NASA Spaceline Current Awareness List #869 11 October 2019 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website athttps://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Sibonga JD, Spector ER, Keyak JH, Zwart SR, Smith SM, Lang TF.
Use of quantitative computed tomography to assess for clinically-relevant skeletal effects of prolonged spaceflight on astronaut hips.
J Clin Densitom. 2019 Aug 26. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: ISS results.
Journal Impact Factor: 2.184
Funding: “The work reported in this paper was supported by the Human Health Countermeasures Element of the National Aeronautics and Space Administration (NASA) Human Research Program (NASA Contract Number NNJ15HK11B).”
2
Ford MM, Smythers AL, McConnell EW, Lowery SC, Kolling DRJ, Hicks LM.
Inhibition of TOR in Chlamydomonas reinhardtii leads to rapid cysteine oxidation reflecting sustained physiological changes.
Cells. 2019 Sep 28;8(10):E1171.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
Journal Impact Factor: 5.656
Funding: “This research was supported by a National Science Foundation CAREER award (MCB-1552522) awarded to L.M.H and a National Science Foundation award (Cooperative Agreement OIA-1458,952) to D.R.J.K. A.L.S. was funded by the NASA West Virginia Space Grant Consortium (NNX15AK74A and NNX15AI01H).”
3
Ikeda H, Muratani M, Hidema J, Hada M, Fujiwara K, Souda H, Yoshida Y, Takahashi A.
Expression profile of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity.
Int J Mol Sci. 2019 Sep 26;20(19):E4791.
https://www.ncbi.nlm.nih.gov/
PI: M. Hada
Note: A 3D clinostat was used. This article may be obtained online without charge.
Journal Impact Factor: 4.183
Funding: “This work was supported by NASA Space Biology Program (80NSSC19K0133) (M.H.), a MEXT Grant-in-Aid for Scientific Research on Innovative Areas “Living in Space” (JP15H05945, JP15H05935, and JP15K21745) (A.T.), and Research Projects with Heavy Ions at the GHMC (A.T.).”
4
Nordberg RC, Mellor LF, Krause AR, Donahue HJ, Loboa EG.
LRP receptors in chondrocytes are modulated by simulated microgravity and cyclic hydrostatic pressure.
PLoS One. 2019 Oct 4;14(10):e0223245.
https://www.ncbi.nlm.nih.gov/
PI: L.F. Mellor, NSBRI Postdoctoral Fellowship Program
Note: A Rotary Wall Vessel bioreactor was used. This article may be obtained online without charge.
Journal Impact Factor: 11.048
Funding: “This study was funded by an NC Space Grant Graduate Research Fellowship (RCN), UNC Summer Research Fellowship (RCN), the National Space Biomedical Research Institute through NASA NCC9-58 (LFM), NIH/NIBIB 1R03EB008790 (EGL), NIH/CTSA 550KR71418 (EGL), NIH/CTSA 550KR61325 (EGL), and NSF/CBET 1133427 and 1702841 (EGL), and the William R. Kenan Institute for Engineering, Technology and Science (EGL).”
5
Malli Mohan GB, Stricker MC, Venkateswaran K.
Microscopic characterization of biological and inert particles associated with spacecraft assembly cleanroom.
Sci Rep. 2019 Oct 3;9(1):14251.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.011
Funding: “Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA.”
6
Panettieri S, Paddibhatla I, Chou J, Rajwani R, Moore R, Goncharuk T, John G, Govind S.
Discovery of aspirin-triggered eicosanoid-like mediators in a Drosophila metainflammation-blood tumor model.
J Cell Sci. 2019 Sep 27. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: S. Govind
Journal Impact Factor: 4.517
Funding: “This work was supported by funds from the National Science Foundation (1121817-SG & 1512458-GJ), NASA (NNX15AB42G-SG), and the National Institutes of Health (S06 GM08168, 8G12MD007603-30-RCMI).”
7
Owen PJ, Rantalainen T, Scheuring RA, Belavy DL.
Serratus anterior contraction during resisted arm extension (GravityFit) assessed by MRI.
Front Physiol. 2019 Sep 11;10:1164.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.201
Funding: “This work was supported by GravityFit (Grant Number: RM32446), manufacturer of the exercise device used in testing.” R.A. Scheuring is affiliated with NASA Johnson Space Center.
8
Sullivan LK, Livingston EW, Lau AG, Rao-Dayton S, Bateman TA.
A mouse model for skeletal structure and function changes caused by radiation therapy and estrogen deficiency.
Calcif Tissue Int. 2019 Oct 3. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: T.A. Bateman
Journal Impact Factor: 3.265
Funding: “This work was supported by the National Institutes of Health Grant 3-R01-AR059221-01A1S1, National Space Biomedical Research Institute BL01302 and the North Carolina Clinical and Translational Sciences Institute.”
9
IJtsma M, Ma LM, Pritchett AR, Feigh KM.
Computational methodology for the allocation of work and interaction in human-robot teams.
J Cogn Eng Decis Mak. 2019 Aug 30. [Article in Press]
https://journals.sagepub.com/
PI: K.M. Feigh
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “The work presented in this paper is sponsored by the National Aeronautics and Space Administration (NASA) Human Research Program with Jessica Marquez serving as Technical Monitor under Grant No. NNJ15ZSA001N.”
______________________________
Other papers of interest:
1
Wood KN, Murray KR, Greaves DK, Hughson RL.
Inflight leg cuff test does not identify the risk for orthostatic hypotension after long-duration spaceflight.
npj Microgravity. 2019 Oct 11;5(1):22.
https://www.nature.com/
Note: ISS results. This article may be obtained online without charge.
2
Krüger J, Richter P, Stoltze J, Strauch SM, Krüger M, Daiker V, Prasad B, Sonnewald S, Reid S, Lebert M.
Changes of gene expression in Euglena gracilis obtained during the 29th DLR Parabolic Flight Campaign.
Sci Rep. 2019 Oct 3;9(1):14260.
https://www.ncbi.nlm.nih.gov/
Note: Parabolic flight results. This article may be obtained online without charge.
3
Gibbons TD, Zuj KA, Prince CN, Kingston DC, Peterson SD, Hughson RL.
Hemodynamic and cerebrovascular effects of intermittent lower leg compression as countermeasure to orthostatic stress.
Exp Physiol. 2019 Oct 3. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
4
Ponomarev S, Kutko O, Rykova M, Kalinin SA, Antropova E, Sadova A, Orlova K, Shulgina S.
Changes in the cellular component of the human innate immunity system in short-term isolation.
Acta Astronaut. 2019 Oct 9. [Article in Press]
http://www.sciencedirect.com/
Note: Results are from the “SIRIUS-17” project conducted in sealed modules at the Institute for Biomedical Problems (IBMP) in Moscow.
5
Jörges B, López-Moliner J.
Earth-gravity congruent motion facilitates ocular control for pursuit of parabolic trajectories.
Sci Rep. 2019 Oct 1;9(1):14094.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
6
Baldelli S, Ciccarone F, Limongi D, Checconi P, Palamara AT, Ciriolo MR.
Glutathione and nitric oxide: Key team players in use and disuse of skeletal muscle.
Nutrients. 2019 Sep 30;11(10):E2318. Review.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
7
Ji LL, Yeo D.
Mitochondrial dysregulation and muscle disuse atrophy.
F1000Res. 2019 Sep 11;8(F1000 Faculty Rev):1621. Review.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
8
Petrov AM, Shalagina MN, Protopopov VA, Sergeev VG, Ovechkin SV, Ovchinina NG, Sekunov AV, Zefirov AL, Zakirjanova GF, Bryndina IG.
Changes in membrane ceramide pools in rat soleus muscle in response to short-term disuse.
Int J Mol Sci. 2019 Sep 30;20(19):E4860.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
9
Bullock WA, Hoggatt AM, Horan DJ, Elmendorf AJ, Sato AY, Bellido T, Loots GG, Pavalko FM, Robling AG.
Lrp4 mediates bone homeostasis and mechanotransduction through interaction with sclerostin in vivo.
iScience. 2019 Sep 18;20:205-15.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
10
Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y.
Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity.
Sci Adv. 2019 Sep 25;5(9):eaau7802.
https://www.ncbi.nlm.nih.gov/
Note: Nerve resection was used to unload hindlimb femurs. This article may be obtained online without charge.
11
Acheva A, Haghdoost S, Sollazzo A, Launonen V, Kämäräinen M.
Presence of stromal cells enhances epithelial-to-mesenchymal transition (EMT) induction in lung bronchial epithelium after protracted exposure to oxidative stress of gamma radiation.
Oxid Med Cell Longev. 2019 Sep 8;2019:4120379.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
12
Smith SM, Giedzinski E, Angulo MC, Lui T, Lu C, Park AL, Tang S, Martirosian V, Ru N, Chmielewski NN, Liang Y, Baulch JE, Acharya MM, Limoli CL.
Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain.
Stem Cells Transl Med. 2019 Sep 30. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
13
Amiri P, Mohebbi A, Kearney R.
Experimental methods to study human postural control.
J Vis Exp. 2019 Sep 11(151):60078.
https://www.ncbi.nlm.nih.gov/
14
Sasahara S, Andrea C-S, Suzuki G, Oi Y, Doki S, Hori D, Ohira T, Matsuda C, Inoue N, Takahashi T, Ohtaki Y, Saito T, Furukawa S, Ogata K, Matsuzaki I.
Effect of exercise on brain function as assessed by functional near-infrared spectroscopy during a verbal fluency test in a simulated International Space Station environment: A single-case, experimental ABA study in Japan.
Acta Astronaut. 2019 Oct 9. [Article in Press]
http://www.sciencedirect.com/
Note: From the abstract: “Study participants . . . were confined in the “confinement environment adaptation training facilities” of the Tsukuba Space Centre for 15 days, in a controlled, confined environment that attempted to closely simulate the conditions experienced by astronauts during the astronaut selection examination and inside the ISS.” This article may be obtained online without charge.
15
Roenneberg T, Winnebeck EC, Klerman EB.
Corrigendum: Daylight saving time and artificial time zones—A battle between biological and social times.
Front Physiol. 2019 Sep 12;10:1177.
https://www.ncbi.nlm.nih.gov/
Note: The corrigendum corrects a mistake in Figure B in: Roenneberg T, Winnebeck EC, Klerman EB. Daylight Saving Time and artificial time zones—A battle between biological and social times. Front Physiol. 2019 Aug 7;10:944. https://www.ncbi.nlm.nih.gov/
16
Szocik K, Braddock M.
Why human enhancement is necessary for successful human deep-space missions.
New Bioeth. 2019 Sep 27. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: From the Introduction: “In this paper, we argue that human astronauts should be augmented for deep-space mission at the pre-launch stage in an alternative way from that offered by space agencies today. . . . Astronaut augmentation may include a human enhancement programme based in part on genetic engineering, nanotechnology, robotics and cognitive science adaptation.” This article may be obtained online without charge.
17
Harkey AF, Yoon GM, Seo DH, DeLong A, Muday GK.
Light modulates ethylene synthesis, signaling, and downstream transcriptional networks to control plant development.
Front Plant Sci. 2019 Sep 12;10:1094.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
18
Dong HS, Chen P, Yu YB, Zang P, Wei Z.
Simulated manned Mars exploration: Effects of dietary and diurnal cycle variations on the gut microbiome of crew members in a controlled ecological life support system.
PeerJ. 2019 Sep 26;7:e7762.
https://www.ncbi.nlm.nih.gov/
Note: Data are from the Chinese Green Star 180-day closed ecological life support system (CELSS) experiment. This article may be obtained online without charge.
19
Marçon B, Ngueyon Sime W, Guillemin F, Hubert N, Lagrange F, Huselstein C, Hubert J.
An ergonomic assessment of four different donor nephrectomy approaches for the surgeons and their assistants.
Res Rep Urol. 2019 Sep 27;11:261-8.
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
Please note: Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite is a new book in Springer’s Research for Development series. From the abstract: “This book presents the life science experiments in a space microgravity environment conducted on board the SJ-10 recoverable satellite, which was launched on April 6th 2016 and recovered on April 18th 2016. It covers 10 scientific projects in radiation biology, gravitational biology and biotechnology that were selected from ~100 proposals from various institutions in China and around the world. Primarily exploring the rhythm of life in a space microgravity environment, all of the experiments – conducted on nine payloads of the SJ-10 satellite – have never been previously conducted in the respective fields. In addition, the book provides extensive information on the mission’s execution, data collection, and scientific outcomes.” The monograph and individual chapters are listed below.
20
Duan E, Long M. (Eds.)
Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite.
Singapore: Springer; 2019. 442 p.
https://www.springer.com/us/
Note: Chinese satellite SJ-10 results.
21
Duan E, Long M.
Introduction to results of life sciences from SJ-10 recoverable satellite.
In: Duan Ei, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 1-8.
https://rd.springer.com/
22
Zhao H, Qiu J, Wang Y.
System design and flight results of China SJ-10 recoverable microgravity experimental satellite.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 9-42.
https://rd.springer.com/
23
Sun Y, Wang W, Zhang M, Zhao L, Mi D, Zhang B, Zhou D, Zhang S.
Space radiation systems biology research in SJ-10 satellite.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 43-68.
https://rd.springer.com/
24
An L, Fan Y, Li C, Ran F, Jiang Y, Liu Y, Cui X, Hang H.
Effects of space environment on genome stability.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 69-108.
https://rd.springer.com/
25
Liu Z, Li Z, Shang P, Huang Y, Tan A.
Effects of the space environment on silkworm development time.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 109-29.
https://rd.springer.com/
26
Cai W, Chen H, Jin J, Xu P, Bi T, Xie Q, Pang X, Hu J.
Plant adaptation to microgravity environment and growth of plant cells in altered gravity conditions.
In: Duan Ei, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 131-66.
https://rd.springer.com/
27
Sun S, Wang C, Li N, Lü D, Chen Q, Long M.
Cell growth and differentiation under microgravity.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 167-88.
https://rd.springer.com/
28
Zheng H, Wang LH, Xie JY.
Flowering of Arabidopsis and rice in space.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 189-204.
https://rd.springer.com/
29
Wang P, Qian J, Tian H, Zhao Y.
The maintaining and directed differentiation of hematopoietic stem cells under microgravity.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 205-33.
https://rd.springer.com/
30
Han J, Cui Y, Xu B, Xue W, Liu S, Dai J.
Three-dimensional cell culture and tissue restoration of neural stem cells under microgravity.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 235-79.
https://rd.springer.com/
31
Lei X, Cao Y, Zhang Y, Duan E.
Advances of mammalian reproduction and embryonic development under microgravity.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 281-315.
https://rd.springer.com/
32
Zhang C, Li L, Wang J.
Effects of space microgravity on the trans-differentiation between osteogenesis and adipogenesis of human marrow-derived mesenchymal stem cells.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 317-59.
https://rd.springer.com/
33
Zhang M, Zheng W, Tong G, Xu Z, Zhang Y, Yuan Y, Sun H, Liu F, Ding K, Zhang T.
Facilities and techniques of space life science.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 361-98.
https://rd.springer.com/
34
Jiang Y, Wang Y, Zhao X, Cui X.
Study on bone marrow box, radiation gene box and integrated electrical control boxes.
In: Duan E, Long M, eds. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Singapore: Springer, 2019. p. 399-442.
https://rd.springer.com/
