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NASA Spaceline Current Awareness List #1,023 4 November 2022 (Space Life Science Research Results)

By Keith Cowing
Press Release
November 4, 2022
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NASA Spaceline Current Awareness List #1,023  4 November  2022 (Space Life Science Research Results)
Space Biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Pardon LP, Greenwald SH, Ferguson CR, Patel NB, Young M, Laurie SS, Macias BR.

Identification of factors associated with the development of optic disc edema during spaceflight.

JAMA Ophthalmol. 2022 Oct 27. Online ahead of print.

PIs: S.S. Laurie, B.R. Macias

Note: ISS results.

Journal Impact Factor: 8.3

Funding: “Dr. Laurie reported receiving grants from the National Aeronautics and Space Administration (NASA) during the conduct of the study. Dr Macias reported receiving grants from NASA during the conduct of the study.”


Stroud JE, Gale MS, Zwart SR, Heer M, Smith SM, Montina T, Metz GAS.

Longitudinal metabolomic profiles reveal sex-specific adjustments to long-duration spaceflight and return to Earth.

Cell Mol Life Sci. 2022 Nov 1;79(11):578.

PIs: S.R. Zwart, S.M. Smith

Note: ISS results.

Journal Impact Factor: 9.207

Funding: “This work was funded by the Natural Sciences and Engineering Research Council of Canada (NSERC), Discovery Grant # 05519 to G.M., an Alberta Innovates (AI) Summer Research Studentship to J.S., and a Health Research Accelerator Fund grant from the University of Lethbridge Research Services Office to G.M. and T.M. The primary studies were funded by the Human Health Countermeasures Element of the NASA Human Research Program. Dr. Heer’s support was provided in part by grant WB 0931 from the German Aerospace Center (DLR), Germany.”


Peng M, Curry SM, Liu Y, Lohawala H, Sharma G, Sharma TP.

The ex vivo human translaminar autonomous system to study spaceflight associated neuro-ocular syndrome pathogenesis.

npj Microgravity. 2022 Oct 28;8:44.

PI: T.P. Sharma

Note: From the abstract: “Spaceflight-Associated Neuro-ocular Syndrome (SANS) is a significant unexplained adverse reaction to long-duration spaceflight. We employ an ex vivo translaminar autonomous system (TAS) to recreate a human ocular ground-based spaceflight analogue model to study SANS pathogenesis.” This article may be obtained online without charge.

Journal Impact Factor: 4.97

Funding: “This work was supported by the Translational Research Institute for Space Health grant through NASA Cooperative Agreement NNX16AO69A. This study was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc. to the Indiana University School of Medicine, Department of Ophthalmology.”


Rosenberg MJ, Koslovsky M, Noyes M, Reschke MF, Clément G.

Tandem walk in simulated Martian gravity and visual environment.

Brain Sci. 2022 Sep 20;12(10):1268.

PI: S. Moudy

Note: From the abstract: “Astronauts returning from long-duration spaceflights experience visual-vestibular conflicts that causes motion sickness, perceptions that the environment is moving when it is not, and problems with walking and other functional tasks. To evaluate whether astronauts will have similar decrements after they land on Mars following exposure to weightlessness, participants were held by a device that offloads their weight, first entirely (0 G), and then partially (0.38 G) or not at all (1 G).” This article is part of “Section Sensory and Motor Neuroscience” ( and may be obtained online without charge.

Journal Impact Factor: 3.333

Funding: “This research was funded the National Aeronautics and Space Administration (NASA), grant number Innovation Charge Account FY17.”


Waisberg E, Ong J, Zaman N, Kamran SA, Lee AG, Tavakkoli A.

Head-mounted dynamic visual acuity for G-transition effects during interplanetary spaceflight: Technology development and results from an early validation study.

Aerosp Med Hum Perform. 2022 Nov 1;93(11):800-5.

PI: A. Tavakkoli

Note: From the abstract: “Dynamic visual acuity (DVA) refers to the ability of the eye to discern detail in a moving object and plays an important role whenever rapid physical responses to environmental changes are required, such as while performing tasks onboard a space shuttle. A significant decrease in DVA has previously been noted after astronauts returned from long-duration spaceflight (0.75 eye chart lines, 24 h after returning from space). As part of a NASA-funded, head-mounted multimodal visual assessment system for monitoring vision changes in spaceflight, we elaborate upon the technical development and engineering of dynamic visual acuity assessments with virtual reality (VR) technology as the first step in assessing astronaut performance when undergoing G-transitional effects. We also report results from an early validation study comparing VR DVA assessment with traditional computer based DVA assessment.”

Journal Impact Factor: 0.889

Funding: “Funding: NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”


Hasenstein KH, Park MR, John SP, Ajala C.

High-gradient magnetic fields and starch metabolism: Results from a space experiment.

Sci Rep. 2022 Oct 29;12:18256.

PI: K.H. Hasenstein

Note: From the introduction: “Here, we report data from a space experiment on the Space-X Crew Resupply Service 3 mission.”

Journal Impact Factor: 4.996

Funding: “This work was supported by the National Aeronautics and Space Administration grants NNX10AP91G, NNH18ZHA004C, and 80NSSC17K0344 to KHH.”


Clary JL, France CS, Lind K, Shi R, Alexander JS, Richards JT, Scott RS, Wang J, Lu X-H, Harrison L.

Development of an inexpensive 3D clinostat and comparison with other microgravity simulators using Mycobacterium marinum.

Front Space Technol. 2022 Oct 28;3:1032610.

PI: L. Harrison

Note: This article is part of Research Topic “Editors’ Showcase: Microgravity – 2022” (—2022#overview). This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was funded by NASA grant number 80NSSC18K1467 (LH) and Louisiana Space Research Enhancement Award number PO-0000138470 (LH) and grant P20GM134974 (RS, JW) that funds the Bioinformatic and Modeling Core.”


Evans AC, Martin KA, Saxena M, Bicher S, Wheeler E, Cordova EJ, Porada CD, Almeida-Porada G, Kato TA, Wilson PF, Coleman MA.

Curcumin nanodiscs improve solubility and serve as radiological protectants against ionizing radiation exposures in a cell-cycle dependent manner.

Nanomaterials (Basel). 2022 Oct 15;12(20):3619.

PI: C.D. Porada

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.719

Funding: “This research was funded by the NASA/Baylor Translational Research Institute for Space Health (TRISH) through Cooperative Agreement NNX16AO69A. Work was also performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344 and supported with funding from the Laboratory Directed Research Development program (LDRD-19-SI-003) at LLNL.”


Verma SD, Passerat de la Chapelle E, Malkani S, Juran CM, Boyko V, Costes SV, Cekanaviciute E.

Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model.

Front Immunol. 2022 Aug 30;13:864923.

PI: E. Cekanaviciute

Note: This article is part of Research Topic “Deciphering Immune and Neuroendocrine Crosstalk in Extreme Environments” ( The Research Topic also includes articles from previous Current Awareness Lists #965 and #990 This article may be obtained online without charge.

Journal Impact Factor: 8.786

Funding: PI reports NASA grant 80NSSC20K0125 funding.


Zablotska LB, Zupunski L, Leuraud K, Lopes J, Hinkle J, Pugeda T, Delgado T, Olschowka J, Williams J, O’Banion MK, Boice JD, Jr., Cohen SS, Mumma MT, Dauer LT, Britten RA, Stephenson S.

Radiation and CNS effects: Summary of evidence from a recent symposium of the Radiation Research Society.

Int J Radiat Biol. 2022 Nov 1;Online ahead of print.

PI: M.K. O’Banion, R.A. Britten

Journal Impact Factor: 3.352

Funding: “Britten and Stephenson would like to acknowledge NASA funding (NNX14AE73G). Hinkle et al. acknowledge research support from NASA (NNX16AE07G and 80NSSC2K0542) and the Del Monte Institute for Neuroscience Pilot Grant Program.”


Kintz JR, Banerjee NT, Zhang JY, Anderson AP, Clark TK.

Estimation of subjectively reported trust, mental workload, and situation awareness using unobtrusive measures.

Hum Factors. 2022 Nov 2:187208221129371. Online ahead of print.

Note: From the abstract: “We use a set of unobtrusive measures to estimate subjectively reported trust, mental workload, and situation awareness (henceforth ‘TWSA’).”

Journal Impact Factor: 3.598

Funding: “This material is based upon work supported by NASA under grant or cooperative agreement award number 80NSSC19K1052.”


Vekilov PG, Wolynes PG.Time-resolved in situ AFM measurement of growth rates of Aβ40 fibrils

In: Cieplak, AS, ed. Protein Aggregation. Methods in Molecular Biology.

Vol. 2551. New York, NY: Humana, 2023. p. 63-77.

PI: P.G. Vekilov

Funding: “This work was supported by NASA (grants NNX14AE79G and NNX14AD68G to PGV) and NSF (DMR-2128121 to PGV). Additional support was provided by the Center for Theoretical Biological Physics at Rice University sponsored by NSF (grant PHY-1427654 to PGW).”


Other papers of interest:


Kuzichkin DS, Nichiporuk IA, Zhuravleva OA, Markin AA, Rykova MP, Zhuravleva TV, Sadova AA, Kutko OV, Shmarov VA, Ponomarev SA.

Endothelial dysfunction markers and immune response indices in cosmonauts’ blood after long-duration space flights.

npj Microgravity. 2022 Nov 2;8:46.

Note: ISS results. This article may be obtained online without charge.


Metelli G, Lampazzi E, Pagliarello R, Garegnani M, Nardi L, Calvitti M, Gugliermetti L, Restivo Alessi R, Benvenuto E, Desiderio A.

Design of a modular controlled unit for the study of bioprocesses: Towards solutions for Bioregenerative Life Support Systems in Space.

Life Sci Space Res. 2022 Oct 28. Online ahead of print.

Note: From the abstract: “

In this work, we have designed and built an experimental chamber, named Growing/Rearing Module (GRM), completely isolated and equipped with micro-environmental monitoring and control systems. This unit is specially intended for the study of single bioprocesses, which can be composed to design functional BLSSs [Bioregenerative Life Support Systems].”


Abitante TJ, Bouxsein ML, Duda KR, Newman DJ.

Potential of neuromuscular electrical stimulation as a bone loss countermeasure in microgravity.

Aerosp Med Hum Perform. 2022;93(11):774-82.

Note: From the abstract: “We measured the maximum isometric force of NMES-induced contractions of the rectus femoris and the hamstrings of 10 subjects (5 male, 5 female), sitting with the hips and knees at 90 degrees of flexion. We employed 2-D biomechanical models of the knee and hip to estimate the hip joint reaction forces, applied these forces to a generic femur finite element analysis model, and qualitatively compared the peak principal strains of the proximal femoral neck to the peak strains modeled in previous studies for other forms of exercise.”


Behrendt T, Altorjay A-C, Bielitzki R, Behrens M, Glazachev OS, Schega L.

Influence of acute and chronic intermittent hypoxic-hyperoxic exposure prior to aerobic exercise on cardiovascular risk factors in geriatric patients—a randomized controlled trial.

Front Physiol. 2022 Oct 28;13:1043536.

Note: This article is part of Research Topic “Long-term effects of hypoxic conditioning on sports performance, health and well-being” ( The Research Topic also includes an article from previous Current Awareness List #1,020 This article may be obtained online without charge.


Kato ET, Morrow DA, Guo J, Berg DD, Blazing MA, Bohula EA, Bonaca MP, Cannon CP, de Lemos JA, Giugliano RP, Jarolim P, Kempf T, Kristin Newby L, O’Donoghue ML, Pfeffer MA, Rifai N, Wiviott SD, Wollert KC, Braunwald E, Sabatine MS.

Growth differentiation factor 15 and cardiovascular risk: Individual patient meta-analysis.

Eur Heart J. 2022 Oct 28;ehac577. Online ahead of print.


Lorenzana-Carrillo MA, Gopal K, Byrne NJ, Tejay S, Saleme B, Das SK, Zhang Y, Haromy A, Eaton F, Mendiola Pla M, Bowles DE, Dyck JRB, Ussher JR, Michelakis ED, Sutendra G.

TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.

Sci Transl Med. 2022 Nov 2;14(669):eabm3565.

Note: From the abstract: “Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that translocates to the nucleus to regulate transcription factors in different tissues or pathologic states. Although studied extensively in cancer, its biological role in the heart remains unresolved. PKM1 is more abundant than the PKM2 isoform in cardiomyocytes, and thus, we speculated that PKM2 is not genetically redundant to PKM1 and may be critical in regulating cardiomyocyte-specific transcription factors important for cardiac survival. Here, we showed that nuclear PKM2 (S37

P-PKM2) in cardiomyocytes interacts with prosurvival and proapoptotic transcription factors, including GATA4, GATA6, and P53.”


Levin DR, Siu M, Kramer K, Kelly E, Alouidor R, Fernandez G, Kamine T.

Time cost of provider skill: A pilot study of medical officer occupied time by knowledge, skill, and ability level.

Aerosp Med Hum Perform. 2022 Nov 1;93(11):816-21.

Note: From the abstract: “On space missions one must consider the operating cost of the medical system on crew time. Medical Officer Occupied Time (MOOT) may vary significantly depending on provider skill. This pilot study assessed the MOOT Skill Effect (MOOTSkE).”


Chatterjee T, Bhattacharyya D, Yadav A, Pal M.

Quantification of physiological and mental workloads of faster and slower finishers of a long-distance military training activity.

BMJ Mil Health. 2022 Oct 25;e002154. Online ahead of print.


Kim J, Cifre A, Bower J, Connaboy C, Simpson R, Alfano C.

Markers of distress among behavioral and physical health evacuees prior to emergency departure from Antarctica.

Acta Astronaut. 2022 Oct 31. Online ahead of print.

Note: From the abstract: “Although incidences of psychological crises occurring during space flight are reportedly rare, such events remain a distinct possibility and potential threat to future long-duration missions (e.g., a Mars mission). Extended residence in Antarctica offers an ideal setting for examining high-risk profiles for psychological crises.”


Li Y, Yang X, Zhao Z, Du J.

SRP54 mediates circadian rhythm-related, temperature-dependent gene expression in Drosophila.

Genomics. 2022 Nov;114(6):110512.

Note: This article may be obtained online without charge.


Nakdimon I, Ben-Ari O.

Mitigating risks of altitude chamber training.

Aerosp Med Hum Perform. 2022 Nov 1;93(11):811-5.

Note: From the abstract: “Altitude chambers are used for training aircrews in a hypobaric hypoxic environment to better prepare them for pressurization and oxygen malfunction incidents during flights. However, adverse effects may occur during training sessions, with decompression sickness (DCS) being a major concern. The aim of this study was to examine the risks of different adverse effects during altitude chamber trainings (ACT) in the Israeli Air Force (IAF) facility and to compare them to other training facilities.”


Négyesi J, Négyesi P, Hortobágyi T, Sun S, Kusuyama J, Kiss RM, Nagatomi R.

Handedness did not affect motor skill acquisition by the dominant hand or interlimb transfer to the non-dominant hand regardless of task complexity level.

Sci Rep. 2022 Oct 28;12:18181.

Note: NASA Task Load Index was used in this study. This article may be obtained online without charge.

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