NASA Spaceline Current Awareness List #910 7 August 2020 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Daudu R, Parker CW, Singh NK, Wood JM, Debieu M, O’Hara NB, Mason CE, Venkateswaran K.
Draft genome sequences of Rhodotorula mucilaginosa strains isolated from the International Space Station.
Microbiol Resour Announc. 2020 Jul 30;9(31):e00570-20.
https://pubmed.ncbi.nlm.nih.
PI: K. Venkateswaran
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 0.88
Funding: “This research was funded by 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to K.V., which also funded a postdoctoral fellowship for C.W.P., a JPL graduate fellowship to R.D., and a subcontract to Biotia, Inc.”
2
Ashari N, Hargens AR.
The mobile lower body negative pressure gravity suit for long-duration spaceflight.
Front Physiol. 2020 Aug 5;11:977.
https://www.frontiersin.org/
PI: A.R. Hargens
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.367
Funding: “This study was supported by NASA grants NNX13AJ12G and NSSC19K0409.”
3
Ronen L, Redden R, Lelkes PI.
Enhanced induction of definitive endoderm differentiation of mouse embryonic stem cells in simulated microgravity.
Stem Cells Dev. 2020 Jul 31. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
PI: P.I. Lelkes
Note: A Rotating Wall Vessel bioreactor was used.
Journal Impact Factor: 3.082
Funding: “This work was supported by the NASA Space Life and Physical Sciences Research and Applications research grant (80NSSC18K1480).”
4
Jaing C, Thissen J, Morrison M, Dillon MB, Waters SM, Graham GT, Be NA, Nicoll P, Verma S, Caro T, Smith DJ.
Sierra Nevada sweep: Metagenomic measurements of bioaerosols vertically distributed across the troposphere.
Sci Rep. 2020 Jul 24;10(1):12399.
https://pubmed.ncbi.nlm.nih.
PI: D.J. Smith
Note: GeneLab: “The raw FASTQ files are available in the NASA GeneLab repository (https://genelab.nasa.gov/) under the accession number GLDS-256.” This article may be obtained online without charge.
Journal Impact Factor: 4.011
Funding: “Our study was funded by two internal awards from NASA Ames Research Center and Lawrence Livermore National Laboratory’s Laboratory Derived Research and Development program in FY18-FY19. C-20A flights were generously provided by the Airborne Science Program at NASA Armstrong Flight Research Center, with special support from J. McGrath and S. Choi, and A. Barry.” PI also reports Space Biology support.
5
Malli Mohan GB, Parker CW, Urbaniak C, Singh NK, Hood A, Minich JJ, Knight R, Rucker M, Venkateswaran K.
Microbiome and metagenome analyses of a closed habitat during human occupation.
mSystems. 2020 Jul 28;5(4):e00367-20.
https://pubmed.ncbi.nlm.nih.
PI: C. Urbaniak, NASA Postdoctoral Program Fellowship
Note: From the Introduction: “The analog habitat tested during this study mimics the ISS in that it is a pressure vessel closed off from the surrounding environment where a crew lives in isolation, similar to what would be experienced during a 3-week-long space mission.” This article may be obtained online without charge.
Journal Impact Factor: 6.280
Funding: “This research was supported by the JPL Advanced Concept Development fund awarded to K.V. that funded a portion of the fellowships for G.B.M.M., N.K.S., and C.W.P. The NASA postdoctoral fellowship supported part of C.U.’s time.”
6
Zwart SR, Smith SM.
Vitamin D and COVID-19: Lessons from spaceflight analogs.
J Nutr. 2020 Jul 25. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
PI: S.M. Smith
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.281
Funding: “Supported by the NASA Human Research Program’s Human Health and Countermeasures Element.”
7
Owlett L, Belcher EK, Dionisio-Santos DA, Williams JP, Olschowka JA, O’Banion MK.
Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer’s disease.
Life Sci Space Res. 2020 Nov;27:89-98. Epub2020 Aug 3.
http://www.sciencedirect.com/
PI: M.K O’Banion
Journal Impact Factor: 2.453
Funding: “This work was supported by the NASA Space Radiation Biology Program grants NNX13AC33G and NNX16AE07G to MKO.”
8
Banerjee NT, Baughman AJ, Lin SY, Witte ZA, Klaus DM, Anderson AP.
Development of alternative reality environments for spacecraft habitat design evaluation.
Virtual Real. 2020 Aug 3. [Article in Press]
https://link.springer.com/
PI: A.P. Anderson
Journal Impact Factor: 3.634
Funding: “This work is funded by the NASA Human Research Program, grant number 80NSSC18K0198.”
9
Burgner SE, Nemali K, Massa GD, Wheeler RM, Morrow RC, Mitchell CA.
Growth and photosynthetic responses of Chinese cabbage (Brassica rapa L. cv. Tokyo Bekana) to chronically super-elevated carbon dioxide in a simulated Space Station “Veggie” crop-production environment.
Life Sci Space Res. 2020 Nov;27:83-8. Epub 2020 Jul 24.
http://www.sciencedirect.com/
PI: G. Massa
Note: The ground-based Veggie-analog chambers are known as “Biomass-Production-Systems-
Journal Impact Factor: 2.453
Funding: “This research was co-funded by the Human Research Program and Space Biology (MTL#1075) in the ILSRA 2015 NRA call and NASA Grant NNX15AN78G to Purdue University.”
10
Gibson CL, Isley JW, Falbel TG, Mattox CT, Lewis DR, Metcalf KE, Muday GK.
A conditional mutation in SCD1 reveals linkage between PIN protein trafficking, auxin transport, gravitropism, and lateral root initiation.
Front Plant Sci. 2020 Jul 7;11:910.
https://pubmed.ncbi.nlm.nih.
PI: G. Muday
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.402
Funding: “This work was supported by NASA Grant No. NNX09AK82G and NSF IOS 1558046 to GM and the WFU Open Access Publication Fund to CG.”
______________________________
Other papers of interest:
1
Laing C, Green DA, Mulder E, Hinghofer-Szalkay H, Blaber AP, Rittweger J, Goswami N.
Effect of novel short-arm human centrifugation induced gravitational gradients upon cardiovascular responses, cerebral perfusion and g-tolerance.
J Physiol. 2020 Jul 27. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: A short-arm human centrifuge was used. This article may be obtained online without charge.
2
Ogneva IV, Usik MA, Biryukov NS, Zhdankina YS.
Sperm motility of mice under simulated microgravity and hypergravity.
Int J Mol Sci. 2020 Jul 17;21(14):E5054.
https://pubmed.ncbi.nlm.nih.
Note: A random positioning machine and a centrifuge were used. This article may be obtained online without charge.
3
Schirato SR, El-Dash I, El-Dash V, Bizzarro B, Marroni A, Pieri M, Cialoni D, Chaui-Berlinck JG.
Association between heart rate variability and decompression-induced physiological stress.
Front Physiol. 2020 Jul 3;11:743.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
4
Yamamoto T, Ikegame M, Kawago U, Tabuchi Y, Hirayama J, Sekiguchi T, Furusawa Y, Yachiguchi K, Matsubara H, Urata M, Hattori A, Suzuki N.
Detection of RANKL-producing cells and osteoclastic activation by the addition of exogenous RANKL in the regenerating scales of goldfish.
Biol Sci Space. 2020 Aug 5;34:34-40.
https://www.jstage.jst.go.jp/
Note: This article may be obtained online without charge.
5
Avitabile E, Fusco L, Minardi S, Orecchioni M, Zavan B, Yilmazer A, Rauner M, Pippia P, Tasciotti E, Delogu LG.
Bioinspired scaffold action under the extreme physiological conditions of simulated space flights: Osteogenesis enhancing under microgravity.
Front Bioeng Biotechnol. 2020 Jul 8;8:722.
https://pubmed.ncbi.nlm.nih.
Note: A random positioning machine was used. This article may be obtained online without charge.
6
Bevelacqua JJ, Welsh J, Mortazavi SMJ.
Comment on “Dexamethasone inhibits spheroid formation of thyroid cancer cells exposed to simulated microgravity.”
Cells. 2020 Jul 21;9(7):E1738.
https://pubmed.ncbi.nlm.nih.
Note: The authors comment on: Melnik D, Sahana J, Corydon TJ, Kopp S, Nassef MZ, Wehland M, Infanger M, Grimm D, Krüger M. Dexamethasone inhibits spheroid formation of thyroid cancer cells exposed to simulated microgravity. Cells. 2020 Feb 5;9(2):E367. https://www.ncbi.nlm.nih.gov/
7
Krüger M, Kopp S, Wehland M, Corydon TJ, Grimm D.
Science between bioreactors and space research–Response to comments by Joseph J. Bevelacqua et al. on “Dexamethasone inhibits spheroid formation of thyroid cancer cells exposed to simulated microgravity.”
Cells. 2020 Jul 23;9(8):E1763.
https://pubmed.ncbi.nlm.nih.
Note: The authors reply to #6 above. This article may be obtained online without charge.
8
Schaefer K, Dambuza IM, Dall’Angelo S, Yuecel R, Jaspars M, Trembleau L, Zanda M, Brown GD, Netea MG, Gow NAR.
A weakened immune response to synthetic exo-peptides predicts a potential biosecurity risk in the retrieval of exo-microorganisms.
Microorganisms. 2020 Jul 17;8(7):E1066.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
9
Manuel J, Färber N, Gerlach DA, Heusser K, Jordan J, Tank J, Beissner F.
Deciphering the neural signature of human cardiovascular regulation.
Elife. 2020 Jul 28;9:e55316.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
10
Parganlija D, Gehlert S, Herrera F, Rittweger J, Bloch W, Zange J.
Enhanced blood supply through lower body negative pressure during slow-paced, high load leg press exercise alters the response of muscle AMPK and circulating angiogenic factors.
Front Physiol. 2020 Jul 30;11:781.
https://www.frontiersin.org/
Note: This article may be obtained online without charge.
11
Kasiviswanathan D, Chinnasamy Perumal R, Bhuvaneswari S, Kumar P, Sundaresan L, Philip M, Puthenpurackal Krishnankutty S, Chatterjee S.
Interactome of miRNAs and transcriptome of human umbilical cord endothelial cells exposed to short-term simulated microgravity.
npj Microgravity. 2020 Jul 30;6(1):18.
https://www.nature.com/
Note: A 3D clinostat was used. This article may be obtained online without charge.
12
Shen G, Link SS, Tao X, Frankfort BJ.
Modeling a potential SANS countermeasure by experimental manipulation of the translaminar pressure difference in mice.
npj Microgravity. 2020 Jul 31;6(1):19.
https://www.nature.com/
Note: This article may be obtained online without charge.
13
Yang JQ, Jiang N, Li ZP, Guo S, Chen ZY, Li BB, Chai SB, Lu SY, Yan HF, Sun PM, Zhang T, Sun H,W Yang JW, Zhou JL, Yang HM, Cui Y.
State and functions of the major digestive organs under microgravity.
Life Sci Space Res. 2020 Nov;27:74-82. Review. Epub 2020 Jul 30.
http://www.sciencedirect.com/
Note: The methods of microgravity simulation are not provided in the available abstract.
14
Dai S, Kong F, Liu C, Xiao F, Dong X, Zhang Y, Wang H.
Effect of simulated microgravity conditions of hindlimb unloading on mice hematopoietic and mesenchymal stromal cells.
Cell Biol Int. 2020 Jul 27. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Hindlimb unloading study. This article may be obtained online without charge.
15
Kakehi S, Tamura Y, Kubota A, Takeno K, Kawaguchi M, Sakuraba K, Kawamori R, Watada H.
Effects of blood flow restriction on muscle size and gene expression in muscle during immobilization: A pilot study.
Physiol Rep. 2020 Jul;8(14):e14516.
https://pubmed.ncbi.nlm.nih.
Note: Cast immobilization was used. This article may be obtained online without charge.
16
Ross SA, Rimkus B, Konow N, Biewener AA, Wakeling JM.
Added mass in rat plantaris muscle causes a reduction in mechanical work.
J Exp Biol. 2020 Jul 31. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
17
Shenkman BS.
How postural muscle senses disuse? Early signs and signals.
Int J Mol Sci. 2020 Jul 16;21(14):E5037. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
18
Kitaura H, Marahleh A, Ohori F, Noguchi T, Shen WR, Qi J, Nara Y, Pramusita A, Kinjo R, Mizoguchi I.
Osteocyte-related cytokines regulate osteoclast formation and bone resorption.
Int J Mol Sci. 2020 Jul 21;21(14):E5169. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
19
Collett G, Craenen K, Young W, Gilhooly M, Anderson RM.
The psychological consequences of (perceived) ionizing radiation exposure: A review on its role in radiation-induced cognitive dysfunction.
Int J Radiat Biol. 2020 Jul 27. [Epub ahead of print] Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
20
Wang J, Kobayashi A, Ohsawa D, Oikawa M, Konishi T.
Cytoplasmic radiation induced radio-adaptive response in human lung fibroblast WI-38 cells.
Radiat Res. 2020 Jul 31. [Article in Press]
https://meridian.allenpress.
21
Wang Q, Lee Y, Shuryak I, Pujol Canadell M, Taveras M, Perrier JR, Bacon BA, Rodrigues MA, Kowalski R, Capaccio C, Brenner DJ, Turner HC.
Development of the FAST-DOSE assay system for high-throughput biodosimetry and radiation triage.
Sci Rep. 2020 Jul 29;10(1):12716.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
22
Zhou G, Hu W, Pei H, Chen H, Hei TK.
Recent progress on the Chinese space programme and radiation research.
Ann ICRP. 2020 Jul 31. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
23
Nunes CP, Rodrigues CC, Cardoso CAF, Cytrynbaum N, Kaufman R, Rzetelna H, Goldwasser G, Santos A, Oliveira L, Geller M.
Clinical evaluation of the use of ginger extract in the preventive management of motion sickness.
Curr Ther Res Clin Exp. 2020 Jun;92:100591.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
24
Babu G, Upchurch BD, Young WH, Levine BD.
Medicine in Extreme Environments: A new medical student elective class for wilderness, aerospace, hyperbaric, exercise, and combat medicine.
Wilderness Environ Med. 2020 Mar;31(1):110-5.
https://pubmed.ncbi.nlm.nih.
Note: The authors describe a course developed at the University of Texas Southwestern Medical Center for first- and second-year medical students. This article may be obtained online without charge.
25
Thirsk RB.
Health care for deep space explorers.
Ann ICRP. 2020 Jul 31. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
26
Ibragimova N, Mokshina N, Ageeva M, Gurjanov O, Mikshina P.
Rearrangement of the cellulose-enriched cell wall in flax phloem fibers over the course of the gravitropic reaction.
Int J Mol Sci. 2020 Jul 27;21(15):E5322.
https://pubmed.ncbi.nlm.nih.
Note: Plant stems were oriented in a horizontal position. This article may be obtained online without charge.
27
Ko DK, Brandizzi F.
Network-based approaches for understanding gene regulation and function in plants.
Plant J. 2020 Jul 27. [Epub ahead of print] Review.
https://pubmed.ncbi.nlm.nih.
28
Guggenberger R, Heringhaus M, Gharabaghi A.
Brain-machine neurofeedback: Robotics or electrical stimulation?
Front Bioeng Biotechnol. 2020 Jul 7;8:639.
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
