NASA Spaceline Current Awareness List #972 22 October 2021 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm . Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
In case you missed it: Medical Xpress, a web-based medical and health news service that is part of the renowned Science X network, recently ran a story titled, “Spaceflight caused DNA to leak out of astronauts’ cell powerhouse” by Thor Christensen which highlights article 1 in the “NASA” section below. To view the full story go to https://medicalxpress.com/news/2021-10-spaceflight-dna-leak-astronauts-cell.html .
Papers deriving from NASA support:
1
Bisserier M, Shanmughapriya S, Rai AK, Gonzalez C, Brojakowska A, Garikipati VNS, Madesh M, Mills PJ, Walsh K, Arakelyan A, Kishore R, Hadri L, Goukassian DA.
Cell-free mitochondrial DNA as a potential biomarker for astronauts’ health.
JAHA. 2021 Oct 20;e022055.
PIs: K. Walsh, D.A. Goukassian
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 4.605
Funding: “This work was supported by the Translational Research Institute for Space Health award FIP0005 (to Dr Goukassian), National Aeronautics and Space Administration grant 80NSSC21K0549 (to Drs Goukassian and Walsh), American Heart Association Career Development Award 18CDA34110277 and start-up funds from the Ohio State University Medical Center (to Dr Garikipati), National Institutes of Health grant R01 HL133554 and American Heart Association 18IPA34170321 (to Dr Hadri), National Institutes of Health 5T32HL007824-22, and the Cardiovascular Medical Research and Education Fund (to Drs Hadri and Bisserier).”
2
Beheshti A, McDonald JT, Hada M, Takahashi A, Mason CE, Mognato M.
Genomic changes driven by radiation-induced DNA damage and microgravity in human cells.
Int J Mol Sci. 2021 Oct;22(19):10507. Review.
PI: A. Beheshti
Note: From the abstract: “In this review, we survey the combined effects from the two main physical components of the space environment, ionizing radiation and microgravity, to alter the genetics and epigenetics of human cells, considering both real and simulated space conditions. Data collected from studies on human cells are discussed for their potential use to estimate individual radiation carcinogenesis risk from space exposure.” This article belongs to Special Issue “Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment” (https://www.mdpi.com/journal/ijms/special_issues/OSaD_space ). The Special Issue also includes articles from Current Awareness Lists #944 https://doi.org/10.3390/ijms22063070 , #947 https://doi.org/10.3390/ijms22073668 , #965 https://doi.org/10.3390/ijms22169020 , and #967 https://doi.org/10.3390/ijms22179470 and https://doi.org/10.3390/ijms22169088 . Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 5.923
Funding: “This research was funded by University of Padova (BIRD-DOR 2020) to M.M. A.B. was supported and funded by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883) and The Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404).”
3
Krukowski K, Grue K, Becker M, Elizarraras E, Frias ES, Halvorsen A, Koenig-Zanoff M, Frattini V, Nimmagadda H, Feng X, Jones T, Nelson G, Ferguson AR, Rosi S.
The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures.
Sci Adv. 2021 Oct 15;7(42):eabg6702.
PI: S. Rosi
Note: This article may be obtained online without charge.
Journal Impact Factor: 14.136
Funding: “This work was supported by NASA grants NNX14AC94G (S.R.) and 80NSSC19K1581 (S.R.). E.S.F. is supported by the National Institute for General Medicine (NIGMS) Initiative for Maximizing Student Development (R25GM056847) and the NSF Graduate Fellowship Program. A.H. was supported by the UCSF Summer Research Training Program. E.E. was supported by the Sally Casanova Pre-Doctoral Scholarship. NIH/NINDS: R01NS088475 (A.R.F.) and UG3NS106899 (A.R.F.); Department of Veterans Affairs: 1I01RX002245 (A.R.F.) and I01RX002787 (A.R.F.); Wings for Life and Craig H. Neilsen Foundation (A.R.F.).”
4
Prelich MT, Matar M, Gokoglu SA, Gallo CA, Schepelmann A, Iqbal AK, Lewandowski BE, Britten RA, Prabhu RK, Myers JG Jr.
Predicting space radiation single ion exposure in rodents: A machine learning approach.
Front Syst Neurosci. 2021 Oct 15;15:715433.
PI: R.A. Britten
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.8
Funding: “The investigation generating the data used in this study was funded by the NASA grant support NNX14AE73G.”
5
Vimal VP, DiZio P, Lackner JR.
The role of spatial acuity in a dynamic balancing task without gravitational cues.
Exp Brain Res. 2021 Oct 15. Online ahead of print.
PI: V.P. Vimal
Journal Impact Factor: 1.972
Funding: “VPV was supported by the Translational Research Institute for Space Health through NASA NNX16AO69A. The MARS device was provided by Air Force Office of Scientific Research AFOSR FA9550-12-1-0395.”
6
Taibbi G, Young M, Vyas RJ, Murray MC, Lim S, Predovic M, Jacobs NM, Askin KN, Mason SS, Zanello SB, Vizzeri G, Theriot CA, Parsons-Wingerter P.
Opposite response of blood vessels in the retina to 6° head-down tilt and long-duration microgravity.
npj Microgravity. 2021 Oct 14;7(1):38.
PI: P. Parsons-Wingerter
Note: Head-down-tilt bed rest study. This article may be obtained online without charge.
Journal Impact Factor: 4.415
Funding: “The research was supported by Grant NNJ12ZSA002N from the Human Health and Countermeasures, Human Research Program (HRP), U. S. National Aeronautics and Space Administration (NASA) to PPW, GV, GT, MY, and SZ. Additional support to PPW was provided by NASA’s HRP and Space Radiation Programs, Vascular Centennial Challenge, Game-Changing Development, and Ames Center Innovation Fund. The authors gratefully acknowledge Rob Ploutz-Snyder (RPS below), University of Michigan, for the original power design of the study. We thank Terry Condrich and Lorie Passe, NASA Publications (LTID) for original art work and layout editing, respectively.”
The following and two citations below in the “Other” section (Herranz et al. and Soga et al.) are part of the Methods in Molecular Biology book series (MIMB, volume 2368), Plant Gravitropism: Methods and Protocols.
7
Basu P, Kruse CPS, Luesse DR, Wyatt SE.
Plant proteomic data acquisition and data analyses: Lessons from spaceflight.
Methods Mol Biol. 2022;2368:199-214. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
PI: S.E. Wyatt
Note: The spaceflight information is not evident in the available abstract.
Journal Impact Factor: 1.17
Funding: “This work was partially funded by NASA # NNX13AM48G awarded to SEW and DRL.”
8
Shymanovich T, Kiss JZ.
Conducting plant experiments in space and on the Moon.
Methods Mol Biol. 2022;2368:165-98. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
PI: J.Z. Kiss
Note: U.S. Space Shuttle, ISS, and former Russian Space Station Mir results. From the abstract: “One of the authors (JZK) has been a principal investigator on eight spaceflight projects. These experiences include using the U.S. Space Shuttle, the former Russian Space Station Mir, and the International Space Station, utilizing the Space Shuttle and Space X as launch vehicles. While there are several ways to fly an experiment into space and to obtain a spaceflight opportunity, this review focuses on using the NASA peer-reviewed sciences approach to get an experiment manifested for flight.”
Journal Impact Factor: 1.17
Funding: “Thanks to NASA for continued financial support of our spaceflight research and to ESA for providing excellent research laboratories for space research. Over the years, we have had fine support from NASA centers (ARC, KSC, JSC, and MSFC) and European facilities (ESTEC and N-USOC). We also wish to acknowledge our colleagues, friends, students, and the many astronauts who have contributed to the successes of our spaceflight projects.”
9
Hasenstein KH.
Blueprints for constructing microgravity analogs.
Methods Mol Biol. 2022;2368:215-32. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
PI: K.H. Hasenstein
Note: A clinostat was used in this study.
Journal Impact Factor: 1.17
Funding: “This chapter is the result of many years of continuous improvement of a variety of specialized clinostats that enabled research supported by NASA. Especially the effect of high gradient magnetic fields, mechanostimulation and longevity of stimulus retention were supported by NASA grants 80NSSC17K0344, NAG10-0190, NNX10AP91G.”
10
Cannon AE, Sabharwal T, Roux SJ.
Spore preparation and protoplast isolation to study gravity perception and response in Ceratopteris richardii.
Methods Mol Biol. 2022;2368:53-60. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
PI: S.J. Roux
Journal Impact Factor: 1.17
Funding: “Work on Ceratopteris is supported by NASA grant NNX13AM54G.”
11
Zhang Y, Richards JT, Hellein JL, Johnson CM, Woodall J, Sorenson T, Neelam S, Ruby AMJ, Levine HG.
NASA’s ground-based microgravity simulation facility.
Methods Mol Biol. 2022;2368:281-99. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
PIs: C.M. Johnson, S. Neelam, NASA Postdoctoral Program Fellowship
Note: This chapter discusses microgravity simulators that include, but are not limited to, 2D clinostats, 3D clinostats, random positioning machines, and rotating wall vessels. From the abstract: “In this chapter, we will discuss current MSSF capabilities, development concepts, and the physical characteristics of these microgravity simulators.”
Journal Impact Factor: 1.17
Funding: “The KSC MSSF facility is supported by NASA’s Biological and Physical Science Division within the NASA Science Mission Directorate. We greatly appreciate the LASSO MSSF science support team, especially Jason Fischer and Stephanie E. Richards for logistic support, Jacob J. Torres, Jonathan R. Gleeson, Lawrence L. Koss, as well as Randall I. Wade and Michael A. Lane from NASA KSC, and Bill Wells from the Bionetics Corporation for hardware design support. We also thank Caesar Udave, Audrey Lee, Antonina Tsinman, Jessica L. Hellein, Julia Woodall, Tait Sorenson, and Emily N. Keith, for their dedication and excellent internship work to improve MSSF operations. Srujana Neelam contributed greatly to the establishment of the MSSF when she was a NASA postdoctoral fellow at KSC through the Universities Space Research Association.”
12
Chin S, Blancaflor EB.
Plant gravitropism: From mechanistic insights into plant function on Earth to plants colonizing other worlds.
Methods Mol Biol. 2022;2368:1-41. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
PI: E.B. Blancaflor
Note: From the abstract: “In this chapter, we review the field of gravitropism by highlighting recent landmark studies that have provided unique insights into this classic research topic while also discussing potential contributions to agriculture on Earth and beyond.”
Journal Impact Factor: 1.17
Funding: “Research on gravitropism in the authors’ laboratory is supported by the National Aeronautics and Space Administration (NASA grants 80NSSC19K0129 and 80NSSC18K1462).”
13
Tolsma JS, Torres JJ, Richards JT, Perera IY, J. Doherty CJ.
Evaluating the effects of the circadian clock and time of day on plant gravitropic responses.
Methods Mol Biol. 2022;2368:301-19. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
PI: C.J. Doherty
Journal Impact Factor: 1.17
Funding: “Current work on the circadian clock and gravity is supported by NASA grant 80NSSC18K1466 and North Carolina Space Grant.”
14
Meyers A, Scinto-Madonich N, Wyatt SE, Wolverton C.
Arabidopsis growth and dissection on Polyethersulfone (PES) membranes for gravitropic studies.
Methods Mol Biol. 2022;2368:233-9. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
PI: C. Wolverton
Journal Impact Factor: 1.17
Funding: “Work in the authors’ labs was supported by NASA Grant NNX15AG55G. The authors wish to thank the EMCS support team at NASA Ames Research Center for their work developing the specialized hardware and growth system from which this technique was modified.”
15
Fitzgerald C, Vens CS, Miller N, Barker R, Westphall M, Lombardino J, Miao J, Swanson SJ, Gilroy S.
Using the Automated Botanical Contact Device (ABCD) to deliver reproducible, intermittent touch stimulation to plants.
Methods Mol Biol. 2022;2368:81-94. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
PI: S. Gilroy
Journal Impact Factor: 1.17
Funding: “This research was supported by grants from the National Science Foundation (IOS1557899) and NASA (NNX13AM50G, NNX17AD52G, and 80NSSC19K0132).”
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Other papers of interest:
1
Dalal SR, Ramachandran V, Khalid R, Keith Manuel F, Knowles JR, Jones JA.
Increased intraocular pressure in glaucomatous, ocular hypertensive, and normotensive space shuttle crew.
Aerosp Med Hum Perform. 2021 Sep;92(9):728-33.
Note: Space Shuttle mission results.
2
Morbidelli L, Genah S, Cialdai F.
Effect of microgravity on endothelial cell function, angiogenesis, and vessel remodeling during wound healing.
Front Bioeng Biotechnol. 2021 Sep;9:720091. Review.
Note: This article is part of Research Topic “Wound Management and Healing in Space” (https://www.frontiersin.org/research-topics/14877/wound-management-and-healing-in-space#articles ). The Research Topic also includes an article from previous Current Awareness List #958 https://doi.org/10.3389/fbioe.2021.679650 . Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
3
von Kroge S, Wölfel EM, Buravkova LB, Atiakshin DA, Markina EA, Schinke T, Rolvien T, Busse B, Jähn-Rickert K.
Bone loss recovery in mice following microgravity with concurrent bone-compartment-specific osteocyte characteristics.
Eur Cell Mater. 2021 Oct 13;41:220-31.
Note: BION-M1 biosatellite mission results. This article may be obtained online without charge.
4
Wang Y, Fan Z, Wang M, Liu J, Xu S, Lu Z, Wang H, Song Y, Wang Y, Qu L, Li Y, Cai X.
Research on the specificity of electrophysiological signals of human acupoints based on the 90-day simulated weightlessness experiment on the ground.
IEEE Trans Neural Syst Rehabil Eng. 2021 Oct 15. Online ahead of print.
Note: Head-down bed rest (HDBR) study. This article may be obtained online without charge.
5
Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Ahmad TAT, Oikawa M, Konishi T.
Hypoxia and proton microbeam: Role of gap junction intercellular communication in inducing bystander responses on human lung cancer cells and normal cells.
Radiat Res. 2022 Oct 11. Online ahead of print.
6
Daniel AR, Luo L, Lee CL, Kirsch DG.
Investigating the role of inflammasome caspases 1 and 11 in the acute radiation syndrome.
Radiat Res. 2021 Oct 13. Online ahead of print.
7
King EJ, Viscariello NN, DeWerd LA.
Development of standard x-ray beams for calibration of radiobiology cabinet and conformal irradiators.
Radiat Res. 2022 Oct 11. Online ahead of print.
8
Precek M, Kubelik P, Vysin L, Schmidhammer U, Larbre JP, Demarque A, Jeunesse P, Mostafavi M, Juha L.
Dose rate effects in fluorescence chemical dosimeters exposed to picosecond electron pulses: An accurate measurement of low doses at high dose rates.
Radiat Res. 2021 Oct 6. Online ahead of print.
9
Shin WG, Sakata D, Lampe N, Belov O, Tran NH, Petrovic I, Ristic-Fira A, Dordevic M, Bernal MA, Bordage MC, Francis Z, Kyriakou I, Perrot Y, Sasaki T, Villagrasa C, Guatelli S, Breton V, Emfietzoglou D, Incerti S.
A Geant4-DNA evaluation of radiation-induced DNA damage on a human fibroblast.
Cancers (Basel). 2021 Oct;13(19):4940.
Note: This article is part of Special Issue “Ionizing Radiation in Therapy and Biology of Cancer: Role of Monte Carlo simulations, Biophysical Modeling, and Radiobiological Techniques” (https://www.mdpi.com/journal/cancers/special_issues/Ionizing_Radiation_Therapy_Biology_Cancer_Role_Monte_Carlo_simulations_Biophysical_Modeling ). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
10
Wei M, Feng S, Zhang L, Wang C, Chu S, Shi T, Zhou W, Zhang Y.
Active fraction combination from Liuwei Dihuang decoction improves adult hippocampal neurogenesis and neurogenic microenvironment in cranially irradiated mice.
Front Pharmacol. 2021 Sep;12:717719.
Note: This article is part of Research Topic “Herbal medicines in Managing Stroke and Neurodegenerative Diseases – Is there Evidence based on Basic and Clinical Studies?” (https://www.frontiersin.org/research-topics/15867/herbal-medicines-in-managing-stroke-and-neurodegenerative-diseases—is-there-evidence-based-on-basi#articles ). This article may be obtained online without charge.
11
Zaripova KA, Kalashnikova EP, Belova SP, Kostrominova TY, Shenkman BS, Nemirovskaya TL.
Role of pannexin 1 ATP-permeable channels in the regulation of signaling pathways during skeletal muscle unloading.
Int J Mol Sci. 2021 Sep 28;22(19):10444.
Note: Hindlimb unloading study. This article is part of Special Issue “Skeletal Muscle Molecular Signalling in Various Models of Disuse and Unloading” (https://www.mdpi.com/journal/ijms/special_issues/Skeletal_Muscle_Molecular_Signalling ). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
12
Gong X, Ye ZQ, Yu G, Zhang W, Zhang WD, Zhou XQ, Li M, Xie WG.
[Changes in the related indicators of bone formation and bone resorption in severely burned rats.]
Zhonghua Shao Shang Za Zhi. 2021 Sep 20;37(9):839-45. Chinese.
13
Xing W, Miller T, Wildy S.
Computational homogenisation based extraction of transverse tensile cohesive responses of cortical bone tissue.
Biomech Model Mechanobiol. 2021 Oct 13. Online ahead of print.
14
Herranz R, Valbuena MA, Manzano A, Kamal KY, Villacampa A, Ciska M, van Loon JJWA, Medina FJ.
Use of reduced gravity simulators for plant biological studies.
Methods Mol Biol. 2022;2368:241-65. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
Note: This book chapter, the chapter below (Soga et al.), and 7-15 in the “NASA” section above are chapters from the book Plant Gravitropism: Methods and Protocols.
15
Soga K, Yano S, Kamada M, Matsumoto S, Hoson T.
Understanding the mechanisms of gravity resistance in plants.
Methods Mol Biol. 2022;2368:267-79. Online ahead of print 14 October 2021. (Plant Gravitropism: Methods and Protocols.).
Note: This book chapter, the chapter above (Herranz et al.), and 7-15 in the “NASA” section above are chapters from the book Plant Gravitropism: Methods and Protocols.
16
Xu L, Zhang L, Zhang X, Li G, Wang Y, Dong J, Wang H, Hu Z, Cao X, Zhang S, Shi F.
HDAC6 negatively regulates miR-155-5p expression to elicit proliferation by targeting RHEB [Ras homolog enriched in brain] in microvascular endothelial cells under mechanical unloading.
Int J Mol Sci. 2021 Oct;22(19):10527.
Note: The process of 2D clinorotation was used in this study. This article is part of Section “Molecular Biology” (https://www.mdpi.com/journal/ijms/sections/Molecular_Biology ). This article may be obtained online without charge.
17
Hsia AW, Jbeily EH, Mendez ME, Cunningham HC, Biris KK, Bang H, Lee CA, Loots GG, Christiansen BA.
Post-traumatic osteoarthritis progression is diminished by early mechanical unloading and anti-inflammatory treatment in mice.
Osteoarthritis Cartilage. 2021 Oct 12. Online ahead of print.
Note: Hindlimb unloading study. This article may be obtained online without charge.
18
Morris MB, Veksler BZ, Krusmark MA, Gaines AR, Jantscher HL, Gunzelmann G.
Aircrew actual vs. prescriptive sleep schedules and resulting fatigue estimates.
Aerosp Med Hum Perform. 2021 Oct;92(10):806-14.
19
Shigeno K, Ogita H, Funabiki K.
Variants of benign paroxysmal positional vertigo in relation to head position during sleep.
J Vestib Res. 2021 Oct 8. Online ahead of print.
20
Venus M, Holtforth MG.
Short and long haul pilots rosters, stress, sleep problems, fatigue, mental health, and well-being.
Aerosp Med Hum Perform. 2021 Oct;92(10):786-97.
21
Besnard S, Bois J, Hitier M, Vogt J, Laforet P, Golding JF.
Motion sickness lessons from the Southern Ocean.
Aerosp Med Hum Perform. 2021 Sep;92(9):720-7.
22
Bateman GA, Bateman AR.
Spaceflight-associated increase in middle cerebral vein velocity: Collapse, collateral flow, or hyperemia?
J Appl Physiol (1985). 2021 Oct 14;131(4):1392-3.
Note: This is a Letter to the Editor in response to an article (Arbeille et al.) that appeared in Current Awareness List #961 https://doi.org/10.1152/japplphysiol.00231.2021 .
23
Wostyn P, Gibson CR, Mader TH.
Acute use of lower body negative pressure during spaceflight does not decrease choroidal thickness.
J Appl Physiol (1985). 2021 Oct 14;131(4):1390-1.
Note: This is a Letter to the Editor in response to an article (Greenwald et al.) that appeared in Current Awareness List #956 https://doi.org/10.1152/japplphysiol.01040.2020 .
