NASA Spaceline Current Awareness List #825 23 November 2018 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Singh NK, Wood JM, Karouia F, Venkateswaran K.
Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces.
Microbiome. 2018 Nov 13;6(1):204.
https://www.ncbi.nlm.nih.gov/
PI: K. Venkateswaran
Note: ISS results. GeneLab: “The metagenomic sequence data generated from this study can be found under NCBI Short Read Archive (SRA) under the bio-project number PRJNA438545 and GeneLab dataset GLDS-69.” GeneLab is available at: https://genelab.nasa.gov/. This article may be obtained online without charge.
Journal Impact Factor: 9.133
Funding: “This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV, which also funded the post-doctoral fellowship for NKS and JMW.”
2
Silverman JD, Durand HK, Bloom RJ, Mukherjee S, David LA.
Dynamic linear models guide design and analysis of microbiota studies within artificial human guts.
Microbiome. 2018 Nov 12;6(1):202.
https://www.ncbi.nlm.nih.gov/
PI: L.A. David
Note: This article may be obtained online without charge.
Journal Impact Factor: 9.133
Funding: “JDS and LAD acknowledge support from the Duke University Medical Scientist Training Program (GM007171), the Global Probiotics Council, a Searle Scholars Award, the Hartwell Foundation, an Alfred P. Sloan Research Fellowship, the Translational Research Institute through Cooperative Agreement NNX16AO69A, the Damon Runyon Cancer Research Foundation, the Hartwell Foundation, and NIH 1R01DK116187-01. SM would like to acknowledge the support of grants NSF IIS-1546331, NSF DMS-1418261, NSF IIS-1320357, NSF DMS-1045153, and NSF DMS1613261.”
3
Mao XW, Boerma M, Rodriguez D, Campbell-Beachler M, Jones T, Stanbouly S, Sridharan V, Nishiyama NC, Wroe A, Nelson GA.
Combined effects of low-dose proton radiation and simulated microgravity on the mouse retina and the hematopoietic system.
Radiat Res. 2018 Nov 15. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: X.W. Mao; M. Boerma/X.W. Mao/G.A. Nelson/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation
Note: Hindlimb unloading study.
Journal Impact Factor: 2.53
Funding: “This study was supported by National Space Biomedical Research Institute (NSBRI) grant no. RE03701 through NASA cooperative agreement NCC 9-58, NASA 80NSSC18K0310 and LLUMC Department of Radiation Medicine.”
4
Krishnamurthy A, Ferl RJ, Paul A-L.
Comparing RNA-Seq and microarray gene expression data in two zones of the Arabidopsis root apex relevant to spaceflight.
Appl Plant Sci. 2018 Nov 14;6(11):e01197.
https://onlinelibrary.wiley.
PIs: R.J. Ferl, A-L. Paul
Note: GeneLab: “All sequence data are archived in the National Center for Biotechnology Information Gene Expression Ominibus (GEO accession no. GSE115555; https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 1.187
Funding: “We thank the Center for the Advancement of Science in Space (CASIS; GA-2013-104) and the National Aeronautics and Space Administration (NASA) Space Life and Physical Sciences (NNX12AN69G) for funding and operational support.”
5
Lim SD, Kim SH, Gilroy S, Cushman JC, Choi WG.
Quantitative ROS bio-reporters: A robust toolkit for studying biological roles of reactive oxygen species in response to abiotic and biotic stresses.
Physiol Plant. 2018 Nov 9. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: S. Gilroy
Journal Impact Factor: 2.58
Funding: “We gratefully acknowledge the support of the National Science Foundation MCB-1329723, IOS-1557899, NASA NNX14AT25G, the Department of Energy, Office of Science, Genomic Science Program under award number DESC0008834, the National Institute of General Medical Sciences of the National Institutes of Health under INBRE Grant Number P20 RR016464 and COBRE Grant Number P20 GM103554, and the OVPRI research funding (University of Nevada, Reno). S.L. acknowledges the support from the National Research Foundation of Korea Postdoctoral Fellowship Abroad Program NRF-2014R1A6A3A03055754.”
______________________________
Other papers of interest:
1
Miyamoto K, Inui A, Uheda E, Oka M, Kamada M, Yamazaki C, Shimazu T, Kasahara H, Sano H, Suzuki T, Higashibata A, Ueda J.
Polar auxin transport is essential to maintain growth and development of etiolated pea and maize seedlings grown under 1 g conditions: Relevance to the International Space Station experiment.
Life Sci Space Res. 2018 Nov 15. [Article in Press]
http://www.sciencedirect.com/
Note: ISS results.
2
Stervbo U, Roch T, Kornprobst T, Sawitzki B, Grütz G, Wilhelm A, Lacombe F, Allou K, Kaymer M, Pacheco A, Vigne J, Westhoff TH, Seibert FS, Babel N.
Gravitational stress during parabolic flights reduces the number of circulating innate and adaptive leukocyte subsets in human blood.
PLoS One. 2018 Nov 14;13(11):e0206272.
https://www.ncbi.nlm.nih.gov/
Note: Parabolic flight results. This article may be obtained online without charge.
3
Wang S, Zhang Y, Guo J, Kang L, Deng Y, Li Y.
Investigation on rat intestinal homeostasis alterations induced by 7-day simulated microgravity effect based on a proteomic approach.
Acta Astronaut. 2018 Nov 14. [Article in Press]
http://www.sciencedirect.com/
Note: Hindlimb unloading study.
4
Powers SK, Duarte JA, Le Nguyen B, Hyatt H.
Endurance exercise protects skeletal muscle against both doxorubicin-induced and inactivity-induced muscle wasting.
Pflugers Arch. 2018 Nov 13. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
5
Kaiser J, Allaire B, Fein PM, Lu D, Jarraya M, Guermazi A, Demissie S, Samelson EJ, Bouxsein ML, Morgan EF.
Correspondence between bone mineral density and intervertebral disc degeneration across age and sex.
Arch Osteoporos. 2018 Nov 12;13(1):123.
https://www.ncbi.nlm.nih.gov/
6
Kang KS, Hong JM, Horan DJ, Lim KE, Bullock WA, Bruzzaniti A, Hann S, Warman ML, Robling AG.
Induction of Lrp5 HBM-causing mutations in cathepsin-K expressing cells alters bone metabolism.
Bone. 2018 Oct 25;120:166-75.
https://www.ncbi.nlm.nih.gov/
7
Markina EA, Andrianova IV, Shtemberg AS, Buravkova LB.
Effect of 30-day hindlimb unloading and hypergravity on bone marrow stromal progenitors in C57Bl/6N mice.
Bull Exp Biol Med. 2018 Nov 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study; centrifugation was used for hypergravity.
8
Nakagawa T, Wakabayashi H, Naito Y, Kato S, Miyamura G, Iino T, Sudo A.
The effects of bisphosphonate on pain-related behavior and immunohistochemical analyses in hindlimb-unloaded mice.
J Orthop Sci. 2018 Nov;23(6):1063-9.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study.
9
Qiao Y, Wang Y, Zhou Y, Jiang F, Huang T, Chen L, Lan J, Yang C, Guo Y, Yan S, Wei Z, Li J.
The role of nervous system in adaptive response of bone to mechanical loading.
J Cell Physiol. 2018 Nov 9. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
10
Vilchinskaya NA, Krivoi, II, Shenkman BS.
AMP-activated protein kinase as a key trigger for the disuse-induced skeletal muscle remodeling.
Int J Mol Sci. 2018 Nov 12;19(11):E3558. Review.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
11
Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang BT.
Long noncoding RNA lncMUMA reverses established skeletal muscle atrophy following mechanical unloading.
Mol Ther. 2018 Nov 7;26(11):2669-80.
https://www.ncbi.nlm.nih.gov/
Note: A random positioning machine was used. This article may be obtained online without charge.
12
Carbonero F, Mayta A, Bolea M, Yu JZ, Lindeblad M, Lyubimov A, Neri F, Szilagyi E, Smith B, Halliday L, Bartholomew A.
Specific members of the gut microbiota are reliable biomarkers of irradiation intensity and lethality in large animal models of human health.
Radiat Res. 2018 Nov 15. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
13
Mitrea DR, Mortazavi Moshkenani H, Hoteiuc OA, Bidian C, Toader AM, Clichici S.
Antioxidant protection against cosmic radiation-induced oxidative stress at commercial flight altitude.
J Physiol Pharmacol. 2018 Aug;69(4):01. Review.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
14
Porseva VV, Emanuilov AI, Masliukov PM.
Changes in the expression of calbindin and calretinin in interneurons of the spinal dorsal horns under conditions of antiorthostatic suspension in mice.
Bull Exp Biol Med. 2018 Nov 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study.
15
Mogilever NB, Zuccarelli L, Burles F, Iaria G, Strapazzon G, Bessone L, Coffey EBJ.
Expedition cognition: A review and prospective of subterranean neuroscience with spaceflight applications.
Front Hum Neurosci. 2018 Oct 30;12:407. Review.
https://www.ncbi.nlm.nih.gov/
Note: From the Introduction: “Our objective here is to foster an exchange between cognitive neuroscientists, and cave expedition and space analog experts, by providing an overview of how laboratory and field research in neuroscience and related areas (i.e., cognition, cognitive psychology, neuropsychology) can be bridged, using caving expeditions as an exemplar space analog and expedition environment.” This article may be obtained online without charge.
16
Zitting KM, Vujovic N, Yuan RK, Isherwood CM, Medina JE, Wang W, Buxton OM, Williams JS, Czeisler CA, Duffy JF.
Human resting energy expenditure varies with circadian phase.
Curr Biol. 2018 Nov 19;28(22):3685-90 e3.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
17
Dong Q, Zhang Z, Liu Y, Tao LZ, Liu H.
FERONIA regulates auxin-mediated lateral root development and primary root gravitropism.
FEBS Lett. 2018 Nov 11. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
18
Tubbs-Cooley HL, Mara CA, Carle AC, Mark BA, Pickler RH.
Association of nurse workload with missed nursing care in the neonatal intensive care unit.
JAMA Pediatr. 2018 Nov 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used.
