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NASA Spaceline Current Awareness List #1,022  28 October 2022 (Space Life Science Research Results)

By Keith Cowing
Press Release
October 28, 2022
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NASA Spaceline Current Awareness List #1,022  28 October 2022 (Space Life Science Research Results)
NASA space plant biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Cope H, Willis CRG, MacKay MJ, Rutter LA, Toh LS, Williams PM, Herranz R, Borg J, Bezdan D, Giacomello S, Muratani M, Mason CE, Etheridge T, Szewczyk NJ.

Routine omics collection is a golden opportunity for European human research in space and analog environments.

Patterns. 2022 Oct 14;3(10):100550. Review. Published online 2022 Jul 30.

PI: C.E. Mason

Note: From the abstract: “Widespread generation and analysis of omics data have revolutionized molecular medicine on Earth, yet its power to yield new mechanistic insights and improve occupational health during spaceflight is still to be fully realized in humans. Nevertheless, rapid technological advancements and ever-regular spaceflight programs mean that longitudinal, standardized, and cost-effective collection of human space omics data are firmly within reach. Here, we consider the practicality and scientific return of different sampling methods and omic types in the context of human spaceflight.” GeneLab is available at This article may be obtained online without charge.

Journal Impact Factor: Available in 2023

Funding: PI reports funding from NASA grants 80NSSC22K0254 and NNX16AO69A.


Vitry G, Finch R, McStay G, Behesti A, Déjean S, Larose T, Wotring V, da Silveira WA.

Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice.

iScience. 2022 Oct 21;25(10):105213.

Note: From the abstract: “Human expansion in space is hampered by the physiological risks of spaceflight. The muscle and the liver are among the most affected tissues during spaceflight and their relationships in response to space exposure have never been studied. We compared the transcriptome response of liver and quadriceps from mice on NASA RR1 mission, after 37 days of exposure to spaceflight using GSEA [Gene Set Enrichment Analysis], ORA [over representation analysis], and sparse partial least square-differential analysis.” GeneLab is available at This article may be obtained online without charge.

Journal Impact Factor: 6.107

Funding: “W.A.d.S. acknowledge this work was partially funded by the ESA grant/contract 4000131202/20/NL/PG/pt ‘”Space Omics: Toward an integrated ESA/NASA–omics database for spaceflight and ground facilities experiments’’ awarded to Raul Herranz. V.W. acknowledges this work was partially funded by the ESA grant/ contract 4000134990/21/UK/AL. This work was allowed by the free access online repository data resources NASA GeneLab. The Rodent Research 1 data collection is supervised by Jonathan Galazka, Project Scientist, NASA GeneLab and Ruth Globus, RR1 Project Scientist NASA ARC.”


Dynan WS, Chang PY, Sishc BJ, Elgart SR.

Breaking the limit: Biological countermeasures for space radiation exposure to enable long-duration spaceflight.

Life Sci Space Res. 2022 Oct 12. Online ahead of print.

PI: W.S. Dynan

Note: Editorial in Life Sciences in Space Research. To view other articles in press go to

Journal Impact Factor: 2.73

Funding: “…We thank the NASA Space Radiation Element for financial support that enabled Open Access publication of this and other articles in the special issue. Writing of this article and editing of the special issue were supported in part by award number 80NSSC18K1116 from the US National Aeronautics and Space Administration to WSD.”


Miller KB, Mi KL, Nelson GA, Norman RB, Patel ZS, Huff JL.

Ionizing radiation, cerebrovascular disease, and consequent dementia: A review and proposed framework relevant to space radiation exposure.

Front Physiol. 2022 Oct 25;13:1008640. Review.

PI: G.A. Nelson

Note: This article is part of Research Topic “The human body, brain, and behaviour in the context of spaceflight and extreme environments” ( This article may be obtained online without charge.

Journal Impact Factor: 4.755

Funding: “This work was supported by the Human Research Program of the Human Exploration and Operations Mission Directorate of the National Aeronautics and Space Administration (NASA) (JLH, RBN); the Human Health and Performance contract NNJ15HK11B (ZSP); the NASA Langley Cooperative Agreement 80LARC17C0004 (KBM); the NASA internship program (KLM) and NASA grant 80NSSC18K0785 (GAN).”


Sishc BJ, Zawaski J, Saha J, Carnell LS, Fabre KM, Elgart SR.

The need for biological countermeasures to mitigate the risk of space radiation-induced carcinogenesis, cardiovascular disease, and central nervous system deficiencies.

Life Sci Space Res. 2022 Jun 14. Online ahead of print. Review.

Note: From the abstract: “This review outlines the unique challenges posed by the space radiation environment, defines the limits of terrestrial radiation protection strategies in space, describes a brief overview of current space radiation countermeasure development strategies, highlights potential new approaches for countermeasure identification and development, and speculates on the potential benefits beyond space exploration.”

Journal Impact Factor: 2.730

Funding: J. Zawaski is affiliated with NASA Johnson Space Center and L.S. Carnell is affiliated with NASA Physical and Biological Sciences Division, NASA Headquarters.


Xue S, Rogers LRK, Zheng M, He J, Piermarocchi C, Mias GI.

Applying differential network analysis to longitudinal gene expression in response to perturbations.

Front Genet. 2022 Oct 17;13:1026487.

PI: G.I. Mias

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.772

Funding: “This work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (project T0412). CP also acknowledges support from NIH/NIGMS (R01GM122085).”


Larson LE, Harris-Watson A, Carter D, Asencio R, DeChurch L, Kanfer R, Zaccaro SJ.

Staying apart to work better together: Team structure in cross-functional teams.

Acad Manag Discov. 2022 Oct 20. Online ahead of print.

PI: D.D. Carter

Journal Impact Factor: 6.527

Funding: “This material is based upon work supported by the National Science Foundation under Grants SMA-1262474, SMA-1063901, SES-1738297, the Army Research Office under Grant W911NF-17-1-0444, and the National Aeronautics and Space Administration under Grant #80NSSC18K0511.”


Lungeanu A, DeChurch LA, Contractor NS.

Leading teams over time through space: Computational experiments on leadership network archetypes.

Leadersh Q. 2022 Jan 12;101595.

PIs: L.A. DeChurch, N.S. Contractor

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.107

Funding: PI reports funding from NASA grants 80NSSC18K0221, 80NSSC18K0276, and NNX15AM32G.


Lungeanu A, Mesmer-Magnus JR, Niler AA, DeChurch LA, Contractor NS.

Organizing for Mars: A task management perspective on work within spaceflight multiteam systems.

Hum Factors. 2022 Oct 18;187208221129939. Online ahead of print.

PI: L.A. DeChurch

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.924

Funding: PI reports NASA grant 80NSSC18K0276 funding.


Other papers of interest:


Ramalho TP, Chopin G, Salman L, Baumgartner V, Heinicke C, Verseux C.

On the growth dynamics of the cyanobacterium Anabaena sp. PCC 7938 in Martian regolith.

npj Microgravity. 2022 Oct 26;8:43.

Note: From the abstract: “The sustainability of crewed infrastructures on Mars will depend on their abilities to produce consumables on site. These abilities may be supported by diazotrophic, rock-leaching cyanobacteria: from resources naturally available on Mars, they could feed downstream biological processes and lead to the production of oxygen, food, fuels, structural materials, pharmaceuticals and more. The relevance of such a system will be dictated largely by the efficiency of regolith utilization by cyanobacteria. We therefore describe the growth dynamics of Anabaena sp. PCC 7938 as a function of MGS-1 concentration (a simulant of a widespread type of Martian regolith), of perchlorate concentration, and of their combination.” This article may be obtained online without charge.

2Gricajeva A, Buchovec I, Kalėdienė L, Badokas K, Vitta P.

Riboflavin- and chlorophyllin-based antimicrobial photoinactivation of Brevundimonas sp. ESA1 biofilms.

Front Cell Infect Microbiol. 2022 Sep 21;12:1006723.

Note: From the abstract: “Some Brevundimonas spp. are globally emerging opportunistic pathogens that can be dangerous to individuals with underlying medical conditions and for those who are immunocompromised. Gram-negative Brevundimonas spp. can form resilient sessile biofilms and are found not only in different confined terrestrial settings (e.g., hospitals) but are also frequently detected in spacecraft, which is inhabited by astronauts that can have altered immunity. Therefore, Brevundimonas spp. pose a serious health hazard in different environments, especially in its biofilm form. Conventional antimicrobials applied to disrupt, inactivate, or prevent biofilm formation have limited efficiency and applicability in different closed-loop systems. Therefore, new, effective, and safe biofilm control technologies are in high demand. The present work aimed to investigate antimicrobial photoinactivation (API) of Brevundimonas sp. ESA1 monocultural biofilms mediated by non-toxic, natural photosensitizers such as riboflavin (RF) and chlorophyllin (Chl) with an emphasis of this technology as an example to be safely used in closed-loop systems such as spacecraft.” This article may be obtained online without charge.


Häder D-P, Hemmersbach R.

Euglena, a gravitactic flagellate of multiple usages.

Life. 2022 Sep 29;12(10):1522. Review.

Note: This article is part of Special Issue “Gravitational Microbiology Research and Applications” ( The Special Issue also includes articles from previous Current Awareness Lists #984; #1,006 and; #1,011; and #1,016 Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.


Kravtsova VV, Fedorova AA, Tishkova MV, Livanova AA, Matytsin VO, Ganapolsky VP, Vetrovoy OV, Krivoi II.

Short-term mild hypoxia modulates Na,K-ATPase to maintain membrane electrogenesis in rat skeletal muscle.

Int J Mol Sci. 2022 Oct 6;23(19):11869.

Note: From the abstract: “The Na,K-ATPase plays an important role in adaptation to hypoxia. Prolonged hypoxia results in loss of skeletal muscle mass, structure, and performance. However, hypoxic preconditioning is known to protect against a variety of functional impairments. In this study, we tested the possibility of mild hypoxia to modulate the Na,K-ATPase and to improve skeletal muscle electrogenesis.”


Tetzlaff K, Swenson ER, Bärtsch P.

An update on environment-induced pulmonary edema – When the lungs leak under water and in thin air.

Front Physiol. 2022 Oct 7;13:1007316.

Note: This article and the article below (Borzykh et al.) are part of Research Topic “Insights in Environmental, Aviation and Space Physiology: 2022” ( The Research Topic also includes an article from previous Current Awareness List #1,003 Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.


Borzykh AA, Gaynullina DK, Shvetsova AA, Kiryukhina OO, Kuzmin IV, Selivanova EK, Nesterenko AM, Vinogradova OL, Tarasova OS.

Voluntary wheel exercise training affects locomotor muscle, but not the diaphragm in the rat.

Front Physiol. 2022 Oct 26;13:1003073.

Note: This article and the article above (Tetzlaff et al.) are part of Research Topic “Insights in Environmental, Aviation and Space Physiology: 2022” ( This article may be obtained online without charge.


Patil VM, Noronha V, Menon N, Rai R, Bhattacharjee A, Singh A, Nawale K, Jogdhankar S, Tambe R, Dhumal S, Sawant R, Alone M, Karla D, Peelay Z, Pathak S, Balaji A, Kumar S, Purandare N, Agarwal A, Puranik A, Mahajan A, Janu A, Kumar Singh G, Mittal N, Yadav S, Banavali S, Prabhash K.

Low-dose immunotherapy in head and neck cancer: A randomized study.

J Clin Oncol. 2022 Oct 20;Jco2201015.


Zhang Y, Li Y, Han Z, Wang D, Fu Q, Umar Shinge SA, Muluh TA, Lu X.

Combined immunotherapy and targeted therapies for cancer treatment: Recent advances and future perspectives.

Curr Cancer Drug Targets. 2022 Oct 20. Review. Online ahead of print.


Jaber M, Poh PSP, Duda GN, Checa S.

PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study.

Front Bioeng Biotechnol. 2022 Sep 23;10:995266.

Note: This article may be obtained online without charge.


Belova SP, Zaripova K, Sharlo K, Kostrominova TY, Shenkman BS, Nemirovskaya TL.

Metformin attenuates an increase of calcium-dependent and ubiquitin-proteasome markers in unloaded muscle.

J Appl Physiol (1985). 2022 Oct 13. Online ahead of print.

Note: Hindlimb unloading study.


Hu Y, Liu Z, Hou A, Wu C, Wei W, Wang Y, Liu M.

On fatigue detection for air traffic controllers based on fuzzy fusion of multiple features.

Comput Math Methods Med. 2022 Oct 11;2022:4911005.

Note: This article may be obtained online without charge.


Kim JM, Lee SH, Kim HJ, Kim JS.

Less talked variants of benign paroxysmal positional vertigo.

J Neurol Sci. 2022 Nov 15;442:120440.

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