New Space and Tech

NASA Spaceline Current Awareness List #1,031 16 January 2023 (Space Life Science Research Results)

By Keith Cowing
Press Release
January 6, 2023
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NASA Spaceline Current Awareness List #1,031  16 January 2023 (Space Life Science Research Results)
space biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at

Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, [email protected].

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Ferguson CR, Pardon LP, Laurie SS, Young MH, Gibson CR, Brunstetter TJ, Tarver WJ, Mason SS, Sibony PA, Macias BR.

Incidence and progression of chorioretinal folds during long-duration spaceflight.

JAMA Ophthalmol. 2023 Jan 5. Online ahead of print.

PI: S.S. Laurie

Note: ISS results.

Journal Impact Factor: 8.3

Funding: “This study was directed by research supported by NASA’s Human Research Program.”


Suman S, Moon BH, Datta K, Kallakury BVS, Fornace AJ Jr.Heavy-ion radiation-induced colitis and colorectal carcinogenesis in Il10-/-mice display co-activation of β-catenin and NF-κB signaling.

PLoS One. 2022 Dec 30;17(12):e0279771.

PI: A.J. Fornace Jr

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This study is supported through NASA grant #NNX09AU95G and 80NSSC22K1279.”


Wei F, Neal CJ, Sakthivel TS, Fu Y, Omer M, Adhikary A, Ward S, Ta KM, Moxon S, Molinari M, Asiatico J, Kinzel M, Yarmolenko SN, San Cheong V, Orlovskaya N, Ghosh R, Seal S, Coathup M.

A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme.

Bioact Mater. 2023 Mar;21:547-65. Published online 21 September 2022.

Journal Impact Factor: 14.3

Funding: “…JA’s work was supported by the National Aeronautics and Space Administration [grant No. 80NSSC21M0309] issued through the NASA Office of STEM Engagement.”


Wong CP, Branscum AJ, Fichter AR, Sargent J, Iwaniec UT, Turner RT.

Cold stress during room temperature housing alters skeletal response to simulated microgravity (hindlimb unloading) in growing female C57BL6 mice.

Biochimie. 2022 Dec 28. Online ahead of print.

PI: R.T. Turner

Note: Hindlimb unloading study.

Journal Impact Factor: 6.9

Funding: “This work was supported by NASA (80NSSC19K0430 and NNX15AL15G).”


Klerman EB, Brager A, Carskadon MA, Depner CM, Foster R, Goel N, Harrington M, Holloway PM, Knauert MP, LeBourgeois MK, Lipton J, Merrow M, Montagnese S, Ning M, Ray D, Scheer F, Shea SA, Skene DJ, Spies C, Staels B, St-Onge MP, Tiedt S, Zee PC, Burgess HJ.

Keeping an eye on circadian time in clinical research and medicine.

Clin Transl Med. 2022 Dec 25;12(12):e1131. Review.

PI: N. Goel

Note: From the abstract: “Daily rhythms are observed in humans and almost all other organisms. Most of these observed rhythms reflect both underlying endogenous circadian rhythms and evoked responses from behaviors such as sleep/wake, eating/fasting, rest/activity, posture changes and exercise. For many research and clinical purposes, it is important to understand the contribution of the endogenous circadian component to these observed rhythms.” This article may be obtained online without charge.

Journal Impact Factor: 8.554

Funding: “…Goel received grants from National Aeronautics and Space Administration (NASA) (grant numbers: NNX14AN49G and 80NSSC20K0243) and NIH (grant number: R01-DK117488), Research startup funds and Rush University Medical Center. …”


McDonagh F, Singh NK, Venkateswaran K, Lonappan AM, Hallahan B, Tuohy A, Burke L, Kovarova A, Miliotis G.

First complete genome of a multidrug resistant strain of the novel human pathogen Kalamiella piersonii (GABEKP28) identified in human saliva.

J Glob Antimicrob Resist. 2022 Dec 28. Online ahead of print.

PI: K. Venkateswaran

Note: From the abstract: “Kalamiella piersonii is a newly identified bacterial species, firstly isolated from surfaces of the International Space Station (ISS). It also appears as a novel human pathogen reported to be implicated in bacteremia and kidney stone disease. Here, we report the first complete genome of a multidrug resistant (MDR) strain of K.piersonii (GABEKP28) isolated from the saliva of a patient with treatment resistant schizophrenia, in order to determine the mobile genetic elements, antibiotic resistance genes (ARGs) and virulence factors (VFs) harbored by such a strain of this novel species.”

Journal Impact Factor: 5.6

Funding: “Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This research was funded by a 2012 Space Biology NNH12ZTT001N grant nos. 19-12829-26 under Task Order NNN13D111T award to KV. Financial support for this research was also provided by a research grant from University of Galway’s School of Medicine: 2021_ECRAward, awarded to GM.”


Vahlensieck C, Thiel CS, Christoffel S, Herbst S, Polzer J, Lauber BA, Wolter S, Layer LE, Hinkelbein J, Tauber S, Ullrich O.

Rapid downregulation of H3K4me3 binding to immunoregulatory genes in altered gravity in primary human M1 macrophages.

Int J Mol Sci. 2023;24(1):603.

Note: This article is part of Special Issue “Molecular Mechanobiology in Space and on Earth 2.0” ( The Research Topic also includes an article from previous Current Awareness List #1,004 This article may be obtained online without charge.

Journal Impact Factor: 6.208

Funding: C.S. Thiel and O. Ullrich are affiliated with Kennedy Space Center.


Shi L, Zhu Q, Wang Y, Hao H, Zhang H, Schwartz J, Amini H, van Donkelaar A, Martin RV, Steenland K, Sarnat JA, Caudle WM, Ma T, Li H, Chang HH, Liu JZ, Wingo T, Mao X, Russell AG, Weber RJ, Liu P.

Incident dementia and long-term exposure to constituents of fine particle air pollution: A national cohort study in the United States.

Proc Natl Acad Sci USA. 2023 Jan 3;120(1):e2211282119.

Note: This article may be obtained online without charge.

Journal Impact Factor: 12.779

Funding: “This study was supported by NIH (R01 AG074357, R21 ES032606), the HERCULES Center (P30 ES019776), and the Emory Goizueta Alzheimer’s Disease Research Center (P50 AG025688). J.S. and H.A. were supported by U.S. EPA (RD-83587201) and NIH (P30 ES000002, R01 ES032418-01). H.A. was supported by Novo Nordisk Foundation (NNF17OC0027812). R.V.M. was supported by NASA HAQAST (Grant 80NSSC21K0508).”


Zenir MC, López-Pozo M, Polutchko SK, Stewart JJ, Adams WW, Escobar A, Demmig-Adams B.

Productivity and nutrient quality of Lemna minor as affected by microbiome, CO2

 level, and nutrient supply.

Stresses. 2023 Dec 31;3(1):69-85.

PI: B. Demmig-Adams

Note: This article is part of Special Issue “Microbiome: A Tool for Plant Stress Management in Future Production Systems” ( This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was funded by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A, National Science Foundation award number IOS-1907338, and the University of Colorado.”


Waisberg E, Ong J, Kamran SA, Paladugu P, Zaman N, Lee AG, Tavakkoli A.

Transfer learning as an AI-based solution to address limited datasets in space medicine.

Life Sci Space Res. 2023 Jan 1. Online ahead of print.

PI: A. Tavakkoli

Journal Impact Factor: 4.1

Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”


Waisberg E, Ong J, Kamran SA, Zaman N, Paladugu P, Sarker P, Tavakkoli A, Lee AG.

Further characterizing the physiological process of posterior globe flattening in spaceflight associated neuro-ocular syndrome with generative adversarial networks.

J Appl Physiol (1985). 2023 Jan 2;134(1):150-1.

PI: A. Tavakkoli

Note: This is a letter to the editor regarding an article titled, “MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6° head-down tilt bed rest with and without daily centrifugation,” by Sater et al. that appeared in Current Awareness list #1,024 This article may be obtained online without charge.

Journal Impact Factor: 3.880

Funding: “The study was supported by National Aeronautics and Space Administration (NASA) Grant No. 80NSSC20K183: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”


Other papers of interest:


Gao T, Huang J, Zhang X, Gao F.

Exercise counteracts vascular aging in long-term spaceflight: Challenges and perspective.

Current Opinion in Physiology. 2023 Jan 2;100628. Review.

Note: From the abstract: “We here briefly review the mechanisms contributing to vascular aging changes in microgravity and exercise-afforded vasoprotection.”


Baghoum H, Alahmed H, Hachim M, Senok A, Jalaleddine N, Al Heialy S.

Simulated microgravity influences immunity-related biomarkers in lung cancer.

International Journal of Molecular Sciences. 2023;24(1):155.

Note: A 2D clinostat was used in this study. This article is part of Section “Molecular Oncology” (


Kim M, Jang G, Kim KS, Shin J.

Detrimental effects of simulated microgravity on mast cell homeostasis and function.

Front Immunol. 2022 Dec 16;13:1055531.

Note: A high-aspect ratio vessel (HARV)-rotary cell culture system was used in this study. This article was part of Research Topic “Advances in Mast Cell Physiology and Mast Cell-Driven Diseases” ( Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.


Kuznetsov MS, Lisyukov AN, Saitov VR, Valiullin VV, Islamov RR.

Zero gravity is a factor that induces negative changes in myelinated fibers of the spinal tracts.

Bull Exp Biol Med. 2023 Jan 5.

Note: From the abstract: “The development of hypogravitational motor syndrome is an essential negative consequence of weightlessness for humans; an important role in the pathogenesis of this syndrome is played by changes in axons of the spinal tracts. Myelinated fibers and transcriptome of the spinal cord were studied in mice exposed to hypogravity during a 30-day flight on a biosatellite.”


Nguyen HP, Shin S, Shin K-J, Tran PH, Park H, De Tran Q, No M-H, Sun JS, Kim KW, Kwak H-B, Lee S, Cho SK, Yang S-G.

Protective effect of TPP-Niacin on microgravity-induced oxidative stress and mitochondrial dysfunction of retinal epithelial cells.

Biochim. Biophys. Acta – Mol. Cell Res. 2023 Jan;1870(1):119384.

Note: A clinostat was used in this study.


Yakabe M, Hosoi T, Sasakawa H, Akishita M, Ogawa S.

Kampo formula hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang, TJ-41) ameliorates muscle atrophy by modulating atrogenes and AMPK in vivo and in vitro.

BMC Complement Med Ther. 2022 Dec 28;22(1):341.

Note: This article may be obtained online without charge.


Heywood HK, Gardner L, Knight MM, Lee DA.

Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: A novel means to integrate biological time within predictive in vitro model systems.

In Vitro Model. 2022 Dec 22;1(6):405-12. Available online 31 August 2022.

Note: This article may be obtained online without charge.

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