NASA Spaceline Current Awareness List #836 15 February 2019 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Beheshti A, McDonald JT, Miller J, Grabham P, Costes SV.
GeneLab database analyses suggest long-term impact of space radiation on the cardiovascular system by the activation of FYN through reactive oxygen species.
Int J Mol Sci. 2019 Feb 3;20(3):E661.
https://www.ncbi.nlm.nih.gov/
Note: ISS results. GeneLab is available at: https://genelab.nasa.gov/. This article may be obtained online without charge.
Journal Impact Factor: 3.687
Funding: “Research funding was provided by the GeneLab Project at NASA Ames Research Center, through NASA’s Space Biology Program in the Division of Space Life and Physical Sciences Research and Applications (SLPSRA).”
2
Sng NJ, Kolaczkowski B, Ferl RJ, Paul A-L.
A member of the CONSTANS-Like protein family is a putative regulator of reactive oxygen species homeostasis and spaceflight physiological adaptation.
AoB Plants. 2019 Feb;11(1):ply075.
https://www.ncbi.nlm.nih.gov/
PIs: A-L. Paul, R.J. Ferl
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 2.281
Funding: “This work was supported by NASA – Space Life and Physical Sciences (NNX09AL96G, NNX07AH27G, NNX12AN69G and NNX14AT24G awarded to R.J.F. and A.-L.P.).”
3
McIntyre ABR, Alexander N, Grigorev K, Bezdan D, Sichtig H, Chiu CY, Mason CE.
Single-molecule sequencing detection of N6-methyladenine in microbial reference materials.
Nat Commun. 2019 Feb 4;10(1):579.
https://www.ncbi.nlm.nih.gov/
PI: C.E. Mason
Note: This article may be obtained online without charge.
Journal Impact Factor: 12.353
Funding: “We would like to thank the National Science and Engineering Research Council, the Starr Cancer Consortium (I9-A9-071), the Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, NNX17AB26G), the National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006, 1R21AI129851, 1R01MH117406), the Bill and Melinda Gates Foundation (OPP1151054), the Leukemia and Lymphoma Society (LLS) grants (LLS 9238-16, Mak, LLS-MCL-982, Chen-Kiang).”
4
Huang EG, Lin Y, Ebert M, Ham DW, Zhang CY, Sachs RK.
Synergy theory for murine Harderian gland tumours after irradiation by mixtures of high-energy ionized atomic nuclei.
Radiat Environ Biophys. 2019 Feb 2. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: E.A. Blakely
Note: This article may be obtained online without charge.
Journal Impact Factor: 1.527
Funding: “RKS is grateful for support from NASA Grant NNJ16HP221.”
5
Doll JR, Thompson RL, Sawtell NM.
Infectious herpes simplex virus in the brainstem is correlated with reactivation in the trigeminal ganglia.
J Virol. 2019 Feb 6. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: N.M. Sawtell
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.368
Funding: “This work was supported by NASA NNX13AO47G and NIH R01 AI093614 to NMS.”
6
McHill AW, Hull JT, Cohen DA, Wang W, Czeisler CA, Klerman EB.
Chronic sleep restriction greatly magnifies performance decrements immediately after awakening.
Sleep. 2019 Feb 5. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: E.B. Klerman, D. Schreckenghost
Journal Impact Factor: 5.135
Funding: “This work was supported by NIH (F32DK107146, T32HL007901, KL2TR002370, K24HL105664, R01HL114088, R01GM105018, R01HL128538, P01AG009975, R21HD086392), Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health Award UL 1TR002541) and financial contributions from Harvard University and its affiliated academic healthcare centers and NSBRI (HFP02802, HFP04201, HDP0006).”
7
Lien MR, Barker RJ, Ye Z, Westphall MH, Gao R, Singh A, Gilroy S, Townsend PA.
A low-cost and open-source platform for automated imaging.
Plant Methods. 2019 Jan 28;15:6.
https://www.ncbi.nlm.nih.gov/
PI: S. Gilroy
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.269
Funding: “Funding for this research was provided to PT by the Wisconsin Potato Industry Board, USDA-NIFA-SCRI Grant 2011-51181-30629, the College of Agricultural and Life Sciences at UW-Madison, Hatch award WIS01874 and NASA Grant NNX15AN25G. SG and RB were supported by NASA Grants NNX14AT25G and NNX17AD52G, and NSF award IOS-1557899.”
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Other papers of interest:
1
Wang P, Tian H, Zhang J, Qian J, Li L, Shi L, Zhao Y.
Spaceflight/microgravity inhibits the proliferation of hematopoietic stem cells by decreasing Kit-Ras/cAMP-CREB pathway networks as evidenced by RNA-Seq assays.
FASEB J. 2019 Feb 5. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Tianzhou-1 and SJ-10 results. Ground-based experiments were conducted in a Rotating Wall Vessel.
2
Nordeen CA, Martin SL.
Engineering human stasis for long-duration spaceflight.
Physiology (Bethesda). 2019 Mar 1;34(2):101-11. Review.
https://www.ncbi.nlm.nih.gov/
Note: The authors review the use of hypothermia and hibernation as methods for suspending animation in humans for long-duration space travel.
3
White O, Barbiero M, Goswami N.
The effects of varying gravito-inertial stressors on grip strength and hemodynamic responses in men and women.
Eur J Appl Physiol. 2019 Feb 7. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Centrifugation was used. This article may be obtained online without charge.
4
Westman AM, Dyer SE, Remer JD, Hu X, Christ GJ, Blemker SS.
A coupled framework of in situ and in silico analysis reveals the role of lateral force transmission in force production in volumetric muscle loss injuries.
J Biomech. 2019 Jan 19. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
5
Ofer L, Dean MN, Zaslansky P, Kult S, Shwartz Y, Zaretsky J, Griess-Fishheimer S, Monsonego-Ornan E, Zelzer E, Shahar R.
A novel nonosteocytic regulatory mechanism of bone modeling.
PLoS Biol. 2019 Feb 1;17(2):e3000140.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
6
Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R.
Using the proton energy spectrum and microdosimetry to model proton relative biological effectiveness.
Int J Radiat Oncol Biol Phys. 2019 Feb 4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
7
Bilgin N, Özgören MK.
Balance-keeping control of a human being upon a sudden external perturbation.
J Biomech Eng. 2019 Feb 4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
8
Stay TL, Laurens J, Sillitoe RV, Angelaki DE.
Genetically eliminating Purkinje neuron GABAergic neurotransmission increases their response gain to vestibular motion.
Proc Natl Acad Sci U S A. 2019 Feb 5. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
9
Chen Y, Pei S, Yan L, Qiu X, Li R, Yu S, Lodhi A, Li B, Manzoor R, Zhang P, Deng Y, Ma H.
Design and surface modification of a microfluidic chip for intercellular interactions research during space flight.
Acta Astronaut. 2019 Feb 5. [Article in Press]
http://www.sciencedirect.com/
10
Ewald R.
Is it worth the risk? – An astronaut’s approach to risk awareness.
Acta Astronaut. 2019 Feb 12. [Article in Press]
http://www.sciencedirect.com/
Note: From the abstract: “In light of future long-term missions; leading humans again from LEO into deep space a sound understanding of this decision process may lead to an improved selection and composition of capable space expedition crews.”
11
Bao Y, Bassham DC, Howell SH.
A functional unfolded protein response is required for normal vegetative development.
Plant Physiol. 2019 Feb 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
12
Trifonov SV, Morozov YA, Kozlova TA.
Processing of household waste in the BTLSS using the wet combustion method.
Life Sci Space Res. 2019 Feb 14. [Article in Press]
http://www.sciencedirect.com/
13
Angerer TB, Chakravarty N, Taylor MJ, Nicora CD, Graham DJ, Anderton CR, Chudler EH, Gamble LJ.
Insights into the histology of planarian flatworm Phagocata gracilis based on location specific, intact lipid information provided by GCIB-ToF-SIMS imaging.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb 4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
14
Georgsson M, Staggers N, Arsand E, Kushniruk A.
Employing a user-centered cognitive walkthrough to evaluate a mHealth diabetes self-management application: A case study and beginning method validation.
J Biomed Inform. 2019 Mar;91:103110. Epub 2019 Feb 2.
https://www.ncbi.nlm.nih.gov/
Note: The NASA Raw Task Load Index (NASA-RTLX) was used.
