NASA Spaceline Current Awareness List #953 11 June 2021 (Space Life Science Research Results)

Papers deriving from NASA support:

 

1

Khodadad CLM, Oubre CM, Castro VA, Flint SM, Roman MC, Ott CM, Spern CJ, Hummerick ME, Maldonado Vazquez GJ, Birmele MN, Whitlock Q, Scullion M, Flowers CM, Wheeler RM, Melendez O.

Life (Basel). 2021 May 27;11(6):492.

Note: ISS results. From the abstract: “The microbial monitoring system (RAZOR^® EX) is a compact, semi-quantitative rugged PCR instrument that was successfully tested on the ISS using station potable water. …We have presented and discussed the attributes and performance of a microbial monitor tested on ISS for the PWD and tested…on Earth to expand its capabilities. The monitoring system improves the capability of detection above what is currently achieved on ISS and can provide rapid and reliable on-orbit detection and identification of up to 10 biological pathogens or bio-fouling microbes, simultaneously.” This article is part of a Special Issue “Space Life Sciences” (https://www.mdpi.com/journal/life/special_issues/space_bio). The Special Issue also includes an article listed below (Berezovskaya et al.) and articles from previous Current Awareness Lists #917 https://doi.org/10.3390/life10090196, #920 https://doi.org/10.3390/life10100235, #933 https://doi.org/10.3390/life11010033 and https://doi.org/10.3390/life11010042, #936 https://doi.org/10.3390/life11020112, #944 https://doi.org/10.3390/life11040283, and #945 https://doi.org/10.3390/life11020109. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 2.991

Funding: “This research was funded by NASA ISS Office, the AES and NASA, KSC CIF Programs.”

2

Paul AM, Overbey EG, da Silveira WA, Szewczyk N, Nishiyama NC, Pecaut MJ, Anand S, Galazka JM, Mao XW.

Sci Rep. 2021 Jun 1;11(1):11452.

PIs: X.W. Mao, A.M. Paul, NASA Postdoctoral Program Fellowship

Note: From the abstract: “Using a ground-based model to simulate spaceflight [21-days of single-housed, hindlimb unloading (HLU) combined with continuous low-dose gamma irradiation (LDR, total dose of 0.04 Gy)], an in-depth survey of the immune and hematological systems of mice at 7-days post-exposure was performed.” GeneLab is available at: https://genelab.nasa.gov. This article may be obtained online without charge.

Journal Impact Factor: 3.998

Funding: “We would like to thank the NASA GeneLab Analysis Working Group for helpful discussions. GeneLab data curators San-Huei Lai Polo, Amanda M. Saravia-Butler, Homer Fogle, Marie T. Dinh, Valery Boyko, Samrawit G. Gebre and Sylvain V. Costes. This research and article processing charge was funded in part by NASA Grant No. 80NSSC17K0693, 80NSSC18K0310, and NNX13AL97G to XWM and by the NASA GeneLab Project through the NASA Space Biology Program administered under the NASA Biological and Physical Sciences Division. The Universities Space Research Association and NASA Space Biology Program to AMP, the NASA grant (NNX15AL16G) and the Osteopathic Heritage Foundation to NS, and the School of Biological Sciences, Queen’s University Belfast and from ESA grant/contract 4000131202/20/NL/PG/pt to WAdS.”

3

Lackner JR.

Front Neurol. 2021 May 14;12:646640. Review.

PI: J.R. Lackner

Note: From the abstract: “This paper describes a series of studies resulting from the finding that when free floating in weightless conditions with eyes closed, all sense of one’s spatial orientation with respect to the aircraft can be lost.” This article may be obtained online without charge.

Journal Impact Factor: 3.292

Funding: “Funding over the years has been provided by NASA, NSF, NIH, ONR, and AFOSR.”

 

4

Burke CS, Wiese CW, Campbell LNP.

Organizational Psychology Review. 2021 Mar 9.

PI: E. Salas

Note: From the abstract: “The prevalence of teams in organizational settings has dramatically increased over the last 50 years, and as such, researchers have made much progress in understanding the conditions and intra-team dynamics that facilitate successful team performance. However, much remains to be learned due to the complexity of teams. This complexity often makes it difficult to study teams operating in context, especially when trying to examine longitudinal aspects of teams. Adding to this difficulty, studying teams in context is resource intensive and access is often a key barrier, especially if the focus is on teams that are elite or that operate in extreme environments. This drives a need to look outside the traditional methodological tools typically utilized to study teams. Thereby, the purpose of this manuscript is to highlight a method that while not typically utilized in the team literature can offer benefits when exploring team dynamics in context—historiometry.” From the publisher’s site: “Article first published online March 9, 2021.”

Journal Impact Factor: 2.864

Funding: “This work was supported by the National Aeronautics and Space Administration [Grant # NNX16AB08G] and the Army Research Institute for the Behavioral and Social Sciences [Grant # W911NF-17-1-0344].”

 

5

Schwendner P, Nguyen AN, Schuerger AC.

Life (Basel). 2021 May 20;11(5):459.

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.991

Funding: “This research was funded by the Planetary Protection Research (PPR) program (80NSSC17K0263).”

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Other papers of interest:

 

1

Farkas Á, Farkas G.

Skin Pharmacol Physiol. 2021 May 31;1-7. Review. Online ahead of print.

Note: ISS results. From the abstract: “This review highlights some of the interactions between the space environment and the skin.” This article may be obtained online without charge.

2

Spatz JM, Hughes-Fulford M, Tsai A, Gaudilliere D, Hedou J, Ganio E, Angst M, Aghaeepour N, Gaudilliere B.

Sci Rep. 2021 Jun 7;11:11872.

Note: Rotating-wall vessels were used in this study. Millie Hughes-Fulford was one of the first American women to fly in space as a NASA payload specialist. Hughes-Fulford flew aboard the Space Shuttle Columbia on the STS-40 Spacelab Life Sciences (SLS 1) mission in June 1991. Additional information is available on the SpaceRef website at http://spaceref.com/space-medicine/space-travel-weakens-our-immune-systems-now-scientists-may-know-why.html. This article may be obtained online without charge.

 

3

Gallagher M, Kearney B, Ferrè ER.

Biol Lett. 2021 Jun;17(6):20210115.

Note: From the abstract: “Participants passively estimated the position of their hand while they were upright and therefore aligned with terrestrial gravity, or pitch-tilted 45° backwards from gravity. Overall participants overestimated the position of their hand in both upright and tilted postures; however, the proprioceptive bias was significantly reduced when participants were tilted. Our findings therefore suggest that the internal model of gravity may influence and update JPS [joint position sense] in order to allow the organism to interact with the environment.”

4

Gregg RK.

Int Rev Cell Mol Biol. 2021;361:107-64. Review.

Note: From the abstract: “This review will summarize findings related to microgravity-mediated alterations in the cell cytoskeleton, cell-cell, and cell-extracellular matrix interactions including cadherins, immunoglobulin superfamily of adhesion molecules, selectins, and integrins and related cell signaling.”

 

5

Ogneva IV, Usik MA.

Curr Issues Mol Biol. 2021 May 22;43(1):176-86.

Note: The antiorthostatic suspension model was used in this study. From the abstract: “The results of this study show that after a full cycle of oogenesis under simulated microgravity, the rate of cellular respiration in the fruit fly ovaries increases, apparently due to complex II of the respiratory chain.” This article may be obtained online without charge.

 

6

Yan R, Liu H, Lv F, Deng Y, Li Y.

Int J Mol Sci. 2021 May 13;22(10):5165.

Note: A 3D clinostat was used in this study. This article may be obtained online without charge.

 

7

Wu HM, Lee SG, Oh CS, Kim SG.

Hypergravity load modulates acetaminophen nephrotoxicity via endoplasmic reticulum stress in association with hepatic microRNA-122 expression.

Int J Mol Sci. 2021 May 5;22(9):4901.

Note: From the introduction: “Given the lack of research on the joint effect of hypergravity and medications on organ functions under outer space environment conditions, this study investigated whether single and multiple loads of hypergravity stress affect APAP nephrotoxicity and hepatotoxicity.” This article and the following two articles are part of Special Issue “Microgravity and Space Medicine 2.0” (https://www.mdpi.com/journal/ijms/special_issues/microgravity_2). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

8

Zhivodernikov I, Ratushnyy A, Buravkova L.

Int J Mol Sci. 2021 May 21;22(11):5428.

Note: A random positioning machine was used in this study. From the abstract: “The presented data demonstrate that ECM-associated molecules of both native and osteocommitted MSCs may be involved in bone matrix reorganization during spaceflight.” This article is part of Special Issue “Microgravity and Space Medicine 2.0” (https://www.mdpi.com/journal/ijms/special_issues/microgravity_2). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

9

Becker I, Prasad B, Ntefidou M, Daiker V, Richter P, Lebert M.

Int J Mol Sci. 2021 Jun 11;22(12):6299.

Note: This article is part of Special Issue “Microgravity and Space Medicine 2.0” (https://www.mdpi.com/journal/ijms/special_issues/microgravity_2). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

10

Bi D, Dai Z, Liu D, Wu F, Liu C, Li Y, Li B, Li Z, Li Y, Ta D.

Ultrasound Med Biol. 2021 May 26;S0301-5629(21)00181-2. Online ahead of print.

Note: Head-down bed-rest study.

 

11

De Martino E, Hides J, Elliott JM, Hoggarth M, Zange J, Lindsay K, Debuse D, Winnard A, Beard D, Cook JA, Salomoni SE, Weber T, Scott J, Hodges PW, Caplan N.

J Appl Physiol (1985). 2021 Jun 3. Online ahead of print.

Note: Head-down tilt bedrest study.

12

Sun P, Yang J, Wang B, Ma H, Zhang Y, Guo J, Chen X, Zhao J, Sun H, Yang J, Yang H, Cui Y.

Sci Rep. 2021 May 31;11(1):11373.

Note: From the article: “The ground-based simulated module (SM) for animal research was used to build compound factors of the space environment. It contains 200 lx Light intensity, the circadian rhythm of 12 h light/darkness respectively; Atmosphere pressure (AP): 0.9 atm pressure; and 85 dBA environment noise.” This article may be obtained online without charge.

 

13

Berezovskaya AS, Tyganov SA, Nikolaeva SD, Naumova AA, Shenkman BS, Glazova MV.

Life (Basel). 2021 May 17;11(5):449.

Note: Hindlimb unloading study. This article and NASA article 1 in this list are part of Special Issue “Space Life Sciences” (https://www.mdpi.com/journal/life/special_issues/space_bio). This article may be obtained online without charge.

 

14

Adamopoulos K, Koutsouris D, Zaravinos A, Lambrou GI.

Molecules. 2021 May 8;26(9):2784. Review.

Note: From the abstract: “Here, we review the significant abnormalities presented in the cardiovascular, immune, vestibular and musculoskeletal systems, due to altered gravity conditions. We also review the impact that gravity played in the anatomy of snakes and amphibians, during their evolution. Overall, it appears that gravity does not only curve the space-time continuum but the biological continuum, as well.” This article may be obtained online without charge.

15

Epperly MW, Shields D, Fisher R, Hou W, Wang H, Hamade DF, Mukherjee A, Greenberger JS.

Radiat Res. 2021 Jun 4. Online ahead of print.

16

Khaksarighiri S, Guo J, Wimmer-Schweingruber R, Narici L.

Sci Rep. 2021 Jun 3;11(1):11687.

Note: From the abstract: “We use a realistic model of the head/brain structure and calculate the radiation deposit therein by realistic SEP events, also under various shielding scenarios. We then determine the relation between the radiation dose deposited in different parts of the brain and the properties of the SEP events and obtain some simple and ready-to-use functions which can be used to quickly and reliably forecast the event dose in the brain. Such a novel tool can be used from fast nowcasting of the consequences of SEP events to optimization of shielding systems and other mitigation strategies of astronauts in space.” This article may be obtained online without charge.

 

17

Noé F, Hachard B, Ceyte H, Bru N, Paillard T.

Exp Brain Res. 2021 Jun 3. Online ahead of print.

Note: From the abstract: “This study investigated the effects of mental fatigue (MF) induced by a 90-min AX-continuous performance test (AX-CPT) on balance control by addressing the issue of the heterogeneity of individuals’ responses.”

18

Lue CH, Buffington ML, Scheffer S, Lewis M, Elliott TA, Lindsey ARI, Driskell A, Jandova A, Kimura MT, Carton Y, Kula RR, Schlenke TA, Mateos M, Govind S, Varaldi J, Guerrieri E, Giorgini M, Xingeng W, Hoelmer K, Daane KM, Abram PK, Pardikes NA, Brown JJ, Thierry M, Poirié M, Goldstein P, Miller SE, Tracey WD, Davis JS, Jiggins FM, Wertheim B, Lewis OT, Leips J, Staniczenko PPA, Hrcek J.

Mol Ecol Resour. 2021 May 29. Online ahead of print.

Note: From the abstract: “Molecular identification is increasingly used to speed up biodiversity surveys and laboratory experiments. However, many groups of organisms cannot be reliably identified using standard databases such as GenBank or BOLD due to lack of sequenced voucher specimens identified by experts. Sometimes a large number of sequences are available, but with too many errors to allow identification. Here we address this problem for parasitoids of Drosophilaby introducing a curated open-access molecular reference database, DROP (Drosophila parasitoids).”