NASA Spaceline Current Awareness List #1,000 20 May 2022 (Space Life Science Research Results)

 

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

 

Papers deriving from NASA support:

 

1

Siamwala JH, Macias BR, Healey R, Bennett B, Hargens AR.

Front Physiol. 2022 May 13;13:893025.

PI: A.R. Hargens

Note: STS-131 and BION-M1 mission results. This article and an article below (Desruelle et al.) in the “Other” section are part of Research Topic “Physiology in extreme conditions: Adaptations and unexpected reactions, Volume II” (https://www.frontiersin.org/research-topics/29492/physiology-in-extreme-conditions-adaptations-and-unexpected-reactions-volume-ii#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

Journal Impact Factor: 4.566

Funding: “AH is a recipient of the following grant: NASA NNX09AP11G; Rodent Spine Deconditioning after 30 Days of Microgravity. JS is a recipient of the following grants: COBRE P20 GM103652 pilot sub grant, National Institute of General Medical Sciences, National Institutes of Health; Rhode Island Foundation grant 20190594, Alzheimer’s Administrative Supplement grant, and TEAM UTRA grant from Brown University.”

 

2

Reyes DP, Masterova KS, Walton M, Kerstman EL, Antonsen EL.

J Womens Health (Larchmt). 2022 May 12. Online ahead of print.

Note: From the abstract: “In this study sex-differences in medical outcomes during spaceflight are reviewed and probabilistic risk assessment (PRA) is used to assess the impact on spaceflight missions of varying lengths.”

Journal Impact Factor: 2.681

Funding: E.L. Antonsen is affiliated with NASA Johnson Space Center.

 

3

Wostyn P, Mader TH, Gibson CR, Nedergaard M.

Eye Brain. 2022 May 4;14:49-58. Review.

Note: From the abstract: “Spaceflight-associated neuro-ocular syndrome (SANS) has been well documented in astronauts both during and after long-duration spaceflight and is characterized by the development of optic disc edema, globe flattening, choroidal folds, and hyperopic refractive error shifts. The exact mechanisms underlying these ophthalmic abnormalities remain unclear. New findings regarding spaceflight-associated alterations in cerebrospinal fluid spaces, specifically perivascular spaces, may shed more light on the pathophysiology of SANS. The preliminary results of a recent brain magnetic resonance imaging study show that perivascular spaces enlarge under prolonged microgravity conditions, and that the amount of fluid in perivascular spaces is linked to SANS. The exact pathophysiological mechanisms underlying enlargement of perivascular spaces in space crews are currently unclear. Here, we speculate that the dilation of perivascular spaces observed in long-duration space travelers may result from impaired cerebral venous outflow and compromised cerebrospinal fluid resorption, leading to obstruction of glymphatic perivenous outflow and increased periarterial cerebrospinal fluid inflow, respectively.” This article may be obtained online without charge.

Journal Impact Factor: 3.93

Funding: C.R. Gibson is affiliated with NASA Space Medicine Operations Division.

 

4

Paul A-L, Elardo SM, Ferl R.

Commun Biol. 2022 May 12;5:382.

PI: A-L. Paul

Note: Apollo 11, 12, and 17 results. From the abstract: “The extent to which plants can enhance human life support on other worlds depends on the ability of plants to thrive in extraterrestrial environments using in-situ resources. Using samples from Apollo 11, 12, and 17, we show that the terrestrial plant Arabidopsis thaliana germinates and grows in diverse lunar regoliths. However, our results show that growth is challenging; the lunar regolith plants were slow to develop and many showed severe stress morphologies.” This article may be obtained online without charge.

Journal Impact Factor: 6.268

Funding: “We thank the members of the UF Space Plants Lab, particularly Jordan Callaham, Natasha Haveman, and Brandon Califar for their support. We thank the NASA AARB (formerly CAPTEM), the NASA Johnson Space Center Curation staff for the allocation of the Apollo samples for this work, and Charles Walkinshaw for insightful discussions. We also thank UF Research and UF-IFAS Communications, particularly Tyler L. Jones for his plant photography. And finally, the UF ICBR Gene Expression (RRID:SCR_019145), NextGen Sequencing (RRID:SCR_019152), and Bioinformatics (RRID:SCR_019120) cores, for their services. Funding for this work included National Aeronautics and Space Administration grant NNX14AT24G (A-LP, RJF), University of Florida Office of Research – Retuned IDC (A-LP, RJF), and National Aeronautics and Space Administration grant 80NSSC19K0752 (SME).”

 

5

Buonanno M, Gonon G, Pandey BN, Azzam EI.

Int J Radiat Biol. 2022 May 13;1-59. Review. Online ahead of print.

PI: E.I. Azzam

Journal Impact Factor: 2.694

Funding: “This work received support from the National Institutes of Health (Grants CA92262 and CA049062), the National Aeronautics and Space Administration (grants NNJ06HD91G and NNX15AD62G), the US department of Energy Low Dose Radiation Research program (DE-FG02-02ER63447), the New Jersey Commission on Cancer Research (Grant No. 02-1081-CCR-S2), and the Federal Nuclear Science and Technology program at Canadian Nuclear Laboratories (project FST-51320.50.19.06).”

 

6

Werneth CM, Slaba TC, Huff JL, Patel ZS, Simonsen LC.

Health Phys. 2022 May 13. Online ahead of print.

Note: From the abstract: “Results from this study provide important information regarding MCM [medical countermeasure] requirements needed to meet NASA limits for planned Mars missions. Insight into the types of countermeasures expected to yield greatest reductions in crew risk is also gained.”

Journal Impact Factor: 1.316

Funding: “This work was supported by the Human Research Program of the Human Exploration and Operations Mission Directorate of the National Aeronautics and Space Administration (CMW, JLH, TCS, LCS) and by the Human Health and Performance contract NNJ15HK11B (ZSP).”

 

7

Macklin BL, Lin YY, Emmerich K, Wisniewski E, Polster BM, Konstantopoulos K, Mumm JS, Gerecht S.

npj Regen Med. 2022 May 12;7:28.

PI: S. Gerecht

Note: This article may be obtained online without charge.

Journal Impact Factor: 10.364

Funding: “Funding for this work was made possible by a NRSA F31 predoctoral fellowship F31HL143972 from NHLBI (awarded to BM), a T32 training award 5T32EY007143-25 and NRSA F31 predoctoral fellowship F31EY032790 from NEI (awarded to KE), and FA9550-20-1-0356 from the Air Force, RAD0102 from the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A; and U54 CA210173-01 from NCI (awarded to SG).”

 

8

Hilditch CJ, Flynn-Evans EE.

Aerosp Med Hum Perform. 2022 May 1;93(5):433-41.

Journal Impact Factor: 1.904

Funding: “Cassie J. Hilditch is supported by the NASA Airspace Operations and Safety Program, System-Wide Safety.”

 

9

Ajala C, Hasenstein KH.

Plants (Basel). 2022 Apr 28;11(9):1191.

PI: K.H. Hasenstein

Note: This article is part of Special Issue “Advances in Plant Physiology and Ecophysiology” (https://www.mdpi.com/journal/plants/special_issues/A_PPE). This article may be obtained online without charge.

Journal Impact Factor: 3.935

Funding: “This research was partially supported by NASA grants NNX10AP91G and 80NSSC17K0344.”

 

10

Blachowicz A, Mhatre S, Singh NK, Wood JM, Parker CW, Ly C, Butler D, Mason CE, Venkateswaran K.

Front Microbiol. 2022 Apr 26;13:777133.

Note: From the abstract: “This study is a first step in characterizing cultivable and viable fungal populations in cleanrooms to assess fungal potential as biocontaminants during interplanetary explorations. The outcomes of this and future studies could be implemented in other cleanrooms that require reducing microbial burden, like intensive care units, operating rooms, or cleanrooms in the semiconducting and pharmaceutical industries.” This article may be obtained online without charge.

Journal Impact Factor: 5.640

Funding: “This research was supported by the NASA Planetary Protection Office 15-PPR15-0001 awarded to KV which also supported the postdoctoral fellowship for AB, SM, and CP.”

 

11

Jamison DA Jr, Anand Narayanan S, Trovão NS, Guarnieri JW, Topper MJ, Moraes-Vieira PM, Zaksas V, Singh KK, Wurtele ES, Beheshti A.

Eur J Hum Genet. 2022 May 16;1-10. Review.

PI: A. Beheshti

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.246

Funding: “This work was supported by supplemental funds for COVID-19 research from Translational Research Institute of Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404) to AB, and by a NASA Space Biology Postdoctoral Fellowship (80NSSC19K0426) to SAN. MJT is a recipient of The Evelyn Grollman Glick Scholar Award and supported by research funding from The Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, Van Andel Research Institute through the Van Andel Research Institute – Stand Up To Cancer Epigenetics Dream Team. Stand Up To Cancer is a program of the Entertainment Industry Foundation, administered by AACR, and Specialized Program of Research Excellence (SPORE) program, through the National Cancer Institute (NCI), grant P50CA254897.”

 

___________________________________________________

 

 

Other papers of interest:

 

1

Chi Y, Wang X, Li F, Zhang Z, Tan P.

Front Microbiol. 2022 Apr 29;13:896556. Review.

Note: From the abstract: “It is highly possible to obtain high-quality microbial products in appreciable amounts, as aerospace technology is advancing continuously. Genome-wide genetic variations in microorganisms can be triggered by space microgravity and radiation. Mutation rate is high, mutant range is wide, and final mutant character is stable. Therefore, space microorganism breeding is growing to be a new and promising area in microbial science and has greatly propelled the development of fermentation technology.”

 

2

Duri LG, Pannico A, Petropoulos SA, Caporale AG, Adamo P, Graziani G, Ritieni A, De Pascale S, Rouphael Y.

Front Nutr. 2022 Apr 29;9:890786.

Note: This article is part of Research Topic “The Chemistry of Food in the Advent of Sustainable Diets” (https://www.frontiersin.org/research-topics/16100/the-chemistry-of-food-in-the-advent-of-sustainable-diets#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

3

Huyan T, Li M, Chen W, Zhou X, Pei D, Shang P, Wu C.

Acta Astronaut. 2022 May 13. Online ahead of print.

Note: A random positioning machine was used in this study.

 

4

Linossier MT, Peurière L, Fernandez P, Normand M, Beck A, Bareille M-P, Bonneau C, Gauquelin-Koch G, Vico L.

Front Physiol. 2022 Apr 27;13:801448.

Note: Dry immersion results.

 

5

Orr S, Casler J, Rhoades J, de León P.

Acta Astronaut. 2022 May 13. Online ahead of print.

Note: The NASA Active Response Gravity Offload System was used in this study to simulate reduced gravity.

 

6

Pradhan GN, Galvan-Garza RC, Perez AM, Stepanek J, Cevette MJ.

Aerosp Med Hum Perform. 2022 May 1;93(5):406-14.

Note: From the abstract: “Virtual reality (VR) is an effective technique to reduce cost and increase fidelity in training programs. In VR, visual and vestibular cues are often in conflict, which may result in simulator-induced motion sickness. The purpose of this study is to investigate the integration of Galvanic Vestibular Stimulation (GVS) with a VR flight training simulator by assessing flight performance, secondary task performance, simulator sickness and presence.”

 

7

Orlov OI, Belakovskiy MS, Kussmaul AR, Tomilovskaya ES.

Front Physiol. 2022 May 13;13:921487.

Note: This article is part of Research Topic “Space Countermeasures and Medicine – Implementation into Earth medicine and Rehabilitation” (https://www.frontiersin.org/research-topics/29370/space-countermeasures-and-medicine–-implementation-into-earth-medicine-and-rehabilitation#articles). The Research Topic also includes an article from previous Current Awareness List #997 https://doi.org/10.3389/fphys.2022.897694. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

8

Li B, Zhao L, Zhang S, Cai H, Xu L, An B, Wang R, Liu G, He Y, Jiao C, Liu L, Xu Y.

Front Plant Sci. 2022 May 11;13:878420.

Note: This article is part of Research Topic “Higher Plants, Algae and Cyanobacteria in Space Environments, Volume II” (https://www.frontiersin.org/research-topics/30023/higher-plants-algae-and-cyanobacteria-in-space-environments-volume-ii#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

9

Xu D, Li H, Katsube T, Huang G, Liu J, Wang B, Zhang H.

Int J Mol Sci. 2022 Apr 27;23(9):4866.

Note: This article is part of Special Issue “Biological Effects of Low Dose and Low Dose-Rate Ionizing Radiation Exposure” (https://www.mdpi.com/journal/ijms/special_issues/Low_Dose). This article may be obtained online without charge.

 

10

Blocker A, Lostroscio K, Carey SL.

Life Sci Space Res. 2022 May 14. Online ahead of print.

Note: From the abstract: “With long-term space flights being planned for the moon and Mars, proper countermeasures must be taken to facilitate human health in microgravity environments. Exercise is a vital countermeasure used to prevent bone and muscle loss, among other health interests. Future exploration missions encourage creating an exercise device that is both compact and can be used to properly execute exercise by the astronauts. Current design considerations include interfacing an exercise device with a vibration isolation and stabilization (VIS) system, which is necessary for protecting the spacecraft and sensitive experiments from harmful vibrations developed during repetitive exercise. This human factor study assesses the feasibility of a VIS system exercise device by using the Computer Assistive Rehabilitation Environment (CAREN) to simulate characteristics of the system.”

 

11

Kramer KEP, Anderson EE.

Aerosp Med Hum Perform. 2022 May 1;93(5):470-1.

Note: From the abstract: “Here, we describe a case of an aviator who experienced tingling extremities, confusion, and loss of consciousness during a flight. The aviator incorrectly believed he was experiencing hypoxia and continued to take multiple steps to troubleshoot the wrong underlying problem for his symptoms. Evaluation after landing suggested this was instead a stress-induced hyperventilation that resulted in symptomatic hypocapnia.”

 

12

Miskovic V, Malafronte E, Minetti C, Machrafi H, Varon C, Iorio CS.

Front Bioeng Biotechnol. 2022 May 12;10:806362.

Note: This article is part of Research Topic “Wound Management and Healing in Space” (https://www.frontiersin.org/research-topics/14877/wound-management-and-healing-in-space#articles). The Research Topic also includes articles from previous Current Awareness Lists #958 https://doi.org/10.3389/fbioe.2021.679650, #972 https://doi.org/10.3389/fbioe.2021.720091, #973 https://doi.org/10.3389/fbioe.2021.720217 and https://doi.org/10.3389/fbioe.2021.716184, #995 https://doi.org/10.3389/fbioe.2022.666434, and #998 https://doi.org/10.3389/fbioe.2022.873384. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

13

Desruelle A-V, Maistre Sd, Gaillard S, Richard S, Tardive C, Martin J-C, Blatteau J-E, Boussuges A, Rives S, Risso J-J, Vallee N.

Front Physiol. 2022 May 17;13:882944.

Note: This article and an article above (Siamwala et al.) in the “NASA” section are part of Research Topic “Physiology in extreme conditions: Adaptations and unexpected reactions, Volume II” (https://www.frontiersin.org/research-topics/29492/physiology-in-extreme-conditions-adaptations-and-unexpected-reactions-volume-ii#articles). This article may be obtained online without charge.

 

14

Goldie C, Stork B, Bernhardt K, Gaydos SJ, Kelley AM.

Aerosp Med Hum Perform. 2022 May 1;93(5):415-20.

 

15

McHill AW, Hull JT, Klerman EB.

Nutrients. 2022 Apr 26;14(9):1800.

Note: This article is part of Special Issue “Nutrition, Circadian Disruption and Cardiometabolic Health” (https://www.mdpi.com/journal/nutrients/special_issues/circadian_cardiometabolic). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

16

Drouot M, Le Bigot N, Bricard E, Bougrenet JL, Nourrit V.

Appl Ergon. 2022 Sep;103:103793.

Note: NASA Task Load Index was used in this study. From the abstract: “Studies examining the potential of augmented reality (AR) to improve assembly tasks are often unrepresentative of real assembly line conditions and assess mental workload only through subjective measurements and leads to conflicting results. We proposed a study directly carried out in industrial settings, to compare the impact of AR-based instructions to computerized instructions, on assembly effectiveness (completion time and errors) and mental workload using objective (eye tracking), subjective (NASA-TLX) and behavioral measurements (dual task paradigm).”