NASA Spaceline Current Awareness List #1,021 21 August 2022 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
David JW, Scheuring R, Doarn CR, Polk JD.
A history of the NASA operational spaceflight surgeon: 1958–present.
Acta Astronaut. 2022 Oct 18. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2022.10.024
Note: From the abstract: “The data gathered for this project were obtained from several sources including personal interviews with actively serving NASA personnel, a literature review identified by searches of MEDLINE, Current Contents, PubMed, Google Scholar, internal NASA records and databases, and references from relevant articles. Only articles published in English between 1961 and 2019 were included.”
Journal Impact Factor: 2.954
Funding: R. Scheuring is affiliated with NASA Johnson Space Center and C.R. Doarn and J.D. Polk are affiliated with NASA Headquarters.
2
Lam CW, Ryder VE.
Spacecraft maximum allowable concentrations for hydrogen fluoride.
Aerosp Med Hum Perform. 2022 Oct;93(10):746-8.
https://pubmed.ncbi.nlm.nih.gov/36243906
Note: From the abstract: “Toxicological data relevant to SMAC [spacecraft maximum allowable concentrations] development were collected from electronic databases using principles of systematic review, and from previous assessments and reviews of HF [hydrogen fluoride].”
Journal Impact Factor: 0.889
Funding: “This project was funded by NASA’s Human Health and Performance Contract to KBR.”
3
Stephenson S, Britten R.
Simulated space radiation exposure effects on switch task performance in rats.
Aerosp Med Hum Perform. 2022 Sep 1;93(9):673-80.
https://pubmed.ncbi.nlm.nih.gov/36224731
PIs: C. Limoli/R. Britten/NSCOR
Note: From the abstract: “Astronauts on the mission to Mars will be subjected to galactic cosmic radiation (GCR) exposures. While ground-based studies suggest that simulated GCR (GCRsim) exposure impairs performance in multiple cognitive tasks, the impact of such exposures on task switching performance (an important skill for all aviators) has not yet been determined.”
Journal Impact Factor: 0.889
Funding: “This work was funded by NASA grant support NNX15AI22G and NNX14AE73G. The authors have no conflict of interests to report for this study.”
4
Hertel NE, Biegalski SR, Nelson VI, Nelson WA, Mukhopadhyay S, Su Z, Chan AM, Kesarwala AH, Dynan WS.
Compact portable sources of high-LET radiation: Validation and potential application for galactic cosmic radiation countermeasure discovery.
Life Sci Space Res. 2022 Oct 19. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.10.002
PI: W.S. Dynan
Note: From the abstract: “Implementation of a systematic program for galactic cosmic radiation (GCR) countermeasure discovery will require convenient access to ground-based space radiation analogs. The current gold standard approach for GCR simulation is to use a particle accelerator for sequential irradiation with ion beams representing different GCR components. This has limitations, particularly for studies of non-acute responses, strategies that require robotic instrumentation, or implementation of complex in vitro models that are emerging as alternatives to animal experimentation. Here, we explore theoretical and practical issues relating to a different approach to provide a high-LET radiation field for space radiation countermeasure discovery, based on use of compact portable sources to generate neutron-induced charged particles. We present modeling studies showing that DD and DT neutron generators, as well as an AmBe radionuclide-based source, generate charged particles with a linear energy transfer (LET) distribution that, within a range of biological interest extending from about 10 to 200 keV/μm, resembles the LET distribution of reference GCR radiation fields experienced in a spacecraft or on the lunar surface. We also demonstrate the feasibility of using DD neutron
s to induce 53BP1 DNA double-strand break repair foci in the HBEC3-KT line of human bronchial epithelial cells, which are widely used for studies of lung carcinogenesis.”
Journal Impact Factor: 2.730
Funding: “This work was supported by award number 80NSSC18K1116 from the US National Aeronautics and Space Administration to WSD and by award number R00CA222493 from the US Public Health Service to AHK.”
5
Ong J, Zaman N, Waisberg E, Kamran SA, Lee AG, Tavakkoli A.
Head-mounted digital metamorphopsia suppression as a countermeasure for macular-related visual distortions for prolonged spaceflight missions and terrestrial health.
Wearable Technologies. 2022 Oct 12;3:e26.
https://doi.org/10.1017/wtc.2022.21
PI: A. Tavakkoli
Note: From the abstract: “During long-duration spaceflight, astronauts are exposed to various risks including spaceflight-associated neuro-ocular syndrome, which serves as a risk to astronaut vision and a potential physiological barrier to future spaceflight. When considering exploration missions that may expose astronauts to longer periods of microgravity, radiation exposure, and natural aging processes during spaceflight, more severe changes to functional vision may occur. The macula plays a critical role in central vision and disruptions to this key area in the eye may compromise functional vision and mission performance. In this article, we describe the development of a countermeasure technique to digitally suppress monocular central visual distortion with head-mounted display technology.” This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) [Grant Number 80NSSC20K1831: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight].”
6
Saravia-Butler AM, Schisler JC, Taylor D, Beheshti A, Butler D, Meydan C, Foox J, Hernandez K, Mozsary C, Mason CE, Meller R.
Host transcriptional responses in nasal swabs identifies potential SARS-CoV-2 infection in PCR negative patients.
iScience. 2022 Oct 7;105310. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36246576
PIs: A. Beheshti, C.E. Mason
Note: This article may be obtained online without charge.
Journal Impact Factor: 6.107
Funding: “RM was funded by R01NS112422. This work used resources services, and support provided via the COVID-19 HPC Consortium (https://covid19-hpc-consortium.org), provided specifically by the NASA High-End Computing (HEC) Program through the NASA Advanced Supercomputing (NAS) Division at Ames Research Center which was awarded to A.B. CEM also thanks Testing for America (501c3), OpenCovidScreen Foundation, the Bert L and N Kuggie Vallee Foundation, Igor Tulchinsky and the WorldQuant Foundation, Bill Ackman and Olivia Flatto and the Pershing Square Foundation, Ken Griffin and Citadel, the US National Institutes of Health (R01AI125416, R21AI129851, R01AI151059, U01DA053941), Rick Bright and Jim Golden from the Rockefeller Foundation’s PPI, and the Alfred P. Sloan Foundation (G-2015-13964). JCS was funded by the National Institute on Aging (R01AG066710 and R01AG061188) and the McAllister Cardiovascular Research Fund.”
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Other papers of interest:
1
Moukhamedieva L, Ozerov D, Pakhomova A.
The distribution of trace contaminants in the manned space station atmosphere.
Acta Astronaut. 2022 Dec;201:597-601.
https://doi.org/10.1016/j.actaastro.2022.09.053
Note: ISS results. From the abstract: “The research is based on the results of air quality monitoring for the period from 2000 to 2020. The air samples have been taken onboard the International Space Station (ISS) using AK-1M samplers and delivered to Earth.”
2
Yamazaki C, Yamazaki T, Kojima M, Takebayashi Y, Sakakibara H, Uheda E, Oka M, Kamada M, Shimazu T, Kasahara H, Sano H, Suzuki T, Higashibata A, Miyamoto K, Ueda J.
Comprehensive analyses of plant hormones in etiolated pea and maize seedlings grown under microgravity conditions in space: Relevance to the International Space Station experiment “Auxin Transport.”
Life Sci Space Res. 2022 Oct 15. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.10.005
Note: ISS results.
3
Smith LM.
The psychology and mental health of the spaceflight environment: A scoping review.
Acta Astronaut. 2022 Dec;201:496-512. Review.
https://doi.org/10.1016/j.actaastro.2022.09.054
4
Kamine TH, Siu M, Kramer K, Kelly E, Alouidor R, Fernandez G, Levin D.
Spatial volume necessary to perform open appendectomy in a spacecraft.
Aerosp Med Hum Perform. 2022 Oct 1;93(10):760-3.
https://pubmed.ncbi.nlm.nih.gov/36243909
Note: From the abstract: “With the increase in crewed commercial spaceflight and expeditions to the Moon and Mars, the risk of critical surgical problems and need for procedures increases. Appendicitis and appendectomy are the most common surgical pathology and procedure performed, respectively. The habitable volume of current spacecraft ranges from 4 m³ (Soyuz) to 425 m³ (International Space Station). We investigated the minimum volume required to perform an appendectomy and compared that to habitable spacecraft volumes.”
5
Ong KM, Rossitto JJ, Ray K, Dufurrena QA, Blue RS.
Blood glucose alterations and continuous glucose monitoring in centrifuge-simulated spaceflight.
Aerosp Med Hum Perform. 2022 Sep 1;93(9):688-95.
https://pubmed.ncbi.nlm.nih.gov/36224737
Note: A long-arm high-performance human centrifuge was used for simulation of hypergravity.
6
Smirnov NN.
Safety in space.
Acta Astronaut. 2022 Oct 18. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2022.10.028
Note: From the abstract: “Launching spacecraft has become an international business: control over the entire set of satellites in near-Earth orbit, providing geolocation, meteorological observation, fast communications, and other needs of states. During the Ninth Space Flights Safety Symposium, the problems of spaceflight safety were discussed, protective measures were presented, and future strategies were discussed aimed at safe and peaceful space missions. The following topics were topics of discussion: fire safety of space vehicles, protection of space structures from space debris collisions and micrometeoroids, propulsion systems modeling and simulations, supercomputer predictive modeling for ensuring space program safety, safety at launch, and during landing or splash down.”
7
Zhang Q, Ding L, Sun C, Feng H, Ma Y, Chen Y, Xin B, Nie J.
Effects of human thermophysiology and psychology in exposure to simulated microgravity.
Acta Astronaut. 2022 Dec;201:445-53.
https://doi.org/10.1016/j.actaastro.2022.09.050
Note: Head-down bedrest study.
8
Jules A, Means D, Troncoso JR, Fernandes A, Dadgar S, Siegel ER, Rajaram N.
Diffuse reflectance spectroscopy of changes in tumor microenvironment in response to different doses of radiation.
Radiat Res. 2022 Oct 14. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36240754
9
Stratis D, Trudel G, Rocheleau L, Pelchat M, Laneuville O.
The characteristic response of the human leukocyte transcriptome to 60 days of bed rest and to reambulation.
Med Sci Sports Exerc. 2022 Oct 17. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36251376
Note: Bedrest study.
10
Laws JM, Bruce-Martin C, Caplan N, Meroni R, Winnard A.
Exercise countermeasure preferences of three male astronauts, a preliminary qualitative study.
Acta Astronaut. 2022 Dec;201:224-9.
https://doi.org/10.1016/j.actaastro.2022.09.012
Note: From the abstract: “The responses of three male astronauts to an open-ended qualitative survey were analyzed using thematic analysis. All participants were required to currently be taking part in, or have previously taken part in, human spaceflight.”
11
Engin Demir A, Ata N.
Hysteria as a trigger for epidemic decompression sickness following hypobaric hypoxia training.
Aerosp Med Hum Perform. 2022 Oct 1;93(10):712-6.
https://pubmed.ncbi.nlm.nih.gov/36243908
12
Leinonen AM, Varis NO, Kokki HJ, Leino TK.
A new method for combined hyperventilation and hypoxia training in a tactical fighter simulator.
Aerosp Med Hum Perform. 2022 Sep 1;93(9):681-7.
https://pubmed.ncbi.nlm.nih.gov/36224739
13
Karim A, Qaisar R, Azeem M, Jose J, Ramachandran G, Ibrahim ZM, Elmoselhi A, Ahmad F, Abdel-Rahman WM, Ranade AV.
Hindlimb unloading induces time-dependent disruption of testicular histology in mice.
Sci Rep. 2022 Oct 18;12(1):17406.
https://pubmed.ncbi.nlm.nih.gov/36258006
Note: Hindlimb unloading study. This article may be obtained online without charge.
14
Plehuna A, Green DA, Amirova LE, Tomilovskaya ES, Rukavishnikov IV, Kozlovskaya IB.
Dry immersion induced acute low back pain and its relationship with trunk myofascial viscoelastic changes.
Front Physiol. 2022 Oct 13;13:1039924.
https://doi.org/10.3389/fphys.2022.1039924
Note: This article is part of Research Topic “Women in Space Physiology 2022” (https://www.frontiersin.org/research-topics/34966/women-in-space-physiology-2022#overview). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
15
Shen B, Tian Z, Li J, Sun Y, Xiao Y, Tang R.
Sleep deprivation influences trial-to-trial transfer but not task performance.
J Clin Med. 2022 Oct;11(19).
https://pubmed.ncbi.nlm.nih.gov/36233381
Note: This article may be obtained online without charge.
