NASA Spaceline Current Awareness List #971 25 September 2020 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website athttps://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Badran BW, Caulfield KA, Cox C, Lopez JW, Borckardt JJ, DeVries WH, Summers P, Kerns S, Hanlon CA, McTeague LM, George MS, Roberts DR.
Brain stimulation in zero gravity: Transcranial magnetic stimulation (TMS) motor threshold decreases during zero gravity induced by parabolic flight.
npj Microgravity. 2020 Sep 21;6(1):26.
https://www.nature.com/
PI: D.R. Roberts
Note: Parabolic flight results. This article may be obtained online without charge.
Journal Impact Factor: 3.380
Funding: “This work is supported by the Translational Research Institute through NASA through NASA NNX16AO69A, National Center of Neuromodulation for Rehabilitation (NC NM4R) (5P2CHD086844-03), COBRE Brain Stimulation Core (5P20GM109040-04).”
2
Martirosyan A, DeLucas LJ, Schmidt C, Perbandt M, McCombs D, Cox M, Radka C, Betzel C.
Effect of macromolecular mass transport in microgravity protein crystallization.
Gravit Space Res. 2019 Sep 10;7(1):33.
https://content.sciendo.com/
PI: L.J. DeLucas
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This research has been supported by the NASA (Grant No. 80NSSC18K0013) and Deutsche Luft und Raumfahrt Agentur (DLR) (Grant No. 50WB1423).”
3
Frett T, Green DA, Mulder E, Noppe A, Arz M, Pustowalow W, Petrat G, Tegtbur U, Jordan J.
Tolerability of daily intermittent or continuous short-arm centrifugation during 60-day 6° head down bed rest (AGBRESA study).
PLoS One. 2020 Sep 18;15(9):e0239228.
https://pubmed.ncbi.nlm.nih.
Note: Bed rest study (AGBRESA is the Artificial Gravity Bed Rest—European Space Agency). A short-arm human centrifuge was used. This article may be obtained online without charge.
Journal Impact Factor: 2.776
Funding: “The “Artificial Bed Rest study with European Space Agency” (ABRESA) study was financed by NASA and ESA.”
4
Neelam S, Richardson B, Barker R, Udave C, Gilroy S, Cameron MJ, Levine HG, Zhang Y.
Changes in nuclear shape and gene expression in response to simulated microgravity are LINC complex-dependent.
Int J Mol Sci. 2020 Sep 15;21(18):E6762.
https://pubmed.ncbi.nlm.nih.
PIs: S. Gilroy; S. Neelam, NASA Postdoctoral Program Fellowship
Note: A 3-D clinostat was used. This article may be obtained online without charge.
Journal Impact Factor: 4.556
Funding: “This work was supported by the NASA Postdoctoral Program (NPP) administered by Universities Space Research Association (USRA) [NNH15C048B] and the NASA Space Biology Program.”
5
Rivas M, Fox GE.
Further characterization of the pseudo-symmetrical ribosomal region.
Life (Basel). 2020 Sep 14;10(9):E201.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.991
Funding: “Mario Rivas Medrano’s research was supported by an appointment to the NASA Postdoctoral Program at the NASA Astrobiology Institute, administered by Universities Space Research Association under contract with NASA. This work was also supported in part by NASA Grant NNX14AK16G to George E. Fox and NASA Contract 80NSSC18K1139 under the Center for Origin of Life, at the Georgia Institute of Technology.”
6
Harper JD, Metzler I, Hall MK, Chen TT, Maxwell AD, Cunitz BW, Dunmire B, Thiel J, Williams JC Jr, Bailey MR, Sorensen MD.
First in-human burst wave lithotripsy (BWL) for kidney stone comminution: Initial 2 case studies.
J Endourol. 2020 Sep 17. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
PI: M.K. Hall
Journal Impact Factor: 2.267
Funding: “BWL and ultrasonic propulsion development and testing is funded by NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant P01 DK043881 and K01 DK104854, NASA has funded the study of facilitating passage of UVJ stones.”
7
Belcher EK, Sweet TB, Karaahmet B, Dionisio-Santos DA, Owlett LD, Leffler KA, Janelsins MC, Williams JP, Olschowka JA, O’Banion MK.
Cranial irradiation acutely and persistently impairs injury-induced microglial proliferation.
Brain Behav Immun. 2020 Apr;4:100057.
http://www.sciencedirect.com/
PI: M. K. O’Banion
Note: This article may be obtained online without charge.
Journal Impact Factor: 6.633
Funding: “This work was supported by research grants from the National Institute of Allergy and Infectious Diseases (U19AI091036) and NASA (NNX16AE07G). EB received support from the National Institute of Neurological Disorders and Stroke F31NS101750 and the National Cancer Institute T32CA102618.”
8
Carnell LS.
Spaceflight medical countermeasures: A strategic approach for mitigating effects from solar particle events.
Int J Radiat Biol. 2020 Sep 18. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.368
Funding: No funding cited. L. Carnell is affiliated with NASA Headquarters and NASA Langley Research Center.
9
Pariset E, Malkani S, Cekanaviciute E, Costes SV.
Ionizing radiation-induced risks to the central nervous system and countermeasures in cellular and rodent models.
Int J Radiat Biol. 2020 Sep 18. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
PI: S.V. Costes
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.368
Funding: “This work was supported by NASA HRP under Grant # NNJ16HP24I.”
10
Yamanouchi S, Rhone J, Mao JH, Fujiwara K, Saganti PB, Takahashi A, Hada M.
Simultaneous exposure of cultured human lymphoblastic cells to simulated microgravity and radiation increases chromosome aberrations.
Life (Basel). 2020 Sep 10;10(9):E187.
https://pubmed.ncbi.nlm.nih.
PI: M. Hada
Note: A 3-D clinostat was used. This article may be obtained online without charge.
Journal Impact Factor: 2.991
Funding: “This work was supported by NASA Space Biology Program (grant no. 80NSSC19K0133) (M.H., K.F. and A.T.), KAKENHI on Innovative Areas “Living in Space” (grant nos. JP15H05945, JP15H05935, and JP15K21745) (A.T.), This work was the result of using research equipment shared in MEXT Project for promoting public utilization of advanced research infrastructure (Program for supporting introduction of the new sharing system) (grant no. JPMXS0430300120) (S.Y. and A.T.), JAXA Front Loading Study (A.T. and M.H.), Research Projects with Heavy Ions at the Gunma University Heavy Ion Medical Center (GHMC) (A.T.).”
11
Zhen S, Bugbee B.
Steady-state stomatal responses of C3 and C4 species to blue light fraction: Interactions with CO2 concentration.
Plant Cell Environ. 2020 Sep 15. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Journal Impact Factor: 6.362
Funding: “This work was supported by the Utah Agricultural Experiment Station, Utah State University; by the NASA-CUBES project award number NNX17AJ31G; and by the USDA-NIFA-SCRI award number 2018-51181-28365 (LAMP Project).”
_______________
Other papers of interest:
1
Jillings S, Van Ombergen A, Tomilovskaya E, Rumshiskaya A, Litvinova L, Nosikova I, Pechenkova E, Rukavishnikov I, Kozlovskaya IB, Manko O, Danilichev S, Sunaert S, Parizel PM, Sinitsyn V, Petrovichev V, Laureys S, Zu Eulenburg P, Sijbers J, Wuyts FL, Jeurissen B.
Macro- and microstructural changes in cosmonauts’ brains after long-duration spaceflight.
Sci Adv. 2020 Sep 4;6(36):eaaz9488.
https://pubmed.ncbi.nlm.nih.
Note: ISS results. This article may be obtained online without charge.
2
Nay K, Koechlin-Ramonatxo C, Rochdi S, Island ML, Orfila L, Treffel L, Bareille MP, Beck A, Gauquelin-Koch G, Ropert M, Loréal O, Derbré F.
Simulated microgravity disturbs iron metabolism and distribution in humans: Lessons from dry immersion, an innovative ground-based human model.
FASEB J. 2020 Sep 12. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Dry immersion was used. This article may be obtained online without charge.
3
Trakaki A, Scharnagl H, Trieb M, Holzer M, Hinghofer-Szalkay H, Goswami N, Marsche G.
Prolonged bedrest reduces plasma high-density lipoprotein levels linked to markedly suppressed cholesterol efflux capacity.
Sci Rep. 2020 Sep 14;10(1):15001.
https://pubmed.ncbi.nlm.nih.
Note: Bed rest study. This article may be obtained online without charge.
4
Fujita SI, Rutter L, Ong Q, Muratani M.
Integrated RNA-seq analysis indicates asynchrony in clock genes between tissues under spaceflight.
Life (Basel). 2020 Sep 11;10(9):E196.
https://pubmed.ncbi.nlm.nih.
Note: From the abstract: “Here, we performed a pilot study to elucidate space biological mechanisms across tissues by reanalyzing mouse RNA-sequencing spaceflight data archived on NASA GeneLab.” GeneLab is available at: https://genelab.nasa.gov/. This article may be obtained online without charge. This article may be obtained online without charge.
5
Roberts DR, Stahn AC, Seidler RD, Wuyts FL.
Towards understanding the effects of spaceflight on the brain.
Lancet Neurol. 2020 Oct;19(10):808. Epub 2020 Sep 16.
https://pubmed.ncbi.nlm.nih.
Note: From the letter: “Beyond structural imaging, we recommend the addition of various MRI sequences to characterise physiological attributes of the brain expected to be vulnerable to long term spaceflight.” This article may be obtained online without charge.
6
Romanella S, Sprugnoli G, Ruffini G, Seyedmadani K, Rossi S, Santarnecchi E.
Noninvasive brain stimulation & space exploration: Opportunities and challenges.
Neurosci Biobehav Rev. 2020 Sep 13. [Epub ahead of print] Review.
https://pubmed.ncbi.nlm.nih.
Note: From the abstract: “We discuss opportunities and challenges of noninvasive brain stimulation (NiBS) methods – including transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES) – to support space exploration in several ways.”
7
Kumar A, Xie L, Ta CM, Hinton AJ, Gunasekar SK, Minerath RA, Shen K, Maurer JM, Grueter CE, Abel ED, Meyer G, Sah R.
SWELL1 regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism.
Elife. 2020 Sep 15;9:e58941.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
8
Rosa-Caldwell ME, Lim S, Haynie WS, Jansen LT, Westervelt LC, Amos MG, Washington TA, Greene NP.
Altering aspects of mitochondrial quality to improve musculoskeletal outcomes in disuse atrophy.
J Appl Physiol (1985). 2020 Sep 17. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Hindlimb unloading study.
9
Roy A, Sharma AK, Nellore K, Narkar VA, Kumar A.
TAK1 preserves skeletal muscle mass and mitochondrial function through redox homeostasis.
FASEB Bioadv. 2020 Sep;2(9):538-53.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
10
Niu YB, Yang YY, Xiao X, Sun Y, Zhou YM, Zhang YH, Dong D, Li CR, Wu XL, Li YH, Mei QB.
Quercetin prevents bone loss in hindlimb suspension mice via stanniocalcin 1-mediated inhibition of osteoclastogenesis.
Acta Pharmacol Sin. 2020 Sep 15. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Hindlimb unloading study.
11
Smith JK.
Osteoclasts and microgravity.
Life (Basel). 2020 Sep 16;10(9):E207. Review.
https://pubmed.ncbi.nlm.nih.
Note: Studies reviewed include results from spaceflight, rotating wall vessel, and hindlimb unloading research. This article may be obtained online without charge.
12
Fry D, Madzunkov S, Simcic J, Hunt AW.
Application of scaling methods to foster ground development of active shielding concepts for space exploration.
Acta Astronaut. 2021 Jan;178:296-307. Epub 2020 Sep 19.
http://www.sciencedirect.com/
13
Guo J, Liu T, Ma L, Hao W, Yan H, Li T, Yang Y, Cai J, Gao F, Xu Z, Liu H.
Polydatin attenuates 14.1 MeV neutron-induced injuries via regulating the apoptosis and antioxidative pathways and improving the hematopoiesis of mice.
Oxid Med Cell Longev. 2020 Aug 31;2020:8905860.
https://pubmed.ncbi.nlm.nih.
Note: The article is part of a special issue, “How Oxidative Stress Affects Multiple Blood Disorders.” This article may be obtained online without charge.
14
Roobol SJ, van den Bent I, van Cappellen WA, Abraham TE, Paul MW, Kanaar R, Houtsmuller AB, van Gent DC, Essers J.
Comparison of high- and low-LET radiation-induced DNA double-strand break processing in living cells.
Int J Mol Sci. 2020 Sep 9;21(18):E6602.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
15
Yan Y, Zhang K, Zhou G, Hu W.
MicroRNAs responding to space radiation.
Int J Mol Sci. 2020 Sep 9;21(18):E6603. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
16
Smyth J, Jennings P, Bennett P, Birrell S.
A novel method for reducing motion sickness susceptibility through training visuospatial ability – A two-part study.
Appl Ergon. 2021 Jan;90:103264. Epub 2020 Sep 10.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
17
Goyens J.
Modelling shows that stimulation of the semicircular canals depends on the rotation centre.
Hear Res. 2020 Oct;396:108071. Epub 2020 Sep 5.
https://pubmed.ncbi.nlm.nih.
18
Werner A, Brauns K, Gunga HC, Kühn S, Stahn AC.
Exercise-induced changes in brain activity during memory encoding and retrieval after long-term bed rest.
Neuroimage. 2020 Dec;223:117359. Epub 2020 Sep 10.
https://pubmed.ncbi.nlm.nih.
Note: Bed rest study. This article may be obtained online without charge.
19
Spiegelman Z, Broshi O, Shahar A, Omer S, Hak H, Wolf S.
Long-distance regulation of shoot gravitropism by Cyclophilin 1 in tomato (Solanum lycopersicum) plants.
Planta. 2020 Sep 16;252(4):50.
https://pubmed.ncbi.nlm.nih.
20
Basu T, Bannova O, Camba JD.
Mixed reality architecture in space habitats.
Acta Astronaut. 2020 Sep 21. [Article in Press]
http://www.sciencedirect.com/
Note: This paper was presented at the 70th International Astronautical Congress (IAC), Washington D.C., 21-25 October 2019.
21
Bertrand AA, Malapati SH, Yamaguchi DT, Lee JC.
The intersection of mechanotransduction and regenerative osteogenic materials.
Adv Healthc Mater. 2020 Sep 16. [Epub ahead of print] Review.
https://pubmed.ncbi.nlm.nih.
22
Ferreira Santos MS, Noell AC, Mora MF.
Methods for onboard monitoring of silver biocide during future human space exploration missions.
Anal Methods. 2020 Jul 7;12(25):3205-9.
https://pubmed.ncbi.nlm.nih.
23
Schmidt TA, Kourdali HK, Nixon J.
Evaluating process-based and crew-centred approaches to procedure design in aviation: Workload and performance changes in go-around manoeuvres.
Appl Ergon. 2021 Jan;90:103244. Epub 2020 Sep 10.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
24
Williams AS, Garcia J, Ortega F.
Understanding multimodal user gesture and speech behavior for object manipulation in augmented reality using elicitation.
IEEE Trans Vis Comput Graph. 2020 Sep 17. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used.
