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NASA Spaceline Current Awareness List #1,019 7 October 2022 (Space Life Science Research Results)

By Keith Cowing
Press Release
October 7, 2022
Filed under , , , , , ,
NASA Spaceline Current Awareness List #1,019 7 October 2022 (Space Life Science Research Results)
Space Biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Burian BK, Ebnali M, Robertson JM, Musson D, Pozner CN, Doyle T, Smink DS, Miccile C, Paladugu P, Atamna B, Lipsitz S, Yule S, Dias RD.

Using extended reality (XR) for medical training and real-time clinical support during deep space missions.

Appl Ergon. 2023 Jan;106:103902.

PI: R.D. Dias

Note: From the abstract: “Medical events can affect space crew health and compromise the success of deep space missions. To successfully manage such events, crew members must be sufficiently prepared to manage certain medical conditions for which they are not technically trained. Extended Reality (XR) can provide an immersive, realistic user experience that, when integrated with augmented clinical tools (ACT), can improve training outcomes and provide real-time guidance during non-routine tasks, diagnostic, and therapeutic procedures. The goal of this study was to develop a framework to guide XR platform development using astronaut medical training and guidance as the domain for illustration.”

Journal Impact Factor: 3.940

Funding: “This work was funded by the Translational Research Institute for Space Health (TRISH) through NASA Cooperative Agreement NNX16AO69A (Grant #T0506).”


Reynolds RJ, Scott RT, Turner RT, Iwaniec UT, Bouxsein ML, Sanders LM, Antonsen EL.

Validating causal diagrams of human health risks for spaceflight: An example using bone data from rodents.

Biomedicines. 2022 Sep 5;10(9):2187.

Note: From the abstract: “As part of the risk management plan for human system risks at the US National Aeronautics and Space Administration (NASA), the NASA Human Systems Risk Board uses causal diagrams (in the form of directed, acyclic graphs, or DAGs) to communicate the complex web of events that leads from exposure to the spaceflight environment to performance and health outcomes. However, the use of DAGs in this way is relatively new at NASA, and thus far, no method has been articulated for testing their veracity using empirical data. In this paper, we demonstrate a set of procedures for doing so, using (a) a DAG related to the risk of bone fracture after exposure to spaceflight; and (b) four datasets originally generated to investigate this phenomenon in rodents.” This article may be obtained online without charge.

Journal Impact Factor: 4.757

Funding: “This project received no external grant funding, though E.L.A. was supported by the Translational Research Institute for Space Health, through NASA NNX16AO69A.”


Wellman LL, Adkins AM, Yoon H, Britten RA, Sanford LD.

Telemetry in rats and mice: Methodological considerations and example studies of stress and anxiety in ground-based spaceflight analogs.

In: Harro J, editor. Psychiatric Vulnerability, Mood, and Anxiety Disorders: Tests and Models in Mice and Rats. Neuromethods, Vol. 190. New York, NY: Humana, 2023. p. 201-22.

PIs: R.A. Britten, L.D. Sanford

Note: From the abstract: “Telemetry can be a powerful tool for assessing physiological responses to emotional stimuli. It can provide continuously recorded data over the course of the stress response and can be incorporated into established behavioral paradigms and procedures in a relatively seamless fashion. Our lab has been using telemetry in conjunction with behavioral paradigms to study the relationship between anxiety and sleep in rat and mouse models for several years. This chapter discusses some of the current, commercially available telemetry systems, how telemetry compares to other recording methods, and a number of its advantages and disadvantages.”

Funding: “This work was supported by NASA grants 80NSSC19K1582 and NNX16AC40G.”


Suman S, Kumar S, Kallakury BVS, Moon BH, Angdisen J, Datta K, Fornace AJ Jr.

Predominant contribution of the dose received from constituent heavy-ions in the induction of gastrointestinal tumorigenesis after simulated space radiation exposure.

Radiat Environ Biophys. 2022 Sep 27.

PI: A.J. Fornace Jr/NSCOR

Journal Impact Factor: 2.017

Funding: “We are thankful to the National Aeronautics and Space Administration (NASA) for funding this study through grant #NNX09AU95G and 80NSSC22K1279. We highly appreciate the outstanding support provided by Dr. Adam Rusek, Dr. Peter Guida, and all the staff members of the NASA Space Radiation Laboratory (NSRL) to conduct space radiation exposures.”


Medina F-J, Manzano A, Herranz R, Kiss JZ.

Red light enhances plant adaptation to spaceflight and Mars g-levels.

Life. 2022 Sep 24;12(10):1484. Review.

PI: J.Z. Kiss

Note: This article is part of Special Issue “Plants and Microgravity” ( and may be obtained online without charge.

Journal Impact Factor: 3.251

Funding: “The research performed in the authors’ laboratory was supported by different grants of the Spanish National Agency for Research of the Spanish Government, e.g., Grants #ESP2015-64323-R and #RTI2018-099309-B-I00 (co-funded by EU-ERDF), and also by a grant from NASA (#80NSSC17K0546). Access to the ISS was made possible by ESA and NASA, and the use of ground-based facilities for microgravity simulation was supported by the ESA-CORA-GBF Program.”


Simmons P, Corley C, Allen AR.

Fractionated proton irradiation does not impair hippocampal-dependent short-term or spatial memory in female mice.

Toxics. 2022 Sep;10(9):507.

PI: A.R. Allen

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.472

Funding: “This research was funded by Translational Research Institute through NASA cooperative agreement NNX16AO69A (A.R.A.), NIH R01CA258673 (A.R.A.). This work was also supported by the Center for Translational Pediatric Research Genomics Core supported by P20 GM121293.”


Fernandez JC, Gilroy S.

Imaging systemic calcium response and its molecular dissection using virus-induced gene silencing.

In: Methods in Enzymology: Academic Press, 2022.

PI: S. Gilroy

Funding: “Supported by NSF MCB2016177 and NASA 80NSSC19K0126.”


Schimmoller BJ, Trovão NS, Isbell M, Goel C, Heck BF, Archer TC, Cardinal KD, Naik NB, Dutta S, Rohr Daniel A, Beheshti A.

COVID-19 Exposure Assessment Tool (CEAT): Exposure quantification based on ventilation, infection prevalence, group characteristics, and behavior.

Sci Adv. 2022 Sep 30;8(39):eabq0593.

PI: A. Beheshti

Note: This article may be obtained online without charge.

Journal Impact Factor: 14.957

Funding: “B.J.S. and M.I. developed the CEAT concept, method, model, code and user interface, conducted literature reviews, and prepared this manuscript using solely Signature Science LLC Internal Research and Development (IR&D) funding. S.D. was supported by the DOE Office of Science through the National Virtual Biotechnology Laboratory (NVBL), a consortium of DOE national laboratories focused on response to COVID-19, with funding provided by the Coronavirus CARES Act. A.B. is supported by supplementary funds for COVID-19 research from Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404) and further funding was provided by KBR Inc.”


Gaidica M, Dantzer B.

An implantable neurophysiology platform: Broadening research capabilities in free-living and non-traditional animals.

Front Neural Circuits. 2022 Sep 23;16:940989.

PI: M. Gaidica

Note: This article is part of Research Topic “Naturalistic Neuroscience–Towards a Full Cycle from Lab to Field” (—towards-a-full-cycle-from-lab-to-field#overview). This article may be obtained online without charge.

Journal Impact Factor: 3.342

Funding: “This work was funded by the University of Michigan and directly supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A.”


Langenfeld NJ, Bugbee B.

Germination and seedling establishment for hydroponics: The benefit of slant boards.

PLoS One. 2022 Oct 5;17(10):e0275710.

Note: This article may be obtained online without charge.

Journal Impact Factor: Not Available for this journal

Funding: “This research was supported by the Utah Agricultural Experiment Station, Utah State University, and approved as journal paper number 9600; NASA, Center for the Utilization of Biological Engineering in Space (grant number NNX17AJ31G).”


Bairamian D, Sha S, Rolhion N, Sokol H, Dorothée G, Lemere CA, Krantic S.

Microbiota in neuroinflammation and synaptic dysfunction: A focus on Alzheimers disease.

Mol Neurodegener. 2022 Mar 5;17:19.

PI: C.A. Lemere

Note: This article may be obtained online without charge.

Journal Impact Factor: 18.879

Funding: “Sorbonne Université and Institut National de la Santé et de la Recherche Médicale (INSERM) to D.B.; Centre National pour la Recherche Scientifque (CNRS) to S.K.; Centre de Recherche Saint Antoine (CRSA) to S.K. and N.R.; France Alzheimer (MicAD) and Fondation Alzheimer (MicIAD) to S.K; and NIH/NIA RF1 AG060057 and NASA 80NSSC18K0810 to C.A.L.”


Other papers of interest:


Moukhamedieva L, Ozerov D, Pakhomova A.

The distribution of trace contaminants in the manned space station atmosphere.

Acta Astronaut. 2022 Sep 28. Online ahead of print.

Note: ISS results.


Zhang P, Yan J, Liu Z, Yu H, Zhao R, Zhou Q.

Extreme conditions affect neuronal oscillations of cerebral cortices in humans in the China Space Station and on Earth.

Commun Biol. 2022 Sep 30;5(1):1041.

Note: From the abstract: “Rhythmical oscillations of neural populations can reflect working memory performance. However, whether neuronal oscillations of the cerebral cortex change in extreme environments, especially in a space station, remains unclear. Here, we recorded electroencephalography (EEG) signals when volunteers and astronauts were executing a memory task in extreme working conditions. Our experiments showed that two extreme conditions affect neuronal oscillations of the cerebral cortex and manifest in different ways. Lengthy periods of mental work impairs the gating mechanism formed by theta-gamma phase-amplitude coupling of two cortical areas, and sleep deprivation disrupts synaptic homeostasis, as reflected by the substantial increase in theta wave activity in the cortical frontal-central area. In addition, we excluded the possibility that nutritional supply or psychological situations caused decoupled theta-gamma phase-amplitude coupling or an imbalance in theta wave activity increase. Therefore, we speculate that the decoupled theta-gamma phase-amplitude coupling detected in astronauts results from their lengthy periods of mental work in the China Space Station.” This article may be obtained online without charge.


Zhang Q, Ding L, Sun C, Feng H, Ma Y, Chen Y, Xin B, Nie J.

Effects of human thermophysiology and psychology in exposure to simulated microgravity.

Acta Astronaut. 2022 Dec 22;201:445-53.

Note: Head-down bedrest study.


An R.

MRTF may be the missing link in a multiscale mechanobiology approach toward macrophage dysfunction in space.

Front Cell Dev Biol. 2022 Sep 12;10:997365.

Note: From the abstract: “Macrophages exhibit impaired phagocytosis, adhesion, migration, and cytokine production in space, hindering their ability to elicit immune responses. Considering that the combined effect of spaceflight microgravity and radiation is multiscale and multifactorial in nature, it is expected that contradictory findings are common in the field. This theory paper reanalyzes research on the macrophage spaceflight response across multiple timescales from seconds to weeks, and spatial scales from the molecular, intracellular, extracellular, to the physiological.” This article may be obtained online without charge.


Baba AI, Mir MY, Riyazuddin R, Cséplő Á, Rigó G, Fehér A.

Plants in microgravity: Molecular and technological perspectives.

Int J Mol Sci. 2022 Sep 11;23(18):10548. Review.

Note: From the abstract: “Here, we briefly review and discuss the current knowledge about plant gravity-sensing mechanisms and the experimental possibilities to research microgravity-effects on plants either on the Earth or in orbit.” This article may be obtained online without charge.


Cialdai F, Risaliti C, Monici M.

Role of fibroblasts in wound healing and tissue remodeling on Earth and in space.

Front Bioeng Biotechnol. 2022 Oct 4;10:958381. Review.

Note: This article is part of Research Topic “Wound Management and Healing in Space” ( The Research Topic also includes articles from previous Current Awareness Lists #958, #972, #973 and, #995, #998, #1,008, and #1,018 This article may be obtained online without charge.


De Micco V, Arena C, Di Fino L, Narici L.

Radiation environment in exploration-class space missions and plants responses relevant for cultivation in bioregenerative life support systems.

Front Plant Sci. 2022 Sep 23;13:1001158.

Note: This article may be obtained online without charge.


Fan T, Aslam MM, Zhou J-L, Chen M-X, Zhang J, Du S, Zhang K-L, Chen Y-S.

A crosstalk of circadian clock and alternative splicing under abiotic stresses in the plants.

Front Plant Sci. 2022 Oct 6;13:976807. Review.

Note: This article is part of Research Topic “Construction of Regulatory Networks in Plant Abiotic Stress Responses, Volume II” ( This article may be obtained online without charge.


Fais G, Manca A, Concas A, Pantaleo A, Cao G.

A novel process to grow edible microalgae on Mars by exploiting in situ-available resources: Experimental investigation.

Acta Astronaut. 2022 Dec;201;454-63.

Note: From the abstract: “The achievement of crewed missions on Mars is one of the main challenges the humanity is going to face in the next future. In this context, the possibility of growing Spirulina (Arthrospira platensis) intended to produce food for crew members on Mars has been investigated in this work.”


Farquharson S, Brouillette C, Shende C, Farquharson D, Morrison C.

Measurement of CO2

 in water from an ultraviolet oxidizer for a space-worthy wastewater recovery system using Raman spectroscopy.

Appl Spectrosc. 2022 Sep 22;37028221130789. Online ahead of print.

Note: From the abstract: “NASA has been developing and testing a water recovery system for over two decades to minimize the amount of water required for long duration human space missions. A key system component is the Total Organic Carbon Analyzer (TOCA) that determines if the recovered water is below the toxicology-defined health limit of 5 mg/L TOC and safe to drink. The TOCA is composed of a liquid phase loop and a gas phase loop. The TOCA employs an oxidizer to convert the organics in the liquid phase to carbon dioxide (CO2) and a liquid/gas separator to isolate the CO2 for measurement in the gas phase by infrared spectroscopy. In an effort to reduce the consumables, mass, volume and power of the system, we investigated the ability of surface-enhanced Raman spectroscopy (SERS), and Raman spectroscopy to measure 5 mg/L carbon in water. The SERS measurement employed silver colloids to increase sensitivity, while the Raman measurements used multiple mirrors to increase sensitivity. Here we present SERS measurements of CO3= at 3 mg/L carbon and Raman measurements of CO2 at 9 mg/L carbon in the effluent water of a new oxidizer being developed for a future TOCA. Both SERS and Raman can determine TOC in the liquid phase, eliminating the need for the gas phase loop and associated supplies and replacement components, which could effectively decrease the size and weight of the current TOCA by as much as 50%.”


Jin X, Wang H, Li F, Liang X, Deng X, Gao S, Ru K, Qiu W, Huai Y, Zhang J, Lai L, Miao Z, Zhang W, Qian A.

Formononetin ameliorates simulated microgravity-induced bone loss by suppressing bone turnover in rats.

Acta Astronaut. 2022 Nov;200:77-85.

Note: Hindlimb unloading study.


Li H, Xue YW, Quan Y, Zhang HY.

Reducing virus infection risk in space environments through nutrient supplementation.

Genes (Basel). 2022 Sep;13(9):1536.

Note: From the abstract: “Space exploration has brought many challenges to human physiology. In order to evaluate and reduce possible pathological reactions triggered by space environments, we conducted bioinformatics analyses on the methylation data of the Mars 520 mission and human transcriptome data in the experiment simulating gravity changes.” GeneLab is available at This article may be obtained online without charge.


Montagna G, Pani G, Flinkman D, Cristofaro F, Pascucci B, Massimino L, Lamparelli LA, Fassina L, James P, Coffey E, Rea G, Visai L, Rizzo AM.

Long-term osteogenic differentiation of human bone marrow stromal cells in simulated microgravity: Novel proteins sighted.

Cell Mol Life Sci. 2022 Oct 1;79(10):536.

Note: A random positioning machine was used in this study. This article may be obtained online without charge.


Pandith JA, Neekhra S, Ahmad S, Sheikh RA.

Recent developments in space food for exploration missions: A review.

Life Sci Space Res. 2022 Sep 24. Review. Online ahead of print.


Tozzo P, Delicati A, Caenazzo L.

Skin microbial changes during space flights: A systematic review.

Life. 2022;12(10):1498.

Note: This is part of Special Issue “Advances in Space Biology” ( The Special Issue also includes articles from previous Current Awareness Lists #1,002 and #1,015 Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.


Vinken M.

Hepatology in space: Effects of spaceflight and simulated microgravity on the liver.

Liver Int. 2022 Oct 2. Review. Online ahead of print.

Note: This article may be obtained online without charge.


Smith LM.

The psychology and mental health of the spaceflight environment: A scoping review.

Acta Astronaut. 2022 Oct 4. Online ahead of print.


Visscher AM, Pritchard HW, Neri G, Ballesteros D.

How do we transport plant species with desiccation-sensitive germplasm in space?

Life Sci Space Res. 2022 Sep. Online ahead of print.


Kurazumi T, Kato T, Konishi T, Ogawa Y, Iwasaki KI.

Alteration in facial skin blood flow during acute exposure to -10° and -30° head-down tilt in young human volunteers.

Exp Physiol. 2022 Oct 2. Online ahead of print.

Note: Head-down tilt study.


Rozhkov SV, Sharlo KA, Shenkman BS, Mirzoev TM.

Inhibition of mTORC1 differentially affects ribosome biogenesis in rat soleus muscle at the early and later stages of hindlimb unloading.

Arch Biochem Biophys. 2022 Nov 15;730:109411.

Note: Hindlimb unloading study.


Yang X, Li P, Lei J, Feng Y, Tang L, Guo J.

Integrated application of low-intensity pulsed ultrasound in diagnosis and treatment of atrophied skeletal muscle induced in tail-suspended rats.

Int J Mol Sci. 2022 Sep;23(18):10369.

Note: Hindlimb unloading study. This article may be obtained online without charge.


Hinzmann D, Singer M, Schmelter V, Kreiser K, Gehling K, Ströber L, Kirschke JS, Schulz CM, Schneider F.

Differences in beginner and expert neurointerventionalists heart rate variability during simulated neuroangiographies.

Interv Neuroradiol. 2022 Sep 19:15910199221128439. Online ahead of print.

Note: This article may be obtained online without charge.


Zhang Y, Ren R, Yang L, Zhang H, Shi Y, Shi J, Sanford LD, Lu L, Vitiello MV, Tang X.

Comparative efficacy and acceptability of psychotherapies, pharmacotherapies, and their combination for the treatment of adult insomnia: A systematic review and network meta-analysis.

Sleep Med Rev. 2022 Oct;65:101687. Review.

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