NASA Spaceline Current Awareness List #1,002 3 June 2022 (Space Life Science Research Results)

 

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

 

Papers deriving from NASA support:

 

1

Barrila J, Yang J, Franco Meléndez KP, Yang S, Buss K, Davis TJ, Aronow BJ, Bean HD, Davis RR, Forsyth RJ, Ott CM, Gangaraju S, Kang BY, Hanratty B, Nydam SD, Nauman EA, Kong W, Steel J, Nickerson CA.

Front Cell Infect Microbiol. 2022 May 31;12:705647.

PI: C.A. Nickerson

Note: A rotating wall vessel was used in this study. To view a full press release of this article on the SpaceRef website go to http://spaceref.com/space-biology/microgravity-analog-culture-profoundly-affects-microbial-infection-process-in-3-d-tuman-tissue-model.html. This article is part of Research Topic “3D Tissue Models in Infection Research” (https://www.frontiersin.org/research-topics/16846/3d-tissue-models-in-infection-research#articles) and may be obtained online without charge.

Journal Impact Factor: 5.293

Funding: “Funding for this study was supported by NASA grants NNX13AM01G (CN, JB, CMO, and BA), NNX15AL06G (CN, JB, and CMO) and 80NSSC18K1478 (CN, JB, CMO, and HB; includes NASA PECASE funding to JB).”

 

2

Tanimura Y, Mabuchi A, Soga K, Wakabayashi K, Hashimoto H, Yano S, Matsumoto S, Kasahara H, Kamada M, Shimazu T, Hashimoto T, Hoson T.

Biol Sci Space. 2022 May 27;36;1-8.

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 1.33

Funding: “The Resist Tubule space experiment was conducted in collaboration with JAXA, the National Aeronautics and Space Administration (NASA), and a number of related organizations and companies. We thank all the colleagues involved in this experiment for their great efforts during the course of the experiment. In particular, the contributions of Astronauts Akihiko Hoshide and Karen Nyberg, and Akira Higashibata (JAXA), Chiaki Yamazaki (JAXA), and Ikuko Osada (Japan Manned Space Systems) are greatly appreciated. The Resist Tubule space experiment was supported by funding provided by JAXA for the Kibo utilization program.”

 

3

Willey JS, Auñón-Chancellor S, Miles LA, Moore JE, Mao XW, Wallace RW, Foy MC.

npj Microgravity. 2022 Jun 2;8:18.

PI: J.S. Willey

Note: ISS and hindlimb unloading results. This article may be obtained online without charge.

Journal Impact Factor: 4.415

Funding: “NASA Space Biology grant NNX15AB50G (JSW).”

 

4

Cao X, Weil MM, Wu JC.

Life Sci Space Res. 2022 May 27. Online ahead of print. Review.

PI: M.M. Weil

Note: From the abstract: “NASA aims to return humans to the Moon within the next five years and to land humans on Mars in a few decades. Space radiation exposure represents a major challenge to astronauts’ health during long-duration missions, as it is linked to increased risks of cancer, cardiovascular dysfunctions, central nervous system (CNS) impairment, and other negative outcomes. Characterization of radiation health effects and developing corresponding countermeasures are high priorities for the preparation of long duration space travel. Due to limitations of animal and cell models, the development of novel physiological relevant radiation models is needed to better predict these individual risks and bridge gaps between preclinical testing and clinical trials in drug development. ‘Clinical Trial in a Dish’ (CTiD) is now possible with the use of human induced pluripotent stem cells (hiPSCs), offering a great tool for drug safety or efficacy testing using patient-specific cell models. Here, we review the development and applications of CTiD for space radiation biology and countermeasure studies, focusing on progress made in the past decade.” This article may be obtained online without charge.

Journal Impact Factor: 2.082

Funding: “This work was supported by National Institutes of Health (NIH) R01 HL126527, UH3 TR002588, and P01 HL141084 (JCW), and The Translational Research Institute for Space Health (TRISH) NNX16AO69A (MMW).”

 

5

Courtney CM, Sharma S, Fallgren C, Weil MM, Chatterjee A, Nagpal P.

Life Sci Space Res. 2022 May 11. Online ahead of print.

PI: M.M. Weil/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.082

Funding: “We acknowledge financial support from National Aeronautics and Space Administration SBIR Contract 80NSSC21C0242 to Sachi Bioworks, funding from Sachi Bioworks, and funding from NASA grant NNX15AK13G to MMW.”

 

6

Peanlikhit T, Honikel L, Liu J, Zimmerman T, Rithidech K.

Life Sci Space Res. 2022 May 28. Online ahead of print.

PI: K. Rithidech

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.082

Funding: “This research was supported by the National Aeronautics and Space Administration (NASA) Grant # 80NSSC19K0435.”

 

7

Christensen L, Mansour K, Pleil JD, Troy R.

J Breath Res. 2022 May 27. Online ahead of print.

Note: From the abstract: “Tunable laser spectroscopy (TLS) near 2683 nm was used to measure carbon dioxide and water vapor inside a pilot mask during jet fighter flights. Measurement frequency was 100 Hz in order to capture breathing profiles and other gas flow dynamics. Analysis of the full inhalation and exhalation breathing cycle allowed precise monitoring of breathing performance and interaction of the pilot with the life-support system. Measurements revealed dynamic phenomena pertaining to mechanical gas flow and pilot respiration that may be used to understand gas delivery stresses imposed upon the pilot and pilot physiology during flight. Typically, such measurements are made with non-dispersive infrared (NDIR) instrumentation for only carbon dioxide with intrinsic challenges regarding time and optical resolution. The TLS approach is a major advance because the sensor is placed directly into the mask improving its time response and enabling use of water vapor measurements that are less impacted from memory effects. This article presents the implementation of TLS and shows highly time-resolved pilot breathing data for high-performance aircraft tests.” This article may be obtained online without charge.

Journal Impact Factor: 3.262

Funding: “The authors are grateful for the support and advice from colleagues Kevin ‘Sonar’ Hall, Marta Shelton and John Graf and others on the NASA Engineering Safety Center (NESC) Pilot Breathing Assessment Team; Michael Davis from Indiana University. The work was funded by NESC Pilot Breathing Assessment and JPL internal support. The research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004).”

 

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Other papers of interest:

 

1

Fais G, Manca A, Bolognesi F, Borselli M, Concas A, Busutti M, Broggi G, Sanna P, Castillo-Aleman YM, Rivero-Jiménez RA, Bencomo-Hernandez AA, Ventura-Carmenate Y, Altea M, Pantaleo A, Gabrielli G, Biglioli F, Cao G, Giannaccare G.

Mar Drugs. 2022 Apr 28;20(5):299. Review.

Note: This article is part of Special Issue “Biotechnology Applications of Microalgae” (https://www.mdpi.com/journal/marinedrugs/special_issues/biotechnology_microalgae). This article may be obtained online without charge.

 

2

Gatti M, Palumbo R, Di Domenico A, Mammarella N.

Heliyon. 2022 May 12;8(5):e09414. Review.

Note: From the abstract: “…we undertook a literature search and reviewed several behavioral simulation studies on Earth that focused on affective components in space. We concluded with studies showing how spaceflight can impact on affective health of astronauts with a positively laden trajectory.” This article may be obtained online without charge.

 

3

Fan C, Wu Z, Cooper DML, Magnus A, Harrison K, Eames BF, Chibbar R, Groot G, Huang J, Genth H, Zhang J, Tan X, Deng Y, Xiang J.

Int J Mol Sci. 2022 May 17;23(10):5593.

Note: Hindlimb unloading and 3D clinostat results. This article and the article below (Guilhot et al.) are part of Special Issue “Cellular and Molecular Signaling Meet the Space Environment” (https://www.mdpi.com/journal/ijms/special_issues/Cellular_molecular_signaling_space). The Special Issue also includes an article from previous Current Awareness List #983 https://doi.org/10.3390/ijms23010075. This article may be obtained online without charge.

 

4

Guilhot C, Fovet T, Delobel P, Dargegen M, Jasmin BJ, Brioche T, Chopard A, Py G.

Int J Mol Sci. 2022 May 14;23(10):5489.

Note: Dry immersion results. This article and the article above (Fan et al.) are part of Special Issue “Cellular and Molecular Signaling Meet the Space Environment” (https://www.mdpi.com/journal/ijms/special_issues/Cellular_molecular_signaling_space). This article may be obtained online without charge.

 

5

Fernander MC, Parsons PK, Khaled B, Bradley A, Graves JL, Thomas MD.

npj Microgravity. 2022 June 2;8:17.

Note: A rotating wall vessel was used in this study. This article may be obtained online without charge.

 

6

Membranes (Basel). 2022 Apr 21;12(5):448.

Note: A rotary cell culture system was used in this study. From the abstract: “The main purpose of the study was to determine whether altered gravity might alter cell viability, improve drug delivery, and modulate the expression of drug resistance-related genes.” This article is part of Special Issue “Modern Studies on Drug-Membrane Interactions” (https://www.mdpi.com/journal/membranes/special_issues/drug_mem_inter). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

7

Zhang B, Bai P, Wang D.

Pol J Microbiol. 2022 May 22. Online ahead of print.

Note: A rotating wall vessel was used in this study. This article may be obtained online without charge.

 

8

Patil VM, Kolkur M, Kumar Chinthala S, Waratkar G, Menon N, Noronha V, Ghosh Laskar S, Simha V, Talreja V, Dhumal S, Chandrasekharan A, Prabhash K.

Oral Oncol. 2022 Jul;130:105908.

 

9

Van Slyke AL, El Khatib M, Velalopoulou A, Diffenderfer E, Shoniyozov K, Kim MM, Karagounis IV, Busch TM, Vinogradov SA, Koch CJ, Wiersma RD.

Radiat Res. 2022 May 31. Online ahead of print.

 

10

Welch D, Kleiman NJ, Arden PC, Kuryla CL, Buonanno M, Ponnaiya B, Wu X, Brenner DJ.

Photochem Photobiol. 2022 May 25. Online ahead of print.

 

11

Anvari S, Watkin LB, Minard CG, Schuster K, Hassan O, Anagnostou A, Orange JS, Corry DB, Davis CM.

PLoS One. 2022 May 26;17(5):e0264674.

Note: This article may be obtained online without charge.

 

12

Vanmunster M, Rojo Garcia AV, Pacolet A, Dalle S, Koppo K, Jonkers I, Lories R, Suhr F.

Cell Mol Life Sci. 2022 May 27;79:321.

Note: Hindlimb unloading results.

 

13

Cariati I, Bonanni R, Scimeca M, Rinaldi AM, Marini M, Tarantino U, Tancredi V.

Life (Basel). 2022 Apr 19;12(5):610.

Note: A random positioning machine was used in this study. From the abstract: “Bone loss is among the most frequent changes seen in astronauts during space missions. Although weightlessness is known to cause high bone resorption and a rapid decrease in bone minerals and calcium, the underlying mechanisms are not yet fully understood. In our work, we investigated the influence of random positioning machine (RPM) exposure on the mineralization process in the SAOS-2 cell line, in osteogenic and non-osteogenic conditions, by examining changes in their mineralizing capacity and in the expression of PTX3, a positive regulator of bone mineralization.” This article may be obtained online without charge.

 

14

Fan Z, Liu H, Shi S, Ding Z, Zhang Z, Lu Q, Kaplan DL.

Mater Today Bio. 2022 Jun;15;100283.

Note: This article may be obtained online without charge.

 

15

Lee J, Min HK, Park CY, Kang HK, Jung SY, Min BM.

J Clin Periodontol. 2022 May 30. Online ahead of print.

 

16

Bujia G, Sclar M, Vita S, Solovey G, Kamienkowski JE.

Front Syst Neurosci. 2022 May 27;16:882315.

Note: From the abstract: “Finding objects is essential for almost any daily-life visual task. Saliency models have been useful to predict fixation locations in natural images during a free-exploring task. However, it is still challenging to predict the sequence of fixations during visual search. Bayesian observer models are particularly suited for this task because they represent visual search as an active sampling process. Nevertheless, how they adapt to natural images remains largely unexplored. Here, we propose a unified Bayesian model for visual search guided by saliency maps as prior information.” This article may be obtained online without charge.

 

17

Petro NM, Ott L, Penhale S, Rempe M, Embury C, Picci G, Wang YP, Stephen JM, Calhoun VD, Wilson TW.

Neuroimage. 2022 May 27;119337. Online ahead of print.

Note: This article may be obtained online without charge.

 

18

Reiser JE, Arnau S, Rinkenauer G, Wascher E.

PLoS One. 2022 May 26;17(5):e0267896.

Note: NASA Task Load Index was used in this study. This article may be obtained online without charge.

 

19

Jung S, Johnson DB.

Oncologist. 2022 May 30;oyac091. Online ahead of print.

Note: From the abstract: “Acral and mucosal melanomas (MM) are rare subtypes of melanoma that are biologically and clinically distinct from cutaneous melanoma. Despite the progress in the treatment of cutaneous melanomas with the development of targeted and immune therapies, the therapeutic options for these less common subtypes remain limited. Difficulties in early diagnosis, the aggressive nature of the disease, and the frequently occult sites of origin have also contributed to the poor prognosis associated with acral and MM, with substantially worse long-term prognosis. The rarity of these subtypes has posed significant barriers to better understanding their biological features and investigating novel therapies. Consequently, establishing standardized treatment guidelines has been a challenge. In this review, we provide a brief overview of the current knowledge regarding acral and MM, focusing on their epidemiology, genetic backgrounds, and unique clinical characteristics.” This article may be obtained online without charge.

 

20

Sadeghian M, Mohammadi Z, Mousavi SM.

Cogn Neurodyn. 2022 Jun;16(3):561-74.

Note: NASA Task Load Index was used in this study. From the abstract: “Most studies have examined the effect of the physical aspects of noise while the effect of exposure to psychoacoustic parameters at different task difficulty levels has been less evaluated. Therefore, this study was performed with the aim of investigating the brainwave in the face of psychoacoustic and the change of difficulty level of task.”

 

21

Szyller J, Kozakiewicz M, Siermontowski P, Kaczerska D.

Oxidative stress, HSP70/HSP90 and eNOS/iNOS serum levels in professional divers during hyperbaric exposition.

Antioxidants (Basel). 2022 May 20;11(5):1008.

Note: From the abstract: “Heat shock proteins (HSPs) have protective effects against oxidative stress and decompression sickness. Nitric oxide may reduce bubble formation during decompression and its activity is regulated by HSPs. A simulated dive can cause the HSP response. The aim of this study was to describe the effect of simulated dives on the antioxidant system, HSPs, and nitric oxide synthase response and demonstrate the relationship between the concentration of HSPs and the intensification of oxidative stress.” This article may be obtained online without charge.

 

22

Van Cutsem J, Pattyn N, Mairesse O, Delwiche B, Fernandez Tellez H, Van Puyvelde M, Lacroix E, McDonnell AC, Eiken O, Mekjavic IB.

Front Neurosci. 2022 May 10;16:852741.

Note: From the abstract: “Hypobaric hypoxic habitats are currently being touted as a potential solution to minimize decompression procedures in preparation for extra vehicular activities during future space missions. Since astronauts will live in hypoxic environments for the duration of such missions, the present study sought to elucidate the separate and combined effects of inactivity [simulated with the experimental bed rest (BR) model] and hypoxia on sleep characteristics in women.” This article may be obtained online without charge.

 

23

Li HC, Li JH, Lu X, He X.

Zhonghua Shao Shang Za Zhi. 2022 May 20;38(5):486-90. Review. Chinese.

Note: From the abstract: “As a new technology of drug-free treatment, virtual reality technique has been used in various medical fields, and is being increasingly applied in the field of wound repair. Virtual reality technology can alleviate the pain caused by acute and chronic wounds, relieve the psychological anxiety of patients with wounds, and then facilitate the recovery of patients. This paper reviews the research progress of virtual reality technique’s application as a clinical adjuvant therapy in wound repair in three aspects: pain treatment, psychological treatment, and functional rehabilitation, analyzes the advantages and disadvantages of this technique, and discusses the prospects of its further application in the field of wound repair.”