NASA Spaceline Current Awareness List #1,035 3 February 2023 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm.
Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
In case you missed it: In a recently published report titled “A Review of Challenges & Opportunities: Variable and Partial Gravity Human Habitats in LEO,” the literature on the implications for creating artificial variable gravity habitats for humans in Low Earth Orbit (LEO) and cis-lunar space is reviewed, and discussed. A brief overview and link to the report are available at https://100yss.org/initiatives/overview.
Papers deriving from NASA support:
1 Tran V, Carpo N, Cepeda C, Espinosa-Jeffrey A.
Oligodendrocyte progenitors display enhanced proliferation and autophagy after spaceflight.
Biomolecules. 2023 Jan 17;13(2):201.
https://doi.org/10.3390/biom13020201
PI: A. Espinosa-Jeffrey
Note: ISS results. This article and an article below in the “Other” section (Jokšienė et al.) are part of Special Issue “Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants” (https://www.mdpi.com/journal/biomolecules/special_issues/5JR4HV8X19). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 6.064
Funding: “NASA Space Biology Grant: NNX15AB43G; the Cell Culture and Imaging Core is supported by the NIH (Grant U54HD08710).”
2 Ong J, Tarver W, Brunstetter T, Mader TH, Gibson CR, Mason SS, Lee A.
Spaceflight associated neuro-ocular syndrome: Proposed pathogenesis, terrestrial analogues, and emerging countermeasures.
Br J Ophthalmol. 2023 Jan 23;bjo-2022-322892. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36690421
Note: From the abstract: “In this paper, we briefly discuss the current hypotheses and contributing factors underlying SANS pathophysiology as well as analogues used to study SANS on Earth. We also review emerging potential countermeasures for SANS including lower body negative pressure, nutritional supplementation and translaminar pressure gradient modulation. Ongoing investigation within these fields will likely be instrumental in preparing and protecting astronaut vision for future spaceflight missions including deep space exploration.” This article may be obtained online without charge.
Journal Impact Factor: 5.907
Funding: W. Tarver, T. Brunstetter, and S.S. Mason are affiliated with NASA Johnson Space Center. C.R. Gibson is affiliated with NASA Space Medicine Operations Division.
3 Buckey JC Jr, Thamer S, Lan M.
Bone loss and kidney stone risk in weightlessness.
Curr Opin Nephrol Hypertens. 2023 Mar 1;32(2):172-6. Review.
https://pubmed.ncbi.nlm.nih.gov/36683542
PI: M. Lan
Note: From the abstract: “Weightlessness increases both bone loss and kidney stone formation risk. The large interior volume of the International Space Station (ISS) has allowed for a mix of exercise devices to help maintain the skeleton. But space exploration is changing. Long stays on the ISS will be replaced by journeys in smaller spacecraft both to and around the Moon. Small private space stations are under development. This will limit the ability to do exercise countermeasures, which can increase both bone loss and kidney stone risk. This review examines this risk and how it can be minimized in this new era of spaceflight.”
Journal Impact Factor: 3.416
Funding: “This work was supported by NASA Grant 80NSSC22K0847 and by a grant from Bisu, Inc.”
4 Cornforth M, Loucas B, Shuryak I.
Dose-dependent transmissibility of chromosome aberrations in human lymphocytes at first mitosis. II. Biological effectiveness of heavy charged particles versus gamma rays.
Radiat Res. 2023 Jan 17. Online ahead of print.
https://doi.org/10.1667/RADE-22-00141.1
PI: M. Cornforth
Journal Impact Factor: 3.372
Funding: “This investigation was funded grants from the National Aeronautics and Space Administration, Human Research Program, NASA HRP grant 80NSSC21K0679 (MC) and by the National Institute of Allergy and Infectious Diseases grant number U19-AI067773(IS).”
5 Jaiswal AS, Kim HS, Schärer OD, Sharma N, Williamson EA, Srinivasan G, Phillips L, Kong K, Arya S, Misra A, Dutta A, Gupta Y, Walter CA, Burma S, Narayan S, Sung P, Nickoloff JA, Hromas R.
EEPD1 promotes repair of oxidatively-stressed replication forks.
NAR Cancer. 2023 Mar;5(1):zcac044.
https://pubmed.ncbi.nlm.nih.gov/36683914
PI: S. Burma
Note: From the abstract: “Unrepaired oxidatively-stressed replication forks can lead to chromosomal instability and neoplastic transformation or cell death. To meet these challenges cells have evolved a robust mechanism to repair oxidative genomic DNA damage through the base excision repair (BER) pathway, but less is known about repair of oxidative damage at replication forks. We found that depletion or genetic deletion of EEPD1 decreases clonogenic cell survival after oxidative DNA damage. We demonstrate that EEPD1 is recruited to replication forks stressed by oxidative damage induced by H2O2 and that EEPD1 promotes replication fork repair and restart and decreases chromosomal abnormalities after such damage.” This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “National Institutes of Health (NIH) [R01 CA139429]; Cancer Prevention and Research Institute of Texas [RP220269 to R.H., R35 CA241801 to P.S.]; American Lung Association [LCD-686552] to J.A.N.; S.B. is supported by NIH [R01 CA197796, NASA NNX16AD78G]; Y.K.G. is supported by the Max and Minnie Tomerlin Voelcker Foundation and NIH [RO1 AI161363].”
6 Rienecker KDA, Grue K, Paladini MS, Frias ES, Frattini V, Borlongan MC, Chou A, Torres-Espin A, Krukowski K, Ferguson AR, Rosi S.
Combined space stressors induce independent behavioral deficits predicted by early peripheral blood monocytes.
Sci Rep. 2023 Jan 31;13(1):1749.
https://pubmed.ncbi.nlm.nih.gov/36720960
PI: S. Rosi
Journal Impact Factor: 4.996
Funding: “This work was supported by NASA grant 80NSSC19K1581 (S.R.).”
7 Sanford LD, Wellman LL, Adkins AM, Guo M-L, Zhang Y, Ren R, Yang L, Tang X.
Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders.
Neurobiol Stress. 2023 Mar 23;23:100517.
https://doi.org/10.1016/j.ynstr.2023.100517
PI: L.D. Sanford
Journal Impact Factor: 7.142
Funding: “Portions of this work were supported by NIH research grant MH64827, NASA research grant 80NSSC19K1582, National Natural Science Foundation of China research grant 82120108002, and an EVMS Multidisciplinary Research (MDR) Grant.”
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Other papers of interest:
1 Yamazaki C, Yamazaki T, Kojima M, Takebayashi Y, Sakakibara H, Uheda E, Oka M, Kamada M, Shimazu T, Kasahara H, Sano H, Suzuki T, Higashibata A, Miyamoto K, Ueda J.
Comprehensive analyses of plant hormones in etiolated pea and maize seedlings grown under microgravity conditions in space: Relevance to the International Space Station experiment “Auxin Transport.”
Life Sci Space Res (Amst). 2023 Feb;36:138-46.
https://pubmed.ncbi.nlm.nih.gov/36682823
Note: ISS results.
2 Jokšienė J, Sahana J, Wehland M, Schulz H, Cortés-Sánchez JL, Prat-Duran J, Grimm D, Simonsen U.
Effects of high glucose on human endothelial cells exposed to simulated microgravity.
Biomolecules. 2023 Jan 17;13(2):189.
https://doi.org/10.3390/biom13020189
Note: A 3D clinostat was used in this study. This article and an article above in the “NASA” section (Tran et al.) are part of Special Issue “Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants” (https://www.mdpi.com/journal/biomolecules/special_issues/5JR4HV8X19). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
3 Liphardt AM, Fernandez-Gonzalo R, Albracht K, Rittweger J, Vico L.
Musculoskeletal research in human spaceflight – unmet needs for the success of crewed deep space exploration.
npj Microgravity. 2023 Jan 28;9:9. Review.
https://pubmed.ncbi.nlm.nih.gov/36707515
Note: From the abstract: “Based on the European Space Agency (ESA) Science in Space Environment (SciSpacE) community White Paper ‘Human Physiology – Musculoskeletal system,’ this perspective highlights unmet needs and suggests new avenues for future studies in musculoskeletal research to enable crewed exploration missions.” This article may be obtained online without charge.
4 Omolaoye TS, Maya WDC, du Plessis SS.
Could exposure to spaceflight cause mutations in genes that affect male fertility?
Life Sci Space Res. 2023 May;37:15-7.
https://doi.org/10.1016/j.lssr.2023.01.006
Note: From the introduction: “Longer space missions, commercial space travel and colonizing space is rapidly becoming a reality. However, there is an urgent need to better understand the consequences of exposure to the stressors associated with spaceflight, such as microgravity and ionizing radiation (IR), on health and survival.”
5 Fogtman A, Baatout S, Baselet B, Berger T, Hellweg CE, Jiggens P, La Tessa C, Narici L, Nieminen P, Sabatier L, Santin G, Schneider U, Straube U, Tabury K, Tinganelli W, Walsh L, Durante M.
Towards sustainable human space exploration-priorities for radiation research to quantify and mitigate radiation risks.
npj Microgravity. 2023 Jan 27;9(1):8. Review.
https://pubmed.ncbi.nlm.nih.gov/36707520
Note: This article may be obtained online without charge.
6 Shishkina V, Kostin A, Volodkin A, Samoilova V, Buchwalow I, Tiemann M, Atiakshin D.
The remodeling of dermal collagen fibrous structures in mice under zero gravity: The role of mast cells.
Int J Mol Sci. 2023 Jan 18;24(3):1939.
https://doi.org/10.3390/ijms24031939
Note: This article is part of Special Issue “Dermal Research: From Molecular Mechanisms to Pathology” (https://www.mdpi.com/journal/ijms/special_issues/dermal_research_molecular_mechanisms_pathology). This article may be obtained online without charge.
7 Teranishi M, Kurose T, Nakagawa K, Kawahara Y, Yuge L.
Hypergravity enhances RBM4 expression in human bone marrow-derived mesenchymal stem cells and accelerates their differentiation into neurons.
Regen Ther. 2023 Mar;22:109-14.
https://pubmed.ncbi.nlm.nih.gov/36712961
Note: From the abstract: “The regulation of stem cell differentiation is important in determining the quality of transplanted cells in regenerative medicine. Physical stimuli are involved in regulating stem cell differentiation, and in particular, research on the regulation of differentiation using gravity is an attractive choice. We have shown that microgravity is useful for maintaining undifferentiated mesenchymal stem cells (MSCs). However, the effects of hypergravity on the differentiation of MSCs, especially on neural differentiation related to neural regeneration, have not been elucidated.”
8 Le Roy B, Martin-Krumm C, Pinol N, Dutheil F, Trousselard M.
Human challenges to adaptation to extreme professional environments: A systematic review.
Neurosci Biobehav Rev. 2023 Mar;146:105054. Review.
https://pubmed.ncbi.nlm.nih.gov/36682426
Note: From the abstract: “NASA is planning human exploration of the Moon, while preparations are underway for human missions to Mars, and deeper into the solar system. These missions will expose space travelers to unusual conditions, which they will have to adapt to. Similar conditions are found in several analogous environments on Earth, and studies can provide an initial understanding of the challenges for human adaptation. Such environments can be marked by an extreme climate, danger, limited facilities and supplies, isolation from loved ones, or mandatory interaction with others. They are rarely encountered by most human beings, and mainly concern certain professions in limited missions. This systematic review focuses on professional extreme environments and captures data from papers published since 2005.”
9 Binneboessel S, Masyuk M, Piayda K, Bruno RR, Wernly B, Jirak P, Wolff G, Gerdes N, Baldia PH, Kelm M, Nienhaus F, Lang A, Winkels H, Geerling G, Guthoff R, Kaya S, Flossmann G, Riemer T, Baertschi M, Jung C.
Rational and design of the REMOTE trial: An exploratory, pilot study to analyze retinal microcirculation in weightlessness.
Clin Hemorheol Microcirc. 2023 Jan 20. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36683506
Note: From the abstract: “Healthy individuals will take part in a parabolic flight campaign, which recreates fractioned total weightlessness periods. The airplane is specifically equipped, and designed for the execution of parabolic flight maneuvers and scientific research in microgravity. Retinal microcirculation will be assessed with a modified fundus camera, which allows dynamic vessel analysis. We will additionally measure intra-ocular pressure and hemodynamic changes during each phase of the flight. Blood samples will be analyzed at baseline, one hour and 24 hours after exposure to weightlessness.”
10 Concas A, Fais G, Enna M, Zucchelli S, Caboni P, Lai N, Alberto C, Giacomo C.
Modeling and experimental assessment of Synechococcus nidulans cultivation using simulated Martian medium and astronauts‘ urine.
Acta Astronaut. 2023 Jan 31. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2023.01.027
Note: From the abstract: “The growth of microalgae as food for astronauts is one of the main challenges in view of future crewed missions on Mars. The possibility of cultivating the cyanobacterium Synechococcus nidulans in a medium consisting of a mixture of simulated regolith leachate and astronauts’ urine, called Martian Medium, is investigated with the aim of reducing the payload deriving from nutrients to bring from Earth.”
11 Cucinotta FA, Pak S.
Isotopic production cross sections in proton-16O and proton-12C interactions for energies from 10 MeV/u to 100 GeV/u.
Nucl Instrum Methods Phys. 2023 Jan 1;534:26-34.
https://pubmed.ncbi.nlm.nih.gov/36644589
Note: From the abstract: “Proton interactions with 16O or 12C nuclei are frequent nuclear interaction leading to secondary radiation in tissues for space radiation and cancer therapy with protons or ion beams. The fragmentation of these ions by protons produces a large number of heavy ion (A>4) target or projectile fragments often with high ionization density. Here, we develop an analytical model of energy dependent proton-16O and proton-12C cross sections for isotopic nuclei production.”
12 Cui X, Song W, Xue Y, Guan H, Zhang J, He X, Ma H, Lei M, Wang J, Li Y.
Numerical investigations of the micro lunar dust particles deposition in the human oral respiratory airway.
J Hazard Mater. 2023 Apr 15;448:130886.
https://pubmed.ncbi.nlm.nih.gov/36716554
13 Cucinotta FA, Smirnova OA.
Effects of flash radiotherapy on blood lymphocytes in humans and small laboratory animals.
Radiat Res. 2023 Jan 24. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36693147
14 Ou W, Stewart S, White A, Kwizera EA, Xu J, Fang Y, Shamul JG, Xie C, Nurudeen S, Tirada NP, Lu X, Tkaczuk KHR, He X.
In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy.
Nat Commun. 2023 Jan 24;14(1):392.
https://pubmed.ncbi.nlm.nih.gov/36693842
Note: This article may be obtained online without charge.
15 Goodman MB, Haswell ES, Vásquez V.
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction.
J Gen Physiol. 2023 Mar 6;155(3):e202213248.
https://pubmed.ncbi.nlm.nih.gov/36696153
Note: This article may be obtained online without charge.
16 Barajas-Bustillos MA, Maldonado-Macías A, Serrano-Rosa MA, Hernandez-Arellano JL, Llamas-Alonso L, Balderrama-Armendariz O.
Impact of experience on the sensitivity, acceptability, and intrusive of two subjective mental workload techniques: The NASA TLX and workload profile.
Work. 2023 Jan 27. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36710696
17 Keshner EA, Mallinson AI, Longridge NS, Sinno S, Petersen H, Perrin P.
Evolution of postural control assessment: From dynamic posturography to virtual reality.
Front Neurol. 2023 Jan 11;13:1054346.
https://pubmed.ncbi.nlm.nih.gov/36712454
Note: This article may be obtained online without charge.
18 Klein T, Braunsmann L, Koschate J, Hoffmann U, Foitschik T, Krieger S, Crucian B, Schneider S, Abeln V.
Short-term isolation effects on the brain, cognitive performance, and sleep—The role of exercise.
Front Physiol. 2023 Jan 30;14:903072.
https://doi.org/10.3389/fphys.2023.903072
Note: This article is part of Research Topic “The Human Body, Brain, and Behavior in the Context of Spaceflight and Extreme Environments” (https://www.frontiersin.org/research-topics/23515/the-human-body-brain-and-behaviour-in-the-context-of-spaceflight-and-extreme-environments#articles). The Research Topic also includes an article from previous Current Awareness List #1,026 https://doi.org/10.3389/frspt.2022.981668. This article may be obtained online without charge.
