NASA Spaceline Current Awareness List #757 14 July 2017 (Space Life Science Research Results)
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Papers deriving from NASA support:
1
Venkateswaran K, Singh NK, Checinska Sielaff A, Pope RK, Bergman NH, van Tongeren SP, Patel NB, Lawson PA, Satomi M, Williamson CHD, Sahl JW, Keim P, Pierson D, Perry J.
Non-toxin-producing Bacillus cereus strains belonging to the B. anthracis clade isolated from the International Space Station.
mSystems. 2017 Jun 27;2(3):e00021-17.
https://www.ncbi.nlm.nih.gov/
PI: K. Venkateswaran
Note: ISS results. NASA GeneLab: “The whole-genome sequences submitted to the NCBI and NASA GeneLab databases were downloaded and characterized during this study. The supporting raw data, scripts, and results are available at ftp://ftp.cbcb.umd.edu/pub/
Journal Impact Factor: Not available for this journal
Funding: “…This research was funded by 2012 Space Biology NNH12ZTT001N grant 19-12829-26 under task order NNN13D111T award to K.V. and funded postdoctoral fellowship support for A.C.S. and N.S. The contribution of S.P.V.T. was supported by the European Space Agency (MAP project AO-LS-99-MAP-LSS-018 biofilms) and SRON (MG-064/MG-068). The contributions of R.K.P. and N.H.B. were funded under contract HSHQDC-07-C-00020.”
2
Blachowicz A, Mayer T, Bashir M, Pieber TR, De Leon P, Venkateswaran K.
Human presence impacts fungal diversity of inflated lunar/Mars analog habitat.
Microbiome. 2017 Jul 11;5(1):62.
https://www.ncbi.nlm.nih.gov/
PI: K. Venkateswaran
Note: An inflatable lunar/Mars analog habitat was used; for this experiment, it was located in Grand Forks, ND. Ars Technica published an article about this study on July 12, see https://arstechnica.com/
Journal Impact Factor: Not available for this journal
Funding: “This research was awarded to K. Venkateswaran and funded by a 2012 Space Biology NNH12ZTT001N Grant No. 19-12829-26 under Task Order NNN13D111T.”
3
Seidel DV, Azcárate-Peril MA, Chapkin RS, Turner ND.
Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk.
Semin Cancer Biol. 2017 Jul 1. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
PI: N.D. Turner
Journal Impact Factor: 9.141
Funding: “Work originating from the authors laboratories described in this review was supported by the United Sorghum Checkoff Program (HVM006-12), the California Dried Plum Board (PN12-20), NASA (NNX15AD64G), the National Institutes of Health (R01 CA168312, R35CA197707, RO1CA202697, RO1ES025713, P30ES02351), the NIH/National Institute of Diabetes and Digestive and Kidney Diseases grant (P30DK34987), and the Cancer Prevention Research Institute of Texas (RP160589IH). Derek Seidel also was supported by the Mentored Research Program in Space Life Sciences funded by the National Space Biomedical Research Institute through NCC 9-58 (EO02001).”
4
Howden M, Siamwala JH, Hargens AR.
Bone microvascular flow differs from skin microvascular flow in response to head-down tilt.
J Appl Physiol (1985). 2017 Jun 29:jap.00881.2016. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
PI: A.R. Hargens
Note: Head-down tilt study.
Journal Impact Factor: 3.351
Funding: “This study was supported by NASA grants NNX13AM89G, NNX13AJ12G and 375 NNX14AP25G.”
5
Ehresmann B, Zeitlin CJ, Hassler DM, Matthiä D, Guo J, Wimmer-Schweingruber RF, Appel JK, Brinza DE, Rafkin SCR, Böttcher SI, Burmeister S, Lohf H, Martin C, Böhm E, Reitz G.
The charged particle radiation environment on Mars measured by MSL/RAD from November 15, 2015 to January 15, 2016.
Life Sci Space Res. 2017 Jul 8. [Article in Press]
http://www.sciencedirect.com/
Journal Impact Factor: 1.97
Funding: “RAD is supported by NASA (HEOMD) under Jet Propulsion Laboratory (JPL) subcontract #1273039 to Southwest Research Institute and in Germany by the German Aerospace Center (DLR) and DLR’s Space Administration grant numbers 50QM0501 and 50QM1201 to the Christian-Albrechts-
6
Sands MM, Borrego D, Maynard MR, Bahadori AA, Bolch WE.
Comparison of methods for individualized astronaut organ dosimetry: Morphometry-based phantom library versus body contour autoscaling of a reference phantom.
Life Sci Space Res. 2017 Nov;15:23-31. Epub 2017 Jul 8.
http://www.sciencedirect.com/
Journal Impact Factor: 1.97
Funding: “This work was supported by Contracts T72472 and T73057 with Wyle Laboratories and NASA Johnson Space Center.”
7
Seawright JW, Samman Y, Sridharan V, Mao XW, Cao M, Singh P, Melnyk S, Koturbash I, Nelson GA, Hauer-Jensen M, Boerma M.
Effects of low-dose rate gamma-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart.
PLoS One. 2017 Jul 5;12(7):e0180594.
https://www.ncbi.nlm.nih.gov/
PIs: X.W. Mao; M. Boerma/X.W. Mao/I. Koturbash/G.A. Nelson/M. Hauer-Jensen/NSBRI Center for Research on Cardiovascular and Acute Effects of Space Radiation
Note: Hindlimb unloading study. This article may be obtained online without charge.
Journal Impact Factor: 2.806
Funding: “This work was supported by the National Space Biomedical Research Institute (www.nsbri.org) (RE03701) through NCC 9-58, the National Aeronautics and Space Administration (www.nasa.gov) (NASA grant number NNX13AL97G), and through an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (www.nigms.nih.gov) under grant number P20 GM109005.”
8
Turker MS, Grygoryev D, Lasarev M, Ohlrich A, Rwatambuga FA, Johnson S, Dan C, Eckelmann B, Hryciw G, Mao JH, Snijders AM, Gauny S, Kronenberg A.
Simulated space radiation-induced mutants in the mouse kidney display widespread genomic change.
PLoS One. 2017 Jul 6;12(7):e0180412.
https://www.ncbi.nlm.nih.gov/
PIs: M.S.Turker, A. Kronenberg
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.806
Funding: “This work was supported by NASA grants NNX10AC12G, NNX14AC97G, NNJ12HB88I, and NNJ16HP23I, Murdock Scholar Fellowships to Gwen Hryciw and Sorrel Johnson, and an Oregon Institute of Occupational Health Sciences summer fellowship to Bradley Eckelmann, and the Ted. R. Lilley Cancer Cure fellowship for high school students.”
9
Yin L, Vaught L, Okunieff P, Casey-Sawicki K, Vidyasagar S.
Amino acid hydration decreases radiation-induced nausea in mice: A pica model.
Adv Exp Med Biol. 2017;977:59-65.
https://www.ncbi.nlm.nih.gov/
PI: S. Vidyasagar
Note: This paper is published as Chapter 9 in Oxygen Transport to Tissue XXXIX, Volume 997 in the Advances in Experimental Medicine and Biology series published by Springer International, Chaum, Switzerland.
Journal Impact Factor: 1.953
Funding: “This research was supported by the National Space Biomedical Research Institute through NASA NCC 9-58 and Entrinsic Health Solutions (P0018160).”
10
Schmidt MA, Goodwin T, Cuttino M.
Personalized medicine in space flight, Part I: Standard clinical approaches.
In: Principles of gender-specific medicine: Gender in the genomic era. 3rd ed. San Diego: Academic Press, 2017. p. 655-72.
http://www.sciencedirect.com/
Journal Impact Factor: Not applicable to this publication
Funding: No funding cited. T. Goodwin was affiliated with NASA Johnson Space Center.
11
Schmidt MA, Goodwin T, Cuttino M.
Personalized medicine in space flight, Part II: Personalized precision medicine approaches.
In: Principles of gender-specific medicine: Gender in the genomic era. 3rd ed. San Diego: Academic Press, 2017. p. 673-93.
http://www.sciencedirect.com/
Journal Impact Factor: Not applicable to this publication.
Funding: No funding cited. T. Goodwin was affiliated with NASA Johnson Space Center.
______________________________
Other papers of interest:
1
Echalier EL, Subramanian PS.
Neuro-ophthalmolmic sequelae of sustained microgravity.
In: Ophthalmology in extreme environments. Cham: Springer International, 2017. p. 1-14.
https://link.springer.com/
Note: The article includes discussion of ISS results and head-down tilt studies.
2
Paul A-L, Sng NJ, Zupanska AK, Krishnamurthy A, Schultz ER, Ferl RJ.
Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight?
PLoS One. 2017 Jun 29;12(6):e0180186.
https://www.ncbi.nlm.nih.gov/
Note: ISS results. NASA GeneLab: “…the gene expression data and spaceflight-relevant metadata are deposited with NASA’s GeneLab repository https://genelab-data.ndc.nasa.
3
Takahashi K, Okumura H, Guo R, Naruse K.
Effect of oxidative stress on cardiovascular system in response to gravity.
Int J Mol Sci. 2017 Jul 4;18(7):E1426. Review.
https://www.ncbi.nlm.nih.gov/
Note: Results from Apollo, bed rest, and hindlimb unloading studies. This article may be obtained online without charge.
4
Cho Y, Porto DA, Hwang H, Grundy LJ, Schafer WR, Lu H.
Automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans.
Lab Chip. 2017 Jun 29. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
5
Tu L, Lu Z, Dieser K, Schmitt C, Chan SW, Ngan MP, Andrews PLR, Nalivaiko E, Rudd JA.
Brain activation by H1 antihistamines challenges conventional view of their mechanism of action in motion sickness: A behavioral, c-fos and physiological study in Suncus murinus(house musk shrew).
Front Physiol. 2017 Jun 14;8:412.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
6
Testoni G, Duran J, Garcia-Rocha M, Vilaplana F, Serrano AL, Sebastián D, López-Soldado I, Sullivan MA, Slebe F, Vilaseca M, Muñoz-Cánoves P, Guinovart JJ.
Lack of glycogenin causes glycogen accumulation and muscle function impairment.
Cell Metab. 2017 Jul 5;26(1):256-66.e4.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
7
Paiva KBS, Granjeiro JM.
Matrix metalloproteinases in bone resorption, remodeling, and repair.
Prog Mol Biol Transl Sci. 2017;148:203-303. Review.
https://www.ncbi.nlm.nih.gov/
8
Zhang G, Li C, Niu Y, Yu Q, Chen Y, Liu E.
Osteoprotective effect of Radix Scutellariae in female hindlimb-suspended Sprague-Dawley rats and the osteogenic differentiation effect of its major constituent.
Molecules. 2017 Jul 3;22(7):E1044.
https://www.ncbi.nlm.nih.gov/
Note: Hindlimb unloading study. This article may be obtained online without charge.
9
Hojo H, Dohmae T, Hotta K, Kohno R, Motegi A, Yagishita A, Makinoshima H, Tsuchihara K, Akimoto T.
Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out Bragg peak.
Radiat Oncol. 2017 Jul 3;12(1):111.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
10
Ratliff HN, Smith MBR, Heilbronn L.
Simulation of the GCR spectrum in the Mars Curiosity Rover’s RAD detector using MCNP6.
Life Sci Space Res. 2017 Jul 6. [Article in Press]
http://www.sciencedirect.com/
11
Stankevicius V, Vasauskas G, Rynkeviciene R, Venius J, Pasukoniene V, Aleknaviciusa E, Suziedelisa K.
Microenvironment and dose-delivery-dependent response after exposure to ionizing radiation in human colorectal cancer cell lines.
Radiat Res. 2017 Jul 7. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
12
Yim JH, Yun JM, Kim JY, Nam SY, Kim CS.
Estimation of low-dose radiation-responsive proteins in the absence of genomic instability in normal human fibroblast cells.
Int J Radiat Biol. 2017 Jul 6. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
13
Yasuda T, Kamahori M, Nagata K, Watanabe-Asaka T, Suzuki M, Funayama T, Mitani H, Oda S.
Abscopal activation of microglia in embryonic fish brain following targeted irradiation with heavy-ion microbeam.
Int J Mol Sci. 2017 Jul 4;18(7):E1428.
https://www.ncbi.nlm.nih.gov/
Note: This article may be obtained online without charge.
14
Morrison SA, Mirnik D, Korsic S, Eiken O, Mekjavic IB, Dolenc-Groselj L.
Bed rest and hypoxic exposure affect sleep architecture and breathing stability.
Front Physiol. 2017 Jun 20;8:410.
https://www.ncbi.nlm.nih.gov/
Note: Bed rest study. This article may be obtained online without charge.
15
Fei Q, Wei S, Zhou Z, Gao H, Li X.
Adaptation of root growth to increased ambient temperature requires auxin and ethylene coordination in Arabidopsis.
Plant Cell Rep. 2017 Jun 28. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/
16
Wasik AA, Schiller HB.
Functional proteomics of cellular mechanosensing mechanisms.
Semin Cell Dev Biol. 2017 Jul 1. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/
