NASA Spaceline Current Awareness List #1,006 1 July 2022 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm . Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Tran V, Carpo N, Shaka S, Zamudio J, Choi S, Cepeda C, Espinosa-Jeffrey A.
Delayed maturation of oligodendrocyte progenitors by microgravity: Implications for multiple sclerosis and space flight.
Life (Basel). 2022 May 27;12(6):797.
PI: A. Espinosa-Jeffrey
Note: ISS results. This is article is part of Special Issue “Multiple Sclerosis: Research in Remyelination, the Next Step” (https://www.mdpi.com/journal/life/special_issues/Multiple_SclerosisRemyelination ). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.251
Funding: “NASA Space Biology Grant: NNX15AB43G; the Cell Culture and Imaging Core is supported by the NIH (Grant U54HD08710).”
2
Gedik E, Olenick J, Chang CHD, Kozlowski SWJ, Hung H.
Capturing interaction quality in long duration (simulated) space missions with wearables.
IEEE Transactions on Affective Computing. 2022: May 23.
PI: S.W.J. Kozlowski
Note: The simulated spaceflight information is not evident in the available abstract. From the abstract: “We evaluate our method on a 4-month simulated space mission where 5 participants wore Sociometric Badges and provided reports on their interactions in terms of effectiveness, frustration, and satisfaction. Our method provides an average ROC-AUC score of 0.64. Since we are not aware of any comparable baselines, we compare our method to hand-crafted features formerly utilized for cohesion estimation in similar scenarios and show it significantly outperforms them. We also present ablation studies where we replace the components in our approach with well-known alternatives and show that they provide better performance than their respective counterparts.”
Journal Impact Factor: 13.99
Funding: “10.13039/100000104-National Aeronautics and Space Administration (Grant Number: NNX13AM77G); 10.13039/501100003246-Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Grant Number: 639.022.606).”
3
Lytle JR, Macias BR, Lee SM, Martin D, Ebert DJ, Hargens AR, Dulchavsky SA, Alferova IV, Stenger MB, Laurie SS.
Cardiovascular responses to mild lower body negative pressure during spaceflight.
The FASEB Journal. 2022 May 23;36(S1).
PIs: A.R. Hargens, S.A. Dulchavsky
Note: The spaceflight information is not evident in the available abstract.
Journal Impact Factor: 5.191
Funding: “This study was supported by National Aeronautics and Space, Administration Grants NNJ11ZSA002NA (to M.B.S.), NNX13AK30G (to S.A.D.), and NNX13AJ12G (to A.R.H.).”
4
Sushenko NS, Singh NK, Vellone DL, Tighe SW, Hedlund BP, Venkateswaran K, Moser DP.
Complete genome sequence of Klebsiella quasipneumoniae subsp. similipneumoniae strain IF3SW-P1, isolated from the International Space Station.
Microbiol Resour Announc. 2022 Jun 23;e0047622. Online ahead of print.
PI: K. Venkateswaran
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 0.877
Funding: “We thank astronaut Terry Virts for collecting samples aboard the ISS, Aleksandra Checinska‐Sielaff for isolating the strain, and the implementation team at NASA Ames Research Center (Fathi Karouia) for coordinating the sampling effort. Part of this research was performed at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported through 2012 Space Biology (NNH12ZTT001N) grant number 19‐12829‐26 under task order NNN13D111T awarded to K.V.; by NASA EPSCoR Rapid Response Research Cooperative Agreement (NNH18ZHA005C) award number 80NSSC19M0169 to D.P.M.; and by project MANGO, a 2018 Space Biology (NNH16ZTT001N) grant under task order 80NM0018F0589. Additional support was provided through the Nevada Space Grant Consortium Graduate Research Opportunity Fellowship award (number 13584) to N.S.S. and the UNLV MSI Open Article Fund.”
5
Urbaniak C, Morrison MD, Thissen JB, Karouia F, Smith DJ, Mehta S, Jaing C, Venkateswaran K.
Microbial tracking-2, a metagenomics analysis of bacteria and fungi onboard the International Space Station.
Microbiome. 2022 Jun 29;10(1):100.
PIs: K. Venkateswaran, C. Jaing, C. Urbaniak, NASA Postdoctoral Program Fellowship
Note: ISS results. GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.
Journal Impact Factor: 14.652
Funding: “This research was funded by a 2014 Space Biology NNH14ZTT002N grant no. 19-12829-38 under Task Order NNN13D111T award to KV. CU was funded by a NASA Space Biology NPP post-doc fellowship. MM, JT, and CJ were funded by the NASA Space Biology under contract #: 80NSSC18K0113. Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. SM was funded by NASA Space Biology under contract #: 80NSSC18K0113. DS was funded by the NASA Ames Space Biology program. FK was supported through the KBRwyle/FILMSS subcontract with the Department of Pharmaceutical Chemistry at the University of California, San Francisco, # NNA14AB82C, at the NASA Ames Research Center.”
6
Chang PY, Bakke J, Rosen CJ, Bjornstad KA, Mao JH, Blakely EA.
Heavy-ion-induced lung tumors: Dose- & LET-dependence.
Life (Basel). 2022 Jun 17;12(6):907.
PI: E.A. Blakely
Note: This is article is part of Special Issue “Space Radiobiology” (https://www.mdpi.com/journal/life/special_issues/space_radiobiology ). The Special Issue also includes articles from previous Current Awareness Lists #968 https://doi.org/10.3390/life11080849 , #977 https://doi.org/10.3390/life11111112 and https://doi.org/10.3390/life11111190 , #989 https://doi.org/10.3390/life12020144 , and #990 https://doi.org/10.3390/life12030358 . This article may be obtained online without charge.
Journal Impact Factor: 3.251
Funding: “This research was funded by NASA Grants #NNJ16HP22I and #80JSC021T0017, under the auspices of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.”
7
Sharma G, Curtis PD.
The impacts of microgravity on bacterial metabolism.
Life (Basel). 2022 May 24;12(6):774. Review.
Note: This article and the article below (An et al.) are part of Special Issue “Gravitational Microbiology Research and Applications” (https://www.mdpi.com/journal/life/special_issues/gravitational_microbiology ). The Special Issue also includes an article from previous Current Awareness List #984 https://doi.org/10.3390/life12010047 . Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.251
Funding: “G.S. was supported by the NASA EPSCoR, Grant Number 80NSSC19M0013.”
8
An R, Lee JA.
CAMDLES: CFD-DEM simulation of microbial communities in spaceflight and artificial microgravity.
Life (Basel). 2022 Apr 29;12(5):660.
Note: From the abstract: “We present CAMDLES (CFD-DEM Artificial Microgravity Developments for Living Ecosystem Simulation), an extension of CFDEM®Coupling to model biological flows, growth, and mass transfer in artificial microgravity devices.” This article and the article above (Sharma et al.) are part of Special Issue “Gravitational Microbiology Research and Applications” (https://www.mdpi.com/journal/life/special_issues/gravitational_microbiology ). This article may be obtained online without charge.
Journal Impact Factor: 3.251
Funding: “Funding for this study was provided by the Space Biology program of NASA’s Biological and Physical Sciences (BPS) Division through the Space Life Sciences Training Program (SLSTP).”
9
Weiss M, Nikisher B, Haran H, Tefft K, Adams J, Edwards JG.
High throughput screen of small molecules as potential countermeasures to galactic cosmic radiation induced cellular dysfunction.
Life Sci Space Res. 2022 Jun 25. Online ahead of print.
PI: J.G. Edwards
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.082
Funding: “This work would not have been possible without the generous help of the faculty and staff of the NASA Space Radiation Laboratory lead by Drs. Adam Rusek and Peter Guida. This project was support by NASA 80NSSC19K0436 and the TCUS Biomedical Education Fund.”
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Other papers of interest:
1
Bai P, Li Y, Bai J, Xu H.
Markedly decreased growth rate and biofilm formation ability of Acinetobacter schindleri after a long-duration (64 days) spaceflight.
Eur Rev Med Pharmacol Sci. 2022 Jun;26(11):4001-15.
Note: China’s Tiangong-2 space laboratory results. This article may be obtained online without charge.
2
Zhao X, Yu Y, Zhang X, Huang B, Xu C, Zhang B, Bai P, Liu C.
Phenotypic, genomic, and transcriptomic changes in an Acinetobacter baumannii strain after spaceflight in China’s Tiangong-2 space laboratory.
Braz J Microbiol. 2022 Jun 28.
Note: China’s Tiangong-2 space laboratory results.
3
Ganse B, Cucchiarini M, Madry H.
Joint cartilage in long-duration spaceflight.
Biomedicines. 2022 Jun 8;10(6):1356. Review.
Note: From the abstract: “This review summarizes the current literature available on joint cartilage alterations in long-duration spaceflight.” This article is part of Topic “Translation from Microgravity Research to Earth Application” (https://www.mdpi.com/topics/microgravity_research ). The Topic also includes articles from previous Current Awareness Lists #970 https://doi.org/10.3390/ijms22189997 and https://doi.org/10.3390/biomedicines9091205 ; #976 https://doi.org/10.3390/ijms222111759 ; #984 https://doi.org/10.3390/biomedicines10010059 ; and #989 https://doi.org/10.3390/biomedicines10020448 . This article may be obtained online without charge.
4
Gatti M, Palumbo R, Di Domenico A, Mammarella N.
Simulating extreme environmental conditions via mental imagery: The case of microgravity and weight estimation.
Front Psychol. 2022 Jun 6;13:913162.
Note: From the introduction: “In order to investigate whether the perception of weightless or, to say it better, the typical effects of weightless, can be reproduced via mental imagery, a group of volunteers performed a weight estimation task before and after a guided-imagery session of a space scenario.” This article may be obtained online without charge.
5
Manis C, Manca A, Murgia A, Uras G, Caboni P, Congiu T, Faa G, Pantaleo A, Cao G.
Understanding the behaviour of human cell types under simulated microgravity conditions: The case of erythrocytes.
Int J Mol Sci. 2022 Jun 20;23(12):6876.
Note: A 3D random positioning machine was used in this study. This article is part of Special Issue “Advances in Membrane Protein Research” (https://www.mdpi.com/journal/ijms/special_issues/Membrane_Protein_Advances ). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
6
Zhang Q, Li L, Hao S, Liu M, Huo C, Wu J, Liu H, Bao W, Zheng H, Li Z, Cheng H, Fung H, Wong T, Leung P, Wang S, Li T, Zhang G, Li M, Zhao Z, Jia W, Bian Z, Mitchison T, Zhang J, Lyu A, Han Q, Sun H.
A lymphatic route for a hyperbranched heteroglycan from Radix Astragali to trigger immune responses after oral dosing.
Carbohydr Polym. 2022 Sep 15;292:119653.
Note: From the abstract: “Gut barrier makes a huge research gap between in vivo and in vitro studies of orally bioactive polysaccharides: whether/how they contact the related cells in vivo. A hyperbranched heteroglycan RAP from Radix Astragali, exerting antitumor and immunomodulatory effects in vitro and in vivo, is an example. Here, we determined first that RAP’s antitumor activity is immune-dependent. Being undegraded and non-absorbing, RAP quickly entered Peyer’s patches (PPs) in 1 h where it directly targeted follicle dendritic cells and initiated antitumor immune responses. RAP was further delivered to mesenteric lymph node, bone marrow, and tumor. By contrast, the control Dendrobium officinale polysaccharide did not enter PPs. These findings revealed a blood/microbiota-independent and selective lymphatic route for orally administrated RAP to directly contact immune cells and trigger antitumor immune responses.”
7
Darvishi E, Ghasemi F, Sadeghi F, Abedi K, Rahmati S, Sadeghzade G.
Risk assessment of the work-related musculoskeletal disorders based on individual characteristics using path analysis models.
BMC Musculoskelet Disord. 2022 Jun 27;23:616.
Note: This article may be obtained online without charge.
8
Kim BJ.
Effects of muscles on bone metabolism-with a focus on myokines.
Ann Geriatr Med Res. 2022 Jun 20. Online ahead of print.
Note: This article may be obtained online without charge.
9
Powers SK, Schrager M.
Redox signaling regulates skeletal muscle remodeling in response to exercise and prolonged inactivity.
Redox Biol. 2022 August;54:102374.
Note: This article may be obtained online without charge.
10
Verbruggen ASK, McCarthy EC, Dwyer RM, McNamara LM.
Temporal and spatial changes in bone mineral content and mechanical properties during breast-cancer bone metastases.
Bone Rep. 2022 Dec;17:101597.
Note: This article may be obtained online without charge.
11
Kusumoto T, Inaniwa T, Mizushima K, Sato S, Hojo S, Kitamura H, Konishi T, Kodaira S.
Radiation chemical yields of 7-hydroxy-coumarin-3-carboxylic acid for proton- and carbon-ion beams at ultra-high dose rates: Potential roles in FLASH effects.
Radiat Res. 2022 Jun 23. Online ahead of print.
12
Pannkuk EL, Laiakis EC, Garty G, Bansal S, Ponnaiya B, Wu X, Ghandhi SA, Amundson SA, Brenner DJ, Fornace AJ Jr.
Biofluid metabolomics and lipidomics of mice exposed to external very high-dose rate radiation.
Metabolites. 2022 Jun 4;12(6):520.
Note: This article is part of Section “Lipid Metabolism” (https://www.mdpi.com/journal/metabolites/sections/lipid-metabolism ). This article may be obtained online without charge.
13
Jacobs CD, Barak I, Jung SH, Rocke DJ, Kahmke RR, Suneja G, Mowery YM.
Prediction model to estimate overall survival benefit of postoperative radiotherapy for resected major salivary gland cancers.
Oral Oncol. 2022 Sep;132:105955.
14
Rabcuka J, Blonski S, Meli A, Sowemimo-Coker S, Zaremba D, Stephenson D, Dzieciatkowska M, Nerguizian D, Cardigan RA, Korczyk PM, Smethurst PA, D’Alessandro A, Swietach P.
Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells.
Blood Adv. 2022 Jun 23. Online ahead of print.
15
Sönksen SE, Kühn S, Basner M, Gerlach D, Hoffmann F, Mühl C, Tank J, Noblé HJ, Akgün K, Ziemssen T, Jordan J, Limper U.
Brain structure and neurocognitive function in two professional mountaineers during 35 days severe normobaric hypoxia.
Eur J Neurol. 2022 Jun 20. Online ahead of print.
Note: This article may be obtained online without charge.
16
Banham N, Hawkings P, Gawthrope I.
A prospective single-blind randomised clinical trial comparing two treatment tables for the initial management of mild decompression sickness.
Diving Hyperb Med. 2022 Jun 30;52(2):78-84.
17
Broberg MA, Boyd BS.
Similarities between explaining dizziness and explaining pain? Exploring common patient experiences, theoretical models, treatment approaches and potential therapeutic narratives for persistent dizziness or pain.
Physiother Theory Pract. 2022 Jun 24;1-18. Online ahead of print.
18
Liu H, Xu J, Zhang X, Gao C, Sun R.
Evaluation method of the driving workload in the horizontal curve section based on the human model of information processing.
Int J Environ Res Public Health. 2022 Jun 9;19(12):7063.
Note: NASA Task Load Index was used in this study. From the abstract: “The aim of this study was to quantify the effect of radius over horizontal curve sections on driving workload (DW). Twenty-five participants participated in the driving simulation experiments and completed five driving scenes.” This article is part of Special Issue “Intelligent Systems for One Digital Health” (https://www.mdpi.com/journal/ijerph/special_issues/AI_Digital_Health ). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
