NASA Spaceline Current Awareness List #819 12 October 2018 (Space Life Science Research Results)
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Please note: SPACELINE Current Awareness Lists from 2016 (Lists #680-729) have been added to the NASA Task Book website and are available at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Mehta SK, Bloom DC, Plante I, Stowe R, Feiveson AH, Renner A, Dhummakupt A, Markan D, Zhang Y, Wu H, Scoles B, Cohen JI, Crucian B, Pierson DL.
Reactivation of latent Epstein-Barr virus: A comparison after exposure to gamma, proton, carbon, and iron radiation.
Int J Mol Sci. 2018 Sep 28;19(10):2961.
https://www.ncbi.nlm.nih.gov/
PI: S.K. Mehta
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.687
Funding: “This research was funded by NASA grants: NASA grant # NNH12ZTT001N to SKM, HHPC contract #NNJ15HK11B to IP, and contract # NNX14AD13G to DCB, NASA grant # NNX14AD14G to RPS. JIC was supported by the intramural research program of the National Institute of Allergy and Infectious Diseases.”
2
Petersen LG, Lawley JS, Lilja-Cyron A, Petersen JC, Howden EJ, Sarma S, Cornwell WK 3rd, Zhang R, Whitworth LA, Williams MA, Juhler M, Levine BD.
Lower body negative pressure to safely reduce intracranial pressure.
J Physiol. 2018 Oct 4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: B.D. Levine; J.S. Lawley, NSBRI Postdoctoral Fellowship Program
Note: Lower body negative pressure was used.
Journal Impact Factor: 4.54
Funding: “LGP was supported by Novo Nordic Foundation grant number NNF15OC0019196; JSL and BDL were supported by National Space Biomedical Research Institute grant number NCC 9-58.”
3
Ko FC, Van Vliet M, Ellman R, Grasso D, Brooks DJ, Spatz JM, Conlon C, Aguirre JI, Wronski TJ, Bouxsein ML.
Treatment with a soluble bone morphogenetic protein type 1A receptor (BMPR1A) fusion protein increases bone mass and bone formation in mice subjected to hindlimb unloading.
JBMR Plus. 2017 Oct;1(2):66-72.
https://www.ncbi.nlm.nih.gov/
PI: M.L. Bouxsein
Note: Hindlimb unloading study. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work was supported by NASA grant NNX10AE39G.”
4
Geng C, Gates D, Bronk L, Ma D, Guan F.
Physical parameter optimization scheme for radiobiological studies of charged particle therapy.
Phys Med. 2018 Jul;51:13-21.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.24
Funding: “This work was supported by the National Cancer Institute – United States [Grant No. U19 CA021239] and the Research Seed Funding Initiative Award from the American Association of Physicists in Medicine – United States.” D. Gates is affiliated with NASA Johnson Space Center.
5
Patel R, Zhang L, Desai A, Hoenerhoff MJ, Kennedy LH, Radivoyevitch T, Ban Y, Chen XS, Gerson SL, Welford SM.
Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure.
Leukemia. 2018 Oct 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: S.L. Gerson
Journal Impact Factor: 10.023
Funding: “This research was funded by NASA grant NNX14AC95G.”
6
Weaver MD, Barger LK, Malone SK, Anderson LS, Klerman EB.
Dose-dependent associations between sleep duration and unsafe behaviors among US high school students.
JAMA Pediatr. 2018 Oct 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: S.W. Lockley, G.C. Brainard
Journal Impact Factor: 10.769
Funding: “Authors were supported in part by grant T32 HL007901 from the National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) Training Program in Sleep, Circadian and Respiratory Neurobiology, and by NHLBI award F32 HL134249 (DrWeaver); grant R01GM105018 from the NIH National Institute of General Medical Sciences (NIGMS), grants NNX14AK53G, NNX15AC14G and NNX15AM28G from the National Aeronautics and Space Administration, grant R01OH010300 from the National Institute for Occupational Safety and Health, and grant U01HL111478 from the NIH NHLBI (Dr Barger); grant K99NR017416 from the NIH National Institute of Nursing Research and New York University Clinical and Translational Science Award UL1TR001445 (Dr Malone); and grants K24HL105664, R01HL128538, and R01HL114088 from the NIH NHLBI, grant R01GM105018 from the NIH NIGMS, grant P01AG009975 from the NIH National Institute of Aging, and grant R21HD086392 from the NIH National Institute of Child Health and Human Development (Dr Klerman).”
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Other papers of interest:
1
Jeong AJ, Kim YJ, Lim MH, Lee H, Noh K, Kim BH, Chung JW, Cho CH, Kim S, Ye SK.
Microgravity induces autophagy via mitochondrial dysfunction in human Hodgkin’s lymphoma cells.
Sci Rep. 2018 Oct 2;8(1):14646.
https://www.ncbi.nlm.nih.gov/
Note: A clinostat was used. This article may be obtained online without charge.
2
Egawa T, Ohno Y, Goto A, Yokoyama S, Hayashi T, Goto K.
AMPK mediates muscle mass change but not the transition of myosin heavy chain isoforms during unloading and reloading of skeletal muscles in mice.
Int J Mol Sci. 2018 Sep 27;19(10):2954.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
3
Fan W, Gao XK, Rao XS, Shi YP, Liu XC, Wang FY, Liu YF, Cong XX, He MY, Xu SB, Shen WL, Shen Y, Yan SG, Luo Y, Low BC, Ouyang H, Bao Z, Zheng LL, Zhou YT.
Hsp70 interacts with MAPK-activated protein kinase 2 to regulate p38MAPK stability and myoblast differentiation during skeletal muscle regeneration.
Mol Cell Biol. 2018 Oct 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
4
Jargin SV.
Studies of radiation risk at low doses and low dose rates: A new approach needed.
Int J Radiat Biol. 2018 Oct 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
5
Gavgani AM, Walker FR, Hodgson DM, Nalivaiko E.
A comparative study of cybersickness during exposure to virtual reality and “classic” motion sickness: Are they different?
J Appl Physiol (1985). 2018 Oct 4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
6
Micarelli A, Candidi M, Viziano A, Alessandrini M.
Vestibular dysfunction, beyond benign paroxysmal positional vertigo, affects mental rotations: Comment on “Visual dependence and spatial orientation in benign paroxysmal positional vertigo.”
J Vestib Res. 2018 Sep 25. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: This articles is a comment on: Nair MA, Mulavara AP, Bloomberg JJ, Sangi-Haghpeykar H, Cohen HS. Visual dependence and spatial orientation in benign paroxysmal positional vertigo. J Vestib Res. 2018;27(5-6):279-86. https://www.ncbi.nlm.nih.gov/
7
Watson LA, Phillips AJK, Hosken IT, McGlashan EM, Anderson C, Lack LC, Lockley SW, Rajaratnam SMW, Cain SW.
Increased sensitivity of the circadian system to light in delayed sleep-wake phase disorder.
J Physiol. 2018 Oct 3. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
8
Yang FN, Xu S, Chai Y, Basner M, Dinges DF, Rao H.
Sleep deprivation enhances inter-stimulus interval effect on vigilant attention performance.
Sleep. 2018 Sep 28. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
9
Laskar RA, Wani MR, Raina A, Amin R, Khan S.
Morphological characterization of gamma rays induced multipodding mutant (mp) in lentil cultivar Pant L 406.
Int J Radiat Biol. 2018 Oct 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
10
Nziengui H, Lasok H, Kochersperger P, Ruperti B, Rebeille F, Palme K, Ditengou FA.
Root gravitropism is regulated by a crosstalk between para-aminobenzoic acid, ethylene, and auxin.
Plant Physiol. 2018 Oct 1. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
11
Tikhomirov AA, Ushakova SA, Velichko VV, Trifonov SV, Tikhomirova NA, Kalacheva GS.
A small test closed ecosystem with an estimated portion of human metabolism.
Life Sci Space Res. 2018 Oct 9. [Article in Press]
http://www.sciencedirect.com/
12
Szocik K, Abood S, Shelhamer M.
Psychological and biological challenges of the Mars mission viewed through the construct of the evolution of fundamental human needs.
Acta Astronaut. 2018 Oct 4. [Article in Press]
http://www.sciencedirect.com/
13
Greenlee ET, Funke GJ, Rice L.
Evaluation of the Team Workload Questionnaire (TWLQ) in a team-choice task.
Hum Factors. 2018 Oct 2. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
14
Zhang J, Liu S, Feng Q, Gao J, Cheng J, Jiang M, Lan Y, Zhang Q.
Ergonomic assessment of the mental workload confronted by surgeons during laparoscopic surgery.
Am Surg. 2018 Sep 1;84(9):1538-43.
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used.
Please note: Space Medicine & Medical Engineering journal recently published an issue with English titles and abstracts. Articles of interest are listed here.
15
Chen S, Deng Y, Li Y.
Major progresses and prospects of space medico-engineering.
Space Med Med Eng. 2018;2018(2):79-89.
http://caod.oriprobe.com/
16
Liu W, Chen J, Deng Y.
Support and promotion of space medico-engineering in construction of China’s Space Station.
Space Med Med Eng. 2018;2018(2):90-6.
http://caod.oriprobe.com/
17
Huang W.
Development and outlook of China’s astronaut selection and training.
Space Med Med Eng. 2018;2018(2):97-104.
http://caod.oriprobe.com/
18
Wu Z, Gao F, Deng Y, Bian Q, Dong W, Liu X, Zhou K, Li Y, Zhao C.
Key technology review of research on regenerative environmental control and life support system for space station.
Space Med Med Eng. 2018;2018(2):105-11.
http://caod.oriprobe.com/
19
Guo S, Dong W.
Analyses on current status and future developing direction of controlled ecological life support techniques in China.
Space Med Med Eng. 2018;2018(2):112-20.
http://caod.oriprobe.com/
20
Zhang W, Li T, Shang K, Li M.
Developments and conceptions of pressure protection technology in spacesuit.
Space Med Med Eng. 2018;2018(2):121-30.
http://caod.oriprobe.com/
21
Wang L, Qu L, Li Y, Chen X, Li Y.
Progresses and prospects of weightlessness physiology in China.
Space Med Med Eng. 2018;2018(2):131-9.
http://caod.oriprobe.com/
Note: Shenzhou and bed rest study results.
22
Li Y, Ling S, Zhao Y, Tan Y, Du R, Song J, Zhao D, Li. Y, Zhong G, Liu Z, Li J.
Advances in cellular and molecular basics of space medical problems.
Space Med Med Eng. 2018;2018(2):140-51. Review.
http://caod.oriprobe.com/
23
Wu D, Zhang H, Zhao Y, Wang H.
Research progress of space radiation for manned spaceflight.
Space Med Med Eng. 2018;2018(2):152-62. Review.
http://caod.oriprobe.com/
24
Wang J, Qin H, Tian L, Wu B, Huang W.
Research and practice of space psychology.
Space Med Med Eng. 2018;2018(2):163-71. Review.
http://caod.oriprobe.com/
25
Wang C, Chen X, Ting J, Wang L, Jiang C, Wang B, Huang S, Xiao Y, Tian Y, Jiao X.
Research and practice in space ergonomics.
Space Med Med Eng. 2018;2018(2):172-81. Review.
http://caod.oriprobe.com/
Note: Shenzhou results.
26
Xu Z, Ming W, Song J, Li Y, Liu B.
Development and prospect of medical monitoring devices in manned spaceflight.
Space Med Med Eng. 2018;2018(2):182-8. Review.
http://caod.oriprobe.com/
27
Cao P, Li H, Lan H.
Developments and expectations of space nutrition and food engineering.
Space Med Med Eng. 2018;2018(2):189-97. Review.
http://caod.oriprobe.com/
28
Chao J, Lin W, Xu X, Liu X, Xiong Y, Yang J.
Research on system construction and key technology of spaceflight training simulator.
Space Med Med Eng. 2018;2018(2):198-204. Review.
http://caod.oriprobe.com/
29
Liu Z, Wu D, Huang W, Wu B, Li Z, Chen Z, Zhong C, Li Y.
Evaluation and prediction of orthostatic tolerance related to gravity re-adaptation.
Space Med Med Eng. 2018;2018(2):205-10.
http://caod.oriprobe.com/
Note: Bed rest study.
30
Gong X, Liu M, Wu P, Wu B, Sun H, Huang W.
Research on influence of repeated body position changes on human head-down tilt tolerance and its duration.
Space Med Med Eng. 2018;2018(2):211-5.
http://caod.oriprobe.com/
Note: Head-down tilt study.
31
Shi Y, Tian Z, Huang W.
An evaluation method for team situation awareness based on teamwork and taskwork.
Space Med Med Eng. 2018;2018(2):216-23.
http://caod.oriprobe.com/
32
Chen S, Wang F, Li W, Zhang P, Liu H, Zhou Y, Chen X.
Screening of serum exercise-sensitive miRNA in mice.
Space Med Med Eng. 2018;2018(2):224-8.
http://caod.oriprobe.com/
33
He N, Chao J, Xu Z, Wei C.
Research on spatial orientation of augmented reality space flight training system.
Space Med Med Eng. 2018;2018(2):255-60.
http://caod.oriprobe.com/
34
Ma A, Shi M, Liu H, Ding L, Li Y, Dong R, Zhao Y, Liu L.
Finite element analysis and test verification of EVA spacesuit under different fixtures.
Space Med Med Eng. 2018;2018(2):261-3.
http://caod.oriprobe.com/
35
Xu Z, Yu Q, Zhang L, Xiong J, Ai W, Qu L, Wu Z, Wang L, Dong W, Guo S, Tang Y, Deng Y, Li Y.
Overview of 4-person 180-day integrated experiment in controlled ecological life support system.
Space Med Med Eng. 2018;2018(2):264-72.
http://caod.oriprobe.com/
36
Zhang L, Li T, Yu Q, Dong W, Yang J, Wang W, Ai W, Wu C, Guo S, Li Y.
Design and operation overview of 4-person 180-day integrated experiment in controlled ecological life support system.
Space Med Med Eng. 2018;2018(2):273-81.
http://caod.oriprobe.com/
37
Xin B, Wang H, Wu Y, Zhong C, Liu J, Chen Z, Dun H, Xie Q.
Analysis on body microbiota of people surviving in controlled ecological life support system of 180 days experiment.
Space Med Med Eng. 2018;2018(2):282-8.
http://caod.oriprobe.com/
38
Wang B, He X, Li Y, Yu N, Yang S, Xu Z, Du F, Xu H, Tong F, Li J, Li X, Cui B, Hu Y, Wen X, Niu C, Li Y, Yang G.
Study on hearing changes of four volunteers in 180-day CELSS integration experiment.
Space Med Med Eng. 2018;2018(2):289-94.
http://caod.oriprobe.com/
39
Dong H, Chen P, Zhao W, Yu Y, Luo M, Han B, Chen B.
Research on changes of small molecule metabolites in human under 180-day CELSS environmental conditions with high resolution mass spectrometry.
Space Med Med Eng. 2018;2018(2):295-300.
http://caod.oriprobe.com/
