NASA Spaceline Current Awareness List #791 23 March 2018 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at
https://taskbook.nasaprs.com/
Senior Editor, SPACELINE@nasaprs.com.
Papers deriving from NASA support:
1
Beheshti A, Cekanaviciute E, Smith DJ, Costes SV.
Global transcriptomic analysis suggests carbon
dioxide as an environmental stressor in spaceflight: A systems biology
GeneLab case study.
Sci Rep. 2018 Mar 8;8(1):4191.
https://www.ncbi.nlm.nih.gov/
Note: STS-70, STS-108, STS-135, Bion-M1 results. NASA’s GeneLab is available at
https://genelab.nasa.gov/. This article may be obtained online without charge.
Journal Impact Factor: 4.259
Funding: “Research funding was provided by
the GeneLab Project at NASA Ames Research Center, through NASA’s Space
Biology Program in the Division of Space Life and Physical Sciences
Research and Applications (SLPSRA).” S. Costes
is affiliated with NASA Ames Research Center.
2
Lee AG, Mader TH, Gibson CR, Brunstetter TJ, Tarver WJ.
Space flight-associated neuro-ocular syndrome (SANS).
Eye (Lond). 2018 Mar 12. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
Note: ISS results.
Journal Impact Factor: 2.275
Funding: No funding cited. T.H. Mader and W.J. Tarver are affiliated with NASA Johnson Space Center.
3
Marshall-Goebel K, Stevens B, Rao CV, Suarez JI, Calvillo E, Arbeille P, Sangi-Haghpeykar H, Donoviel DB, Mulder E, Bershad EM.
Internal jugular vein volume during head-down tilt and carbon dioxide exposure in the SPACECOT study.
Aerosp Med Hum Perform. 2018 Apr;89(4):351-6.
https://www.ingentaconnect.
PI: E.M. Bershad
Note: Head-down tilt bed rest study.
Journal Impact Factor: 0.933
Funding: “This study was supported by the
National Space Biomedical Research Institute (NSBRI) through NASA NCC
9-58, Baylor College of Medicine Center for Space Medicine and the
German Aerospace Center (DLR) Institute of Aerospace
Medicine.”
4
Limpose KL, Trego KS, Li Z, Leung SW, Sarker AH, Shah JA, Ramalingam SS, Werner EM, Dynan WS, Cooper PK, Corbett AH, Doetsch PW.
Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer.
Nucleic Acids Res. 2018 Mar 7. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: W.S. Dynan
Note: This article may be obtained online without charge.
Journal Impact Factor: 10.162
Funding: “National Institutes of Health
[ES011163 to P.W.D. while employed at Emory University, GM058728 to
A.H.C., ES019935 to P.K.C.]; NASA [NNX15AD63G to W.S.D.]; National
Center for Advancing Translational Sciences of the National
Institutes of Health [UL1TR000454]; Winship Cancer Institute of Emory
University and NIH/NCI (in part) [P30CA138292]; Maiola Family Fund for
lung cancer research. This research was supported in part by the
Intramural Research Program of the NIH, National Institute
of Environmental Health Sciences (to P.W.D.).”
5
Becker RL, Siamwala JH, Macias BR, Hargens AR.
Tibia bone microvascular flow dynamics as compared to anterior tibial artery flow during body tilt.
Aerosp Med Hum Perform. 2018 Apr;89(4):357-64.
https://www.ingentaconnect.
PI: A.R. Hargens
Journal Impact Factor: 0.933
Funding: “This study was supported by NASA grant number NNX13AJ12G.”
6
Carr H, Alexander TC, Groves T, Kiffer F, Wang J, Price E, Boerma M, Allen AR.
Early effects of 16O radiation on neuronal morphology and cognition in a murine model.
Life Sci Space Res. 2018 Mar 14. [Article in Press]
https://www.sciencedirect.com/
PI: M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation
Journal Impact Factor: 1.97
Funding: “This work was supported by NSBRI Grant RE03701 thru NCC 9-58.”
7
Kiffer F, Howe AK, Carr H, Wang J, Alexander T, Anderson JE, Groves T, Seawright JW, Sridharan V, Carter G, Boerma M, Allen AR.
Late effects of 1H irradiation on hippocampal physiology.
Life Sci Space Res. 2018 Mar 15. [Article in Press]
https://www.sciencedirect.com/
PI: M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation
Journal Impact Factor: 1.97
Funding: “This work was supported by the
National Space Biomedical Research Institute (NSBRI) Grant RE03701
through NASA cooperative agreement NCC 9-58. The funders had no role in
study design, data collection and analysis, decision
to publish, or preparation of the manuscript. This work was also
supported by Core Facilities of the Center for Translational
Neuroscience IDeA program award P30 GM110702.”
8
Parihar VK, Maroso M, Syage A, Allen BD, Angulo MC, Soltesz I, Limoli CL.
Persistent nature of alterations in cognition
and neuronal circuit excitability after exposure to simulated cosmic
radiation in mice.
Exp Neurol. 2018 Mar 11. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: C.L. Limoli/V. Parihar/I. Soltesz/NSCOR
Journal Impact Factor: 4.706
Funding: “This work was supported by NASA Grant NNX15AI22G (IS, CLL).”
9
Boyle R, Ehsanian R, Mofrad A, Popova Y, Varelas J.
Morphology of the utricular otolith organ in the toadfish,
Opsanus tau.
J Comp Neurol. 2018 Mar 10. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: R. Boyle
Journal Impact Factor: 3.266
Funding: “We would like to gratefully
acknowledge the funding from research grants NIH/NIDCD (P01 DC01837) and
NASA (03-OBPR-04 and 11_Omni_2-0002) to RB, the NASA Postdoctoral
Program administered by Oak Ridge Associated Universities
(to YP), the Ames Associates Program (to RE and AM), and the support
from the NASA Human Research and Space Biology Programs (to RB).”
10
Höhner R, Marques JV, Ito T, Amakura Y, Budgeon AD, Weitz K, Hixson KK, Davin LB, Kirchhoff H, Lewis NG.
Reduced arogenate dehydratase expression: Ramifications for photosynthesis and metabolism.
Plant Physiol. 2018 Mar 9. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: N.G. Lewis
Note: This article may be obtained online without charge.
Journal Impact Factor: 6.456
Funding: “This work was mainly funded by the
Chemical Sciences, Geosciences and Biosciences Division, U.S.
Department of Energy Office of Basic Energy Sciences
(DE-FG-0397ER20259), the National Aeronautics and Space Administration
(NNX15AG56G), and by the US National Institute of Food and Agriculture
(NIFA, 2011-68005-30416).”
______________________________
Other papers of interest:
1
Aunins TR, Erickson KE, Prasad N, Levy SE, Jones A, Shrestha S, Mastracchio R, Stodieck L, Klaus D, Zea L, Chatterjee AR.
Spaceflight modifies Escherichia coli gene expression in response to antibiotic exposure and reveals role of oxidative stress response.
Front Microbiol. 2018 Mar 16;9:310.
https://www.frontiersin.org/
Note: ISS results. This article may be obtained online without charge.
2
Pastushkova LK, Kashirina DN, Kononikhin AS,
Brzhozovsky AG, Ivanisenko VA, Tiys ES, Novosyolova AM, Custaud M-A,
Nikolaev EN, Larina IM.
The effect of long-term space flights on human urine proteins functionally related to endothelium.
Hum Physiol. 2018 Jan 1;44(1):60-7.
https://link.springer.com/
Note: ISS results. Originally published in Russian in Fiziologiya Cheloveka, 2018;44(1):72–81.
3
Fomina EV, Lysova NY, Savinkina AO.
Axial load during the performance of locomotor training in microgravity as a factor of hypogravity countermeasure efficiency.
Hum Physiol. 2018 Jan 1;44(1):47-53.
https://link.springer.com/
Note: ISS results. Originally published in Russian in Fiziologiya Cheloveka, 2018;44(1):56–63.
4
Zhang C, Li L, Jiang Y, Wang C, Geng B, Wang Y, Chen J, Liu F, Qiu P, Zhai G, Chen P, Quan R, Wang J.
Space microgravity drives transdifferentiation
of human bone marrow-derived mesenchymal stem cells from osteogenesis to
adipogenesis.
FASEB J. 2018 Mar 13:fj201700208RR.
https://www.ncbi.nlm.nih.gov/
Note: Chinese SJ-10 Recoverable Scientific Satellite results. This article may be obtained online without charge.
5
Niederwieser T, Kociolek P, Klaus D.
A review of algal research in space.
Acta Astronaut. 2018 May;146:359-67. Epub 2018 Mar 16.
https://www.sciencedirect.com/
Note: Spaceflight results. From the
abstract: “This paper reviews past algal experiments flown in space from
1960 until today. Experimental methods and results from 51
investigations utilizing either green algae (Chlorophyta), cyanobacteria
(Cyanophyta), or Euglenophyta are analyzed and categorized by a variety
of parameters, including size, species and duration.”
6
Komorowski M, Campbell MR.
The Bion Project and the history of post-spaceflight primate anesthesia.
Aerosp Med Hum Perform. 2018 Apr;89(4):414-5.
https://www.ingentaconnect.
Note: Bion Project history.
7
Floreani M, Rejc E, Taboga P, Ganzini A, Pišot R,
Šimunič B, Biolo G, Reggiani C, Passaro A, Narici M, Rittweger J, di
Prampero PE, Lazzer S.
Effects of 14 days of bed rest and following
physical training on metabolic cost, mechanical work, and efficiency
during walking in older and young healthy males.
PLoS One. 2018 Mar 12;13(3):e0194291.
https://www.ncbi.nlm.nih.gov/
Note: Bed rest study. This article may be obtained online without charge.
8
Garvican-Lewis LA, Vuong VL, Govus AD, Peeling P, Jung G, Nemeth E, Hughes D, Lovell G, Eichner D, Gore CJ.
Intravenous iron does not augment the haemoglobin mass response to simulated hypoxia.
Med Sci Sports Exerc. 2018 Mar 12. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Athletes trained at a simulated altitude (normobaric hypoxia) of 3000 m during the study.
9
O’Brien KA, Pollock RD, Stroud M, Lambert RJ, Kumar A, Atkinson RA, Green DA, Anton-Solanas A, Edwards LM, Harridge SDR.
Human physiological and metabolic responses to
an attempted winter crossing of Antarctica: The effects of prolonged
hypobaric hypoxia.
Physiol Rep. 2018 Mar 4;6(5):e13613.
https://www.ncbi.nlm.nih.gov/
Note: From the abstract: “In this applied
field study, subjects (n = 5, male, age 28–54 years) undertook a 40 week
Antarctica expedition in the winter months, which included 24 weeks
residing above 2500 m. Measurements taken pre-
and post-expedition revealed alterations to glucose and fatty acid
resonances within the serum metabolic profile, a 7.8 (+/-3.6)% increase
in respiratory exchange ratio measured during incremental exercise (area
under curve, P > 0.01, mean +/- SD) and a 2.1(+/-
0.8) % decrease in fat tissue (P < 0.05) postexpedition." This
article may be obtained online without charge.
10
Wrzesinski K, Fey SJ.
Metabolic reprogramming and the recovery of physiological functionality in 3d cultures in micro-bioreactors.
Bioengineering (Basel). 2018 Mar 7;5(1):E22.
https://www.ncbi.nlm.nih.gov/
Note: From the abstract: “The aim of this
study was to identify these basic principles and describe how they are
regulated so that they can be taken in consideration when
micro-bioreactors are designed. Here, we provide evidence
that one of these basic principles is hypoxia, which is a natural
consequence of multicellular structures grown in microgravity cultures.”
11
Zhou S, Yang X, Hu J, Mo C, Cao Y, Yang C.
Continuous hypergravity alters the cytoplasmic elasticity of MC3T3-E1 osteoblasts via actin filaments.
J Biomech. 2018 Feb 24.
https://www.ncbi.nlm.nih.gov/
Note: Centrifugation was used.
12
Jiang M, Lyu Q, Bai YG, Liu H, Yang J, Cheng JH, Zheng M, Ma J.
Focal adhesions are involved in simulated microgravity-induced basilar and femoral arterial remodelling in rats.
Can J Physiol Pharmacol. 2018 Mar 11. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study.
13
Kurazumi T, Ogawa Y, Yanagida R, Morisaki H, Iwasaki K.
Non-invasive intracranial pressure estimation during combined exposure to CO2 and head-down tilt.
Aerosp Med Hum Perform. 2018 Apr;89(4):365-70.
https://www.ingentaconnect.
14
Kramerova I, Torres JA, Eskin A, Nelson SF, Spencer MJ.
Calpain 3 and CaMKIIβ signaling are required to induce HSP70 necessary for adaptive muscle growth after atrophy.
Hum Mol Genet. 2018 Mar 8. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study.
15
Liporaci RF, Saad MC, Crescéencio JC, Marques F, Bevilaqua-Grossi D, Gallo-Júnior L.
Cardiac and musculoskeletal responses to the effects of passive and active tilt test in healthy subjects.
Arq Bras Cardiol. 2018 Jan;110(1):74-83.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
16
Zhou Z, Shi G, Zheng X, Jiang S, Jiang L.
Autophagy activation facilitates mechanical
stimulation-promoted osteoblast differentiation and ameliorates hindlimb
unloading-induced bone loss.
Biochem Biophys Res Commun. 2018 Mar 15. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study.
17
Braga-Tanaka I, Tanaka S, Kohda A, Takai D, Nakamura S, Ono T, Tanaka K, Komura JI.
Experimental studies on the biological effects
of chronic low dose-rate radiation exposure in mice: Overview of the
studies at Institute for Environmental Sciences.
Int J Radiat Biol. 2018 Mar 13. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
18
Britel M, Bourguignon M, Foray N.
The use of the term “radiosensitivity” through history of radiation: From clarity to confusion.
Int J Radiat Biol. 2018 Mar 13. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
19
Cline JM, Dugan G, Bourland JD, Perry DL, Stitzel
JD, Weaver AA, Jiang C, Tovmasyan A, Owzar K, Spasojevic I,
Batinic-Haberle I, Vujaskovic Z.
Post-irradiation treatment with a superoxide
dismutase mimic, MnTnHex-2-PyP(5+), mitigates radiation injury in the
lungs of non-human primates after whole-thorax exposure to ionizing
radiation.
Antioxidants (Basel). 2018 Mar 7;7(3):40.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
20
Szatmári T, Persa E, Kis E, Benedek A, Hargitai R, Sáfrány G, Lumniczky K.
Extracellular vesicles mediate low dose ionizing radiation-induced immune and inflammatory responses in the blood.
Int J Radiat Biol. 2018 Mar 13. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
21
Zhang P, Hu X, Liu B, Liu Z, Liu C, Cai J, Gao F, Cui J, Li B, Yang Y.
Effects of 12C6+ heavy ion radiation on dendritic cells function.
Med Sci Monit. 2018 Mar 11;24:1457-63.
https://www.ncbi.nlm.nih.gov/
22
Golding JF, Wesnes KA, Leaker BR.
The effects of the selective muscarinic M3
receptor antagonist Darifenacin, and of Hyoscine (scopolamine), on
motion sickness, skin conductance & cognitive function.
Br J Clin Pharmacol. 2018 Mar 9. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
23
Muller L, Bennett MJ, French A, Wells DM, Swarup R.
Root gravitropism: Quantification, challenges, and solutions.
Methods Mol Biol. 2018;1761:103-12.
https://www.ncbi.nlm.nih.gov/
24
Schöller M, Kleine-Vehn J, Feraru E.
Cortical cell length analysis during gravitropic root growth.
Methods Mol Biol. 2018;1761:191-7.
https://www.ncbi.nlm.nih.gov/
25
Schöller M, Sarkel E, Kleine-Vehn J, Feraru E.
Growth rate normalization method to assess gravitropic root growth.
Methods Mol Biol. 2018;1761:199-208.
https://www.ncbi.nlm.nih.gov/
26
Xuan W, Opdenacker D, Vanneste S, Beeckman T.
Long-term in vivo imaging of luciferase-based reporter gene expression in Arabidopsis roots.
Methods Mol Biol. 2018;1761:177-90.
https://www.ncbi.nlm.nih.gov/
27
Maggi F, Tang FHM, Pallud C, Gu C.
A urine-fuelled soil-based bioregenerative life support system for long-term and long-distance manned space missions.
Life Sci Space Res. 2018 May;17:1-14. Epub 2018 Mar 20.
https://www.sciencedirect.com/
28
Gou X, Li A, Tian H, Wang C, Lu H.
Overload control of artificial gravity facility using spinning tether system for high eccentricity transfer orbits.
Acta Astronaut. 2018 Mar 14. [Article in Press]
https://www.sciencedirect.com/
Note: The authors propose a method of creating artificial gravity during long-duration spaceflights.
29
Braddock M.
Factors driving benefit and risk for astronaut health on deep space missions.
Occup Med Health Aff. 2018 Feb 11;6(1):e114.
Note: This article may be obtained online without charge.
