NASA Spaceline Current Awareness List #1,026 2 December 2022 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm.
Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Clément G, Moudy SC, Macaulay TR, Bishop MO, Wood SJ.
Mission-critical tasks for assessing risks from vestibular and sensorimotor adaptation during space exploration.
Front Physiol. 2022 Nov 25;13:1029161.
https://doi.org/10.3389/fphys.2022.1029161
PIs: G. Clément, S.C. Moudy, T.R. Macaulay, S.J. Wood
Note: ISS results. This article is part of Research Topic “Insights in Environmental, Aviation and Space Physiology: 2022” (https://www.frontiersin.org/research-topics/34248/insights-in-environmental-aviation-and-space-physiology-2022#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,003 https://doi.org/10.3389/fphys.2022.907651 and #1,022 https://doi.org/10.3389/fphys.2022.1007316 and https://doi.org/10.3389/fphys.2022.1003073. This article may be obtained online without charge.
Journal Impact Factor: 4.755
Funding: “This study was funded by the National Aeronautics and Space Administration (NASA). The data reported here were from the NASA Human Research Program Standard Measures Cross-Cutting Project.”
2
Shaka S, Carpo N, Tran V, Cepeda C, Espinosa-Jeffrey A.
Space microgravity alters neural stem cell division: Implications for brain cancer research on Earth and in space.
Int J Mol Sci. 2022 Nov 18;23(22):14320.
https://pubmed.ncbi.nlm.nih.gov/36430810
PI: A. Espinosa-Jeffrey
Note: ISS results. This article is part of Special Issue “Microgravity and Space Medicine in Cancer Cell Activity” (https://www.mdpi.com/journal/ijms/special_issues/Microgravity_Space_CancerCell). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 6.208
Funding: “NASA Space Biology for Grant: NNX15AB43G as well as NIH/NICHD grant number U54HD087101-05, which supports the IDDRC Cell Culture Core.”
3
Haveman NJ, Zhou M, Callaham J, Strickland HF, Houze D, Manning-Roach S, Newsham G, Paul AL, Ferl RJ.
Utilizing the KSC fixation tube to conduct human-tended plant biology experiments on a suborbital spaceflight.
Life (Basel). 2022 Nov 13;12(11):1871.
https://pubmed.ncbi.nlm.nih.gov/36431005
Note: From the abstract: “Suborbital spaceflights now enable human-tended research investigating short-term gravitational effects in biological systems, eliminating the need for complex automation. Here, we discuss a method utilizing KSC Fixation Tubes (KFTs) to both carry biology to suborbital space as well as fix that biology at certain stages of flight.” This article is part of Special Issue “Plants and Microgravity” (https://www.mdpi.com/journal/life/special_issues/plants_microgravity). The Special Issue also includes an article from previous Current Awareness List #1,025 https://doi.org/10.3390/life12111809. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.253
Funding: “This study was funded by NASA Flight Opportunities and Biological and Physical Sciences grant 80NSSC18K1294 rewarded to R.J.F. and A.-L.P.”
4
Polutchko SK, Stewart JJ, McNamara M, Doherty Garcia N, López-Pozo M, Adams WW, Demmig-Adams B.
Lemna as a sustainable, highly nutritious crop: Nutrient production in different light environments.
Nutraceuticals. 2022 Nov 11;2(4):350-64.
https://doi.org/10.3390/nutraceuticals2040027
PI: B. Demmig-Adams
Note: This article is part of Special Issue “Pigments in Food: Chemistry, Biological Activities and Therapeutical Potential of a Rainbow for Human Health” (https://www.mdpi.com/journal/nutraceuticals/special_issues/Pigments_Food). This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work was funded by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A, the National Science Foundation award number IOS-1907338, and the University of Colorado.”
5
Alvarado KA, García Martínez JB, Brown MM, Christodoulou X, Bryson S, Denkenberger DC.
Food production in space from CO2
using microbial electrosynthesis.
Bioelectrochemistry. 2023 Feb;149:108320.
https://pubmed.ncbi.nlm.nih.gov/36401963
Note: From the article: “In this study, the ESM [Equivalent System Mass] of MES [microbial electrosynthesis] was calculated and compared to the ESM of prepackaged food, microalgae SCP [single cell protein], and HOB [hydrogen-oxidizing bacteria] SCP.”
Journal Impact Factor: 5.76
Funding: “This work was supported by the Alaska Space Grant Program at the University of Alaska Fairbanks from the National Aeronautics and Space Administration [Cooperative Agreement 80NSSC20M0070].”
6
Wei F, Flowerdew K, Kinzel M, Perotti LE, Asiatico J, Omer M, Hovell C, Reumers V, Coathup MJ.
Changes in interstitial fluid flow, mass transport and the bone cell response in microgravity and normogravity.
Bone Res. 2022 Nov 21;10:65. Review.
https://pubmed.ncbi.nlm.nih.gov/36411278
Note: From the abstract: “This review explores the role of interstitial fluid motion and solute transport in porous bone under two different conditions: normogravity and microgravity.” This article may be obtained online without charge.
Journal Impact Factor: 13.362
Funding: “This study was internally funded. Author JA’s work was supported by the National Aeronautics and Space Administration [grant No. 80NSSC21M0309] issued through the NASA Office of STEM Engagement.”
7
Sempionatto JR, Lasalde-Ramírez JA, Mahato K, Wang J, Gao W.
Wearable chemical sensors for biomarker discovery in the omics era.
Nat Rev Chem. 2022 Nov 15;1-17. Review.
https://pubmed.ncbi.nlm.nih.gov/36406054
PI: W. Gao
Note: This article may be obtained online without charge.
Journal Impact Factor: 34.571
Funding: “This project was supported by National Institutes of Health (NIH) grant R01HL155815; National Science Foundation (NSF) grant 2145802; Ofice of Naval Research grants N00014-21-1-2483 and N00014-21-1-2845; the Translational Research Institute for Space Health through NASA NNX16AO69A; American Cancer Society Research Scholar Grant RSG-21-181-01-CTPS; High Impact Pilot Research Award T31IP1666 from the Tobacco-Related Disease Research Program; and the Center of Wearable Sensors at University of California San Diego.”
8
Sung JK, Kassel R, Hargens A, Huang AS.
Potential countermeasures for Spaceflight Associated Neuro-Ocular Syndrome.
In: Lee AG, Ong J, eds. Spaceflight Associated Neuro-Ocular Syndrome. Academic Press, 2022. p. 155-73.
https://doi.org/10.1016/B978-0-323-91524-3.00006-5
PI: A.S. Huang
Note: From the abstract: “Spaceflight Associated Neuro-Ocular Syndrome (SANS) is a novel optic neuropathy arising from exposure to a weightless environment. This only occurs on the International Space Station to astronauts. SANS represents a major hurdle to long-haul space travel given potential risk to vision and being able to safely complete mission objectives. While the etiology of SANS is not fully understood, simultaneous efforts are aimed at parallel development of potential SANS countermeasures associated with leading SANS hypotheses. Here, we raise the various SANS etiological hypotheses and discuss the current state of countermeasure development for each.”
Funding: “NASA 80NSSC20K1034 [AHS], NASA NNJ15KK11B [ASH], an unrestricted grant from Research to Prevent Blindness [UCSD].”
9
Mansisidor AR, Risca VI.
Chromatin accessibility: Methods, mechanisms, and biological insights.
Nucleus. 2022 Dec;13(1):236-76. Review.
https://pubmed.ncbi.nlm.nih.gov/36404679
PI: V.I. Risca
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.590
Funding: “This work was supported by the Irma T. Hirschl/Monique Weill-Caulier Trust [Career Scientist Award] to V.I.R.; NIH Office of the Director [1DP2GM150021-01] to V.I.R.; National Institute of General Medical Sciences [F32 GM140551] to A.R.M.; NASA Space Operations Mission Directorate Human Research Program [80NSSC21K0565] to V.I.R.; Rita Allen Foundation [Scholar Award] to A.R.M.; V Foundation for Cancer Research [V Scholar Award V2019-011] to V.I.R.”
___________________________________________________
Other papers of interest:
1
Siems K, Runzheimer K, Rehm A, Schwengers O, Heidler von Heilborn D, Kaser L, Arndt F, Neidhöfer C, Mengel JP, Parcina M, Lipski A, Hain T, Moeller R.
Phenotypic and genomic assessment of the potential threat of human spaceflight-relevant Staphylococcus capitis isolates under stress conditions.
Front Microbiol. 2022 Nov 3;13:1007143.
https://pubmed.ncbi.nlm.nih.gov/36406458
Note: ISS results. This article is part of Research Topic “Rising Stars in Space Microbiology: 2022” (https://www.frontiersin.org/research-topics/27421/rising-stars-in-space-microbiology-2022#overview). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
2
Chaloulakou S, Poulia KA, Karayiannis D.
Physiological alterations in relation to space flight: The role of nutrition.
Nutrients. 2022 Nov 19;14(22):4896. Review.
https://pubmed.ncbi.nlm.nih.gov/36432580
Note: This article is part of Section “Nutrition and Metabolism” (https://www.mdpi.com/journal/nutrients/sections/Nutrition_Metabolism). This article may be obtained online without charge.
3
Gao Q, Li J, Zhu Y, Wang S, Liufu J, Liu J.
Hand gesture teleoperation for dexterous manipulators in space station by using monocular hand motion capture.
Acta Astronaut. 2022 Nov 26. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2022.11.047
Note: From the abstract “Space robots in the space station can assist or substitute astronauts to conduct some in-cabin tasks to alleviate the problems of heavy tasks and the limited number of astronauts in the space station. In response to these problems, a hand gesture teleoperation method is proposed for controlling of dexterous manipulators in the space station, which is based on monocular hand motion capture and video-calling tools.”
4
Jin H, Fu X, Yu X, Zhu L, Yang Q, Yuan F.
Genome-wide comparison of structural variations and transposon alterations in soybean cultivars induced by spaceflight.
Int J Mol Sci. 2022 Nov 8;23(22):13721.
https://pubmed.ncbi.nlm.nih.gov/36430198
Note: This article is part of Special Issue “Soybean Molecular Breeding and Genetics 2.0” (https://www.mdpi.com/journal/ijms/special_issues/Soybean_Molecular_Breeding_and_Genetics_2). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
5
Meigal A, Gerasimova-Meigal L.
Cold for gravity, heat for microgravity: A critical analysis of the “Baby Astronaut“ concept.
Front Space Technol. 2022 Nov 22;3:981668.
https://doi.org/10.3389/frspt.2022.981668
Note: This article is part of Research Topic “The Human Body, Brain, and Behaviour in the Context of Spaceflight and Extreme Environments” (https://www.frontiersin.org/research-topics/23515/the-human-body-brain-and-behaviour-in-the-context-of-spaceflight-and-extreme-environments#overview). This article may be obtained online without charge.
6
Millar-Wilson A, Ward Ó, Duffy E, Hardiman G.
Multiscale modeling in the framework of biological systems and its potential for spaceflight biology studies.
iScience. 2022 Nov 18;25(11):105421. Review.
https://pubmed.ncbi.nlm.nih.gov/36388986
Note: This article may be obtained online without charge.
7
D’Agostino M, Babin AL, Zaffino M, Frippiat JP, Machouart M, Debourgogne A.
Simulated microgravity created using a random positioning machine induces changes in the physiology of the Fusarium solani species complex.
Microorganisms. 2022 Nov 16;10(11):2270.
https://pubmed.ncbi.nlm.nih.gov/36422340
Note: A random positioning machine was used in this study. This article belongs to Section “Medical Microbiology” (https://www.mdpi.com/journal/microorganisms/sections/medical_microbiology). This article may be obtained online without charge.
8
Nistorescu A, Busnatu SS, Dinculescu A, Olteanu G, Marin M, Jercalau CE, Vizitiu C, Papacocea IR.
Striated muscle evaluation based on velocity and amortization ratio of mechanical impulse propagation in simulated microgravity environment.
Biology (Basel). 2022 Nov 18;11(11):1677.
https://pubmed.ncbi.nlm.nih.gov/36421391
Note: From the abstract: “Long-duration space flight missions impose extreme physiological stress and changes on the crew due to the microgravity exposure. The herein study was performed by using MusTone, a device developed by the Institute of Space Science, to understand the influence of microgravity physiological stress on striated muscles and to provide countermeasures that are able to minimize the negative effects of weightlessness on musculoskeletal function. The results emerged following a statistical analysis performed on the data collected from six subjects engaged in a 21-days Dry Immersion (DI) experiment.” This article may be obtained online without charge.
9
Zhang X, Xue T, Hu Z, Guo X, Li G, Wang Y, Zhang L, Xu L, Cao X, Zhang S, Shi F, Wang K.
Bioinformatic analysis of the RNA expression patterns in microgravity-induced bone loss.
Front Genet. 2022 Nov 8;13:985025.
https://pubmed.ncbi.nlm.nih.gov/36425065
Note: This article is part of Research Topic “Genetic and Environmental Roles in Bone and Joint Diseases” (https://www.frontiersin.org/research-topics/37705/genetic-and-environmental-roles-in-bone-and-joint-diseases#overview). This article may be obtained online without charge.
10
Abe C, Katayama C, Horii K, Okada R, Kamimura D, Nin F, Morita H.
Changes in metabolism and vestibular function depend on gravitational load in mice.
J Appl Physiol (1985). 2022 Nov 17. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36395381
11
Herssens N, Cowburn J, Albracht K, Braunstein B, Cazzola D, Colyer S, Minetti AE, Pavei G, Rittweger J, Weber T, Green DA.
Movement in low gravity environments (MoLo) programme-The MoLo-L.O.O.P. study protocol.
PLoS One. 2022 Nov 23;17(11):e0278051.
https://pubmed.ncbi.nlm.nih.gov/36417480
Note: From the abstract: “Twenty-six healthy participants will be recruited for this cross-sectional study. Participants will walk, skip and run, at speeds ranging between 0.56-3.6 m/s, and perform plyometric movement trials at each gravity level (1, 0.7, 0.5, 0.38, 0.27 and 0.16g) in a randomized order. Through the collection of state-of-the-art kinetics, kinematics, muscle activation and muscle-tendon behaviour, a musculoskeletal modelling framework will be used to estimate lower limb joint reaction forces via tracking simulations.” This article may be obtained online without charge.
12
Amelard R, Flannigan N, Patterson CA, Heigold H, Hughson RL, Robertson AD.
Assessing jugular venous compliance with optical hemodynamic imaging by modulating intrathoracic pressure.
J Biomed Opt. 2022 Nov 17;27(11):116005.
https://pubmed.ncbi.nlm.nih.gov/36385200
Note: This article may be obtained online without charge.
13
Baek Y, Jung K, Kim H, Lee S.
Partial sleep restriction-induced changes in stress, quality of life, and lipid metabolism in relation to cold hypersensitivity: A before-and-after intervention study.
Medicine (Baltimore). 2022 Nov 18;101(46):e31933.
https://pubmed.ncbi.nlm.nih.gov/36401418
Note: This article may be obtained online without charge.
14
Bezerra A, Freitas L, Maciel L, Fonseca H.
Bone tissue responsiveness to mechanical loading-possible long-term implications of swimming on bone health and bone development.
Curr Osteoporos Rep. 2022 Nov 19. Review.
https://pubmed.ncbi.nlm.nih.gov/36401774
Note: From the abstract: “The purpose of this review is to revisit the bone tissue mechanotransduction mechanisms behind the bone tissue response to mechanical loading and, within this context, explore the possible negative influence of regular swimming practice on bone health, particularly during the growth and development period.”
15
Bowles NP, Thosar SS, Butler MP, Clemons NA, Robinson LD, Ordaz OH, Herzig MX, McHill AW, Rice SPM, Emens J, Shea SA.
The circadian system modulates the cortisol awakening response in humans.
Front Neurosci. 2022 Nov 3;16:995452.
https://pubmed.ncbi.nlm.nih.gov/36408390
Note: This article may be obtained online without charge.
16
Kim E, Yoo SH, Chen Z.
Circadian stabilization loop: The regulatory hub and therapeutic target promoting circadian resilience and physiological health.
F1000Res. 2022 Oct 31;11:1236.
https://pubmed.ncbi.nlm.nih.gov/36415204
Note: This article may be obtained online without charge.
17
Egli J, Heiler S, Weber F, Steiner G, Schwandt T, Bray-French K, Klein C, Fenn S, Lotz GP, Opolka-Hoffmann E, Kraft TE, Petersen L, Moser R, DeGeer J, Siegel M, Finke D, Bessa J, Iglesias A.
Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice.
MAbs. 2022 Nov 17;14(1):2143009.
https://pubmed.ncbi.nlm.nih.gov/36394299
18
Zhang Q, Chiu Y, Chen Y, Wu Y, Dunne LW, Largo RD, Chang EI, Adelman DM, Schaverien MV, Butler CE.
Harnessing the synergy of perfusable muscle flap matrix and adipose-derived stem cells for prevascularization and macrophage polarization to reconstruct volumetric muscle loss.
Bioact Mater. 2023 Apr;22:588-614.
https://pubmed.ncbi.nlm.nih.gov/36382023
Note: This article may be obtained online without charge.
19
Kutz L, Zhou T, Chen Q, Zhu H.
A surgical approach to hindlimb suspension: A mouse model of disuse-induced atrophy.
In: Lucas, A.R., ed. Chemokine-Glycosaminoglycan Interactions. Methods in Molecular Biology. Vol 2597. New York: Humana, 2022. p. 1-9.
https://pubmed.ncbi.nlm.nih.gov/36374409
20
Siddiqui R, Qaisar R, Khan NA, Alharbi AM, Alfahemi H, Elmoselhi A.
Effect of microgravity on the gut microbiota bacterial composition in a hindlimb unloading model.
Life (Basel). 2022 Nov 12;12(11):1865.
https://pubmed.ncbi.nlm.nih.gov/36431000
Note: Hindlimb unloading study. This article may be obtained online without charge.
21
Hua C, Pan Y, Li J, Wang Z.
Gait recognition by combining the long-short-term attention network and personal physiological features.
Sensors (Basel). 2022 Nov 14;22(22):8779.
https://pubmed.ncbi.nlm.nih.gov/36433380
Note: This article is part of Special Issue “Sensor Technologies for Gait Analysis” (https://www.mdpi.com/journal/sensors/special_issues/STfGA). This article may be obtained online without charge.
22
Lizamore CA, Stoner L, Kathiravel Y, Elliott J, Hamlin MJ.
Does intermittent hypoxic exposure enhance the cardioprotective effect of exercise in an inactive population?
Front Physiol. 2022 Nov 21;13:1005113.
https://doi.org/10.3389/fphys.2022.1005113
Note: This article is part of Research Topic “Long-term effects of hypoxic conditioning on sports performance, health and well-being” (https://www.frontiersin.org/research-topics/34247/long-term-effects-of-hypoxic-conditioning-on-sports-performance-health-and-well-being#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,020 https://doi.org/10.3389/fphys.2022.1010086 and #1,023 https://doi.org/10.3389/fphys.2022.1043536. This article may be obtained online without charge.
23
Mansisidor AR, Risca VI.
Chromatin accessibility: Methods, mechanisms, and biological insights.
Nucleus. 2022 Nov 2;13(1):236-76. Review.
https://pubmed.ncbi.nlm.nih.gov/36404679
Note: This article may be obtained online without charge.
24
Ke X, Tang S, Wang H, Cai Y, Dong Z, Li M, Yang J, Xu X, Luo J, Li J.
Natural small biological molecule based supramolecular bioadhesives with innate photothermal antibacterial capability for nonpressing hemostasis and effective wound healing.
ACS Appl Mater Interfaces. 2022 Nov 18. Online ahead of print.
