NASA Spaceline Current Awareness List #808 20 July 2018 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
In case you missed it: On July 6, 2018, Scientific American posted an interview with William Daniels, PhD. (University of Massachusetts Amherst) about his experience during the Campaign 4 study in the Human Exploration Research Analog (HERA) at NASA Johnson Space Center from May 4 through June 18, 2018. Daniels talks about the normal schedule, sleep deprivation, hygiene, contact with the outside world, and isolation. The interview can be found at https://www.
Papers deriving from NASA support:
1
Dagdeviren D, Beallias J, Khan I, Mednieks MI, Hand AR.
Response of the mouse sublingual gland to spaceflight.
Eur J Oral Sci. 2018 Jul 9. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: M.I. Mednieks
Note: STS-131 and STS-135 results.
Journal Impact Factor: 1.54
Funding: “This study was supported by NASA Grant NNX09AP13G (MIM), Connecticut Space Grant College Consortium Grant P-536 (ARH), NIH Shared Instrumentation Grant 1S10RR024742 (ARH), and the Summer Research Program of the School of Dental Medicine (JB and IK).”
2
Reschke MF, Wood SJ, Clément GR.
A case study of severe space motion sickness.
Aerosp Med Hum Perform. 2018 Aug;89(8):749-53.
https://www.ingentaconnect.
Note: Shuttle results.
Journal Impact Factor: 0.933
Funding: “This work was supported by the National Aeronautics and Space Administration (NASA).”
3
Prisk GK.
Effects of partial gravity on the function and particle handling of the human lung.
Curr Pathobiol Rep. 2018 July 13. [Article in Press] Review.
https://link.springer.com/
PI: G.K. Prisk
Note: Apollo, Skylab, SLS-1, SLS-2, and ISS results are cited. This article is part of the journal’s Topical Collection on the “Effects of the Space Environments on Human Pathobiology.”
Journal Impact Factor: Not available for this journal
Funding: “Many of the studies were funded by NASA or the National Space Biomedical Research Institute under various contracts and grants. GK Prisk is currently funded by NIH under R01 HL119263.”
4
Crucian BE, Choukèr A, Simpson RJ, Mehta S, Marshall G, Smith SM, Zwart SR, Heer M, Ponomarev S, Whitmire A, Frippiat JP, Douglas GL, Lorenzi H, Buchheim JI, Makedonas G, Ginsburg GS, Ott CM, Pierson DL, Krieger SS, Baecker N, Sams C.
Immune system dysregulation during spaceflight: Potential countermeasures for deep space exploration missions.
Front Immunol. 2018 Jun 28;9:1437. Review.
https://www.ncbi.nlm.nih.gov/
Note: From the abstract: “This article will review relevant in-place operational countermeasures onboard ISS and discuss a myriad of potential immune countermeasures for exploration missions. Discussion points include nutritional supplementation and functional foods, exercise and immunity, pharmacological options, the relationship between bone and immune countermeasures, and vaccination to mitigate herpes (and possibly other) virus risks.” This article may be obtained online without charge.
Journal Impact Factor: 6.429
Funding: “The authors also wish to acknowledge support for this product provided by the NASA Human Research Program, Human Health and Countermeasures Element. AC and JIB are funded under the German National Space Program (DLR) on behalf of the German Ministry of Economics and Energy (BWMi grant 50WB1622).” The following authors are affiliated with NASA Johnson Space Center or have been funded by NASA for related projects: B.E. Crucian, R.J. Simpson, S. Mehta, S.M. Smith, S.R. Zwart, A. Whitmire, G.L. Douglas, H. Lorenzi, C.M. Ott, D.L. Pierson, S.S. Krieger, and C. Sams.
5
Masterova KS, Anderson AP, Cowan DR, Fellows AM, Zegans ME, Buckey JC.
Portable autorefractors for detecting axial length changes in space.
Aerosp Med Hum Perform. 2018 Aug;89(8):724-30.
https://www.ingentaconnect.
Journal Impact Factor: 0.933
Funding: “This work was supported by NASA grant NH-NNX16AD51A to the New Hampshire NASA Experimental Program to Stimulate Competitive Research (EPSCoR).”
6
Ghanem MA, Maxwell AD, Kreider W, Cunitz BW, Khokhlova VA, Sapozhnikov OA, Bailey MR.
Field characterization and compensation of vibrational non-uniformity for a 256-element focused ultrasound phased array.
IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Jun 27. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: M.R. Bailey, V.A. Khokhlova
Journal Impact Factor: 2.743
Funding: “The work was supported by the NSBRI through NASA NCC 9-58, RSF 14-12-00974, NIH NIBIB RO1-EB007643, NIDDK P01-DK043881, NIH R01-EB025187 and K01-DK104854.”
______________________________
Other papers of interest:
1
Kopp S, Krüger M, Feldmann S, Oltmann H, Schütte A, Schmitz B, Bauer J, Schulz H, Saar K, Huebner N, Wehland M, Nassef MZ, Melnik D, Meltendorf S, Infanger M, Grimm D.
Thyroid cancer cells in space during the TEXUS-53 sounding rocket mission – The THYROID Project.
Sci Rep. 2018 Jul 9;8(1):10355.
https://www.ncbi.nlm.nih.gov/
Note: TEXUS-53 results. This article may be obtained online without charge.
2
Lei X, Cao Y, Zhang Y, Qian J, Zhao Q, Liu F, Zhang T, Zhou J, Gu Y, Xia G, Duan E.
Effect of microgravity on proliferation and differentiation of embryonic stem cells in an automated culturing system during the TZ-1 space mission.
Cell Prolif. 2018 Jul 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Chinese TZ-1 results.
3
Otsuka K, Cornelissen G, Kubo Y, Shibata K, Hayashi M, Mizuno K, Ohshima H, Furukawa S, Mukai C.
Circadian challenge of astronauts’ unconscious mind adapting to microgravity in space, estimated by heart rate variability.
Sci Rep. 2018 Jul 10;8(1):10381.
https://www.ncbi.nlm.nih.gov/
Note: ISS results. This article may be obtained online without charge.
4
Markolefa I, Lambrous GI.
The role of autophagy during osteoclastogenesis under microgravity conditions.
Int J Astrobiology. 2018 Jul 10. [Article in Press] Review.
Note: Spaceflight studies cited are from Skylab, Mir, and ISS missions. Simulation studies cited used hindlimb unloading, bed rest, and rotating wall vessels.
5
Gerbaix M, White H, Courbon G, Shenkman B, Gauquelin-Koch G, Vico L.
Eight days of Earth reambulation worsen bone loss induced by 1-month spaceflight in the major weight-bearing ankle bones of mature mice.
Front Physiol. 2018 Jun 25;9:746.
https://www.ncbi.nlm.nih.gov/
Note: Bion M-1 results. This article may be obtained online without charge.
6
Zhao T, Li R, Tan X, Zhang J, Fan C, Zhao Q, Deng Y, Xu A, Lukong KE, Genth H, Xiang J.
Simulated microgravity reduces focal adhesions and alters cytoskeleton and nuclear positioning leading to enhanced apoptosis via suppressing FAK/RhoA-mediated mTORC1/NF-κB and ERK1/2 pathways.
Int J Mol Sci. 2018 Jul 8;19(7):E1994.
https://www.ncbi.nlm.nih.gov/
Note: A random positioning machine was used. This article may be obtained online without charge.
7
Inprasit C, Lin YW, Huang CP, Wu SY, Hsieh CL.
Targeting TRPV1 to relieve motion sickness symptoms in mice by electroacupuncture and gene deletion.
Sci Rep. 2018 Jul 9;8(1):10365.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
8
Verma AK, Xu D, Bruner M, Garg A, Goswami N, Blaber AP, Tavakolian K.
Comparison of autonomic control of blood pressure during standing and artificial gravity induced via short-arm human centrifuge.
Front Physiol. 2018 Jun 25;9:712.
https://www.ncbi.nlm.nih.gov/
Note: Centrifugation was used. This article may be obtained online without charge.
9
Rinaldi S, Meloni MA, Galleri G, Maioli M, Pigliaru G, Cugia G, Santaniello S, Castagna A, Fontani V.
Radio Electric Asymmetric Conveyer (REAC) technology to obviate loss of T cell responsiveness under simulated microgravity.
PLoS One. 2018 Jul 6;13(7):e0200128.
https://www.ncbi.nlm.nih.gov/
Note: A random positioning machine was used. This article may be obtained online without charge.
10
Shinojima A, Kakeya I, Tada S.
Association of space flight with problems of the brain and eyes.
JAMA Ophthalmol. 2018 Jul 5.
https://www.ncbi.nlm.nih.gov/
Note: From the Methods section: “We created a model of the optic nerve sheath (ONS) as a tube including a cylinder. This modeling allowed us to apply the material mechanics theory of thin-walled tubes.”
11
Soeken TA, Alonso A, Grant A, Calvillo E, Gutierrez-Flores B, Clark JB, Donoviel D, Bershad EM.
Quantitative pupillometry for detection of intracranial pressure changes during head-down tilt.
Aerosp Med Hum Perform. 2018 Aug;89(8):717-23.
https://www.ingentaconnect.
Note: Head-down tilt study.
12
Arentson-Lantz E, Galvan E, Wacher A, Fry CS, Paddon-Jones D.
2000 Steps/day does not fully protect skeletal muscle health in older adults during bed rest.
J Aging Phys Act. 2018 Jul 10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Bed rest study.
13
Myers CM, Kim JS, Florian JP.
Effects of repeated long-duration water immersions on skeletal muscle performance in well-trained male divers.
Eur J Appl Physiol. 2018 Jul 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Water immersion was used.
14
Rullman E, Fernandez-Gonzalo R, Mekjavic IB, Gustaffsson T, Eiken O.
Mef2 as upstream regulator of the transcriptome signature in human skeletal muscle during unloading.
Am J Physiol Regul Integr Comp Physiol. 2018 Jul 11. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Bed rest study, part of the PlanHab Project sponsored by the European Union and the European Space Agency.
15
Moore ER, Zhu YX, Ryu HS, Jacobs CR.
Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation.
Stem Cell Res Ther. 2018 Jul 11;9(1):190.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
16
Shi X, Guo TZ, Li W, Sahbaie P, Rice KC, Sulima A, Clark JD, Kingery WS.
Exercise reverses nociceptive sensitization, upregulated neuropeptide signaling, inflammatory changes, anxiety, and memory impairment in a mouse tibia fracture model.
Anesthesiology. 2018 Jul 10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
17
He Y, Zhang Y, Li H, Zhang H, Li Z, Xiao L, Hu J, Ma Y, Zhang Q, Zhao X.
Comparative profiling of microRNAs reveals the underlying toxicological mechanism in mice testis following carbon ion radiation.
Dose Response. 2018 Apr-Jun;16(2):
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
18
Shimura N, Kojima S.
The lowest radiation dose having molecular changes in the living body.
Dose Response. 2018 Apr-Jun;16(2):
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
19
Xu F, Jia X, Lu W, Zhou C, Guo Y, Fei J, Yang C.
Utilization of trash for radiation protection during manned space missions.
Acta Astronaut. 2018 Oct;151:585-94. Epub 2017 Dec 30.
http://www.sciencedirect.com/
20
Dal Maso F, Desormeau B, Boudrias MH, Roig M.
Acute cardiovascular exercise promotes functional changes in cortico-motor networks during the early stages of motor memory consolidation.
Neuroimage. 2018 Jul 1;174:380-92.
https://www.ncbi.nlm.nih.gov/
21
Cheung B, Ercoline W.
Semicircular canal size and shape influence on disorientation.
Aerosp Med Hum Perform. 2018 Aug;89(8):744-8. Review.
https://www.ingentaconnect.
22
Brinkert K, Richter MH, Akay Ö, Liedtke J, Giersig M, Fountaine KT, Lewerenz HJ.
Efficient solar hydrogen generation in microgravity environment.
Nat Commun. 2018 Jul 10;9(1):2527.
https://www.ncbi.nlm.nih.gov/
Note: A drop tower was used. This article may be obtained online without charge.
23
Meena YK, Cecotti H, Wong-Lin KF, Dutta A, Prasad G.
Towards optimization of gaze-controlled human-computer interaction: Application to Hindi virtual keyboard for stroke patients.
IEEE Trans Neural Syst Rehabil Eng. 2018 Mar 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used.
