NASA Spaceline Current Awareness List #929 18 December 2020 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Banker LA, Salazar AP, Lee JK, Gadd N, Kofman I, De Dios Y, Mulder E, Bloomberg JJ, Mulavara A, Seidler RD.
The effects of a spaceflight analog with elevated CO2 on sensorimotor adaptation.
J Neurophysiol. 2020 Dec 9. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
PI: R.D. Seidler
Note: Head-down tilt bed rest study.
Journal Impact Factor: 2.234
Funding: “This work was supported by grants from the National Aeronautics and Space Administration 489 (NASA #80NSSC17K0021).”
2
Rivas E, Allie KN, Salvador PM, Schoech L, Martinez M.
Sex difference in cerebral blood flow velocity during exercise hyperthermia.
J Therm Biol. 2020 Dec;94:102741.
https://pubmed.ncbi.nlm.nih.
Journal Impact Factor: 2.361
Funding: “This project was supported by start-up awards from the Texas Tech University Office of Vice President for Research.” E. Rivas is affiliated with NASA Johnson Space Center.
3
Bell LC, Meydan C, Kim J, Foox J, Butler D, Mason CE, Shapira SD, Noursadeghi M, Pollara G.
Transcriptional response modules characterise IL-1β and IL-6 activity in COVID-19.
bioRxiv. 2020 Dec 3. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
PI: C.E. Mason
Note: This article is a preprint and has not been peer reviewed. This article may be obtained online without charge.
Journal Impact Factor: Not applicable to this publication
Funding: “This work was supported by grant funding from the Wellcome Trust to MN (207511/Z/17/Z) and GP (WT101766/Z/13/Z), by Clinical Lectureship and Clinical Fellowship posts funded by the National Institute for Health Research (NIHR) to GP and LCKB respectively, and by NIH grants 5R01GM109018 and 5U54CA209997 to SDS. CEM would like to thank the Scientific Computing Unit (SCU), XSEDE Supercomputing Resources, the Starr Cancer Consortium (I13-0052), and funding from the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, NNX17AB26G), the National Institutes of Health (R21AI129851, R01MH117406, R01AI151059).”
4
Lenarczyk M, Laiakis EC, Mattson DL, Johnson BD, Kronenberg A, North PE, Komorowski R, Mäder M, Baker JE.
Irradiation of the kidneys causes pathologic remodeling in the nontargeted heart: A role for the immune system.
FASEB Bioadv. 2020 Dec;2(12):705-19.
https://faseb.onlinelibrary.
PI: J. Baker
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “Supported by grants from the National Institutes of Health (HL116264, HL137748), National Aeronautical and Space Administration (NNX15AD69G, 80NSSC19K0498), the Greater Milwaukee Foundation, the We Care Fund and the Foundation for Heart Science. The project was also supported by Award Number P30 CA051008 (P.I. Louis Weiner) from the National Cancer Institute.”
5
Harris KM, Petersen LG, Weber T.
Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity.
npj Microgravity. 2020 Dec 17;6(1):38.
https://www.nature.com/
PI: L.G. Petersen
Note: Lower body negative pressure study. This article may be obtained online without charge.
Journal Impact Factor: 3.380
Funding: “This project was supported by the ESA Space Medicine Team (HRE-OM), NASA HRP (80NSSC19K0020), and the Novo Nordic Foundation (NNF15OC0019196). The project was funded by the Space Medicine Team of the European Space Agency and KBR GmbH.”
6
Ramesh S, Chen TT, Maxwell AD, Cunitz BW, Dunmire B, Thiel J, Williams JC, Gardner A, Liu Z, Metzler I, Harper JD, Sorensen MD, Bailey MR.
In vitro evaluation of urinary stone comminution with a clinical burst wave lithotripsy system.
J Endourol. 2020 Nov;34(11):1167-73.
https://pubmed.ncbi.nlm.nih.
PI: M.K. Hall
Journal Impact Factor: 2.328
Funding: “The work was supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P01-DK043881 and K01-DK104854.” PI reports funding under NASA project “Renal Stone Ureter Management Technology Development and Clinical Validation Study.”
7
Narici L, Titova E, Obenaus A, Wroe A, Loredo L, Schulte R, Slater JD, Nelson GA.
Multiple sensory illusions are evoked during the course of proton therapy.
Life Sci Space Res. 2020 Aug;26:140-8.
https://pubmed.ncbi.nlm.nih.
PI: G.A. Nelson
Journal Impact Factor: 2.453
Funding: “The authors express their thanks to the National Aeronautics and Space Administration for support under grants (NNX10AD59G and NNX10AJ31G) and the Department of Radiation Medicine for access to patient and dosimetry records.”
______________________________
Other papers of interest:
1
Wang D, Zhang T, Ye H, Hao H, Zhang H, Zhao C.
In vitro probiotic screening and evaluation of space-induced mutant Lactobacillus plantarum.
Food Sci Nutr. 2020 Nov;8(11):6031-6.
https://pubmed.ncbi.nlm.nih.
Note: Shenzhou-11 results. This article may be obtained online without charge.
2
Pastushkova LK, Koloteva MI, Goncharova AG, Glebova TM, Goncharov IN, Kashirina DN, Brzezhovsky AG, Kireev KS, Larina IM.
[Changes in blood proteome of cosmonauts with micro- and macrovascular injuries due to g-loads at the final stage of long-duration space missions].
Aviakosm Ekolog Med. 2020;54(5):5-14. Russian.
https://www.elibrary.ru/item.
Note: ISS results.
3
Larina IM, Kashirina DN, Kireev KS, Grigoriev AI.
[Repeated long-term space flights: Proteomic investigations of cosmonauts’ blood].
Aviakosm Ekolog Med. 2020;54(5):15-22. Russian.
https://www.elibrary.ru/item.
Note: ISS results.
4
Fomina EV, Kukoba TB.
[Characteristics of post-flight muscle strength and velocity dynamics in cosmonauts as a function of weight loading during long-term space missions].
Aviakosm Ekolog Med. 2020;54(5):23-8. Russian.
https://www.elibrary.ru/item.
Note: ISS results.
5
Abnous K, Storey KB.
5′-Adenosine monophosphate deaminase regulation in ground squirrels during hibernation.
Comp Biochem Physiol B Biochem Mol Biol. 2021 Apr-May;253:110543. Epub 2020 Dec 8.
https://pubmed.ncbi.nlm.nih.
6
Boyer C, Cussonneau L, Brun C, Deval C, Pais de Barros JP, Chanon S, Bernoud-Hubac N, Daira P, Evans AL, Arnemo JM, Swenson JE, Gauquelin-Koch G, Simon C, Blanc S, Combaret L, Bertile F, Lefai E.
Specific shifts in the endocannabinoid system in hibernating brown bears.
Front Zool. 2020 Nov 23;17(1):35.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
7
Diemin DB.
[Significance of the hypothermia level for neurophysiological reactions of human organism to experimental whole-body cooling].
Aviakosm Ekolog Med. 2020;54(5):57-64. Russian.
https://www.elibrary.ru/item.
8
Limper U, Ahnert T, Maegele M, Froehlich M, Grau M, Gauger P, Bauerfeind U, Görlinger K, Pötzsch B, Jordan J.
Simulated hypergravity activates hemostasis in healthy volunteers.
J Am Heart Assoc. 2020 Dec 15;9(24):e016479.
https://pubmed.ncbi.nlm.nih.
Note: A long-arm centrifuge was used. This article may be obtained online without charge.
9
Liu H, Tian L, Wang D.
Notch receptor GLP-1 regulates toxicity of simulated microgravity stress by activating germline-intestine communication of insulin signaling in C. elegans.
Biochem Biophys Res Commun. 2020 Dec 3. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The method of microgravity simulation is not provided in the available abstract.
10
Rice SA, Ten Have GAM, Reisz JA, Gehrke S, Stefanoni D, Frare C, Barati Z, Coker RH, D’Alessandro A, Deutz NEP, Drew KL.
Nitrogen recycling buffers against ammonia toxicity from skeletal muscle breakdown in hibernating arctic ground squirrels.
Nat Metab. 2020 Dec 7. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
11
Yasnetsov VV, Kaurova DE, Bersenev EY.
[Investigation of the anti-hypoxia properties of new nicotinic acid derivatives].
Aviakosm Ekolog Med. 2020;54(5):73-6. Russian.
https://www.elibrary.ru/item.
12
Tu MY, Chu H, Lin YJ, Chiang KT, Chen CM, Chen HH, Yang CS, Lai CY.
Combined effect of heart rate responses and the anti-G straining manoeuvre effectiveness on G tolerance in a human centrifuge.
Sci Rep. 2020 Dec 10;10(1):21611.
https://pubmed.ncbi.nlm.nih.
Note: A human centrifuge was used. This article may be obtained online without charge.
13
Kriushev ES, Moreva TI.
[The condition of the optic nerve sheaths and blood outflow pathways from the cranial cavity in a 21-day dry immersion according to the ultrasound research methods].
Aviakosm Ekolog Med. 2020;54(5):39-44. Russian.
https://www.elibrary.ru/item.
Note: Dry immersion was used.
14
Kim C, Hwang JK.
Flavonoids: Nutraceutical potential for counteracting muscle atrophy.
Food Sci Biotechnol. 2020 Dec;29(12):1619-40. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
15
Stens NA, Hisdal J, Bakke EF, Kaur N, Sharma A, Stranden E, Thijssen DHJ, Høiseth LØ.
Factors mediating the pressor response to isometric muscle contraction: An experimental study in healthy volunteers during lower body negative pressure.
PLoS One. 2020 Dec 9;15(12):e0243627.
https://pubmed.ncbi.nlm.nih.
Note: Lower body negative pressure study. This article may be obtained online without charge.
16
Uda M, Yoshihara T, Ichinoseki-Sekine N, Baba T, Yoshioka T.
Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult rats.
PLoS One. 2020 Dec 9;15(12):e0243660.
https://pubmed.ncbi.nlm.nih.
Note: Hindlimb unloading study. This article may be obtained online without charge.
17
Dechaumet B, Cleret D, Linossier MT, Vanden-Bossche A, Chanon S, Lefai E, Laroche N, Lafage-Proust MH, Vico L.
Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model.
PLoS One. 2020 Dec 9;15(12):e0243098.
https://pubmed.ncbi.nlm.nih.
Note: Centrifugation was used. This article may be obtained online without charge.
18
Patil S, Dang K, Zhao X, Gao Y, Qian A.
Role of lncRNAs and circRNAs in bone metabolism and osteoporosis.
Front Genet. 2020 Nov 13;11:584118. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
19
Clayton NP, Khan-Malek RC, Dangler CA, Zhang D, Ascah A, Gains M, Gardner B, Mockbee C, Keutzer JM, McManus J, Authier S.
Sargramostim (rhu GM-CSF) improves survival of non-human primates with severe bone marrow suppression after acute, high-dose, whole-body irradiation.
Radiat Res. 2020 Dec 10. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
20
Deshevaya ЕА, Khamidullina NM, Chasovskikh AV, Kharin SS, Novikova ND, Sychev VN.
[Potentiality of radiation sterilization in preparation for the ExoMars mission].
Aviakosm Ekolog Med. 2020;54(5):65-72. Russian.
https://www.elibrary.ru/item.
21
Limoli C.
Can a comparison of clinical and deep space irradiation scenarios shed light on the radiation response of the brain?
Br J Radiol. 2020 Nov 1;93(1115):20200245.
https://pubmed.ncbi.nlm.nih.
22
Patterson AM, Wu T, Chua HL, Sampson CH, Fisher A, Singh P, Guise TA, Feng H, Muldoon J, Wright L, Plett PA, Pelus LM, Orschell CM.
Optimizing and profiling prostaglandin E2 as a medical countermeasure for the hematopoietic acute radiation syndrome.
Radiat Res. 2020 Dec 10. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
23
Paunesku T, Stevanović A, Popović J, Woloschak GE.
Effects of low dose and low dose rate low linear energy transfer radiation on animals – Review of recent studies relevant for carcinogenesis.
Int J Radiat Biol. 2020 Dec 8. [Epub ahead of print] Review.
https://pubmed.ncbi.nlm.nih.
24
Susam LA, Alan HY, Yilmaz A, Erol A, Inci CI, Akinci FC, Akkus B, Demir M, Emirhan ME, Faydasicok O, Gudekli E.
Cosmic radiation exposure calculations for international and domestic flights departs from Istanbul and Ankara.
Radiat Prot Dosimetry. 2020 Dec 10. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
25
Xue X, Ali YF, Liu C, Hong Z, Luo W, Nie J, Li B, Jiao Y, Liu NA.
Geomagnetic shielding enhances radiation resistance by promoting DNA repair process in human bronchial epithelial cells.
Int J Mol Sci. 2020 Dec 6;21(23):9304.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
26
Batuk IT, Batuk MO, Aksoy S.
Evaluation of the postural balance and visual perception in young adults with acute sleep deprivation.
J Vestib Res. 2020 Nov 28. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
27
Gushchin VI, Kuvshinova OL, Shalina OS, Suedfeld P, Johnson PJ.
[Structure of autobiographic representation of veteran cosmonauts].
Aviakosm Ekolog Med. 2020;54(5):29-38. Russian.
https://www.elibrary.ru/item.
28
Nakai R, Azuma T, Nakaso Y, Sawa S, Demura T.
Development of a dynamic imaging method for gravitropism in pea sprouts using clinical magnetic resonance imaging system.
Plant Biotechnol. 2020 Dec 11. [Article in Press]
https://www.jstage.jst.go.jp/
Note: This article may be obtained online without charge.
29
Watanabe A, Rahman A, Nishitani K, Yamada R, Takahashi M, Tsugawa S, Demura T.
Laser micromarking technique in studying the negative gravitropism in pea stem.
Plant Biotechnol. 2020 Dec 11. [Article in Press]
https://www.jstage.jst.go.jp/
Note: This article may be obtained online without charge.
30
Alvarado KA, Martínez JBG, Matassa S, Egbejimba J, Denkenberger D.
Food in space from hydrogen oxidizing bacteria.
Acta Astronaut. 2020 Dec 14. [Article in Press]
http://www.sciencedirect.com/
31
Mazur LM, Adams R, Mosaly PR, Stiegler MP, Nuamah J, Adapa K, Chera B, Marks LB.
Impact of simulation-based training on radiation therapists’ workload, situation awareness, and performance.
Adv Radiat Oncol. 2020 Nov-Dec;5(6):1106-14.
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
32
Melnick ER, Harry E, Sinsky CA, Dyrbye LN, Wang H, Trockel MT, West CP, Shanafelt T.
Perceived electronic health record usability as a predictor of task load and burnout among US physicians: A mediation analysis.
J Med Internet Res. 2020 Dec 7. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
33
Mohammady MJ, Sedighi A, Khaleghdoost T, Nejad EK, Javadi-Pashaki N.
Impacts of occupational cognitive failure and subjective workload on patient safety incidents among intensive care units nurses.
Indian J Occup Environ Med. 2020 May-Aug;24(2):96-101.
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
