NASA Spaceline Current Awareness List #888 28 February 2020 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website athttps://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Roberts DR, Asemani D, Nietert PJ, Eckert MA, Inglesby DC, Bloomberg JJ, George MS, Brown TR.
Reply [to: The possible role of elastic properties of the brain and optic nerve sheath in the development of spaceflight-associated neuro-ocular syndrome].
AJNR Am J Neuroradiol. 2020 Feb 20. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: D.R. Roberts
Note: ISS and Shuttle results. The authors reply to #5 in the ‘Others papers of interest’ section.
Journal Impact Factor: 3.256
Funding: From the original article: “This study was funded by a grant from the National Aeronautics and Space Administration (NNX13AJ92G). Dr Nieter’s time on this project was funded, in part, by the National Institutes of Health National Center for Advancing Translational Science (grant No. UL1-TR001450) and the National Institute of General Medical Sciences (grant No. U54-GM104941). Dr Inglesby’s time on this project was funded by a Minorities in STEM Student Scholarship from the South Carolina Space Grant Consortium (grant No. NNX15AL49H).”
2
Almeida-Porada G, Atala AJ, Porada CD.
Therapeutic mesenchymal stromal cells for immunotherapy and for gene and drug delivery.
Mol Ther Methods Clin Dev. 2020 Mar 13;16:204-24. Review.
https://www.ncbi.nlm.nih.gov/
PI: C.D. Porada
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.875
Funding: “G.A.P. and C.D.P. are supported by the following NIH grants from the NHLBI: HL130856, HL135853, HL148681, and by grant NNJ16ZSA001N-TRIRT from the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A with NASA.”
3
Blachowicz A, Raffa N, Bok JW, Choera T, Knox B, Lim FY, Huttenlocher A, Wang CCC, Venkateswaran K, Keller NP.
Contributions of spore secondary metabolites to UV-C protection and virulence vary in different Aspergillus fumigatus strains.
MBio. 2020 Feb 18;11(1):e03415-19.
https://www.ncbi.nlm.nih.gov/
PI: N.P. Keller
Note: This article may be obtained online without charge.
Journal Impact Factor: 6.747
Funding: “Part of the research described in this publication was carried out at the Jet Propulsion Laboratory (JPL), California Institute of Technology, under a contract with the National Aeronautics and Space Administration (NASA). This research was funded by NASA’s Space Biology grant NNH16ZTT001N NRA awarded to N.P.K. and funded student fellowships to A.B. and N.R.”
4
Manning B, Singleterry R.
Radiation engineering analysis of shielding materials to assess their ability to protect astronauts in deep space from energetic particle radiation.
Acta Astronaut. 2020 Feb 15. [Article in Press]
http://www.sciencedirect.com/
Journal Impact Factor: 2.482
Funding: No funding cited. R. Singleterry is affiliated with NASA Langley Research Center.
5
Shaler T, Lin HT, Bakke J, Chen S, Grover A, Chang P.
Particle radiation-induced dysregulation of protein homeostasis in primary human and mouse neuronal cells.
Life Sci Space Res. 2020 Feb 21. [Article in Press]
http://www.sciencedirect.com/
PI: P. Chang
Journal Impact Factor: 2.066
Funding: “The authors would like to acknowledge the funding support of NASA Grant #NNX14AE69G.”
6
Sridharan DM, Chien L-C, Cucinotta FA, Pluth JM.
Comparison of signaling profiles in the low dose range following low and high LET radiation.
Life Sci Space Res. 2020 Feb 22. [Article in Press]
http://www.sciencedirect.com/
PI: J.M. Pluth
Journal Impact Factor: 2.066
Funding: “This work was supported by NASA grant # NNA06CD66I to JMP.”
7
Whoolery CW, Yun S, Reynolds RP, Lucero MJ, Soler I, Tran FH, Ito N, Redfield RL, Richardson DR, Shih HY, Rivera PD, Chen BPC, Birnbaum SG, Stowe AM, Eisch AJ.
Multi-domain cognitive assessment of male mice shows space radiation is not harmful to high-level cognition and actually improves pattern separation.
Sci Rep. 2020 Feb 17;10(1):2737.
https://www.ncbi.nlm.nih.gov/
PIs: A.J. Eisch, B.P.C. Chen
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.011
Funding: “Research supported by NASA grants NNX07AP84G (to BPC and AJE), NNX12AB55G (to AJE and BPC), and NNX15AE09G (to AJE) and NIH grants to AJE DA007290, DA023555, and DA016765. CWW was supported by an NIH Institutional Training grant (DA007290, PI: AJE, David W. Self), and SY was supported by an NIH Institutional Training Grant (MH076690, PI: CA Tamminga), a PENN McCabe award, an 2019 IBRO travel grant and NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation.”
8
Sirmons TA, Roma PG, Whitmire AM, Smith SM, Zwart SR, Young M, Douglas GL.
Meal replacement in isolated and confined mission environments: Consumption, acceptability, and implications for physical and behavioral health.
Physiol Behav. 2020 Feb 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: T.A. Sirmons
Journal Impact Factor: 2.635
Funding: “This work was funded by the National Aeronautics and Space Administration Human Research Program’s Human Health Countermeasures Element.”
______________________________
Other papers of interest:
1
Li Y, Lv X, Geng L, Yang C, Sun W, Deng Y.
A chip-based scientific payload technology for visual detection of proteins and its application in spaceflight.
Acta Astronaut. 2020 Feb 24. [Article in Press]
http://www.sciencedirect.com/
Note: Tianzhou-1 results.
2
Al-Awaida WJ, Sharab AS, Al-Ameer HJ, Ayoub NY.
Effect of simulated microgravity on the antidiabetic properties of wheatgrass (Triticum aestivum) in streptozotocin-induced diabetic rats.
npj Microgravity. 2020 Feb 24;6(1):6.
https://www.nature.com/
Note: A 3D clinostat was used. This article may be obtained online without charge.
3
Shi S, Li Q, Cao Q, Diao Y, Zhang Y, Yue L, Wei L.
EMT transcription factors are involved in the altered cell adhesion under simulated microgravity effect or overloading by regulation of E-cadherin.
Int J Mol Sci. 2020 Feb 17;21(4):E1349.
https://www.ncbi.nlm.nih.gov/
Note: A Rotating Wall Vessel bioreactor was used. This article may be obtained online without charge.
4
Tang SE, Liao WI, Wu SY, Pao HP, Huang KL, Chu SJ.
The blockade of store-operated calcium channels improves decompression sickness in rats.
Front Physiol. 2019 Jan 31;10:1616.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
5
Wostyn P, Mader TH, Gibson CR, Wuyts FL, Van Ombergen A, zu Eulenburg P, De Deyn PP.
The possible role of elastic properties of the brain and optic nerve sheath in the development of spaceflight-associated neuro-ocular syndrome.
AJNR Am J Neuroradiol. 2020 Feb 20. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The authors comment on: Roberts DR, Brown TR, Nietert PJ, Eckert MA, Inglesby DC, Bloomberg JJ, George MS, Asemani D. Prolonged microgravity affects human brain structure and function. AJNR Am J Neuroradiol. 2019 Nov;40(11):1878-1885. https://www.ncbi.nlm.nih.gov/
6
Ohira T, Ino Y, Nakai Y, Morita H, Kimura A, Kurata Y, Kagawa H, Kimura M, Egashira K, Moriya S, Hiramatsu K, Kawakita M, Kimura Y, Hirano H.
Proteomic analysis revealed different responses to hypergravity of soleus and extensor digitorum longus muscles in mice.
J Proteomics. 2020 Apr;217:103686. Epub 2020 Feb 12.
https://www.ncbi.nlm.nih.gov/
Note: Centrifugation was used.
7
Theeuwes WF, Pansters NAM, Gosker HR, Schols A, Verhees KJP, de Theije CC, van Gorp RHP, Kelders M, Ronda O, Haegens A, Remels AHV, Langen RCJ.
Recovery of muscle mass and muscle oxidative phenotype following disuse does not require GSK-3 inactivation.
Biochim Biophys Acta Mol Basis Dis. 2020 Feb 19. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
8
Baron C, Nguyen VH, Naili S, Guivier-Curien C.
Interaction of ultrasound waves with bone remodelling: A multiscale computational study.
Biomech Model Mechanobiol. 2020 Feb 20. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
9
Chen Z, Zhang Y, Zhao F, Yin C, Yang C, Wang X, Wu Z, Liang S, Li D, Lin X, Tian Y, Hu L, Li Y, Qian A.
Recombinant irisin prevents the reduction of osteoblast differentiation induced by stimulated microgravity through increasing β-catenin expression.
Int J Mol Sci. 2020 Feb 13;21(4):E1259.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading and a random positioning machine were used. This article may be obtained online without charge.
10
Chowdhury S, Schulz LC, Palmisano B, Singh P, Berger JM, Yadav VK, Mera P, Ellingsgaard H, Hidalgo J, Brüning JC, Karsenty G.
Muscle derived interleukin-6 increases exercise capacity by signaling in osteoblasts.
J Clin Invest. 2020 Feb 20. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
11
Wang Y, Wang K, Zhang L, Tan Y, Hu Z, Dang L, Zhou H, Li G, Wang H, Zhang S, Shi F, Cao X, Zhang G.
Targeted overexpression of the long noncoding RNA ODSM can regulate osteoblast function in vitro and in vivo.
Cell Death Dis. 2020 Feb 18;11(2):133.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
12
Nowrouzi A, Sertorio MG, Akbarpour M, Knoll M, Krunic D, Kuhar M, Schwager C, Brons S, Debus J, Wells SI, Wells JM, Abdollahi A.
Personalized assessment of normal tissue radiosensitivity via transcriptome response to photon, proton and carbon irradiation in patient-derived human intestinal organoids.
Cancers (Basel). 2020 Feb 18;12(2):E469.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
13
Shuryak I, Turner HC, Perrier JR, Cunha L, Canadell MP, Durrani MH, Harken A, Bertucci A, Taveras M, Garty G, Brenner DJ.
A high throughput approach to reconstruct partial-body and neutron radiation exposures on an individual basis.
Sci Rep. 2020 Feb 19;10(1):2899.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
14
Vyšín L, Wachulak P, Toufarova M, Medvedev N, Voronkov RA, Bartnik A, Fiedorowicz H, Juha L.
Chemical dosimetry in the “water window:” Ferric ions and hydroxyl radicals produced by intense soft X rays.
Radiat Res. 2020 Feb 25. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
15
Wedtgrube A, Bockisch CJ, Tarnutzer AA.
Effects of prolonged roll-tilt on the subjective visual and haptic vertical in healthy human subjects.
J Vestib Res. 2020 Feb 15. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
16
Wibble T, Engström J, Verrecchia L, Pansell T.
The effects of meclizine on motion sickness revisited.
Br J Clin Pharmacol. 2020 Feb 19. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
17
Bowers SJ, Vargas F, González A, He S, Jiang P, Dorrestein PC, Knight R, Wright KP Jr, Lowry CA, Fleshner M, Vitaterna MH, Turek FW.
Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome.
PLoS One. 2020 Feb 20;15(2):e0229001.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
18
Arquilla K, Webb AK, Anderson AP.
Textile electrocardiogram (ECG) electrodes for wearable health monitoring.
Sensors (Basel). 2020 Feb 13;20(4):E1013.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
19
Laws J, Caplan N, Bruce C, McGrogan C, Lindsay K, Wild B, Debuse D, Wotring V, Winnard A.
Systematic review of the technical and physiological constraints of the Orion Multi-Purpose Crew Vehicle that affect the capability of astronauts to exercise effectively during spaceflight.
Acta Astronaut. 2020 Feb 22. [Article in Press] Review.
http://www.sciencedirect.com/
20
Muthert LWF, Izzo LG, van Zanten M, Aronne G.
Root tropisms: Investigations on Earth and in space to unravel plant growth direction.
Front Plant Sci. 2020 Feb 21;10:1807. Review.
https://www.frontiersin.org/
Note: This article may be obtained online without charge.
21
Xu W, Liang HN, Zhang Z, Baghaei N.
Studying the effect of display type and viewing perspective on user experience in virtual reality exergames.
Games Health J. 2020 Feb 19. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used.
