NASA Spaceline Current Awareness List #933 22 January 2021 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
A note from the Editor: This will be the last SPACELINE Current Awareness with me as Editor. Next week Shawna Byrd takes over as new Editor. Retirement beckons. I have thoroughly enjoyed compiling the Lists for the past 6-1/2 years and hope these Lists have, in some way, contributed to the field of space life sciences. – Robyn Ertwine
Papers deriving from NASA support:
1
Nelson CA, Acuna AU, Paul AM, Scott RT, Butte AJ, Cekanaviciute E, Baranzini SE, Costes SV.
Knowledge network embedding of transcriptomic data from spaceflown mice uncovers signs and symptoms associated with terrestrial diseases.
Life (Basel). 2021 Jan 12;11(1):E42.
https://pubmed.ncbi.nlm.nih.
Note: Results are from studies conducted on various spaceflight missions. GeneLab is available at: https://genelab.nasa.gov. This article may be obtained online without charge.
Journal Impact Factor: 2.991
Funding: “This research was funded by [National Science Foundation] grant number [NSF_2033569]. S.E.B. is the Distinguished Professor in Neurology at UCSF and holds the Heidrich Friends and Family endowed chair in Neurology at UCSF. GeneLab Project at NASA Ames Research Center, through NASA’s Space Biology Program in the Division of Biological and Physical Sciences (BPS) of the Science Mission Directorate.”
2
Zea L, McLean RJC, Rook TA, Angle G, Carter DL, Delegard A, Denvir A, Gerlach R, Gorti S, McIlwaine D, Nur M, Peyton BM, Stewart PS, Sturman P, Velez Justiniano YA.
Potential biofilm control strategies for extended spaceflight missions.
Biofilm. 2020 Dec;2:100026.
https://pubmed.ncbi.nlm.nih.
PIs: L. Zea, R.J.C. McLean
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “LZ and RJCM also gratefully acknowledge research support from NASA (80NSSC17K0036 (LZ) and (NNX17AC79G) (RJCM)).”
3
Mias GI, Singh VV, Rogers LRK, Xue S, Zheng M, Domanskyi S, Kanada M, Piermarocchi C, He J.
Longitudinal saliva omics responses to immune perturbation: A case study.
Sci Rep. 2021 Jan 12;11(1):710.
https://pubmed.ncbi.nlm.nih.
PI: G.I. Mias
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.998
Funding: “G.I.M., M.Z., S.D., S.X., C.P., and research reported is supported by Project Number T0412 Grant by the Translational Research Institute for Space Health, funded under NASA Cooperative Agreement NNX16AO69A.”
4
Bemben DA, Baker BS, Buchanan SR, Ade CJ.
Circulating MiR-21 expression is upregulated after 30 days of head-down tilt bed rest.
Osteoporos Int. 2021 Jan 11. Online ahead of print.
https://pubmed.ncbi.nlm.nih.
PI: C.J. Ade
Note: Head-down tilt bed rest study.
Journal Impact Factor: 3.864
Funding: “This study was funded by a National Aeronautics and Space Administration (NASA) research grant (#NNX16AR26G) awarded to C.J. Ade and D.A. Bemben.”
5
Klein PM, Parihar VK, Szabo GG, Zöldi M, Angulo MC, Allen BD, Amin AN, Nguyen QA, Katona I, Baulch JE, Limoli CL, Soltesz I.
Detrimental impacts of mixed-ion radiation on nervous system function.
Neurobiol Dis. 2021 Jan 5. Online ahead of print.
https://pubmed.ncbi.nlm.nih.
PIs: C. Limoli/V.K. Parihar/J.E. Baulch/I. Soltesz/NSCOR
Note: This article may be obtained online without charge.
Journal Impact Factor: 5.332
Funding: “This work was supported by NASA Specialized Center of Research grant NNX15AI22G (CLL, IS) and by the National Research, Development and Innovation Office of Hungary Frontier Program grant 129961 (MZ).”
6
Fajardo-Cavazos P, Nicholson WL.
Mechanotransduction in prokaryotes: A possible mechanism of spaceflight adaptation.
Life (Basel). 2021 Jan 7;11(1):E33.
https://pubmed.ncbi.nlm.nih.
PI: W.L. Nicholson
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.991
Funding: “This research was funded by a grant (80NSSC21K0319) from the NASA Space Biology program.”
______________________________
Other papers of interest:
1
Buoite Stella A, Ajčević M, Furlanis G, Manganotti P.
Neurophysiological adaptations to spaceflight and simulated microgravity.
Clin Neurophysiol. 2021 Feb;132(2):498-504. Review.
https://pubmed.ncbi.nlm.nih.
Note: Bed rest studies are reviewed.
2
Koschate J, Thieschäfer L, Drescher U, Zieschang T, Hoffmann U.
Time-series analysis of heart rate and blood pressure in response to changes in work rate before and after 60 days of 6° head down tilt bed rest.
Eur J Appl Physiol. 2020 Dec 29. Online ahead of print.
https://pubmed.ncbi.nlm.nih.
Note: Head-down tilt bed rest study. This article may be obtained online without charge.
3
Zhao H, Shi Y, Qiu C, Zhao J, Gong Y, Nie C, Wu B, Yang Y, Wang F, Luo L.
Effects of simulated microgravity on ultrastructure and apoptosis of choroidal vascular endothelial cells.
Front Physiol. 2021 Jan 18;11:1668.
https://www.frontiersin.org/
Note: A Rotary Cell Culture System was used. This article may be obtained online without charge.
4
Du J, Cui J, Yang J, Wang P, Zhang L, Luo B, Han B.
Alterations in cerebral hemodynamics during microgravity: A literature review.
Med Sci Monit. 2021 Jan 15;27:e928108. Review.
https://pubmed.ncbi.nlm.nih.
Note: Spaceflight and bed rest studies are reviewed. This article may be obtained online without charge at the publisher’s website: https://www.medscimonit.com/
5
Yokoyama Y, Yamada Y, Kosugi K, Yamada M, Narita K, Nakahara T, Fujiwara H, Toda M, Jinzaki M.
Effect of gravity on brain structure as indicated on upright computed tomography.
Sci Rep. 2021 Jan 11;11(1):392.
https://pubmed.ncbi.nlm.nih.
Note: Head-down tilt bed rest study. This article may be obtained online without charge.
6
Cui Q, Yang H, Gu Y, Zong C, Chen X, Lin Y, Sun H, Shen Y, Zhu J.
RNA sequencing (RNA-seq) analysis of gene expression provides new insights into hindlimb unloading-induced skeletal muscle atrophy.
Ann Transl Med. 2020 Dec;8(23):1595.
https://pubmed.ncbi.nlm.nih.
Note: Hindlimb unloading study. This article may be obtained online without charge.
7
Ikumi A, Funayama T, Terajima S, Matsuura S, Yamaji A, Nogami Y, Okuwaki S, Kawamura H, Yamazaki M.
Effects of conservative treatment of 2-week rigorous bed rest on muscle disuse atrophy in osteoporotic vertebral fracture patients.
J Rural Med. 2021 Jan;16(1):8-13.
https://pubmed.ncbi.nlm.nih.
Note: Bed rest study. This article may be obtained online without charge.
8
MacLennan RJ, Ogilvie D, McDorman J, Vargas E, Grusky AR, Kim Y, Garcia JM, Stock MS.
The time course of neuromuscular impairment during short-term disuse in young women.
Physiol Rep. 2021 Jan;9(1):e14677.
https://pubmed.ncbi.nlm.nih.
Note: Knee immobilization via bracing was used. This article may be obtained online without charge.
9
Nemoto A, Goyagi T.
Tail suspension is useful as a sarcopenia model in rats.
Lab Anim Res. 2021 Jan 13;37(1):7.
https://pubmed.ncbi.nlm.nih.
Note: Hindlimb unloading study. This article may be obtained online without charge.
10
Villota-Narvaez Y, Garzon-Alvarado DA, Ramirez-Martinez AM.
A dynamical system for the IGF1-AKT signaling pathway in skeletal muscle adaptation.
Biosystems. 2021 Jan 13:104355.
https://pubmed.ncbi.nlm.nih.
11
Donahue SW, Wojda SJ, McGee-Lawrence ME, Auger J, Black HL.
Osteoporosis prevention in an extraordinary hibernating bear.
Bone. 2021 Apr;145:115845. Epub 2021 Jan 13.
https://pubmed.ncbi.nlm.nih.
12
El-Gazzar A, Högler W.
Mechanisms of bone fragility: From osteogenesis imperfecta to secondary osteoporosis.
Int J Mol Sci. 2021 Jan 10;22(2):E625. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
13
Mehner C, Krishnan S, Chou J, Freeman ML, Freeman WD, Patel T, Turnbull MT.
GCR versus simulated GCR for investigating cancer risk in the hematopoietic system – Are we comparing apples to apples?
Life Sci Space Res. 2021 Jan 16. Article in press.
http://www.sciencedirect.com/
14
Miyazaki J, Yamamoto H, Ichimura Y, Yamashiro H, Murase T, Yamamoto T, Umeda M, Higuchi T.
Resting-state functional connectivity predicts recovery from visually induced motion sickness.
Exp Brain Res. 2021 Jan 13. Online ahead of print.
https://pubmed.ncbi.nlm.nih.
15
Korovin IS, Klimenko AB, Kalyaev IA, Safronenkova IB.
An experience of the cognitive map-based classifier usage in astronaut’s emotional state monitoring.
Acta Astronaut. 2021 Jan 20. Article in press.
http://www.sciencedirect.com/
Note: From the abstract: “The main contribution of this paper is the development of the cognitive-map based classifier.”
16
Warnecke T, Dauth L, Ahlbäck A, DuCanto J, Fleischhammer E, Glatz C, Kerkhoff S, Mathes A, Schmitz J, Starck C, Thierry S, Hinkelbein J.
Time to ventilation and success rate of airway devices in microgravity: A randomized crossover manikin-trial using an underwater setting.
Acta Anaesthesiol Scand. 2021 Jan 13. Online ahead of print.
https://pubmed.ncbi.nlm.nih.
Note: A neutrally buoyant free-floating underwater manikin was used.
17
García-González J, Lacek J, Retzer K.
Dissecting hierarchies between light, sugar and auxin action underpinning root and root hair growth.
Plants (Basel). 2021 Jan 7;10(1):E111.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
18
Kordyum E, Hasenstein KH.
Plant biology for space exploration – Building on the past, preparing for the future.
http://www.sciencedirect.com/
Note: This article may be obtained online without charge.
19
Okamoto T, Takatani S, Motose H, Iida H, Takahashi T.
The root growth reduction in response to mechanical stress involves ethylene-mediated microtubule reorganization and transmembrane receptor-mediated signal transduction in Arabidopsis.
Plant Cell Rep. 2021 Jan 13. Online ahead of print.
https://pubmed.ncbi.nlm.nih.
20
Macharoen K, McDonald KA, Nandi S.
A method to simplify bioreactor processing for recombinant protein production in rice cell suspension cultures.
MethodsX. 2020;7:101139.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
