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NASA Spaceline Current Awareness List #1,029 23 December 2022 (Space Life Science Research Results)

By Keith Cowing
Press Release
December 23, 2022
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NASA Spaceline Current Awareness List #1,029  23 December 2022 (Space Life Science Research Results)
Space Biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Douglas GL, DeKerlegand D, Dlouhy H, Dumont-Leblond N, Fields E, Heer M, Krieger S, Mehta S, Rooney BV, Torralba MG, Whiting SE, Crucian B, Lorenzi H, Smith SM, Young M, Zwart SR.

Impact of diet on human nutrition, immune response, gut microbiome, and cognition in an isolated and confined mission environment.

Sci Rep. 2022 Dec 15;12:20847.

Note: From the abstract: “Long-duration spaceflight impacts human physiology, including well documented immune system dysregulation. The space food system has the potential to serve as a countermeasure to maladaptive physiological changes during spaceflight. However, the relationship between dietary requirements, the food system, and spaceflight adaptation requires further investigation to adequately define countermeasures and prioritize resources on future spaceflight missions. We evaluated the impact of an enhanced spaceflight diet, with increased quantity and variety of fruits, vegetables, fish, and other foods rich in flavonoids and omega-3 fatty acids, compared to a standard spaceflight diet on multiple health and performance outcomes in 16 subjects over four 45-day closed chamber missions in the NASA Human Exploration Research Analog (HERA).”

Journal Impact Factor: 4.996

Funding: “This work was funded through NASA Research Announcement NNH14ZTT002N. Previously published PVT data were acquired and provided by the NASA Behavioral Health & Performance Laboratory, as part of the Human Factors and Behavioral Performance Exploration Measures in HERA through support from the NASA Human Research Program (NASA Research Announcement NNJ15HK11B).”


Teng Z, Luo Y, Pearlstein DJ, Wheeler RM, Johnson CM, Wang Q, Fonseca J.

Microgreens for home, commercial, and space farming: A comprehensive update of the most recent developments.

Annu Rev Food Sci Technol. 2022 Dec 16. Review. Online ahead of print.

Note: From the abstract: “Microgreens are edible young plants that have recently attracted interest because of their color and flavor diversity, phytonutrient abundance, short growth cycle, and minimal space and nutrient requirements. They can be cultivated in a variety of systems from simple home gardens to sophisticated vertical farms with automated irrigation, fertilizer delivery, and lighting controls. Microgreens have also attracted attention from space agencies hoping that their sensory qualities can contribute to the diet of astronauts in microgravity and their cultivation might help maintain crew physical and psychological health on long-duration spaceflight missions. However, many technical challenges and data gaps for growing microgreens both on and off Earth remain unaddressed. This review summarizes recent studies on multiple aspects of microgreens, including nutritional and socioeconomic benefits, cultivation systems, operative conditions, innovative treatments, autonomous facilities, and potential space applications.”

Journal Impact Factor: 14.714

Funding: R.M. Wheeler and C.M. Johnson are affiliated with NASA Kennedy Space Center.


McGrath ER, Frings-Meuthen P, Sibonga J, Heer M, Clément GR, Mulder E, Smith SM, Zwart SR.

Bone metabolism during strict head-down tilt bedrest and exposure to elevated levels of ambient CO2


npj Microgravity. 2022 Dec 16;8:57.

Note: Head-down tilt bedrest study. This article may be obtained online without charge.

Journal Impact Factor: 4.97

Funding: “The data reported here were from the NASA Human Research Program Standard Measures Cross-Cutting Project. Funding was provided by the NASA Human Research Program’s Human Health Countermeasures Element. ERM was funded through a summer fellowship with the NASA Space Life Sciences Summer Institute.”


Puscas M, Martineau G, Bhella G, Bonnen PE, Carr P, Lim R, Mitchell J, Osmond M, Urquieta E, Flamenbaum J, Iaria G, Joly Y, Richer É, Saary J, Saint-Jacques D, Buckley N, Low-Decarie E.

Rare diseases and space health: Optimizing synergies from scientific questions to care.

npj Microgravity. 2022 Dec 22;8:58. Review.

Note: From the abstract: “Knowledge transfer among research disciplines can lead to substantial research progress. At first glance, astronaut health and rare diseases may be seen as having little common ground for such an exchange. However, deleterious health conditions linked to human space exploration may well be considered as a narrow sub-category of rare diseases. Here, we compare and contrast research and healthcare in the contexts of rare diseases and space health and identify common barriers and avenues of improvement.” This article may be obtained online without charge.

Journal Impact Factor: 4.97

Funding: “E.U. was supported by the Translational Research Institute for Space Health through NASA NNX16AO69A.”


Kumar S, Suman S, Moon BH, Fornace AJ Jr, Datta K.

Low dose radiation upregulates Ras/p38 and NADPH oxidase in mouse colon two months after exposure.

Mol Biol Rep. 2022 Dec 21.

PIs: A.J. Fornace Jr, K. Datta

Journal Impact Factor: 2.742

Funding: “This study was supported in part by National Aeronautics and Space Administration (NASA) Grant Numbers NNX13AD58G, NNX09AU95G, and 80NSSC22K1279. The authors acknowledge the Lombardi Comprehensive Cancer Shared Resources (MSR), which are in part supported by award number P30CA051008 (P.I. Louis Weiner) from the National Cancer Institute.”


Waisberg E, Ong J, Paladugu P, Kamran SA, Zaman N, Tavakkoli A, Lee AG.

Applying generative adversarial network techniques to portable ophthalmic imaging.

Eye (Lond). 2022 Dec 12. Online ahead of print.

PI: A. Tavakkoli

Note: This is a correspondence letter.

Journal Impact Factor: 4.456

Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”


Park J, Kim J, Lewy T, Rice CM, Elemento O, Rendeiro AF, Mason CE.

Spatial omics technologies at multimodal and single cell/subcellular level.

Genome Biol. 2022 Dec 13;23:256. Review.

PI: C.E. Mason

Note: From the abstract: “Spatial omics technologies enable a deeper understanding of cellular organizations and interactions within a tissue of interest. These assays can identify specific compartments or regions in a tissue with differential transcript or protein abundance, delineate their interactions, and complement other methods in defining cellular phenotypes. A variety of spatial methodologies are being developed and commercialized; however, these techniques differ in spatial resolution, multiplexing capability, scale/throughput, and coverage. Here, we review the current and prospective landscape of single cell to subcellular resolution spatial omics technologies and analysis tools to provide a comprehensive picture for both research and clinical applications.” This article may be obtained online without charge.

Journal Impact Factor: 17.906

Funding: “We would like to thank the Scientific Computing Unit (SCU) and funding from the WorldQuant Foundation, NASA (NNH18ZTT001N-FG2, 80NSSC22K0254), the Leukemia and Lymphoma Society (LLS) grants (MCL7001-18, LLS 9238-16, LLS-MCL7001-18), and the National Institutes of Health (R01MH117406, R01AI151059, R01AI158676, R01CA249054, R01AI161444).”


Yau A, Wang Z, Ponthempilly N, Zhang Y, Wang X, Chen Y.

Biosensor integrated tissue chips and their applications on Earth and in space.

Biosens Bioelectron. 2022 Oct 20;222:114820.

Note: From the astract: “This article reviews the endless benefits of space technology, the development of integrated biosensors in tissue chips and their applications to better understand human biology, physiology, and diseases in space and on Earth, followed by future perspectives of tissue chip applications on Earth and in space.” This article may be obtained online without charge.

Journal Impact Factor: 12.545

Funding: “This work was supported by This study is supported by NIH 7R01AR072027, NIH 1R21AR079153-01A1, NSF Career Award 1905785, NSF 2025362, DOD W81XWH2110274, NASA 80JSC022CA006 and the University of Connecticut. X.J. Wang and Z.Z. Wang would like to acknowledge the support from the Research Excellence Program (REP) at the Office of the Vice President for Research at the University of Connecticut and NIH 1R21EB033495-01.”


Other papers of interest:


Holt S.

Virtual reality, augmented reality, and mixed reality: For astronaut mental health; and space tourism, education, and outreach.

Acta Astronaut. 2023 Feb;203:436-46. Online ahead of print.

Note: From the introduction: “Virtual reality (VR), augmented reality (AR) and mixed reality (MR) can evoke a sense of presence, where a person can feel as though they are physically present in a virtual environment. The intention of this research is to understand whether VR/AR/MR can create human connection and experience through interactions with virtual environments to assist in the prevention and treatment of psychological impacts to astronaut health during long-term and long-distance space missions (experiencing Earth from space); and for space tourism, education and outreach purposes as a cost-effective way for people to experience space; to help people understand how important the space industry is to our lives; and to inspire future careers (experiencing space from Earth).”


Siu M, Levin D, Christensen R, Kelly E, Alouidor R, Kamine TH.

Prophylactic splenectomy and hyposplenism in spaceflight.

Aerosp Med Hum Perform. 2022 Dec;93(12):877-81. Review.

Note: From the abstract: “There is debate whether astronauts traveling to space should undergo a prophylactic splenectomy prior to long duration spaceflight. Risks to the spleen during flight include radiation and trauma. However, splenectomy also carries significant risks.”


Smith TG, Pollock RD, Britton JK, Green NDC, Hodkinson PD, Mitchell SJ, Stevenson AT.

Physiological effects of centrifuge-simulated suborbital spaceflight.

Aerosp Med Hum Perform. 2022 Dec;93(12):830-9.

Note: From the abstract: “High-G acceleration experienced during launch and reentry of suborbital spaceflights may present challenges for older or medically susceptible participants. A detailed understanding of the associated physiological responses would support the development of an evidence-based medical approach to commercial suborbital spaceflight.”


Elkhatib W, Herrigel D, Harrison M, Flipse T, Speicher L.

Cardiovascular concerns from COVID-19 in pilots.

Aerosp Med Hum Perform. 2022 Dec;93(12):855-65.

Note: From the abstract: “Cardiovascular disease, now complicated by the COVID-19 pandemic, remains a leading cause of death and risk for sudden incapacitation for pilots during flight. The capacity for aeromedically significant cardiovascular sequelae with potentially imperceptible clinical symptoms elicits concern both during and following resolution of acute COVID-19 in pilots.”


Hosamani R, Swamy BK, Dsouza A, Sathasivam M.

Plant responses to hypergravity: A comprehensive review.

Planta. 2022 Dec 19;257(1):17. Review.

Note: From the abstract: “Hypergravity is an effective novel stimulus to elucidate plant gravitational and mechanobiological behavior. Here, we review the current understanding of phenotypic, physio-biochemical, and molecular plant responses to simulated hypergravity.”


Delbarre M, Crepy P, Froussart-Maille F.

Keratoconus and fitness to fly.

Aerosp Med Hum Perform. 2022 Dec;93(12):840-5.

Note: From the abstract: “Of the body senses, vision is the most important for safe flight. Keratoconus causes progressive blurring and distortion of vision, which threatens the career of a civilian or military aviator. The goal of this retrospective study was to describe a series of keratoconus cases in a pilot population and to discuss decisions about their flight waivers.”


Liu J, Ladbury C, Tam A, Chao J, Kim J, McGee HM, Williams TM, Amini A, Chen YJ.

Current landscape of radiation oncology in esophageal cancer: A narrative review.

J Thorac Dis. 2022 Nov;14(11):4494-505. Review.

Note: This article may be obtained online without charge.


Liu X, Yan Z, Cai J, Wang D, Yang Y, Ding Y, Shao X, Hao X, Luo E, Guo XE, Luo P, Shen L, Jing D.

Glucose- and glutamine-dependent bioenergetics sensitize bone mechanoresponse after unloading by modulating osteocyte calcium dynamics.

J Clin Invest. 2022 Dec 13. Online ahead of print.

Note: This article may be obtained online without charge.


Ghimire J, Kim JH, Choi DY.

Compact wideband double-slot microstrip feed engraved TEM horn strip antennas on a multilayer substrate board for in bed resting body positions determination based on artificial intelligence.

Sensors (Basel). 2022 Dec 6;22(23):9555.

Note: From the abstract: “In this paper, a horn-shaped strip antenna exponentially tapered carved on a multilayer dielectric substrate for an indoor body position tracking system is proposed.” This article may be obtained online without charge.


Murgia M, Brocca L, Monti E, Franchi MV, Zwiebel M, Steigerwald S, Giacomello E, Sartori R, Zampieri S, Capovilla G, Gasparini M, Biolo G, Sandri M, Mann M, Narici MV.

Plasma proteome profiling of healthy subjects undergoing bedrest reveals unloading-dependent changes linked to muscle atrophy.

J Cachexia Sarcopenia Muscle. 2022 Dec 14. Online ahead of print.

Note: Bedrest study. This article may be obtained online without charge.


Peuriere L, Mastrandrea C, Vanden-Bossche A, Linossier MT, Thomas M, Normand M, Lafage-Proust MH, Vico L.

Hindlimb unloading in C57BL/6J mice induces bone loss at thermoneutrality without change in osteocyte and lacuno-canalicular network.

Bone. 2022 Dec 13;116640. Online ahead of print.

Note: Hindlimb unloading study.


Lerner DJ, Pohlen MS, Apland RC, Parivash SN.

Just-in-time training with remote guidance for ultrasound-guided percutaneous intervention.

Aerosp Med Hum Perform. 2022 Dec;93(12):882-6.

Note: From the abstract: “Management of surgical emergencies in spaceflight will pose a challenge as the era of exploration class missions dawns, requiring increased crew autonomy at a time when training and supplies will be limited. Ultrasound-guided percutaneous intervention would allow for the management of a variety of pathologies with largely shared equipment and training. This proof-of-concept work attempts to determine the feasibility of ‘just-in-time’ remote teaching and guidance of a sample procedure of this type.”


Jiang A, Zhu Y, Yao X, Foing BH, Westland S, Hemingray C.

The effect of three body positions on color preference: An exploration of microgravity and lunar gravity simulations.

Acta Astronaut. 2022 Dec 22. Online ahead of print.

Note: Head-up and head-down tilt bedrest study. From the abstract: “Understanding the colour preference in microgravity environments will enable better design of future spacecraft and extra-terrestrial environments. In this study, a space station’s crew cabin was simulated and evaluated in 33 different colors by 55 participants using a standard body position change methodology in controlled conditions.”

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