NASA Spaceline Current Awareness List #998 6 May 2022 (Space Life Science Research Results)

 

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

 

Papers deriving from NASA support:

 

1

Koppelmans V, Mulavara AP, Seidler RD, De Dios YE, Bloomberg JJ, Wood SJ.

Brain Struct Funct. 2022 Apr 25.

PIs: A.P. Mulavara, J.J. Bloomberg, S.J. Wood

Note: ISS results. From the abstract: “Here, we measured if metrics derived from MRI scans collected from astronauts can predict motor performance post-flight. Structural and diffusion MRI scans from 14 astronauts collected before launch, and motor measures (balance performance, speed of recovery from fall, and tandem walk step accuracy) collected pre-flight and post-flight were analyzed.”

Journal Impact Factor: 3.270

Funding: “This work is supported by a grant from the NASA Human Research Program (HRP) Health Human Countermeasures Element (‘Sensorimotor Predictors of Postlanding Functional Task Performance’) awarded to APM (principal investigators: APM, JJB, SJW). The authors gratefully acknowledge participation of the ISS crewmembers and support from members of the Neuroscience Laboratory, HRP Research and Operations Integration Element, and Lifetime Surveillance of Astronaut Health. The funding source had no role in study design; the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.”

 

2

Mettler MK, Parker CW, Venkateswaran K, Peyton BM.

Front Microbiol. 2022 Apr 7;13:874236.

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 5.640

Funding: “This research was supported by the ISS Advanced Exploration System Life Support System program funded to JPL and supported post-doctoral fellowship to CWP. The funders had no role in study design, data collection and interpretation, the writing of the manuscript, or the decision to submit the work for publication. No funding was obtained from the company that developed and provided the coating. MSU support for a graduate fellowship to MKM was provided by JPL under subcontract #1635633.”

 

3

Griko YV, Loftus DJ, Stolc V, Peletskaya E.

Life Sci Space Res. 2022 May;33:41-7. Review.

Note: From the abstract: “As NASA and other space agencies make plans to proceed with human exploration missions beyond low Earth orbit (LEO), the private sector, including Space X, Virgin Galactic, Blue Origin, Space Adventures and others, echo these plans with initiatives of their own to send humans further into space. Development of more sub-orbital flight opportunities, orbital flight opportunities to LEO and even higher risk endeavors will certainly result in exposure to medical risks for an expanding and heterogeneous population of civilians. To date, a handful of ‘space tourists ‘ have flown to the International Space Station (ISS), at their own expense, ushering in a new era in which anyone with reasonably good health and even those with physical disability may consider becoming space travelers. Indeed, medical and behavioral issues of healthy, professional astronauts, have not been problematic on short orbital flights. However, recent attempts to test the potential limitations in astronauts on extended duration orbital flights in preparation for future missions beyond LEO raise concern about individual differences in ability to tolerate the hazardous spaceflight environment. Given the rapid development of opportunities for non-professionals and the employees of private companies to travel into space, this is an appropriate time to consider the development of selection strategies for non-government space travelers, including the development of genomic and other modern tools to assess susceptibility to spaceflight risk.”

Journal Impact Factor: 2.082

Funding: Y.V. Griko, D.J. Loftus, and V. Stolc are affiliated with NASA Ames Research Center.

 

4

Crichton DJ, Cinquini L, Kincaid H, Mahabal A, Altinok A, Anton K, Colbert M, Kelly S, Liu D, Patriotis C, Lombeyda S, Srivastava S.

Cancer Biomark. 2022 Apr 18;33(4):479-88.

Note: From the abstract: “NASA’s Jet Propulsion Laboratory (JPL) is advancing research capabilities for data science with two of the National Cancer Institute’s major research programs, the Early Detection Research Network (EDRN) and the Molecular and Cellular Characterization of Screen-Detected Lesions (MCL), by enabling data-driven discovery for cancer biomarker research. The research team pioneered a national data science ecosystem for cancer biomarker research to capture, process, manage, share, and analyze data across multiple research centers. By collaborating on software and data-driven methods developed for space and Earth science research, the biomarker research community is heavily leveraging similar capabilities to support the data and computational demands to analyze research data.” This article may be obtained online without charge.

Journal Impact Factor: 4.388

Funding: “The research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004).”

 

5

Pavela J, Sargsyan A, Bedi D, Everson A, Charvat J, Mason S, Johansen B, Marshall-Goebel K, Mercaldo S, Shah R, Moll S.

Vasc Med. 2022 May 3;1358863×221086619. Online ahead of print.

Note: The Commentary to this article by Drudi et al. (https://pubmed.ncbi.nlm.nih.gov/35502900) is below in the “Other” section.

Journal Impact Factor: 3.530

Funding: “Institutional support was provided by NASA.”

 

6

Blackwell AA, Fesshaye A, Tidmore A, R IL, Wallace DG, Britten RA.

Behav Brain Res. 2022 Apr 29;113907. Online ahead of print.

PI: R.A. Britten

Journal Impact Factor: 3.332

Funding: “This work was funded by NASA grant support NNX14AE73G and NNX16AC40G.”

 

7

Möstl S, Hoffmann F, Hönemann JN, Alvero-Cruz JR, Rittweger J, Tank J, Jordan J.

Elife. 2022 May 3;11:e73428.

Journal Impact Factor: 8.140

Funding: “The AGBRESA-Study was funded by the German Aerospace Center (DLR), the European Space Agency (ESA, contract number 4000113871/15/NL/PG) and the National Aeronautics and Space Administration (NASA, contract number 80JSC018P0078). FH received funding by the DLR and the German Federal Ministry of Economy and Technology, BMWi (50WB1816). SM, JT and JJ were supported by the Austrian Federal Ministry for Climate Action, Environment, Energy, Mobility, Innovation and Technology, BMK (SPACE4ALL Project, FFG No. 866761).”

 

8

Nwanaji-Enwerem JC, Boileau P, Galazka JM, Cardenas A.

Environ Mol Mutagen. 2022 Apr 25. Online ahead of print.

Journal Impact Factor: 3.216

Funding: J.M. Galazka is affiliated with NASA Ames Research Center.

 

9

Wong AJ, Teh BS, Nguyen BT, Pino R, Bretana ME, Bernicker EH, Chevez-Barrios P, Butler EB, Schefler AC.

J Contemp Brachytherapy. 2022 Apr;14(2):130-9.

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.656

Funding: “…Patricia Chevez-Barrios report grants or contracts from any entity, past 36 months: Adopt-A-Scientist (retinoblastoma), NASA (space flight effect on eyes). …”

 

10

Xue C, Salunkhe SJ, Tomimatsu N, Kawale AS, Kwon Y, Burma S, Sung P, Greene EC.

Nat Commun. 2022 Apr 26;13:2248.

PI: S. Burma

Note: This article may be obtained online without charge.

Journal Impact Factor: 14.919

Funding: “We thank Prof. Jeremy Stark (Department of Cancer Genetics and Epigenetics, City of Hope Comprehensive Cancer Center) for reporter assay cell lines. This research was funded by National Institutes of Health grants R01CA236606, R01CA221858 and R35GM118026 (E.C.G.); National Institutes of Health grants R35CA241801, P01CA092584, ES007061, a Gray Foundation Team Science Grant (P.S.); a Wellcome Trust Collaborative Award in Science (Grant. No. 206292/D/17/Z; E.C.G.); and National Institutes of Health Grants R01CA258381 and R01CA246807 (S.B.) and National Aeronautics and Space Administration Award 80NSSC20K0732 (S.B.). P.S. is the recipient of a CPRIT REI Award (RR180029) and holder of the Robert A. Welch Distinguished Chair in Biochemistry (AQ-0012). A.S.K. was the recipient of a CPRIT Postdoctoral Fellowship (RP170345).”

 

11

Zhuang RZ, Lock R, Liu B, Vunjak-Novakovic G. Review.

Nat Biomed Eng. 2022 Apr 27;6(4):327-38. Review.

PI: G. Vunjak-Novakovic

Journal Impact Factor: 25.671

Funding: “We gratefully acknowledge the funding support for our cardiac research by NIH (grants UH3EB025765, P41EB027062, HL076485, F30HL145921), NSF (grant ERC 1647837) and NASA (NNX16AO69A).”

 

12

Barker R, Johns S, Trane R, Gilroy S.

In: Duque P., Szakonyi D, eds. Environmental Responses in Plants. Methods in Molecular Biology. Vol 2494. New York, NY: Humana, 2022. p. 3-16.

PI: S. Gilroy

Funding: “This work is supported by NASA 80NSSC19K0126, 80NSSC21K0577 and NSF MCB2016177.”

 

13

McNulty MJ, Schwartz A, Delzio J, Karuppanan K, Jacobson A, Hart O, Dandekar A, Giritch A, Nandi S, Gleba Y, McDonald KA.

Front Bioeng Biotechnol. 2022 Apr 27;10:865481.

PI: K.A. McDonald

Journal Impact Factor: 5.890

Funding: “This material is based upon work supported by the NASA under grant or cooperative agreement award number NNX17AJ31G. This work was also supported by a NASA Space Technology Research Fellowship (NASA grant number 80NSSC18K1157). This work is supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Aeronautics and Space Administration (NASA) or the Translational Research Institute for Space Health (TRISH).”

 

___________________________________________________

 

 

Other papers of interest:

 

1

Drudi LM, Grenon SM.

Vasc Med. 2022 May 3;1358863×221093667. Online ahead of print.

Note: This article is a Commentary on an article above (Pavela et al. https://pubmed.ncbi.nlm.nih.gov/35502899) in the “NASA” section.

 

2

Arquilla K, Webb AK, Anderson AP.

Acta Astronautica. 2022 Apr 29. Online ahead of print.

Note: From the abstract: “We administered a survey three times with 7 days between administrations. A total of 82 participants completed all three survey sessions, and these participants were divided into three groups for analysis. The first group is those with prior experience in an ICE environment (n = 17; 7F/10 M), the second is those aged 30-55 with a master’s or doctoral degree or ‘astronaut-like’ (n = 22; 10F/12 M), and the third is the general population (n = 43; 27F/16 M). Linear mixed models were used for statistical analysis of the results, given the unequal sample sizes.”

 

3

Locatelli L, Castiglioni S, Maier JAM.

Front Bioeng Biotechnol. 2022 Apr 5;10:862059. Review.

Note: From the abstract: “Life evolved on this planet under the pull of gravity, shielded from radiation by the magnetosphere and shaped by circadian rhythms due to Earth’s rotation on its axis. Once living beings leave such a protective environment, adaptive responses are activated to grant survival. In view of long manned mission out of Earth’s orbit, it is relevant to understand how humans adapt to space and if the responses activated might reveal detrimental in the long run. Here, we review present knowledge about the effects on the vessels of various extraterrestrial factors on humans as well as in vivo and in vitro experimental models.” This article is part of Research Topic “Space (Nano)Medicine” (https://www.frontiersin.org/research-topics/18488/space-nanomedicine#articles). The Research Topic also includes an articles from previous Current Awareness List #950 https://doi.org/10.3389/fbioe.2021.666683 and #981 https://doi.org/10.3389/fbioe.2021.739747. This article may be obtained online without charge.

 

4

Marvasi M, Monici M, Pantalone D, Cavalieri D.

Front Bioeng Biotechnol. 2022 Apr 29;10:873384.

Note: This article is part of Research Topic “Wound Management and Healing in Space” (https://www.frontiersin.org/research-topics/14877/wound-management-and-healing-in-space#articles). The Research Topic also includes articles from previous Current Awareness Lists #958 https://doi.org/10.3389/fbioe.2021.679650, #972 https://doi.org/10.3389/fbioe.2021.720091, #973 https://doi.org/10.3389/fbioe.2021.720217 and https://doi.org/10.3389/fbioe.2021.716184, and #995 https://doi.org/10.3389/fbioe.2022.666434. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

5

Tikhomirov A, Ushakova S, Velichko V, Trifonov S, Tikhomirova N, Skhizhnyak S.

Life Sci Space Res. 2022 May;33:33-40.

Note: From the abstract: “The purpose of the present study is to consider a number of possible risks that may emerge when processed human wastes are involved into mass exchange processes as fertilizers for plants cultivated in the experimental model of the closed ecosystem (CEEM).”

 

6

Xu Y, Pei W, Hu W.

Front Cell Dev Biol. 2022 Apr 12;10:861006. Review.

Note: This article may be obtained online without charge.

 

7

Wang C, Xing W, Lu F.

Acta Astronautica. 2022 July;196:215-9.

Note: From the abstract: “In the treatment of bacterial infections acquired during spaceflight, changes in bacterial virulence, infection process and antibiotic resistance under microgravity need to be taken into consideration. We therefore summarized previous investigations of the microgravity effects on bacterial virulence, infection and antibiotic resistance in this article. Some of the previous studies were carried out in microgravity environment during spaceflight, while others were carried out in simulated microgravity environment using rotating-wall vessel bioreactor or Rotary Cell Culture System.”

 

8

Wang D, Li W, Ding Z, Shi Q, Zhang S, Zhang Z, Liu Z, Wang X, Yan M.

Stem Cells Int. 2022 Apr 18;2022:5719077.

Note: A 2D clinostat was used in this study. This article is part of Special Issue “Mechanobiology of Musculoskeletal Stem and Progenitor Cells” (https://www.hindawi.com/journals/sci/si/179868). This article may be obtained online without charge.

 

9

Bernardini GFP, Bortolussi S, Koivunoro H, Provenzano L, Ferrari C, Cansolino L, Postuma I, Carando DG, Kankaanranta L, Joensuu H, González SJ.

Radiat Res. 2022 May 3. Online ahead of print.

 

10

Iacono D, Murphy EK, Sherman PM, Chapapas H, Cerqueira B, Christensen C, Perl DP, Sladky J.

Sci Rep. 2022 Apr 27;12(1):6839.

Note: This article may be obtained online without charge.

 

11

Malacrida S, Strapazzon G, Mrakic-Sposta S, Pun M, Cogo A.

Front Physiol. 2022 Apr 29;13:888005.

Note: This article is part of Research Topic “Human Molecular and Physiological Responses to Hypoxia” (https://www.frontiersin.org/research-topics/15703/human-molecular-and-physiological-responses-to-hypoxia#articles). This article may be obtained online without charge.

 

12

Francis JH, Canestraro J, Abramson DH, Barker CA, Shoushtari AN.

Am J Ophthalmol Case Rep. 2022 Jun;26:101519.

Note: This article may be obtained online without charge.

 

13

Borbély A.

J Sleep Res. 2022 May 3;e13598. Review. Online ahead of print.

 

14

Li Y, Xu Z, Zhang Y, Cao Z, Chen H.

Physiol Meas. 2022 Apr 29. Online ahead of print.

 

15

Ohki S, Kunimatsu M, Ogawa S, Takano H, Furihata T, Shibasaki H, Yokokawa A.

Chem Pharm Bull (Tokyo). 2022 Apr 27;70(5):375-82.

Note: From the abstract: “Evaluation of endogenous melatonin (MEL) secretion using its urinary metabolites is useful for the treatment of circadian rhythm sleep disorders. The primary melatonin metabolites excreted in the urine are 6-hydroxymelatonin (6-O-MEL) sulfate (S-O-MEL) and 6-O-MEL glucuronate, which result from sequential MEL metabolism by phases I and II drug metabolizing enzymes. To determine the accurate MEL secretion level, these urinary metabolites should be enzymatically deconjugated and converted into MEL.” This article may be obtained online without charge.