondary objective is to propose a standardized evaluation process for SANS-induced ODE across International Space Station Partner Agencies.”

Journal Impact Factor: 4.415

Funding: S.S. Mason, T.J. Brunstetter, A.E. Sargsyan, W.J. Tarver, and M.G. Van Baalen are affiliated with NASA Johnson Space Center.

4 Paromita P, Khader A, Begerowski S, Bell ST, Chaspari T.

Linguistic and vocal markers of microbehaviors between team members during analog space exploration missions.

IEEE Pervasive Comput. 2023 Jan 31;1-12. Online ahead of print.

PIs: S.T. Bell, T. Chaspari

Note: From the abstract: “We used machine learning classifiers and dialog state tracking models, combined with natural language processing techniques relying on lexicon-based methods and data-driven methods, to automatically detect positive and negative microbehaviors between team members in nine, four-person teams in a simulated space habitat.”

Journal Impact Factor: 1.603

Funding: “This work was supported by NASA through Human Research Program under Grant NNX16AQ48G (PI=Bell), Grant #80NSSC22K0775 (PI=Chaspari) and in part by NASA through Human Health and Performance Contract NNJ15HK11B.”

5 Cotter KM, Bancroft GL, Haas HA, Shi R, Clarkson AN, Croxall ME, Stowe AM, Yun S, Eisch AJ.

Use of an automated mouse touchscreen platform for quantification of cognitive deficits after central nervous system injury.

In: Karamyan, VT, Stowe, AM, eds. Neural Repair. Methods in Molecular Biology. Vol. 2616. New York, NY: Humana, 2023. p. 279-326.

PI: S. Yun

Funding: “NIH (NS 088555-07A1, PI: AMS), NASA (80NSSC21K0814, PI: SY), University of Pennsylvania (Dept Radiation Oncology Pilot Grant, co-PI: AJE; Undergraduate Research Foundation, PI: SY; Trainees: GLB, HAH), the Brain and Behavior Research Foundation (2019 NARSAD Young Investigator Grant, PI: SY), Children Hospital of Philadelphia (2022 Forderer Grant, co-PI: SY).”

6 Schulte SJ, Huang J, Pierce NA.

Hybridization chain reaction lateral flow assays for amplified instrument-free at-home SARS-CoV-2 testing.

ACS Infectious Diseases. 2023 Feb 03. Online ahead of print.

Journal Impact Factor: 5.578

Funding: “This work was funded by the Shurl and Kay Curci Foundation, by the Richard N. Merkin Institute for Translational Research at Caltech, by the National Aeronautics and Space Administration (Translational Research Institute for Space Health; NNX16AO69A), and by the National Institutes of Health (NIBIB R01EB006192 and NIGMS training grant GM008042 to S.J.S.).”


Other papers of interest:

1 Li W, Shu X, Zhang X, Zhang Z, Sun S, Li N, Long M.

Potential roles of YAP/TAZ mechanotransduction in spaceflight-induced liver dysfunction.

Int J Mol Sci. 2023 Jan 22;24(3):2197. Review.

Note: This article is part of Special Issue “Molecular Mechanobiology in Space and on Earth 2.0” ( The Special Issue also includes articles from previous Current Awareness Lists #1,004 and #1,031 This article may be obtained online without charge.

2 Divsalar DN, Sadeghian F, Burville K, Tremblay MF, Thomas J, Richter S, Blaber AP.

A spacecraft-compatible combined artificial gravity and exercise (CAGE) system to sustain astronaut health in the next generation of long-term spaceflight.

J Space Saf Eng. 2022 Dec;9(4):577-81.

3 Ramos RL, Carante MP, Ferrari A, Sala P, Vercesi V, Ballarini F.

A mission to Mars: Prediction of GCR doses and comparison with astronaut dose limits.

Int J Mol Sci. 2023 Jan 24;24(3):2328.

Note: This article is part of Special Issue “Radiation Damage in Biomolecules and Cells 3.0” ( and may be obtained online without charge.

4 Liu L-J, Fan Y-B, Wang S-H, Wu X-T, Yang X, Sun L-W.

Enhanced osteogenic potential of periosteal stem cells maintained cortical bone relatively stable under microgravity.

Acta Astronaut. 2023 Apr;205:163-71.

Note: Hindlimb unloading study.

5 Sahana J, Cortés-Sánchez JL, Sandt V, Melnik D, Corydon TJ, Schulz H, Cai Z, Evert K, Grimm D, Wehland M.

Long-term simulation of microgravity induces changes in gene expression in breast cancer cells.

Int J Mol Sci. 2023 Jan 7;24(2):1181.

Note: This article is part of Special Issue “Recent Advances in Breast Cancer Research” ( The Special Issue also includes an article from previous Current Awareness List #1,030 This article may be obtained online without charge.

6 Giacinto O, Pelliccia F, Minati A, De Crescenzo F, Garo ML, Chello M, Lusini M.

Cosmic radiations and the cardiovascular system: A narrative review.

Cardiol Rev. 2022 Dec 28. Review. Online ahead of print.

7 Haddon A, Kanhai J, Nako O, Smith TG, Hodkinson PD, Pollock RD.

Cardiorespiratory responses to voluntary hyperventilation during normobaric hypoxia.

Aerosp Med Hum Perform. 2023 Feb;94(2):59-65.

Note: From the abstract: “Unexplained physiological events (PE), possibly related to hypoxia and hyperventilation, are a concern for some air forces. Physiological monitoring could aid research into PEs, with measurement of arterial oxygen saturation (Sp


) often suggested despite potential limitations in its use. Given similar physiological responses to hypoxia and hyperventilation, the present study characterized the cardiovascular and respiratory responses to each.”

8 Griswold CA, Vento KA, Blacker KJ.

Voluntary urinary retention effects on cognitive performance.

Aerosp Med Hum Perform. 2023 Feb;94(2):79-85.

Note: From the abstract: “Aircrew in-flight bladder relief remains an understudied stressor, specifically the effects of withholding urination on flight-relevant cognitive performance. This quasi-experimental study investigated whether voluntary urinary retention over a 3-h period negatively impacted cognitive performance.”

9 Páez V, Rodriguez-Fernandez M, Silva-Urra J, Núñez-Espinosa C, Lang M.

Maximal pulmonary ventilation and lactate affect the anaerobic performance in young women exposed to hypobaric hypoxia.

Front Physiol. 2023 Feb 8;14:1110477.

Note: This article is part of Research Topic “Women in Environmental Physiology 2022” ( The Research Topic also includes articles from previous Current Awareness Lists #982 and #1,027 This article may be obtained online without charge.

10 Lovell J, Rabin J.

A comparison between three computer-based cone specific color vision tests.

Aerosp Med Hum Perform. 2023 Feb;94(2):54-8.

Note: From the abstract: “Computerized color contrast sensitivity (CS) tests that aim to determine presence, type, and severity of color vision deficiency have been developed and are available, but data on agreement between tests is lacking. The purpose of the present study was to determine data agreement between three computerized color vision tests.”

11 Juliana N, Azmi L, Effendy NM, Mohd Fahmi Teng NI, Abu IF, Abu Bakar NN, Azmani S, Yazit NAA, Kadiman S, Das S.

Effect of circadian rhythm disturbance on the human musculoskeletal system and the importance of nutritional strategies.

Nutrients. 2023 Feb 1;15(3):734.

Note: This article is part of Research Topic “Circadian Clock and Nutrition” ( and may be obtained online without charge.

12 Shattuck NL, Matsangas P, Reily J, McDonough M, Giles KB.

Using light to facilitate circadian entrainment from day to night flights.

Aerosp Med Hum Perform. 2023 Feb;94(2):66-73.

13 Zhang Y, Li Y, Yuan Y, Wang J, Zhang S, Zhu R, Wang Y, Wu Y, Liao X, Mi J.

Reducing light exposure enhances the circadian rhythm of the biological clock through interactions with the gut microbiota.

Sci Total Environ. 2023 Feb 1;858:160041.

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