NASA Spaceline Current Awareness List #930 31 December 2020 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website athttps://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Angelos E, Ko DK, Zemelis-Durfee S, Brandizzi F.
Relevance of the unfolded protein response to spaceflight-induced transcriptional reprogramming in Arabidopsis.
Astrobiology. 2020 Dec 15. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
PI: F. Brandizzi
Note: ISS results.
Journal Impact Factor: 4.091
Funding: “This work was supported primarily by NASA NNX12AN71G with contributing support from Training Program in Plant Biotechnology for Health and Sustainability (T32-GM110523), the DOE Great Lakes Bioenergy Research Center (DOE BER Office of Science DE-FC02-07ER64494 and DE-SC0018409), the Chemical Sciences, Geosciences, and Biosciences Division, Office of Basic Energy Sciences, Office of Science, US Department of Energy (award number DE-FG02-91ER20021), National Institutes of Health (GM101038), and AgBioResearch (MICL02598) to F.B.”
2
Mylabathula PL, Li L, Bigley AB, Markofski MM, Crucian BE, Mehta SK, Pierson DL, Laughlin MS, Rezvani K, Simpson RJ.
Simulated microgravity disarms human NK-cells and inhibits anti-tumor cytotoxicity in vitro.
Acta Astronaut. 2020 Sep;174:32-40.
http://www.sciencedirect.com/
PIs: R.J. Simpson; A. Bigley, NSBRI Postdoctoral Fellowship Program
Note: A Rotary Cell Culture System was used.
Journal Impact Factor: 2.83
Funding: “This work was supported by NASA grants NNX16AB29G, NNX16AG02G and 80NSSC19K1059 to R.J. Simpson, and a National Space Biomedical Research Institute (NSBRI) post-doctoral fellowship (NCC 9-58) to A.B. Bigley.”
3
Luxton JJ, Bailey SM.
Twins, telomeres, and aging-in space!
Plast Reconstr Surg. 2021 Jan 1;147(1S-2S):7S-14S.
https://pubmed.ncbi.nlm.nih.
PI: S.M. Bailey
Note: The article is part of a special supplement entitled “The Science of Aging.” The full issue may be obtained online without charge at https://journals.lww.com/
Journal Impact Factor: 4.209
Funding: No funding cited. PI reports grant numbers are NNX14AH51G and NNX14AB02G.
4
Eren AM, Kiefl E, Shaiber A, Veseli I, Miller SE, Schechter MS, Fink I, Pan JN, Yousef M, Fogarty EC, Trigodet F, Watson AR, Esen ÖC, Moore RM, Clayssen Q, Lee MD, Kivenson V, Graham ED, Merrill BD, Karkman A, Blankenberg D, Eppley JM, Sjödin A, Scott JJ, Vázquez-Campos X, McKay LJ, McDaniel EA, Stevens SLR, Anderson RE, Fuessel J, Fernandez-Guerra A, Maignien L, Delmont TO, Willis AD.
Community-led, integrated, reproducible multi-omics with anvi’o.
Nat Microbiol. 2021 Jan;6(1):3-6.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
Journal Impact Factor: 14.300
Funding: “We gratefully acknowledge support for anvi’o from the Simons Foundation and Alfred P. Sloan Foundation.” M.D. Lee is affiliated with NASA Ames Research Center.
5
Karmali F, Bermúdez Rey MC, Clark TK, Wang W, Merfeld DM.
Corrigendum: Multivariate analyses of balance test performance, vestibular thresholds, and age.
Front Neurol. 2020 Nov 26;11:556797.
https://pubmed.ncbi.nlm.nih.
PI: T.K. Clark, NSBRI Postdoctoral Fellowship Program
Note: The authors correct “a typographical error in a sentence of the Results section that describes a previous paper, such that the “y-” and “z-” were reversed.” The article was originally published in Front Neurol. 2017 Nov 8;8:578. https://pubmed.ncbi.nlm.nih.
Journal Impact Factor: 2.889
Funding: From the original article: “This research was supported by NIH/NIDCD R01-DC01458, R01-DC014924 and R03-DC013635.” PI reports funding under NSBRI NCC 9-58-PF03502.
6
Noohi F, Kinnaird C, De Dios Y, Kofman IS, Wood SJ, Bloomberg J, Mulavara A, Sienko KH, Polk TA, Seidler RD.
Age differences in vestibular brain connectivity are associated with balance performance.
Front Aging Neurosci. 2020 Nov 16;12:566331.
https://pubmed.ncbi.nlm.nih.
PI: R.D. Seidler
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.362
Funding: “This work was supported by grants from the National Space Biomedical Research Institute (NASA NCC 9-58), NASA (NNX11AR02G), and NIH Grant 1S10OD012240-01A1.”
7
Trainer HM, Jones JM, Pendergraft JG, Maupin CK, Carter DR.
Team membership change “events”: A review and reconceptualization.
Group Organ Manage. 2020 Apr;45(2):219-51.
https://journals.sagepub.com/
PI: D.R. Carter
Note: This article is part of the special collection “Organizational Performance, Organizational Change & Identification” and may be obtained online without charge.
Journal Impact Factor: 2.527
Funding: “This study was supported by The National Aeronautics and Space Administration (NASA) #80NSSC18K0511 and U.S. Army Research Institute (ARI) Contract #W911NF1920173.”
8
Demmig-Adams B, Stewart JJ, López-Pozo M, Polutchko SK, Adams WW 3rd.
Zeaxanthin, a molecule for photoprotection in many different environments.
Molecules. 2020 Dec 10;25(24):E5825. Review.
https://pubmed.ncbi.nlm.nih.
PI: B. Demmig-Adams
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.463
Funding: “This work was funded by the Translational Research Institute for Space Health through Agreement NNX16AO69A and by the University of Colorado.”
9
John SP, Hasenstein KH.
Desiccation mitigates heat stress in the resurrection fern, Pleopeltis polypodioides.
Front Plant Sci. 2020 Nov 30;11:597731.
https://pubmed.ncbi.nlm.nih.
PI: K.H. Hasenstein
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.402
Funding: “This research was partially supported by NASA grants NNX10AP91G and NNX13AN05A.”
10
Lukas H, Xu C, Yu Y, Gao W.
Emerging telemedicine tools for remote COVID-19 diagnosis, monitoring, and management.
ACS Nano. 2020 Dec 22;14(12):16180-93.
https://pubmed.ncbi.nlm.nih.
PI: W. Gao
Note: This article may be obtained online without charge.
Journal Impact Factor: 14.588
Funding: “This project was supported by the Merkin Institute for Translational Research at Caltech, COVID-19 Research Funding from the Tobacco Related-Disease Research Program (TRDRP), the Translational Research Institute for Space Health through NASA NNX16AO69A, and an American Heart Association grant no. 19TPA34850157.”
11
Reyes DP, Carroll DJ, Walton ME, Antonsen EL, Kerstman EL.
Probabilistic risk assessment of prophylactic surgery before extended-duration spaceflight.
Surg Innov. 2020 Dec 18. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Journal Impact Factor: 1.458
Funding: “The work was supported by NASA Human Health and Performance Contract, NNJ15HK11B.”
12
Robertson J, Dias R, Musson D, Yule S.
Response regarding: “How to manage head injury with COVID-19 pneumonitis on Mars? Rare but high impact complex medical emergencies in space.”
J Surg Res. 2021 Feb;258:460. Epub 2020 Dec 16.
https://pubmed.ncbi.nlm.nih.
PI: S. Yule
Note: The authors reply to: Brzezicki MA, Crockett DC, Cooney A, Strachan JM. Letter Regarding “How to manage head injury with COVID-19 pneumonitis on Mars? Rare but high impact complex medical emergencies in space.” J Surg Res. 2021 Feb;258:457-459. https://pubmed.ncbi.nlm.nih.
Journal Impact Factor: 1.841
Funding: From the original article: “This work was supported by the National Space Biomedical Research Institute-National Aeronautics and Space Administration (HPF04501).”
______________________________
Other papers of interest:
1
Kurtz CC, Otis JP, Regan MD, Carey HV.
How the gut and liver hibernate.
Comp Biochem Physiol A Mol Integr Physiol. 2021 Mar;253:110875. Review. Epub 2020 Dec 25.
https://pubmed.ncbi.nlm.nih.
2
Matsushita H, Isoguchi A, Okada M, Masuda T, Misumi Y, Ichiki Y, Ueda M, Ando Y.
Amyloid fibril formation is suppressed in microgravity.
Biochem Biophys Rep. 2021 Mar 1;25:100875. Epub 2020 Dec 17.
https://pubmed.ncbi.nlm.nih.
Note: A 3-D clinostat was used. This article may be obtained online without charge.
3
Shahin N, Louati H, Trudel G.
Measuring human hemolysis clinically and in extreme environments using endogenous carbon monoxide elimination.
Ann Biomed Eng. 2020 May;48(5):1540-50.
https://pubmed.ncbi.nlm.nih.
4
Shi Z, Qin M, Huang L, Xu T, Chen Y, Hu Q, Peng S, Peng Z, Qu LN, Chen SG, Tuo QH, Liao DF, Wang XP, Wu RR, Yuan TF, Li YH, Liu XM.
Human torpor: Translating insights from nature into manned deep space expedition.
Biol Rev Camb Philos Soc. 2020 Dec 14. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
5
Zhang J, Chang H, Yin R, Xu S, Wang H, Gao Y.
A temporal study on musculoskeletal morphology and metabolism in hibernating Daurian ground squirrels (Spermophilus dauricus).
Bone. 2021 Mar;144:115826. Epub 2020 Dec 19.
https://pubmed.ncbi.nlm.nih.
6
Zhang Y, You B, Chen Y, Yang J, Xie C, Huang G, Li R, Hu P.
Effect of transcriptional regulatory factor FoxO3a on central nervous system oxygen toxicity.
Front Physiol. 2020 Dec 18;11:1648.
https://www.frontiersin.org/
Note: This article may be obtained online without charge.
7
Prasad B, Grimm D, Strauch SM, Erzinger GS, Corydon TJ, Lebert M, Magnusson NE, Infanger M, Richter P, Krüger M.
Influence of microgravity on apoptosis in cells, tissues, and other systems in vivo and in vitro.
Int J Mol Sci. 2020 Dec 9;21(24):E9373. Review.
https://pubmed.ncbi.nlm.nih.
Note: From the Introduction: “This review describes the spaceflight options and ground-based techniques suitable for microgravity-based research, the process of programmed cell death, and the current knowledge of apoptosis in small animals, e.g., mice, in space.” This article may be obtained online without charge.
8
Wostyn P, Gibson CR, Mader TH.
Choroidal thickness changes in astronauts during and after spaceflight.
Retina. 2020 Dec 7. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The authors comment on the article: Spaide RF. Choroidal blood flow: Review and potential explanation for the choroidal venous anatomy including the vortex vein system. Retina. 2020 Oct;40(10):1851-1864. https://pubmed.ncbi.nlm.nih.
9
Kizhakke Puliyakote AS, Holverda S, Sá RC, Arai TJ, Theilmann RJ, Botros L, Bogaard HJ, Prisk GK, Hopkins SR.
Prone positioning redistributes gravitational stress in the lung under normal conditions and in simulations of edema.
Exp Physiol. 2020 Dec 21. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Supine and prone positions were used. This article may be obtained online without charge.
10
Ali MM, McMillan RP, Fausnacht DW, Kavanaugh JW, Harvey MM, Stevens JR, Wu Y, Mynatt RL, Hulver MW.
Muscle-specific deletion of toll-like receptor 4 impairs metabolic adaptation to wheel running in mice.
Med Sci Sports Exerc. 2020 Dec 11. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
11
Reidy PT, Monning JM, Pickering CE, Funai K, Drummond MJ.
Pre-clinical rodent models of physical inactivity-induced muscle insulin resistance: Challenges and solutions.
J Appl Physiol (1985). 2020 Dec 24. [Epub ahead of print] Review.
https://pubmed.ncbi.nlm.nih.
12
Du J, Yang J, He Z, Cui J, Yang Y, Xu M, Qu X, Zhao N, Yan M, Li H, Yu Z.
Osteoblast and osteoclast activity affect bone remodeling upon regulation by mechanical loading-induced leukemia inhibitory factor expression in osteocytes.
Front Mol Biosci. 2020 Nov 26;7:585056.
https://pubmed.ncbi.nlm.nih.
Note: Hindlimb unloading study. This article may be obtained online without charge.
13
Tang Y, Luo K, Chen Y, Gao X, Tan J, Dai Q, Xu J, Dong S, Luo F.
[Effect of demineralized bone matrix modified by laminin α4 chain functional peptide on H-type angiogenesis and osteogenesis to promote bone defect repair].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2020 Dec 15;34(12):1594-601. Chinese.
https://pubmed.ncbi.nlm.nih.
14
Teguh DA, Nustad JL, Craven AE, Brooks DJ, Arlt H, Hu D, Baron R, Lanske B, Bouxsein ML.
Abaloparatide treatment increases bone formation, bone density and bone strength without increasing bone resorption in a rat model of hindlimb unloading.
Bone. 2021 Mar;144:115801. Epub 2020 Dec 15.
https://pubmed.ncbi.nlm.nih.
Note: Hindlimb unloading study.
15
Zhang L, Yuan Y, Wu W, Sun Z, Lei L, Fan J, Gao B, Zou J.
Medium-intensity treadmill exercise exerts beneficial effects on bone modeling through bone marrow mesenchymal stromal cells.
Front Cell Dev Biol. 2020 Nov 24;8:600639.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
16
Markarian M, Krattli RP, Baddour JD, Alikhani L, Giedzinski E, Usmani MT, Agrawal A, Baulch JE, Tenner AJ, Acharya MM.
Glia-selective deletion of complement C1q prevents radiation-induced cognitive deficits and neuroinflammation.
Cancer Res. 2020 Dec 15. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
17
Oizumi T, Ohno R, Yamabe S, Funayama T, Nakamura AJ.
Repair kinetics of DNA double strand breaks induced by simulated space radiation.
Life (Basel). 2020 Dec 10;10(12):E341.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
18
Perez-Gelvez YNC, Unger S, Kurz S, Rosenbalm K, Wright WM, Rhodes OE Jr, Tiemeyer M, Bergmann CW.
Chronic exposure to low doses of ionizing radiation impacts the processing of glycoprotein N-linked glycans in Medaka (Oryzias latipes).
Int J Radiat Biol. 2020 Dec 21. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
19
Yang X, Ma L, Ye Z, Shi W, Zhang L, Wang J, Yang H.
Radiation-induced bystander effects may contribute to radiation-induced cognitive impairment.
Int J Radiat Biol. 2020 Dec 17. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
20
Stewart CE, Holt AG, Altschuler RA, Cacace AT, Hall CD, Murnane OD, King WM, Akin FW.
Effects of noise exposure on the vestibular system: A systematic review.
Front Neurol. 2020 Nov 25;11:593919. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
21
Wehland M, Steinwerth P, Aleshcheva G, Sahana J, Hemmersbach R, Lützenberg R, Kopp S, Infanger M, Grimm D.
Tissue engineering of cartilage using a Random Positioning Machine.
Int J Mol Sci. 2020 Dec 16;21(24):9596.
https://pubmed.ncbi.nlm.nih.
Note: A Random Positioning Machine was used. This article may be obtained online without charge.
22
Taylor AJ, Beauchamp JD, Briand L, Heer M, Hummel T, Margot C, McGrane S, Pieters S, Pittia P, Spence C.
Factors affecting flavor perception in space: Does the spacecraft environment influence food intake by astronauts?
Compr Rev Food Sci Food Saf. 2020 Nov;19(6):3439-75. Review.
https://pubmed.ncbi.nlm.nih.
Note: From the abstract: “The key areas investigated in this review for their potential impact on food intake are the effects of food shelf life, physiological changes, noise, air and water quality on the perception of food flavor, as well as the link between food flavor and food intake.” This article may be obtained online without charge.
23
Bao Y, Bassham DC.
ER-Phagy and its role in ER homeostasis in plants.
Plants (Basel). 2020 Dec 14;9(12):E1771. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
24
Brzezicki MA, Crockett DC, Cooney A, Strachan JM.
Letter regarding “How to manage head injury with COVID-19 pneumonitis on Mars? Rare but high impact complex medical emergencies in space.”
J Surg Res. 2021 Feb;258:457-9.
https://pubmed.ncbi.nlm.nih.
Note: The authors comment on: Robertson JM, Dias RD, Gupta A, Marshburn T, Lipsitz SR, Pozner CN, Doyle TE, Smink DS, Musson DM, Yule S. Medical event management for future deep space exploration missions to Mars. J Surg Res. 2020 Feb;246:305-14. https://www.ncbi.nlm.nih.gov/
25
Albuquerque I, Tiwari A, Parent M, Cassani R, Gagnon JF, Lafond D, Tremblay S, Falk TH.
WAUC: A multi-modal database for mental workload assessment under physical activity.
Front Neurosci. 2020 Dec 1;14:549524.
https://pubmed.ncbi.nlm.nih.
Note: The NASA Revised Multi-Attribute Task Battery II and the NASA Task Load Index were used. This article may be obtained online without charge.
26
Devos H, Gustafson K, Ahmadnezhad P, Liao K, Mahnken JD, Brooks WM, Burns JM.
Psychometric properties of NASA-TLX and Index of Cognitive Activity as measures of cognitive workload in older adults.
Brain Sci. 2020 Dec 16;10(12):994.
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
27
Han L, Zhang H, Xiang Z, Shang J, Anjani S, Song Y, Vink P.
Desktop lighting for comfortable use of a computer screen.
Work. 2020 Dec 11. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
28
Hoang I, Ranchet M, Derollepot R, Moreau F, Paire-Ficout L.
Measuring the cognitive workload during dual-task walking in young adults: A combination of neurophysiological and subjective measures.
Front Hum Neurosci. 2020 Nov 20;14:592532.
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
