New Space and Tech

NASA Spaceline Current Awareness List #1,030 30 December 2022 (Space Life Science Research Results)

By Keith Cowing
Press Release
December 30, 2022
NASA Spaceline Current Awareness List #1,030 30 December 2022 (Space Life Science Research Results)
Genetic Expression In Microbes

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at

Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, [email protected].

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Bowman RN, McKay CP, Kiss JZ.

Design of spaceflight hardware for plant growth in a sealed habitat for experiments on the Moon.

Gravit Space Res. 2022 Dec 24;10(1):37-44.

Note: ISS results. From the abstract: “Plant growth experiments on near-term lunar landers need to be relatively small, lightweight, and self-contained. Here, we report on the design of a ~1 liter volume (1U Cubesat size) hermetically sealed habitat suitable for plant growth experiments during the first 10 days of seedling development of Arabidopsis thaliana and Brassica nigra.”

Journal Impact Factor: Not available for this journal

Funding: R.N. Bowman and C.P. McKay are affiliated with NASA Ames Research Center.


Gatt C, Tierney BT, Madrigal P, Mason CE, Beheshti A, Telzerow A, Benes V, Zahra G, Bonett J, Cassar K, Borg J.

The Maleth program: Malta’s first space mission discoveries on the microbiome of diabetic foot ulcers.

Heliyon. 2022 Dec 4;8(12):e12075.

Note: ISS and ground-based model results. From the abstract: “The purpose of the Maleth Program, also known as Project Maleth, is Malta’s first space program to evaluate human skin tissue microbiome changes in type 2 diabetes mellitus (T2DM) patients afflicted with diabetic foot ulcers (DFU). This was carried out in both ground-based models and spaceflight.” GeneLab is available at This article may be obtained online without charge.

Journal Impact Factor: 3.776

Funding: A. Beheshti is affiliated with NASA Ames Research Center.


Krittanawong C, Singh NK, Scheuring RA, Urquieta E, Bershad EM, Macaulay TR, Kaplin S, Dunn C, Kry SF, Russomano T, Shepanek M, Stowe RP, Kirkpatrick AW, Broderick TJ, Sibonga JD, Lee AG, Crucian BE.

Human health during space travel: State-of-the-art review.

Cells. 2022 Dec 23;12(1):40. Review.

Note: This article is part of Special Issue “Research Advances Related to Cardiovascular System” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 7.666

Funding: N.K. Singh is affiliated with NASA Jet Propulsion Laboratory. R.A. Scheuring and B.E. Crucian are affiliated with NASA Johnson Space Center. M. Shepanek is affiliated with NASA Office of the Chief Health and Medical Officer. J.D. Sibonga is affiliated with NASA Lyndon B. Johnson Space Center.


Blackwell AA, Tracz JA, Fesshaye AS, Tidmore A, Osterlund Oltmanns JR, Schaeffer EA, Lake RI, Wallace DG, Britten RA.

Fine motor deficits exhibited in rat string-pulling behavior following exposure to sleep fragmentation and deep space radiation.

Exp Brain Res. 2022 Dec 27.

PI: R.A. Britten

Journal Impact Factor: 2.064

Funding: “This work was partly supported by NASA grants [NNX14AE73G and NNX16AC40G].”


Kim H-C, Lee W, Kowsari K, Weisholtz DS, Yoo S-S.

Effects of focused ultrasound pulse duration on stimulating cortical and subcortical motor circuits in awake sheep.

PLoS One. 2022 Dec 13;17(12):e0278865.

PI: S-S. Yoo

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was supported by National Aeronautics and Space Administration (NASA) grant NNX16AO69A-T0415 (to SSY).”


Lenarczyk M, Alsheikh AJ, Cohen EP, Schaue D, Kronenberg A, Geurts A, Klawikowski S, Mattson D, Baker JE.

T cells contribute to pathological responses in the non-targeted rat heart following irradiation of the kidneys.

Toxics. 2022 Dec 18;10(12):797.

PI: J.E. Baker

Note: This article is part of Special Issue “Radiation Exposure and Health Effects” ( The Special Issue also includes an article from previous Current Awareness List #1,019 This article may be obtained online without charge.

Journal Impact Factor: 4.472

Funding: “This research was funded by the National Aeronautical and Space Administration, grant numbers NNX15AD69G and 80NSSC19K0498 and by an unrestricted grant from the Foundation for Heart Science.”


Weng Y, Han S, Sekyi MT, Su T, Mattis AN, Chang TT.

Self-assembled Matrigel-free iPSC-derived liver organoids demonstrate wide-ranging highly-differentiated liver functions.

Stem Cells. 2022 Dec 27. Online ahead of print.

PI: T.T. Chang

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.845

Funding: “This research was funded by NIH/NIDDK R01-DK114311, NSF 1830768, NASA 80NSSC18K1470, Open Philanthropy Project, and American College of Surgeons Clowes Award to TTC; NIH/NIDDK K08-DK098270, R01-DK130391, and CIRM DISC2-12358 to ANM; additional funding by NIH/NIDDK P30-DK026743.”


Pachade S, Coronado I, Abdelkhaleq R, Yan J, Salazar-Marioni S, Jagolino A, Green C, Bahrainian M, Channa R, Sheth SA, Giancardo L.

Detection of stroke with retinal microvascular density and self-supervised learning using OCT-A and fundus imaging.

J Clin Med. 2022 Dec 14;11(24):7408.

PI: L. Giancardo

Note: This article is part of Topic “Retinal Imaging and Systemic Vascular Disease: Recent Advances and Perspective” ( This article may be obtained online without charge.

Journal Impact Factor: 4.964

Funding: “This work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A. L.G. is supported in part by a Learning Healthcare Award funded by the UTHealth Center for Clinical and Translational Science (CCTS), NIH Grants UL1TR003167 and R01NS121154, and a Cancer Prevention and Research Institute of Texas grant (RP 170668). I.C. is supported by a training fellowship from the Gulf Coast Consortia, on the NLM Training Program in Biomedical Informatics & Data Science (T15LM007093). R.C. and M.B. were supported in part by an Unrestricted Grant from Research to Prevent Blindness, Inc. to the UW-Madison Department of Ophthalmology and Visual Sciences.”


Bakshi A, Gilroy S.

Analysis of plant flooding response.

In: Methods in Enzymology. Academic Press, 2022.

PI: S. Gilroy

Impact Factor: 1.682

Funding: “Supported by NSF MCB2016177 and NASA 80NSSC19K0126 and 80NSSC21K0577.”


Rosa-Caldwell ME, Eddy KT, Rutkove SB, Breithaupt L.

Anorexia nervosa and muscle health: A systematic review of our current understanding and future recommendations for study.

International Journal of Eating Disorders. 2022 Dec 18;1-18. Review.

PI: M.E. Rosa-Caldwell

Journal Impact Factor: 5.791

Funding: “National Aeronautics and Space Administration, Grant/Award Number: 80NSSC21K0311; National Institutes of Health, Grant/Award Numbers: K23MH127465, KL2TR002542, R03MH126143.”


Other papers of interest:


Wise PM, Sahana J, Neviani P, Corydon TJ, Schulz H, Wehland M, Infanger M, Grimm D.

Prolonged exposure to simulated microgravity changes release of small extracellular vesicle in breast cancer cells.

Int J Mol Sci. 2022 Dec 17;23(24):16095.

Note: A random positioning machine was used in this study. This article is part of Special Issue “Recent Advances in Breast Cancer Research” ( This article may be obtained online without charge.


Debenham MIB, Grantham TDA, Smirl JD, Foster GE, Dalton BH.

The effects of acute normobaric hypoxia on vestibular-evoked balance responses in humans.

J Vestib Res. 2022 Dec 13. Online ahead of print.

Note: From the abstract: “The purpose here was to investigate the effect of hypoxia on the vestibular control of balance.”


Overbeek R, Schmitz J, Rehnberg L, Benyoucef Y, Dusse F, Russomano T, Hinkelbein J.

Effectiveness of CPR in hypogravity conditions-A systematic review.

Life (Basel). 2022 Nov 23;12(12):1958. Review.

Note: This article is part of Collection “Feature Review Papers for Life” ( This article may be obtained online without charge.


Zhang Z, Shan L, Wang Y, Li W, Jiang M, Liang F, Feng S, Lu Z, Wang H, Dai J.

Primate preoptic neurons drive hypothermia and cold defense.

The Innovation. 2022 Jan 23;4(1):100358.

Note: To view a full press release of this article on the SpaceRef website go to This article may be obtained online without charge.


Liu CT, Tsai T, Allaire BT, Bouxsein ML, Hannan MT, Travison TG, Kiel DP.

Accumulation in visceral adipose tissue over six years is associated with lower paraspinal muscle density.

J Clin Endocrinol Metab. 2022 Dec 22;dgac744. Online ahead of print.


Bhushan S, Singh S, Maiti TK, Sharma C, Dutt D, Sharma S, Li C, Tag Eldin EM.

Scaffold fabrication techniques of biomaterials for bone tissue engineering: A critical review.

Bioengineering (Basel). 2022 Nov 24;9(12):728. Review.

Note: This article is part of Special Issue “Current Developments and Applications in Bone Tissue Engineering” ( This article may be obtained online without charge.


Cunningham HC, Orr S, Murugesh DK, Hsia AW, Osipov B, Go L, Wu PH, Wong A, Loots GG, Kazakia GJ, Christiansen BA.

Differential bone adaptation to mechanical unloading and reloading in young, old, and osteocyte deficient mice.

Bone. 2023 Feb;167:116646.

Note: Hindlimb unloading study.


Ferroni L, D’Amora U, Leo S, Tremoli E, Raucci MG, Ronca A, Ambrosio L, Zavan B.

PEEK and hyaluronan-based 3D printed structures: Promising combination to improve bone regeneration.

Molecules. 2022 Dec 9;27(24):8749.

Note: This article was part of Special Issue “Polymer Scaffolds for Biomedical Applications” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.


Reyes Fernandez PC, Wright CS, Masterson AN, Yi X, Tellman TV, Bonteanu A, Rust K, Noonan ML, White KE, Lewis KJ, Sankar U, Hum JM, Bix G, Wu D, Robling AG, Sardar R, Farach-Carson MC, Thompson WR.Gabapentin disrupts binding of perlecan to the α2δ1 voltage sensitive calcium channel subunit and impairs skeletal mechanosensation.

Biomolecules. 2022 Dec 12;12(12):1857.

Note: This article may be obtained online without charge.


Nguyen M, Knowling M, Tran NN, Burgess A, Fisk I, Watt M, Escribà-Gelonch M, This H, Culton J, Hessel V.

Space farming: Horticulture systems on spacecraft and outlook to planetary space exploration.

Plant Physiol Biochem. 2022 Dec 21;194:708-21. Review.

Note: From the abstract: “Successful human space exploration requires more products than can be taken as payload. There is a need, therefore, for in-space circular manufacturing. Requirements for this include limited resource inflow, from either Earth or other planets and the generation of minimal waste. The provision of nutritious food is a clear need for human survival on the Moon or Mars and is one of the most complex to solve. Demand in large quantities, constant and reliable provision of food requires the development of specialist agricultural technologies. Here, we review the history of space farming over the past five decades.”


Joshi A, Kaur T, Joshi A, Gugulothu SB, Choudhury S, Singh N.

Light-mediated 3D printing of micro-pyramid-decorated tailorable wound dressings with endogenous growth factor sequestration for improved wound healing.

ACS Appl Mater Interfaces. 2022 Dec 23.

Note: From the abstract: “Medical dressings play an important role in the field of tissue engineering owing to their ability to accelerate the process of wound healing. Great efforts have been made to fabricate wound dressings with distinctive features for promoting wound healing. However, most of the current synthesis methods either generate dressings of uniform size or involve complex fabrication techniques, thus limiting their commercialization for the personalized dressings. We report here a dressing, which presents a paradigm shift in the design of the dressing from uniform films to a micro-patterned film.”

SpaceRef co-founder, Explorers Club Fellow, ex-NASA, Away Teams, Journalist, Space & Astrobiology, Lapsed climber.