NASA Spaceline Current Awareness List #732 20 January 2017 (Space Life Science Research Results)

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Papers deriving from NASA support:
 
1
Romoser AA, Scully RR, Limero TF, De Vera V, Cheng PF, Hand JJ, James JT, Ryder VE.
Predicting air quality at first ingress into vehicles visiting the International Space Station.
Aerosp Med Hum Perform. 2017 Feb;88(2):104-13.
http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000002/art00007
Note: ISS results.
Journal Impact Factor: 0.755
Funding: No funding cited. A.A. Romoser, R.R. Scully, T.F. Limero, V. De Vera, P.F. Chen, and V.E. Ryder are affiliated with NASA Johnson Space Center.
 
2
Nadir AJ, Sato K.
A hitchhiker’s guide to an ISS experiment in under 9 months.
npj Microgravity. 2017 Jan 12;3(1):6.
http://www.nature.com/articles/s41526-016-0003-7
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: No funding cited. K. Sato is at NASA Ames Research Center.
 
3
Orsini SS, Lewis AM, Rice KC.
Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression.
npj Microgravity. 2017 Jan 12;3(1):4.
http://www.nature.com/articles/s41526-016-0006-4
PI: K.C. Rice
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work was funded in part by a Florida Education Fund McKnight Doctoral Fellowship to S.S.O, NASA grant NNX13AM09G to K.C.R., and NIH grant R01 AI118999 to K.C.R.”
 
4
Raykin J, Snider E, Bheri S, Mulvihill J, Ethier CR.
A modified gelatin zymography technique incorporating total protein normalization.
Anal Biochem. 2017 Mar 15;521:8-10. Epub 2017 Jan 6.
https://www.ncbi.nlm.nih.gov/pubmed/28069453
PI: J. Raykin
Journal Impact Factor: 2.243
Funding: “This work was supported by the National Space Biomedical Research Institute through NCC 9e58, the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1148903, ELEVATE: Irish Research Council International Career Development Fellowship (co-funded by Marie Curie Actions), and by the Georgia Research Alliance.”
 
5
Philbrick KA, Wong CP, Branscum AJ, Turner RT, Iwaniec UT.
Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism.
J Endocrinol. 2017 Jan 5. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28057869
PI: R.T. Turner
Journal Impact Factor: 4.498
Funding: “This work was supported by grants from the NIH (AR060913), NASA (NNX12AL24G), and USDA (38420-17804).”
 
6
Spatz JM, Ellman R, Cloutier AM, Louis L, van Vliet M, Dwyer D, Stolina M, Ke HZ, Bouxsein ML.
Sclerostin antibody inhibits skeletal deterioration in mice exposed to partial weight-bearing.
Life Sci Space Res. 2017 Feb;12:32-8. Epub 2017 Jan 12.
http://www.sciencedirect.com/science/article/pii/S2214552416300554
PI: M.L. Bouxsein
Journal Impact Factor: Not available for this journal
Funding: “Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number R21 AR057522 and S10RR017868. The work was also supported by NASA NNX10AE39G, the National Space Biomedical Research Institute through NASA NCC 9-58, and a research grant from Amgen. RE was supported by a NASA Jenkins pre-doctoral fellowship. JMS was supported by a Northrop Grumman Aerospace Systems Ph.D. Training Fellowship and Hugh Hampton Young Fellowship.”
 
7
Alwood JS, Ronca AE, Mains RC, Shelhamer MJ, Smith JD, Goodwin TJ.
From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions.
npj Microgravity. 2017 Jan 12;3(1):5.
http://www.nature.com/articles/s41526-016-0002-8
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “The Human Health Countermeasures element of the HRP at NASA provided funding for this paper.”
 
8
Davis CM, Roma PG, Hienz RD.
The Rodent Psychomotor Vigilance Test (rPVT): A method for assessing neurobehavioral performance in rats and mice.
J Vis Exp. 2016 Dec 29;(118).
https://www.ncbi.nlm.nih.gov/pubmed/28060276
PI: C.M. Davis, R.D. Hienz
Journal Impact Factor: 1.24
Funding: “This research was supported by NASA (NNX15AC71G to CMD), and by NASA cooperative agreement NCC 9-58 (E000010 to CMD, NBPF02802 and NBPF04201 to RDH) with the National Space Biomedical Research Institute.”
______________________________________________________
 
Other papers of interest:
 
1
Gambara G, Salanova M, Ciciliot S, Furlan S, Gutsmann M, Schiffl G, Ungethuem U, Volpe P, Gunga HC, Blottner D.
Gene expression profiling in slow-type calf soleus muscle of 30 days space-flown mice.
PLoS One. 2017 Jan 11;12(1):e0169314.
https://www.ncbi.nlm.nih.gov/pubmed/28076365
Note: BION-M1 results. This article may be obtained online without charge.
 
2
Harris LR, Jenkin M, Jenkin H, Zacher JE, Dyde RT.
The effect of long-term exposure to microgravity on the perception of upright.
npj Microgravity. 2017 Jan 12;3(1):3.
http://www.nature.com/articles/s41526-016-0005-5
Note: ISS results. This article may be obtained online without charge.
 
3
Van Ombergen A, Laureys S, Sunaert S, Tomilovskaya E, Parizel PM, Wuyts FL.
Spaceflight-induced neuroplasticity in humans as measured by MRI: What do we know so far?
npj Microgravity. 2017 Jan 10;3(1):2. Review.
http://www.nature.com/articles/s41526-016-0010-8
Note: The single spaceflight study reviewed was based on a case study of an ISS crewmember. Spaceflight alternative studies reviewed include dry immersion; head-down bedrest; parabolic flight; and isolation studies conducted in Antarctica, undersea, and the MARS500 study.
 
4
Mehta P, Bhayani D.
Impact of space environment on stability of medicines: Challenges and prospects.
J Pharm Biomed Anal. 2017 Jan 03;136:111-9. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/pubmed/28068518
Note: Mercury, Gemini, Apollo, Skylab, Space Shuttle, and ISS missions are included in the review.
 
5
McFarlane SV, Mathers KE, Staples JF.
Reversible temperature-dependent differences in brown adipose tissue respiration during torpor in a mammalian hibernator.
Am J Physiol Regul Integr Comp Physiol. 2017 Jan 11:ajpregu.00316.2016. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28077390
 
6
Chung JH, Ahn CB, Son KH, Yi E, Son HS, Kim H-S, Lee SH.
Simulated microgravity effects on nonsmall cell lung cancer cell proliferation and migration.
Aerosp Med Hum Perform. 2017 Feb;88(2):82-9.
http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/0000 0002/art00004
Note: A 3D clinostat was used.
 
7
Cialdai F, Vignali L, Morbidelli L, Colciago A, Celotti F, Santi A, Caselli A, Cirri P, Monici M.
Modeled microgravity affects fibroblast functions related to wound healing.
Microgravity Sci Technol. 2017 Jan 18:1-12. [Article in Press]
http://link.springer.com/article/10.1007%2Fs12217-016-9532-7
Note: A Rotary Cell Culture System (RCCS) was used.
 
8
Persat A.
Bacterial mechanotransduction.
Curr Opin Microbiol. 2017 Jan 06;36:1-6. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28068612
 
9
Ishibashi K, Oyama F, Yoshida H, Iwanaga K.
Additive effects of sinusoidal lower body negative pressure on cardiovascular responses.
Aerosp Med Hum Perform. 2017 Feb;88(2):137-41.
http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000002/art00011
 
10
Chen Y, Xu C, Wang P, Cai Y, Ma H.
Effect of long-term simulated microgravity on immune system and lung tissues in rhesus macaque.
Inflammation. 2017 Jan 09. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28070761
Note: Head-down tilt study.
 
11
Pozdnyakova N, Pastukhov A, Dudarenko M, Borysov A, Krisanova N, Nazarova A, Borisova T.
Enrichment of inorganic Martian dust simulant with carbon component can provoke neurotoxicity.
Microgravity Sci Technol. 2017 Jan 4:1-12. [Article in Press]
http://link.springer.com/article/10.1007%2Fs12217-016-9533-6
 
12
Begue G, Raue U, Jemiolo B, Trappe SW.
DNA methylation assessment from human slow- and fast-twitch skeletal muscle fibers.
J Appl Physiol (1985). 2017 Jan 05:jap.00867.2016. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28057818
 
13
Honkanen T, Oksa J, Mäntysaari MJ, Kyröläinen H, Avela J.
Neck and shoulder muscle activation among experienced and inexperienced pilots in +Gz exposure.
Aerosp Med Hum Perform. 2017 Feb;88(2):90-5.
http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000002/art00005
Note: A centrifuge was used.
 
14
Kramer A, Kümmel J, Mulder E, Gollhofer A, Frings-Meuthen P, Gruber M.
High-intensity jump training is tolerated during 60 days of bed rest and is very effective in preserving leg power and lean body mass: An overview of the Cologne RSL study.
PLoS One. 2017 Jan 12;12(1):e0169793.
https://www.ncbi.nlm.nih.gov/pubmed/28081223
Note: Bed rest study. The authors describe the Köln Langzeit-Bettruhe Studie (RSL), conducted in the :envihab facility of the Institute of Aerospace Medicine at the German Aerospace Center (DLR) in Cologne, Germany. This article may be obtained online without charge
 
15
Dittmer KE, Firth EC.
Mechanisms of bone response to injury.
J Vet Diagn Invest. 2017 Jan 1:1040638716679861. [Epub ahead of print] Review.
https://www.ncbi.nlm.nih.gov/pubmed/28061633
Note: This article may be obtained online without charge.
 
16
Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galan-Diez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G.
Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise.
Cell Metab. 2017 Jan 10;25(1):218.
https://www.ncbi.nlm.nih.gov/pubmed/28076763
Note: This is a correction to the original article: Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galán-Diez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G. Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise. Cell Metab. 2016 Jun 14;23(6):1078-92. http://www.ncbi.nlm.nih.gov/pubmed/27304508, which appeared in SPACELINE Current Awareness List #704, 24 Jun 2016.
 
17
Yang H, Embry RE, Main RP.
Effects of loading duration and short rest insertion on cancellous and cortical bone adaptation in the mouse tibia.
PLoS One. 2017 Jan 11;12(1):e0169519.
https://www.ncbi.nlm.nih.gov/pubmed/28076363
Note: This article may be obtained online without charge.
 
18
Grün R, Friedrich T, Kramer M, Scholz M.
Systematics of relative biological effectiveness measurements for proton radiation along the spread out Bragg peak: Experimental validation of the local effect model.
Phys Med Biol. 2017 Feb 7;62(3):890-908. Epub 2017 Jan 10.
https://www.ncbi.nlm.nih.gov/pubmed/28072575
 
19
Khan SI, Hübner PP, Brichta AM, Smith DW, Migliaccio AA.
Aging reduces the high-frequency and short-term adaptation of the vestibulo-ocular reflex in mice.
Neurobiol Aging. 2016 Dec 18;51:122-31. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28063365
Note: Rotation was used.
 
20
Laurens J, Liu S, Yu XJ, Chan R, Dickman D, DeAngelis GC, Angelaki DE.
Transformation of spatiotemporal dynamics in the macaque vestibular system from otolith afferents to cortex.
Elife. 2017 Jan 11;6:e20787.
https://www.ncbi.nlm.nih.gov/pubmed/28075326
Note: This article may be obtained online without charge.
 
21
Talts K, Ilau B, Ojangu EL, Tanner K, Peremyslov VV, Dolja VV, Truve E, Paves H.
Arabidopsis myosins XI1, XI2, and XIK are crucial for gravity-induced bending of inflorescence stems.
Front Plant Sci. 2016 Dec 21;7:1932.
https://www.ncbi.nlm.nih.gov/pubmed/28066484
Note: This article may be obtained online without charge.
 
22
Doarn CR.
Interview with Dr. Arnold S. Barer, a Soviet space medicine pioneer.
Aerosp Med Hum Perform. 2017 Feb;88(2):154-5.
http://www.ingentaconnect.com/content/asma/amhp/2017/00000088/00000002/art00015
 
23
Dong C, Fu Y, Xie B, Wang M, Liu H.
Element cycling and energy flux responses in ecosystem simulations conducted at the Chinese Lunar Palace-1.
Astrobiology. 2017 Jan;17(1):78-86.
https://www.ncbi.nlm.nih.gov/pubmed/28068148
Note: The study was conducted in Lunar Palace 1, a bioregenerative life support system.