NASA Spaceline Current Awareness List #798 11 May 2018 (Space Life Science Research Results)
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Papers deriving from NASA support:
1
Zwart SR, Rice BL, Dlouhy H, Shackelford LC, Heer M, Koslovsky MD, Smith SM.
Dietary acid load and bone turnover during long-duration spaceflight and bed rest.
Am J Clin Nutr. 2018 May 1;107(5):834-44.
https://www.ncbi.nlm.nih.gov/
PI:
S.M. Smith
Note: ISS and bed rest study results. An editorial about this study appears in the same
issue: Frassetto L. Another strategy to help counter the effects of low gravity? Am J Clin Nutr. 2018 May 1;107(5):681-2.
https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 6.926
Funding:
“This
study was supported by the Human Health Countermeasures Element of the
NASA Human Research Program and by the Institute for Translational
Sciences at the University of Texas
Medical Branch, and in part by a Clinical and Translational Science
Award (UL1TR000071) from the National Center for Advancing Translational
Sciences, National Institutes of Health. The research was also funded
in part by the German Aerospace Center DLR, Space
Program, Grant 50WB1231.”
2
Kunz HE, Spielmann G, Agha NH, O’Connor DP, Bollard CM, Simpson RJ.
A single exercise bout augments adenovirus-specific T-cell mobilization and function.
Physiol Behav. 2018 Oct 1;194:56-65. Epub 2018 Apr 30.
https://www.ncbi.nlm.nih.gov/
PI: R.J. Simpson
Journal Impact Factor: 2.341
Funding:
“This work was supported by an American College of Sports Medicine
Foundational
Research Grant to H.E. Kunz and NASA grants NNX12AB48G; NNX16AB29G;
NNX16AG02G, and NIH Grant R21 CA197527-01A1 to R.J. Simpson.”
3
Craig JC, Broxterman RM, Smith JR, Allen JD, Barstow TJ.
Effect
of dietary nitrate supplementation on conduit artery blood flow, muscle
oxygenation, and metabolic rate during handgrip exercise.
J Appl Physiol (1985). 2018 May 3. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI:
T.J. Barstow
Journal Impact Factor: 3.351
Funding:
“This work was supported by National Aeronautics and Space
Administration (NASA)
Grant NNX10AK60G awarded to T. J. Barstow, by NASA Experimental Program
to Stimulate Competitive Research Grant NNX11AM05A supporting R. M.
Broxterman, and by the Kansas State University College of Veterinary
Medicine Dr. Albert Borroughs Memorial Award granted
to R. M. Broxterman.”
4
Elefteriou F.
Impact of the autonomic nervous system on the skeleton.
Physiol Rev. 2018 Jul 1;98(3):1083-112. Review. Epub 2018 May 2.
https://www.ncbi.nlm.nih.gov/
PI:
F. Elefteriou
Journal Impact Factor: 27.312
Funding:
“The work from the author related to this review is supported by
National Institute
of Diabetes and Digestive and Kidney Diseases Grant R01 DK082471,
National Institute on Aging Grant R01 AG055394, National Cancer
Institute Grant R01 CA168717-03, and National Aeronautics and Space
Administration Grant NNX12AL35G.”
5
Farris M, McTyre ER, Okoukoni C, Dugan G, Johnson BJ, Blackstock AW, Munley MT, Bourland JD, Cline JM, Willey JS.
Cortical thinning and structural bone changes in non-human primates after single-fraction whole-chest irradiation.
Radiat Res. 2018 May 8. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: J.S. Willey
Journal Impact Factor:
2.539
Funding:
“This
research was supported by the National Institutes of Health (U19
AI67798 and T35 OD010946 to JSW) and the National Aeronautics and Space
Administration (NNX15AB50G to JSW).”
6
Kennedy EM, Powell DR, Li Z, Bell JSK, Barwick BG, Feng H, McCrary MR, Dwivedi B, Kowalski J, Dynan WS, Conneely KN, Vertino PM.
Galactic cosmic radiation induces persistent epigenome alterations relevant to human lung cancer.
Sci Rep. 2018 Apr 30;8(1):6709.
https://www.ncbi.nlm.nih.gov/
PIs: W.S. Dynan; Y. Wang/W.S. Dynan/P.M. Vertino/NSCOR
Note:
This article may be obtained online without charge.
Journal Impact Factor: 4.259
Funding:
“Supported
by the US National Aeronautics and Space Administration NSCOR Program
grant NNX11AC30G (to PMV and WSD) and NNX15AD63G (to WSD). This project
was supported in part by the
Winship Biostatistics and Bioinformatics Shared Resource and the Emory
Integrated Genomics Shared Resource with support of the NCI Cancer
Center Support Grant 1P30- CA0138292 to the Winship Cancer Institute of
Emory University.”
7
Mao XW, Boerma M, Rodriguez D, Campbell-Beachler M, Jones T, Stanbouly S, Sridharan V, Wroe A, Nelson GA.
Acute effect of low-dose space radiation on mouse retina and retinal endothelial cells.
Radiat Res. 2018 May 9. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: M. Boerma/X.W. Mao/G.A. Nelson/NSBRI Center for Research on Cardiac, Vascular, and
Acute Effects of Space Radiation
Journal Impact Factor: 2.539
Funding: “This study was supported by National Space Biomedical Research Institute (NSBRI)
grant no. RE03701 through NASA cooperative agreement NCC 9-5884.”
8
Golden SJ, Chang C-H, Kozlowski SWJ.
Teams in isolated, confined, and extreme (ICE) environments: Review and integration.
J Organ Behav. 2018 Apr 19. [Epub ahead of print] Review.
https://onlinelibrary.wiley.
PI:
S.W.J. Kozlowski
Journal Impact Factor: 3.607
Funding:
“We gratefully acknowledge the National Aeronautics and Space
Administration (NASA;
NNX13AM77G and NNX16AR52G, S.W.J. Kozlowski, Principal Investigator,
C.‐H. Chang, Co‐Investigator) for support that contributed to the
composition of this article.”
9
Rahman SA, St Hilaire MA, Gronfier C, Chang AM, Santhi N, Czeisler CA, Klerman EB, Lockley SW.
Functional decoupling of melatonin suppression and circadian phase resetting in humans.
J Physiol. 2018 Apr 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: C.A. Czeisler, E.B. Klerman, S.W. Lockley
Note: This article may be obtained online without charge until May 31, 2018.
Journal Impact Factor:
4.739
Funding:
“This
work was supported by NASA NAG 5-3952, NSBRI HFP02801, HFP02802, and
NIH P01-AG09975, R01-HL114088 (E.B.K.), RC2-HL101340-0 (E.B.K., S.W.L.,
S.A.R.), K02-HD045459 (E.B.K.),
K24-HL105664 (E.B.K.), T32-HL07901 (M.S.H., S.A.R.), HL094654 (C.A.C.).
The project described was supported by grants from the National Centre
for Research Resources to the General Clinical Research Centre
GCRC-M01-RR02635, NIH Grant Number 1UL1 TR001102-01,
8UL1TR000170-05, UL1 RR 025758, Harvard Clinical and Translational
Science Centre, from the National Centre for Advancing Translational
Science.”
10
Angelos E, Ruberti C, Kim SJ, Brandizzi F.
Maintaining the factory: The roles of the unfolded protein response in cellular homeostasis in plants.
Plant J. 2017 May;90(4):671-82. Review.
https://www.ncbi.nlm.nih.gov/
PI: F. Brandizzi
Note: This article may be obtained online without charge.
Journal Impact Factor:
5.901
Funding:
“We acknowledge support by the Chemical Sciences, Geosciences and
Biosciences Division,
Office of Basic Energy Sciences, Office of Science, US Department of
Energy (award number DE-FG02-91ER20021) for infrastructure, NASA (award
NNX12AN71G), NIH R01-GM101038, the DOE Great Lakes Bioenergy Research
Center [DOE Office of Science BER DE-FC02-07ER64494],
AgBioResearch, and a fellowship from Michigan State University, USA,
under the Training Program in Plant Biotechnology for Health and
Sustainability (T32-GM110523).”
11
Lionheart G, Vandenbrink JP, Hoeksema JD, Kiss JZ.
The impact of simulated microgravity on the growth of different genotypes of the model legume plant
Medicago truncatula.
Microgravity Sci Technol. 2018 May 8. [Article in Press]
https://link.springer.com/
PI:
J.Z. Kiss
Note: A rotating clinostat was used.
Journal Impact Factor:
1.188
Funding: No funding cited. The PI reports funding under NASA grant “Novel Explorations into
the Interactions between Light and Gravity Sensing in Plants” (80NSSC17K0546).
12
Mulugeta L, Drach A, Erdemir A, Hunt CA, Horner M, Ku JP, Myers JG Jr, Vadigepalli R, Lytton WW.
Credibility, replicability, and reproducibility in simulation for biomedicine and clinical applications in neuroscience.
Front Neuroinform. 2018 Apr 16;12:18. Review.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding:
“This research was supported by NIH R01GM104139, R01EB024573, and
USAMRMC W81XWH-15-1-0232
(AE); NIH R01 GM107340, U54 EB020405, P2C HD065690; USAMRMC
W81XWH-15-1-0232 (JK); NIBIB U01 EB023224, NHLBI U01 HL133360, NIH OT2
OD023848 (RV); and NIH R01-EB022903, U01-EB017695, R01-MH086638, NYS
DOH01-C32250GG-3450000 (WL).” J.G. Myers Jr. is affiliated
with NASA Glenn Research Center.
______________________________
Other papers of interest:
1
Barabanov VM, Gulimova VI, Berdiev RK, Saveliev SV.
Attachment of Turner’s thick-toed geckos (Chondrodactylus turneri GRAY 1864) during weightlessness and their responses to flotation.
Life Sci Space Res. 2018 May 5. [Article in Press]
http://www.sciencedirect.com/
Note: Bion-M1 results.
2
Beck P, Tank J, Gauger P, Beck LEJ, Zirngibl H, Jordan J, Limper U.
Modeling human orthostatic responses on the Moon and on Mars.
Clin Auton Res. 2018 Apr 26. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Parabolic flight results.
3
Avan P, Normand H, Giraudet F, Gerenton G, Denise P.
Noninvasive in-ear monitoring of intracranial pressure during microgravity in parabolic flights.
J Appl Physiol (1985). 2018 May 3. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
Parabolic flight results.
4
Vista SSEP Mission 11 Team, Hagstrom D, Bartee C, Collins E-MS.
Studying planarian regeneration aboard the International Space Station within the Student Space Flight Experimental Program.
Front Astron Space Sci. 2018 May 7;5:12.
https://www.frontiersin.org/
Note: ISS results. This article may be obtained online without charge.
5
Bimpong-Buta NY, Jirak P, Wernly B, Lichtenauer M, Masyuk M, Muessig JM, Braun K, Kaya S, Kelm M, Jung C.
Analysis of human microcirculation in weightlessness: Study protocol and pre-study experiments.
Clin Hemorheol Microcirc. 2018 Apr 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The paper presents the protocol for a parabolic flight study.
6
Chibalin AV, Benziane B, Zakyrjanova GF, Kravtsova VV, Krivoi, II.
Early endplate remodeling and skeletal muscle signaling events following rat hindlimb suspension.
J Cell Physiol. 2018 May 2. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study.
7
Frassetto L.
Another strategy to help counter the effects of low gravity?
Am J Clin Nutr. 2018 May 1;107(5):681-2.
https://www.ncbi.nlm.nih.gov/
Note: Comment on Zwart SR, Rice BL, Dlouhy H, Shackelford LC, Heer M, Koslovsky MD, Smith
SM. Dietary acid load and bone turnover during long-duration spaceflight and bed rest. Am J Clin Nutr. 2018 May 1;107(5):834-44.
https://www.ncbi.nlm.nih.gov/
8
Hughes
JM, Gaffney-Stomberg E, Guerriere KI, Taylor KM, Popp KL, Xu C,
Unnikrishnan G, Staab JS, Matheny RW Jr, McClung JP, Reifman J, Bouxsein
ML.
Changes in tibial bone microarchitecture in female recruits in response to 8 weeks of U.S. Army Basic Combat Training.
Bone. 2018 Apr 27. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
9
Sfeir JG, Drake MT, Atkinson EJ, Achenbach SJ, Camp JJ, Tweed AJ, McCready LK, Yu L, Adkins MC, Amin S, Khosla S.
Evaluation
of cross-sectional and longitudinal changes in volumetric bone mineral
density in postmenopausal women using single- versus dual-energy
quantitative computed
tomography.
Bone. 2018 Apr 25;112:145-52.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
10
Jin X, Li F, Liu B, Zheng X, Li H, Ye F, Chen W, Li Q.
Different
mitochondrial fragmentation after irradiation with X-rays and carbon
ions in HeLa cells and its influence on cellular apoptosis.
Biochem Biophys Res Commun. 2018 May 2. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
11
Goetzke R, Sechi A, De Laporte L, Neuss S, Wagner W.
Why the impact of mechanical stimuli on stem cells remains a challenge.
Cell Mol Life Sci. 2018 May 4. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
12
Javaheri B, Carriero A, Wood M, De Souza R, Lee PD, Shefelbine S, Pitsillides AA.
Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response.
Sci Rep. 2018 Apr 27;8(1):6636.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
13
Meng F, Murray GF, Kurgan L, Donahue HJ.
Functional
and structural characterization of osteocytic MLO-Y4 cell proteins
encoded by genes differentially expressed in response to mechanical
signals
in vitro.
Sci Rep. 2018 Apr 30;8(1):6716.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
14
Bérut A, Chauvet H, Legué V, Moulia B, Pouliquen O, Forterre Y.
Gravisensors in plant cells behave like an active granular liquid.
Proc Natl Acad Sci U S A. 2018 Apr 30. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
15
Elhakeem A, Markovic D, Broberg A, Anten NPR, Ninkovic V.
Aboveground mechanical stimuli affect belowground plant-plant communication.
PLoS One. 2018 May 2;13(5):e0195646.
https://www.ncbi.nlm.nih.gov/
Note:
This article may be obtained online without charge.
16
Nugroho WD, Nakaba S, Yamagishi Y, Begum S, Rahman MH, Kudo K, Marsoem SN, Funada R.
Stem gravitropism and tension wood formation in
Acacia mangium seedlings inclined at various angles.
Ann Bot. 2018 May 3. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
17
Mansikka H, Virtanen K, Harris D.
Comparison
of NASA-TLX scale, Modified Cooper-Harper scale and mean inter-beat
interval as measures of pilot mental workload during simulated flight
tasks.
Ergonomics. 2018 Apr 30:1-22. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note:
The NASA Task Load Index was used.
