NASA Spaceline Current Awareness List #994 8 April 2022 (Space Life Science Research Results)

 

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

 

Papers deriving from NASA support:

 

1

Mhatre SD, Iyer J, Puukila S, Paul AM, Tahimic CGT, Rubinstein L, Lowe M, Alwood JS, Sowa MB, Bhattacharya S, Globus RK, Ronca AE.

Neurosci Biobehav Rev. 2022 Jan;132:908-35. Review.

PI: A.E. Ronca

Note: From the introduction: “This review summarizes the current literature on the neural consequences of spaceflight, describes potential mechanisms contributing to the structural and physiological alterations in the CNS, and discusses potential countermeasures effective in mitigating these effects.”

Journal Impact Factor: 8.989

Funding: “Funding was provided by the National Aeronautics and Space Administration (NASA)Human Research Program (HRP)Human Factors Behavioral Performance Element Grant 18-18FLAG_2-0028.”

 

2

Wostyn P, Gibson CR, Mader TH.

Aerosp Med Hum Perform. 2022 Apr;93(4):396-8.

Note: From the abstract: “Optic disc edema has been well documented in astronauts both during and after long-duration spaceflight and is hypothesized to largely result from increased pressure within the orbital subarachnoid space brought about by a generalized rise in intracranial pressure or from sequestration of cerebrospinal fluid within the orbital subarachnoid space with locally elevated optic nerve sheath pressure. In addition, a recent prospective study documented substantial spaceflight-associated peripapillary choroidal thickening, which may be a contributing factor in spaceflight-associated neuro-ocular syndrome. In the present article, based on the above, we offer a new perspective on the pathogenesis of microgravity-induced optic disc edema from a choroidal point of view.”

Journal Impact Factor: 0.889

Funding: C.R. Gibson is affiliated with NASA Space Medicine Operations Division, Houston, TX.

 

3

Bishawi M, Lee FH, Abraham DM, Glass C, Blocker SJ, Cox DJ, Brown ZD, Rockman HA, Mao L, Slaba TC, Dewhirst MW, Truskey GA, Bowles DE.

iScience. 2022 Apr 15;25(4):104086.

PI: D.E. Bowles

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “…This work is supported by NASA research grant NNX16AK20G to DEB, Translational Research Institute though NASA cooperative agreement NNX16AK20G to DEB, National Institutes of Health 100000002grants NIH-NHLBI 1R38HL143612-01 to M.B., 1K08HL125905-01 to D.M. A, and HL056687 and HL075443 to H.A.R. …”

 

4

Goldford JE, George AB, Flamholz AI, Segrè D.

Proc Natl Acad Sci USA. 2022 Apr 5;119(14):e2110787119.

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.733

Funding: “GBMF4513/Gordon and Betty Moore Foundation (Gordon E. and Betty I. Moore Foundation); 80NSSC17K0295/NASA/NASA/United States; 80NSSC17K0296/NASA/NASA/United States; 1724150/NSF | BIO | Division of Emerging Frontiers (EF).”

 

5

Kaplonek P, Cizmeci D, Fischinger S, Collier AR, Suscovich T, Linde C, Broge T, Mann C, Amanat F, Dayal D, Rhee J, de St Aubin M, Nilles EJ, Musk ER, Menon AS, Saphire EO, Krammer F, Lauffenburger DA, Barouch DH, Alter G.

Sci Transl Med. 2022 Mar 29;eabm2311. Online ahead of print.

PI: A.S. Menon

Note: This article may be obtained online without charge.

Journal Impact Factor: 17.956

Funding: “We acknowledge the Reproductive Scientist Development Program from the Eunice Kennedy Shriver National Institute of Child Health & Human Development and Burroughs Wellcome Fund HD000849 (A.Y.C.) and the support from the Ragon Institute of MGH, MIT, and Harvard (G.A). This work was also supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (D.D., E.R.M and A.S.M), the Massachusetts Consortium on Pathogen Readiness (MassCPR) (G.A.), and the National Institutes of Health (3R37AI080289-11S1, R01AI146785, U19AI42790-01, U19AI135995-02, U19AI42790-01, 1U01CA260476 – 01, CIVIC75N93019C00052) (G.A.). SpaceX provided in-kind contributions in support of the research such as logistical coordination and access to facilities (E.R.M.).”

 

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Other papers of interest:

 

1

Glukhikh DO, Naumov IA, Schoenmaekers C, Kornilova LN, Wuyts FL.

Front Physiol. 2022 Mar 14;13:743855.

Note: ISS results. This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior” (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). The Research Topic also includes articles from previous Current Awareness Lists #956 https://doi.org/10.3389/fncir.2021.659557; #967 https://doi.org/10.3389/fphys.2021.654906; #969 https://doi.org/10.3389/fphys.2021.746509; #973 https://doi.org/10.3389/fncir.2021.723504; #975 https://doi.org/10.3389/fncir.2021.757817, https://doi.org/10.3389/fncir.2021.760313, and https://doi.org/10.3389/fphys.2021.750414; #976 https://doi.org/10.3389/fphys.2021.770502; #977 https://doi.org/10.3389/fphys.2021.782860; #979 https://doi.org/10.3389/fncir.2021.750176; #982 https://doi.org/10.3389/fphys.2021.795321; #985 https://doi.org/10.3389/fphys.2022.806357; #987 https://doi.org/10.3389/fphys.2021.751016; #988 https://doi.org/10.3389/fncir.2022.815838; #991 https://doi.org/10.3389/fphys.2022.743855; and #992 https://doi.org/10.3389/fncir.2022.784280. This article may be obtained online without charge.

 

2

Hagio S, Ishihara A, Terada M, Tanabe H, Kibushi B, Higashibata A, Yamada S, Furukawa S, Mukai C, Ishioka N, Kouzaki M.

J Neurophysiol. 2022 Mar 30. Online ahead of print.

Note: The spaceflight information is not evident in the available abstract.

 

3

Wildman JL, Fedele D, Wilder A, Curtis MT, DiazGranados D.

Hum Factors. 2022 Mar 30;187208221076185. Online ahead of print.

Note: From the abstract: “Based on themes drawn from nine subject matter expert interviews combined with an extensive literature review on related concepts, we developed an integrative conceptual framework of the key inputs, processes, and outputs involved in TSM within LDSE contexts.”

 

4

Corbett MA, Newman DG.

Aerosp Med Hum Perform. 2022 Apr;93(4):354-61.

 

5

Groner O, Frenkel-Nir Y, Erlich-Shoham Y, Shoval G, Gordon B.

Aerosp Med Hum Perform. 2022 Apr;93(4):384-9.

 

6

Rempe MJ, Basiarz E, Rasmussen I, Belenky G, Lamp A.

Aerosp Med Hum Perform. 2022 Apr;93(4):368-75.

 

7

Kurazumi T, Ogawa Y, Takko C, Kato T, Konishi T, Iwasaki KI.

Aerosp Med Hum Perform. 2022 Apr;93(4):347-53.

Note: From the abstract: “Short-term fluid loading is used as part of post-spaceflight medical procedures and clinical treatment in hospitals. Hypervolemia with hemodilution induced by rapid fluid infusion reportedly impaired dynamic cerebral autoregulation. However, the effects on intracranial pressure (ICP) remain unknown. Therefore, we estimated ICP noninvasively (nICP) to examine whether rapid fluid infusion would raise ICP.”

 

8

Mitchell SJ, Bennett MH, Moon RE.

N Engl J Med. 2022 Mar 31;386(13):1254-64. Review.

 

9

Mori S, Kosaki K, Matsui M, Takahashi K, Yoshioka M, Tarumi T, Sugawara J, Shibata A, Kuro OM, Saito C, Yamagata K, Oka K, Maeda S.

Hypertens Res. 2022 Apr 4.

 

10

Piening BD, Dowdell AK, Zhang M, Loza BL, Walls D, Gao H, Mohebnasab M, Li YR, Elftmann E, Wei E, Gandla D, Lad H, Chaib H, Sweitzer NK, Deng M, Pereira AC, Cadeiras M, Shaked A, Snyder MP, Keating BJ.

J Heart Lung Transplant. 2022 Feb 3;S1053-2498(22)01394-8. Online ahead of print.

 

11

Davidson T, Zhang H, Dong H, Grams MP, Park SS, Yan Y.

Adv Radiat Oncol. 2022 Jul 1;7(4):100931.

Note: This article may be obtained online without charge.

 

12

Van Averbeke V, Berkell M, Mysara M, Rodriguez-Ruiz JP, Xavier BB, De Winter FHR, Jongers B, Jairam RK, Hotterbeekx A, Goossens H, Cohen ES, Malhotra-Kumar S, Kumar-Singh S.

Front Immunol. 2022 Mar 15;13:828016.

Note: This article may be obtained online without charge.

 

13

Xin Y, Ji H, Cho E, Roh KB, You J, Park D, Jung E.

Biochem Biophys Rep. 2022 Jul;30:101256.

Note: This article may be obtained online without charge.

 

14

Mann AO, Hanna BS, Muñoz-Rojas AR, Sandrock I, Prinz I, Benoist C, Mathis D.

J Exp Med. 2022 May 2;219(5):e20211504.

 

15

Watkins B, Schuster HM, Gerwin L, Schoser B, Kröger S.

Muscle Nerve. 2022 Apr 3. Online ahead of print.

Note: This article may be obtained online without charge.

 

16

Man J, Graham T, Squires-Donelly G, Laslett AL.

npj Microgravity. 2022 Apr 5;8(1):9. Review.

Note: From the abstract: “This review introduces a plethora of on-ground research that elucidate the intricate process of bone loss, utilizing technology that simulates microgravity. Observations from these studies are largely congruent to data obtained from spaceflight experiments, while offering more insights behind the molecular mechanisms leading to microgravity-induced bone loss. These insights are discussed herein, as well as how that knowledge has contributed to studies of current therapeutic agents. This review also points out discrepancies in existing data, highlighting knowledge gaps in our current understanding. Further dissection of the exact mechanisms of microgravity-induced bone loss will enable the development of more effective preventative and therapeutic measures to protect against bone loss, both in space and possibly on ground.” This article may be obtained online without charge.

 

17

Ke P, Zheng C, Liu F, Wu L, Tang Y, Wu Y, Lv D, Chen H, Qian L, Wu X, Zeng K.

PeerJ. 2022 Mar 21;10:e13165.

Note: This article may be obtained online without charge.

 

18

Cheng Y, Zhang Y, Chen F, Chen Z, Xue T, Zhang Q, Xu M.

Acta Otolaryngol. 2022 Apr 6;1-7. Online ahead of print.

Note: Head tilt results.

 

19

Fell CA, Brooks-Richards TL, Woodruff M, Allenby MC.

Biofabrication. 2022 Apr 4. Online ahead of print.

 

20

Mohan AT, Abdelrahman AM, Anding WJ, Lowndes BR, Blocker RC, Hallbeck MS, Bakri K, Moran SL, Mardini S.

J Plast Reconstr Aesthet Surg. 2022 Feb 19;S1748-6815(22)00075-4. Online ahead of print.

Note: NASA Task Load Index assessment.