NASA Spaceline Current Awareness List #1,028 16 December 2022 (Space Life Science Research Results)

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. 

Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:

1

Tierney BT, Singh NK, Simpson AC, Hujer AM, Bonomo RA, Mason CE, Venkateswaran K.

Multidrug-resistant Acinetobacter pittii is adapting to and exhibiting potential succession aboard the International Space Station.

Microbiome. 2022 Dec 12;10:210.

https://pubmed.ncbi.nlm.nih.gov/36503581

PIs: N.K. Singh, C.E. Mason, K. Venkateswaran

Note: ISS results. From the abstract: “Monitoring the adaptation of microorganisms to the extreme environment of the International Space Station (ISS) is crucial to understanding microbial evolution and infection prevention. Acinetobacter pittii is an opportunistic nosocomial pathogen, primarily impacting immunocompromised patients, that was recently isolated from two missions aboard the ISS.”

Journal Impact Factor: 16.837

Funding: “The research described in this manuscript was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV. We acknowledge the support from the project ‘MANGO,’ a 2018 Space Biology NNH16ZTT001N grant under Task Order #80NM0018F0589, and NASA grant 80NSSC22K0254. We also thank WorldQuant Foundation for their support, as well as the Starr Cancer Consortium: (I13-0052), the National Institutes of Health (R01AI151059, U01DA053941, R35GM138152), the Bill and Melinda Gates Foundation (OPP1151054), and the Alfred P. Sloan Foundation (G-2015-13964).”

2

Mitchell K, Raymond L, Wood J, Su J, Zhang J, Jin Y.

Material extrusion of helical shape memory polymer artificial muscles for human space exploration apparatus.

Polymers (Basel). 2022 Dec 6;14(23):5325.

https://pubmed.ncbi.nlm.nih.gov/36501720

Note: From the abstract: “Astronauts suffer skeletal muscle atrophy in microgravity and/or zero-gravity environments. Artificial muscle-actuated exoskeletons can aid astronauts in physically strenuous situations to mitigate risk during spaceflight missions. Current artificial muscle fabrication methods are technically challenging to be performed during spaceflight. The objective of this research is to unveil the effects of critical operating conditions on artificial muscle formation and geometry in a newly developed helical fiber extrusion method.” This article is part of Special Issue “Advanced Additive Processes and 3D Printing for Polymer Composites” (https://www.mdpi.com/journal/polymers/special_issues/processes_3D_printing). This article may be obtained online without charge.

Journal Impact Factor: 4.967

Funding: “The research was funded by the Nevada NASA Space Grant Consortium, grant number: 80NSSC20M0043.”

3

Bishé B, Golden SS, Golden JW.

Glycogen metabolism is required for optimal cyanobacterial growth in the rapid light-dark cycle of low-Earth orbit.

Life Sci Space Res. 2023 Feb;36:18-26.

https://doi.org/10.1016/j.lssr.2022.11.001

PI: B. Bishé

Note: From the abstract: “Some designs for bioregenerative life support systems to enable human space missions incorporate cyanobacteria for removal of carbon dioxide, generation of oxygen, and treatment of wastewater, as well as providing a source of nutrition. In this study, we examined the effects of the short light-dark (LD) cycle of low-Earth orbit on algal and cyanobacterial growth, approximating conditions on the International Space Station, which orbits Earth roughly every 90 minutes.”

Journal Impact Factor: 2.73

Funding: “Funding was made available by the National Aeronautics and Space Administration (NASA) Space Biology Program grant number 80NSSC19K0136. Research reported in this publication was supported in part by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R35GM118290 (to SSG). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This material is also based in part upon work supported by the National Science Foundation under Grant number IOS-1754946 (to JWG).”

4

Simmons P, Trujillo M, McElroy T, Binz R, Pathak R, Allen AR.

Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance.

Front Neurosci. 2022 Dec 6;16:908632.

https://doi.org/10.3389/fnins.2022.908632

PI: A.R. Allen

Journal Impact Factor: 5.152

Funding: “This research was funded by Translational Research Institute through NASA cooperative agreement NNX16AO69A (PS and AA) and NIH R01CA258673 (AA).”

5

LaGoy AD, Conkright WR, Proessl F, Sinnott AM, Beckner ME, Jabloner L, Eagle SR, Sekel NM, Roma PG, Dretsch MN, Flanagan SD, Mi Q, Nindl BC, Germain A, Connaboy C, Ferrarelli F.

Less daytime sleepiness and slow wave activity during sleep predict better physical readiness in military personnel.

Sleep Health. 2022 Dec 9. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/36503874

Journal Impact Factor: 4.450

Funding: “This work was supported by the Department of Defense (#W81XWH-17-2-0070). P.G.R. was supported in part by KBR’s Human Health and Performance Contract NNJ15HK11B through the National Aeronautics and SpaceAdministration.”

6

St Hilaire MA, Ámundadóttir ML, Rahman SA, Rajaratnam SMW, Rüger M, Brainard GC, Czeisler CA, Andersen M, Gooley JJ, Lockley SW.

The spectral sensitivity of human circadian phase resetting and melatonin suppression to light changes dynamically with light duration.

Proc Natl Acad Sci USA. 2022 Dec 20;119(51):e2205301119. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/36508661

PIs: C.A. Czeisler, S.W. Lockley

Journal Impact Factor: 12.779

Funding: “NASA, NIH, National Institute for Occupational Safety and Health–Centers for Disease Control and Prevention, National Space Biomedical Research Institute, and Department of Homeland Security’s Federal Emergency Management Agency.”

7

Whittle RS, Diaz-Artiles A.

Gravitational effects on carotid and jugular characteristics in graded head-up and head-down tilt.

J Appl Physiol (1985). 2022 Dec 8. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/36476158

PI: A. Diaz-Artiles

Note: Head-up and head-down tilt study. From the abstract: “Altered-gravity affects hemodynamics and blood flow in the neck. At least one incidence of jugular venous thrombosis has been reported in an astronaut on the International Space Station. This investigation explores the impact of changes in the direction of the gravitational vector on the characteristics of the neck arteries and veins.”

Journal Impact Factor: 3.880

Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) Human Research Program (HRP), Grant 80NSSC20K1521.”

8

Waisberg E, Ong J, Paladugu P, Kamran SA, Zaman N, Tavakkoli A, Lee AG.

Advances in machine learning to detect preventable causes of blindness.

Eye (Lond). 2022 Dec 10.

https://pubmed.ncbi.nlm.nih.gov/36496462

PI: A. Tavakkoli

Note: This is a correspondence.

Journal Impact Factor: 4.456

Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”

___________________________________________________

Other papers of interest:

1

Ogneva IV, Golubkova MA, Biryukov NS, Kotov OV.

Drosophila melanogaster oocytes after spaceflight: The early period of adaptation to the force of gravity.

Cells. 2022 Dec 1;11(23):3871.

https://pubmed.ncbi.nlm.nih.gov/36497128

Note: ISS results. This article may be obtained online without charge.

2

Barkaszi I, Ehmann B, Tölgyesi B, Balázs L, Altbäcker A.

Are head-down tilt bedrest studies capturing the true nature of spaceflight-induced cognitive changes? A review.

Frontiers in Physiology. 2022 2022-December-13;13:1008508. Review.

https://doi.org/10.3389/fphys.2022.1008508

Note: This article is part of Research Topic “Insights in Environmental, Aviation and Space Physiology: 2022” (https://www.frontiersin.org/research-topics/34248/insights-in-environmental-aviation-and-space-physiology-2022#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,003 https://doi.org/10.3389/fphys.2022.907651, #1,022 https://doi.org/10.3389/fphys.2022.1007316and https://doi.org/10.3389/fphys.2022.1003073 and #1,026 https://doi.org/10.3389/fphys.2022.1029161. This article may be obtained online without charge.

3

Samoilenko TV, Shishkina VV, Antakova LN, Atyakshin DA.

Smooth muscle tissue–a potential target of translational researches in space biomedicine.

Aviakosm Ekolog Med. 2022;56(6):5-15. Review. Russian.

https://www.elibrary.ru/item.asp?id=49834438

4

Tyrina EA, Andreeva ER, Buravkova LB.

Simulated microgravity affects stroma-dependent ex vivo myelopoiesis.

Tissue Cell. 2023 Feb;80:101987.

https://pubmed.ncbi.nlm.nih.gov/36481580

Note: A random positioning machine was used in this study.

5

Shoshina II, Kotova DA, Zelenskaya IS, Lyapunov SI, Lyapunov IS, Bekreneva MP, Tomilovskaya ES.

Contrast sensitivity and ocular tremulous micro-motions: A model study of changed gravity effects on visual perception.

Aviakosm Ekolog Med. 2022;56(6):23-30. Russian.

https://www.elibrary.ru/item.asp?id=49834440

Note: From the abstract: “Visual contrast sensitivity and tremulous micro-movements of eyes were evaluated in 10 human subjects volunteered for dry immersion (DI) as a model of the physiological effects of microgravity.”

6

Pastuhkova LK, Goncharova AG, Kashirina DN, Chebotok AN, Kononikhin AS, Brzhozovsky AG, Larina IM, Ilyin EA, Orlov OI.

Characteristics of the protein composition of the blood of a healthy human in the course of a year-long stay on the Antarctic station “Vostok.”

Aviakosm Ekolog Med. 2022;56(6):31-6. Russian.

https://www.elibrary.ru/item.asp?id=49834441

7

Bouredji Z, Argaw A, Frenette J.

The inflammatory response, a mixed blessing for muscle homeostasis and plasticity.

Front Physiol. 2022 Nov 23;13:1032450. Review.

https://pubmed.ncbi.nlm.nih.gov/36505042

Note: This article is part of Research Topic “Oxidative Stress and Inflammation in Skeletal Muscle Atrophy” (https://www.frontiersin.org/research-topics/32959/oxidative-stress-and-inflammation-in-skeletal-muscle-atrophy#overview). This article may be obtained online without charge.

8

Roy BL, Aufauvre-Poupon C, Ferragu A, Vannier A, Martin-Krumm C, Trousselard M.

Cardiac biosignal in confined nuclear submarine patrol: Heart rate variability a marker of adaptation.

Acta Astronaut. 2022 Dec 16. Online ahead of print.

https://doi.org/10.1016/j.actaastro.2022.12.014

Note: From the abstract: “Extreme and unusual, and isolated and confined environments are characterized by unique sensory stimulation. They are known to adversely affect human psychology and physiology, and threaten the outcome of spatial, polar, or submarine missions. This exploratory study evaluates the negative impact of a submarine patrol on the psychological and sensory performances according to heart rate variability.”

9Oranger A, Storlino G, Dicarlo M, Zerlotin R, Pignataro P, Sanesi L, Narici M, Pišot R, Simunič B, Colaianni G, Grano M, Colucci S.

Impact of 10-day bedrest on serum levels of irisin and markers of musculoskeletal metabolism.

FASEB J. 2022 Dec 7;37:e22668. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/36475382

Note: Bedrest study.

10

Belyak AM, Shilovich AA, Krivobok AS, Nikitin VB, Bibikova TN.

Evaluation of the effect of directed lighting by blue light-emitting diodes on growth of tap roots of Arabidopsis thaliana seedlings during slow 2D-clinostat rotation.

Aviakosm Ekolog Med. 2022;56(6):79-87. Russian.

https://www.elibrary.ru/item.asp?id=49834448

Note: A 2D clinostat was used in this study. From the abstract: “This paper presents the results of experiments with 48-hour horizontal and vertical clinosttating of 5-day-old Arabidopsis thaliana seedlings in 2 types of lighting, white light and lateral blue light.”

11

Osipova PD, Karpov DS, Domashin AI, Polyakov NB, Soloviev AI, Zubasheva MV, Zhukhovitsky VG, Poddubko SV.

Molecular mechanisms of super resistance of the Bacillus pumilus to antibiotics and oxidative stress.

Aviakosm Ekolog Med. 2022;56(6):70-8. Russian.

https://www.elibrary.ru/item.asp?id=49834447

Note: From the abstract: “This study was conducted to determine the resistance of the Bacillus pumilus strain to oxidizing agents, antibiotics, as well as to analyze the expression of genes associated with the cellular response to DNA damage and the level of hydrogen sulfide production.”

12

Setiawan GD, Treesubsuntorn C, Krobthong S, Yingchutrakul Y, Thiravetyan P.

Using multi-omics approach to investigate the effect of a moon soil simulant on Vigna radiata seedling root and shoot growth, stress responses, and photosynthesis.

Acta Astronaut. 2023 Jan;202:550-63.

https://doi.org/10.1016/j.actaastro.2022.11.022

Note: From the abstract: “The Moon’s first habitats with a support system and semi-permanent lunar settlement are projected for the 2030s. Growing plants for a food supply is one of the most important factors supporting human life on the Moon. A Moon soil simulant was used in this study as a simulation of the use of available resources on the Moon and a representation of one of the possible alternatives to Moon agriculture.”

13

Hu J, Li S, Liu H, Hu D.

Reliability and lifetime estimation of bioregenerative life support system based on 370-day closed human experiment of Lunar Palace 1 and Monte Carlo simulation.

Acta Astronaut. 2023 Jan;202:609-16.

https://doi.org/10.1016/j.actaastro.2022.11.021

Note: From the abstract: “It is extremely important to accurately estimate reliability and lifetime of Bioregenerative Life Support System (BLSS) for its proper design, building and operation. However, this problem remains unsolved due to data deficiency of long-period prototype experiments. In this paper, the first ground-based experimental prototype of BLSS in China, Lunar Palace 1 (LP1), was selected as representative to estimate the reliability and lifetime of BLSS, because the number and time of each unit failure of LP1 was accurately recorded during the 370-day closed human experiment of LP1.”

…