NASA Spaceline Current Awareness List #763 1 September 2017 (Space Life Science Research Results))
SPACELINE Current Awareness Lists are distributed via listserv. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,rertwine@nasaprs.com.
Papers deriving from NASA support:
1
Morrison MD, Fajardo-Cavazos P, Nicholson WL.
Cultivation in space flight produces minimal alterations in the susceptibility of Bacillus subtilis cells to 72 different antibiotics and growth-inhibiting compounds.
Appl Environ Microbiol. 2017 Aug 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: W.L. Nicholson
Note: ISS results.
Journal Impact Factor: 3.807
Funding: “This work was supported by NASA Research Opportunities in Space Biology grant NNX14AT38G to W.L.N. and P.F.-C. This work was supported by NASA Research
409 Opportunities in Space Biology grant NNX14AT38G to W.L.N. and P.F.-C.”
2
Venkateswaran K, Checinska Sielaff A, Ratnayake S, Pope RK, Blank TE, Stepanov VG, Fox GE, van Tongeren SP, Torres C, Allen J, Jaing C, Pierson D, Perry J, Koren S, Phillippy A, Klubnik J, Treangen TJ, Rosovitz MJ, Bergman NH.
Draft genome sequences from a novel clade of Bacillus cereus Sensu Lato strains, isolated from the International Space Station.
Genome Announc. 2017 Aug 10;5(32):e00680-17.
https://www.ncbi.nlm.nih.gov/
PIs: K. Venkateswaran, C. Jaing
Note: ISS results. GeneLab: “The complete genome sequences were deposited in NCBI under the accession numbers listed in Table 1 and can be accessed from the NASA GeneLab system (GLDS-64; https://genelab-data.ndc.nasa.
Journal Impact Factor: Not available for this journal
Funding: “Part of the research described in this publication was carried out at the Jet Propulsion Laboratory (JPL), California Institute of Technology, under a contract with NASA. The contributions of S.R., R.K.P., T.E.B., S.K., A.P., J.K., T.J.T., M.J.R., and N.H.B. were funded under contract no. HSHQDC-07-C-00020 awarded by the Department of Homeland Security (DHS) Science and Technology Directorate (S&T) for the management and operation of the National Biodefense Analysis and Countermeasures Center (NBACC), a Federally Funded Research and Development Center. This research was also funded by 2012 Space Biology (NNH12ZTT001N) grant no. 19-12829-26 under Task Order NNN13D111T awarded to K.V., which also funded the postdoctoral fellowship for A.C.S., and by JPL subcontract 1506453 to G.E.F. The research carried out at Lawrence Livermore National Laboratory was funded by 2014 Space Biology (NNH14ZTT002N) grant no. NNX15AJ29G awarded to C.J., which also funded J.A. and C.T. The contribution of S.P.V.T. was supported by the European Space Agency (MAP Project no. AO-LS-99-MAP-LSS-018 “biofilms”) and SRON (MG-064/MG-068).”
3
Radugina EA, Almeida EAC, Blaber E, Poplinskaya VA, Markitantova YV, Grigoryan EN.
Exposure to microgravity for 30 days onboard Bion M1 caused muscle atrophy and decreased regeneration in murine femoral quadriceps.
Life Sci Space Res. 2017 Aug 24. [Article in Press]
http://www.sciencedirect.com/
PI: E.A. Almeida
Note: Bion-M1 results.
Journal Impact Factor: 1.97
Funding: PI reports funding under NASA grant “The Role of the p53 Pathway in Spaceflight-Induced Tissue Degeneration.”
4
Shen H, Lim C, Schwartz AG, Andreev-Andrievskiy A, Deymier AC, Thomopoulos S.
Effects of spaceflight on the muscles of the murine shoulder.
FASEB J. 2017 Aug 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PIs: S. Thomopoulos; A.C. Deymier, NSBRI Postdoctoral Fellowship Program
Note: STS-131, STS-135, and Bion-M1 results.
Journal Impact Factor: 5.498
Funding: “This work was supported by Grants NASA NNX09AP05G and NSBRI PD13-0019, and the Plan for Fundamental Research of the State Research Centre of the Russian Federation (SRC RF) Institute of Biomedical Problems, Russian Academy of Science. Proteomics analysis was supported by a U.S. National Institutes of Health (NIH), National Cancer Institute Grant P30-CA91842”
5
Macaulay TR, Siamwala JH, Hargens AR, Macias BR.
Thirty days of spaceflight does not alter murine calvariae structure despite increased Sostexpression.
Bone Rep. 2017 Dec;7:57-62. Epub 2017 Aug 18.
http://www.sciencedirect.com/
PIs: A.R. Hargens, B.R. Macias
Note: STS-131 results. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This study was funded by the National Space Biomedical Research Institute through NCC 9-58 to BRM, and by NASA through NNX09AP11G to ARH.”
6
Johnson CM, Subramanian A, Pattathil S, Correll MJ, Kiss JZ.
Comparative transcriptomics indicate changes in cell wall organization and stress response in seedlings during spaceflight.
Am J Bot. 2017 Aug 21. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: J.Z. Kiss
Note: STS-131 results. GeneLab: From the Analysis of Microarrays: “BRIC-16-Cyt data were deposited in the NASA GeneLab under accession number GLDS-121 (https://genelab-data.ndc.
Journal Impact Factor: 3.05
Funding: “Financial support for BRIC-16-Cyt (J. Z. Kiss, Principal Investigator) was provided by NASA grant (NNX10AF44G). The authors thank Michael G. Hahn at CCRC, UGA for the glycome profiling platform. The generation of the CCRC series of plant cell wall glycan-directed monoclonal antibodies used in this work was supported by the NSF Plant Genome Program (DBI-0421683 and IOS-0923922).”
7
Schmidt MA, Bailey SM, Goodwin TJ, Jones JA, Killian JP, Legato MJ, Limoli C, Moussa S, Ploutz-Snyder L.
Men, women, and space travel: Gene-linked molecular networks, human countermeasures, and legal and ethical considerations.
Gend Genome. 2017 Jun 1;1(2):54-67.
http://online.liebertpub.com/
PI: S.M. Bailey
Note: ISS results are discussed. This roundtable discussion considers the many issues surrounding the personalized assessment and preparation of individual space travelers.
Journal Impact Factor: Not available for this journal
Funding: PI reports funding under NASA grant NNX14AB02G.
8
Lindner JR.
The fast and the curious: Physiological insights from fast frame rate imaging.
JACC Cardiovasc Imaging. 2017 Aug 11. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: J.R. Lindner
Note: This article is an Editorial Comment on: Maresca D, Correia M, Villemain O, Bizé A, Sambin L, Tanter M, Ghaleh B, Pernot M. Noninvasive imaging of the coronary vasculature using ultrafast ultrasound. JACC Cardiovasc Imaging. 2017 Aug 11. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 10.189
Funding: “Dr. Lindner is supported by grants R01-HL078610 and R01-HL130046 from the National Institutes of Health and grant 14NSBRI1-0025 from the National Space Biomedical Research Institute (NASA).”
9
Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK.
Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome.
Microbiome. 2017 Aug 18;5(1):105.
https://www.ncbi.nlm.nih.gov/
PIs: M. Boerma/I. Koturbash/G.A. Nelson/M. Hauer-Jensen/NSBRI Center for Research on Cardiovascular and Acute Effects of Space Radiation
Note: This article may be obtained online without charge.
Journal Impact Factor: 8.496
Funding: “This study was supported by the National Space Biomedical Research Institute [RE03701 through NCC 9–58] and the NIH National Center for Advancing Translational Science (NCATS) UCLA CTSI Grant Number UL1TR00188. The authors would also like to acknowledge the Metabolomics Shared Resource in Georgetown University (Washington DC, USA) partially supported by NIH/NCI/CCSG grant P30-CA051008.”
10
McKenna MJ, Bailey SM.
Chromosomal and telomeric biomarkers of normal tissue injury to evaluate risk of degenerative health effects (secondary malignancy, cardiovascular disease) post radiation therapy.
Translational Cancer Research. 2017 Jul;6(Suppl 5):S789-S794.
http://tcr.amegroups.com/
PI: S.M. Bailey
Note: This article may be obtained online without charge.
Journal Impact Factor: 1.29
Funding: “Support from NASA (NNX14AB02G; NNX14AH51G) is gratefully acknowledged.”
11
Paloski WH, Reschke MF, Feiveson AH.
Bed rest and intermittent centrifugation effects on human balance and neuromotor reflexes.
Aerosp Med Hum Perform. 2017 Sep 1;88(9):812-8.
https://www.ncbi.nlm.nih.gov/
Note: Centrifugation and bed rest were used.
Journal Impact Factor: 0.933
Funding: “This project was supported by the NASA Human Research Program, including grant # NNJ04HD64G to MIT. The study was conducted at the NIH-funded [M01 RR 0073] GCRC at the University of Texas Medical Branch, Galveston, TX.” The authors are affiliated with NASA Johnson Space Center.
______________________________
Other papers of interest:
1
Anselm V, Novikova S, Zgoda V.
Re-adaption on Earth after spaceflights affects the mouse liver proteome.
Int J Mol Sci. 2017 Aug 12;18(8).
https://www.ncbi.nlm.nih.gov/
Note: Bion-M1 results. This article may be obtained online without charge.
2
Demontis GC, Germani MM, Caiani EG, Barravecchia I, Passino C, Angeloni D.
Human pathophysiological adaptations to the space environment.
Front Physiol. 2017 Aug 2;8:547. Review.
https://www.ncbi.nlm.nih.gov/
Note: Specific space missions are not identified. This article may be obtained online without charge.
3
Larina IM, Percy AJ, Yang J, Borchers CH, Nosovsky AM, Grigoriev AI, Nikolaev EN.
Protein expression changes caused by spaceflight as measured for 18 Russian cosmonauts.
Sci Rep. 2017 Aug 15;7(1):8142.
https://www.ncbi.nlm.nih.gov/
Note: ISS results. This article may be obtained online without charge.
4
Thiel CS, Huge A, Hauschild S, Tauber S, Lauber BA, Polzer J, Paulsen K, Lier H, Engelmann F, Schmitz B, Schütte A, Layer LE, Ullrich O.
Stability of gene expression in human T cells in different gravity environments is clustered in chromosomal region 11p15.4.
npj Microgravity. 2017 Aug 31;3(1):22.
https://www.nature.com/
Note: Parabolic flight, TEXUS-51, and 2D clinostat results. This article may be obtained online without charge.
5
Fomina E, Savinkina A.
Locomotion strategy and magnitude of ground reaction forces during treadmill training on ISS.
Aerosp Med Hum Perform. 2017 Sep 1;88(9):841-9.
https://www.ncbi.nlm.nih.gov/
6
Wang H, Li W, Gu L, Gao X, Ni B, Deng H, Yang R, Han Y.
Emergence of two distinct subpopulations from Klebsiella pneumoniae grown in the simulated microgravity environment.
Future Microbiol. 2017 Sep;12:939-51.
https://www.ncbi.nlm.nih.gov/
Note: A rotating wall vessel bioreactor was used.
7
Maresca D, Correia M, Villemain O, Bizé A, Sambin L, Tanter M, Ghaleh B, Pernot M.
Noninvasive imaging of the coronary vasculature using ultrafast ultrasound.
JACC Cardiovasc Imaging. 2017 Aug 11. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: This article is the subject of an Editorial Comment by Lindner JR. The fast and the curious: Physiological insights from fast frame rate imaging. JACC Cardiovasc Imaging. 2017 Aug 11. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/
8
Kurazumi T, Ogawa Y, Yanagida R, Morisaki H, Iwasaki KI.
Dynamic cerebral autoregulation during the combination of mild hypercapnia and cephalad fluid shift.
Aerosp Med Hum Perform. 2017 Sep 1;88(9):819-26.
https://www.ncbi.nlm.nih.gov/
9
Marshall-Goebel K, Terlević R, Gerlach DA, Kuehn S, Mulder E, Rittweger J.
Lower body negative pressure reduces optic nerve sheath diameter during head-down tilt.
J Appl Physiol (1985). 2017 Aug 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Head-down tilt study.
10
Fisher AG, Seaborne RA, Hughes TM, Gutteridge A, Stewart C, Coulson JM, Sharples AP, Jarvis JC.
Transcriptomic and epigenetic regulation of disuse atrophy and the return to activity in skeletal muscle.
FASEB J. 2017 Aug 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Mouse tibialis anterior muscles were exposed to tetradotoxin (TTX).
11
Fry AC, Housh TJ, Cramer JB, Weir JP, Beck TW, Schilling BK, Miller JD, Nicoll JX.
Noninvasive assessment of skeletal muscle myosin heavy chain expression in trained and untrained men.
J Strength Cond Res. 2017 Sep;31(9):2355-62.
https://www.ncbi.nlm.nih.gov/
12
Ito M, Kudo N, Miyake Y, Imai T, Unno T, Yamashita Y, Hirota Y, Ashida H, Osakabe N.
Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice.
Exp Gerontol. 2017 Aug 12;98:120-3. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study.
13
Kanazawa Y, Ikegami K, Sujino M, Koinuma S, Nagano M, Oi Y, Onishi T, Sugiyo S, Takeda I, Kaji H, Shigeyoshi Y.
Effects of aging on basement membrane of the soleus muscle during recovery following disuse atrophy in rats.
Exp Gerontol. 2017 Aug 10;98:153-61.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study.
14
Leite MA, de Mattia TM, Kakihata CMM, Bortolini BM, de Carli Rodrigues PH, Bertolini GRF, Brancalhão RMC, Ribeiro LFC, Nassar CA, Nassar PO.
Experimental periodontitis in the potentialization of the effects of immobilism in the skeletal striated muscle.
Inflammation. 2017 Aug 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb immobilization was accomplished by using a molded orthosis.
15
Whiteman JP, Harlow HJ, Durner GM, Regehr EV, Rourke BC, Robles M, Amstrup SC, Ben-David M.
Polar bears experience skeletal muscle atrophy in response to food deprivation and reduced activity in winter and summer.
Conserv Physiol. 2017 Aug 9;5(1):cox049.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
16
Arvind V, Huang AH.
Mechanobiology of limb musculoskeletal development.
Ann N Y Acad Sci. 2017 Aug 22. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
17
Hunckler MD, Chu ED, Baumann AP, Curtis TE, Ravosa MJ, Allen MR, Roeder RK.
The fracture toughness of small animal cortical bone measured using arc-shaped tension specimens: Effects of bisphosphonate and deproteinization treatments.
Bone. 2017 Aug 18;105:67-74.
https://www.ncbi.nlm.nih.gov/
18
Linossier MT, Amirova LE, Thomas M, Normand M, Bareille MP, Gauquelin-Koch G, Beck A, Costes-Salon MC, Bonneau C, Gharib C, Custaud MA, Vico L.
Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines.
PLoS One. 2017 Aug 14;12(8):e0182970.
https://www.ncbi.nlm.nih.gov/
Note: Dry immersion was used. This article may be obtained online without charge.
19
Pineda N, Owen M, Tucker C, Wojda S, Kitchen S, Black H, Donahue S.
Hibernating little pocket mice show few seasonal changes in bone properties.
Anat Rec (Hoboken). 2017 Aug 14. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
20
Murley JS, Miller RC, Weichselbaum RR, Grdina DJ.
TP53 mutational status and ROS effect the expression of the survivin-associated radio-adaptive response.
Radiat Res. 2017 Aug 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
21
Sollazzo A, Brzozowska B, Cheng L, Lundholm L, Haghdoost S, Scherthan H, Wojcik A.
Alpha particles and X rays interact in inducing DNA damage in U2OS cells.
Radiat Res. 2017 Aug 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
22
Shima K, Shimatani K, Sato G, Sakata M, Giannoni P, Morasso P.
A fundamental study on how holding a helium-filled balloon affects stability in human standing.
IEEE Int Conf Rehabil Robot. 2017 Jul;2017:1061-6.
https://www.ncbi.nlm.nih.gov/
23
Gimmon Y, Millar J, Pak R, Liu E, Schubert MC.
Central not peripheral vestibular processing impairs gait coordination.
Exp Brain Res. 2017 Aug 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
24
Mathews MA, Camp AJ, Murray AJ.
Reviewing the role of the efferent vestibular system in motor and vestibular circuits.
Front Physiol. 2017 Aug 2;8:552. Review.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
25
Pomante A, Selen LPJ, Medendorp WP.
Perception of the dynamic visual vertical during sinusoidal linear motion.
J Neurophysiol. 2017 Aug 16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: From the Abstract: “We devised a novel paradigm to psychometrically characterize the dynamic visual vertical – as a proxy for the tilt percept – during passive sinusoidal linear motion along the inter-aural axis (0.33Hz motion frequency, 1.75m/s2 peak acceleration, 80cm displacement). While subjects (n=10) kept fixation on a central body-fixed light, a line was briefly flashed (5ms) at different phases of the motion, the orientation of which had to be judged relative to gravity.”
26
Ramos de Miguel A, Falcon Gonzalez JC, Ramos Macias A.
Vestibular response to electrical stimulation of the otolith organs. Implications in the development of a vestibular implant for the improvement of the sensation of gravitoinertial accelerations.
J Int Adv Otol. 2017 Aug;13(2):154-61.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
27
Tachibana K, Tachibana S, Inoue N.
From outer space to Earth—The social significance of isolated and confined environment research in human space exploration.
Acta Astronaut. 2017 Aug 13. [Article in Press]
http://www.sciencedirect.com/
28
Campbell MR.
Dr. William Carpentier-Apollo 11 Flight Surgeon.
Aerosp Med Hum Perform. 2017 Sep 1;88(9):892-3.
https://www.ncbi.nlm.nih.gov/
29
Fal K, Asnacios A, Chabouté ME, Hamant O.
Nuclear envelope: A new frontier in plant mechanosensing?
Biophys Rev. 2017 Aug 12. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
30
He Y, Shi Y, Zhang X, Wang H, Xu X, Wu J.
Identification of a gravitropism-deficient mutant in rice.
Rice Science. 2017 Mar;24(2):109-18.
http://www.sciencedirect.com/
31
Singh M, Gupta A, Laxmi A.
Striking the right chord: Signaling enigma during root gravitropism.
Front Plant Sci. 2017 Jul 27;8:1304.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
32
Yoshihara T, Spalding EP.
LAZY genes mediate the effects of gravity on auxin gradients and plant architecture.
Plant Physiol. 2017 Aug 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
33
Upadhyaya A.
Mechanosensing in the immune response.
Semin Cell Dev Biol. 2017 Aug 19. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
34
Zhou L, Zhang C, Zhang F, Lu S, Sun S, Lu D, Long M.
Theoretical modeling of mechanical homeostasis of a mammalian cell under gravity-directed vector.
Biomech Model Mechanobiol. 2017 Aug 17. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: From the Introduction: “Recently, we developed an orientation-varied assay to quantify the impact of gravity vector on mechanical stability and biological phenotype of a typical mammalian cell type of MC3T3-E1 cells. By placing the cells onto an upward (U)-, downward (D)-, or edge-on (E)-orientated substrate, longtime nucleus longitudinal translocation initiates the CSK remodeling to resist the translocation mechanically and then mediate the focal adhesion complex (FAC) reorganization to anchor the cell stably on the substrate (Zhang et al. 2017). This orientation-varied approach is based on the strategy that vector-directed gravity varies in a constant angle, rather than that changed periodically in clinostat (Vorselen et al. 2014), with respect to the culture substrate, which brings up an opportunity to conduct theoretical analyses on how the cytoskeleton itself is affected and how the CSK network is reorganized to maintain mechanical homeostasis on altered gravity vector in long time.”
35
Dai K, Yu Q, Zhang Z, Wang Y, Wang X.
Aromatic hydrocarbons in a controlled ecological life support system during a 4-person-180-day integrated experiment.
Sci Total Environ. 2018 Jan 1;610-611:905-11. Epub 2017 Aug 19.
https://www.ncbi.nlm.nih.gov/
Note: From the Methods section: “The 4-person-180-day experiment was conducted inside the controlled ecological life support system (CELSS) in Shenzhen, China: four researchers lived in this closed ecosystem for 180 days from 17 June to 14 December 2016.” This article may be obtained online without charge.
36
Lehnert C, Karlsson E, Giannopapa C.
Global risk & global challenges – Space as a game changer for socioeconomic sustainable development.
Acta Astronautica. 2017 Nov;140:59-65. Epub 2017 Aug 9.
http://www.sciencedirect.com/
37
Galy E, Paxion J, Berthelon C.
Measuring mental workload with the NASA-TLX needs to examine each dimension rather than relying on the global score: An example with driving.
Ergonomics. 2017 Aug 17:1-27. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used.
38
Yan S, Tran CC, Wei Y, Habiyaremye JL.
Driver’s mental workload prediction model based on physiological indices.
Int J Occup Saf Ergon. 2017 Aug 18. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
Note: The NASA Task Load Index was used.
