Status Report

NASA Spaceline Current Awareness List #725 28 November 2016 (Space Life Science Research Results)

By SpaceRef Editor

November 28, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

Benardini JN, Venkateswaran K.

Application of the ATP assay to rapidly assess cleanliness of spacecraft surfaces: A path to set a standard for future missions.

AMB Express. 2016 Dec;6(1):113.

https://www.ncbi.nlm.nih.gov/pubmed/27844457

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.167

Funding: “Part of the research described in this paper was carried out by the Jet Propulsion Laboratory, California Institute of Technology, under contract with NASA.” K. Venkateswaran is affiliated with the NASA Jet Propulsion Laboratory.

Siranart N, Blakely EA, Cheng A, Handa N, Sachs RK.

Mixed beam murine Harderian gland tumorigenesis: Predicted dose-effect relationships if neither synergism nor antagonism occurs.

Radiat Res. 2016 Nov 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27874325

PI: E.A. Blakely

Journal Impact Factor: 3.022

Funding: “This research was supported by NASA [grant no. NNJ16HP22I (RKS and EAB)] under U.S. Department of Energy contract no. DE-AC02-05CH11231. Additional support was provided by the Undergraduate Research Apprenticeship Program (URAP) at UC Berkeley (NS, AC and NH).”

Bianchi MT, Phillips AJ, Wang W, Klerman EB.

Statistics for sleep and biological rhythms research: From distributions and displays to correlation and causation.

J Biol Rhythms. 2016 Oct 24. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27836938

PI: E.B. Klerman

Journal Impact Factor: 2.824

Funding: “This work was supported by NIH K99/R00 HL119618 (AJKP); NIH K24-HL105664 (EBK), R01-HL-114088, R01-GM-105018 and P01-AG009975, and NSBRI HFP02802; MGH Neurology Department (MTB).”

Klerman EB, Wang W, Phillips AJ, Bianchi MT.

Statistics for sleep and biological rhythms research: Longitudinal analysis of biological rhythms data.

J Biol Rhythms. 2016 Oct 24. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27836939

PI: E.B. Klerman

Journal Impact Factor: 2.842

Funding: “This work was supported by NIH K99/R00 HL119618 (AJKP); NIH K24-HL105664 (EBK), R01-HL-114088, R01-GM-105018 and P01-AG009975, and NSBRI HFP02802; MGH Neurology Department (MTB).”

Crucian B, Babiak-Vazquez A, Johnston S, Pierson DL, Ott CM, Sams C.

Incidence of clinical symptoms during long-duration orbital spaceflight.

Int J Gen Med. 2016 Nov 3;9:383-91.

https://www.ncbi.nlm.nih.gov/pubmed/27843335

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: No funding cited. B. Crucian, S. Johnston, D.L. Pierson, C.M. Ott, and C. Sams are affiliated with NASA Johnson Space Center.

Doarn CR, Pantalos G, Strangman GE, Broderick TJ.

Surgical capabilities for exploration and colonization space flight – An exploratory symposium. December 2015, National Space Biomedical Research Institute, Houston, TX.

Houston, TX: NASA Johnson Space Center, 2016 Nov. 220 p. NASA/TP-2016-219281.

https://ston.jsc.nasa.gov/collections/TRS/listfiles.cgi?DOC=TP-2016-219281

Note: From the Executive Summary: “. . .This two day symposia included comprehensive sessions that addressed the challenges that we all face in developing, deploying, and utilizing surgical care capabilities in all human space missions, regardless of mission duration or profile.” This publication may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: No funding cited. The National Space Biomedical Research Institute was funded by NASA.

Feltz DL, Ploutz-Snyder L, Winn B, Kerr NL, Pivarnik JM, Ede A, Hill C, Samendinger S, Jeffery W.

Simulated Partners and Collaborative Exercise (SPACE) to boost motivation for astronauts: Study protocol.

BMC Psychol. 2016 Nov 14;4(1):54.

https://www.ncbi.nlm.nih.gov/pubmed/27842603

PI: D.L. Feltz

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “SPACE is funded by NASA/National Space Biomedical Research Institute, MA03401.”

______________________________________________________

Other papers of interest:

Sunagawa GA, Takahashi M.

Hypometabolism during daily torpor in mice is dominated by reduction in the sensitivity of the thermoregulatory system.

Sci Rep. 2016 Nov 15;6:37011.

https://www.ncbi.nlm.nih.gov/pubmed/27845399

Note: This article may be obtained online without charge.

Corydon TJ, Mann V, Slumstrup L, Kopp S, Sahana J, Askou AL, Magnusson NE, Echegoyen D, Bek T, Sundaresan A, Riwaldt S, Bauer J, Infanger M, Grimm D.

Reduced expression of cytoskeletal and extracellular matrix genes in human adult retinal pigment epithelium cells exposed to simulated microgravity.

Cell Physiol Biochem. 2016;40(1-2):1-17. Epub 2016 Nov 14.

https://www.ncbi.nlm.nih.gov/pubmed/27842307

Note: A Random Positioning Machine was used. This article may be obtained online without charge.

Eiken O, Keramidas ME, Taylor NA, Grönkvist M.

Intraocular pressure and cerebral oxygenation during prolonged headward acceleration.

Eur J Appl Physiol. 2016 Nov 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27837370

Note: A 7.25m centrifuge was used. This article may be obtained online without charge.

Chang H, Jiang SF, Dang K, Wang HP, Xu SH, Gao YF.

iTRAQ-based proteomic analysis of myofibrillar contents and relevant synthesis and proteolytic proteins in soleus muscle of hibernating Daurian ground squirrels (Spermophilus dauricus).

Proteome Sci. 2016 Nov 8;14:16.

https://www.ncbi.nlm.nih.gov/pubmed/27833457

Note: This article may be obtained online without charge.

Jang J, Park J, Chang H, Lim K.

l-Carnitine supplement reduces skeletal muscle atrophy induced by prolonged hindlimb suspension in rats.

Appl Physiol Nutr Metab. 2016 Dec;41(12):1240-7.

https://www.ncbi.nlm.nih.gov/pu bmed/27841025

Note: Hindlimb unloading study.

Ashry OM, Hussein EM, Abd El-Azime AS.

Restorative role of persimmon leaf (Diospyros kaki) to gamma irradiation induced oxidative stress and tissue injury in rats.

Int J Radiat Biol. 2016 Nov 11:1-24. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27834112

Freese S, Police Reddy A, Lehnhardt K.

Radiation impacts on human health during spaceflight beyond low Earth orbit.

REACH. 2016 Nov 16. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2352309316300062

Rabender C, Mezzaroma E, Mauro AG, Mullangi R, Abbate A, Anscher M, Hart B, Mikkelsen R.

IPW-5371 proves effective as a radiation countermeasure by mitigating radiation-induced late effects.

Radiat Res. 2016 Nov;186(5):478-88.

https://www.ncbi.nlm.nih.gov/pubmed/27841740

Tang H, Chen L, Chen L, Chen B, Wang T, Yang A, Zhan F, Wu L, Bian P.

Interaction between radioadaptive response and radiation-induced bystander effect in Caenorhabditis elegans: A unique role of the DNA damage checkpoint.

Radiat Res. 2016 Nov 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27874324

Kalichamy SS, Lee TY, Yoon KH, Lee JI.

Hypergravity hinders axonal development of motor neurons in Caenorhabditis elegans.

PeerJ. 2016 Nov 3;4:e2666.

https://www.ncbi.nlm.nih.gov/pubmed/27833821

Note: Centrifugation was used. This article may be obtained online without charge.

Barra J, Senot P, Auclair L.

Internal model of gravity influences configural body processing.

Cognition. 2016 Nov 11;158:208-14. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27842273

Note: From the Introduction: “Human beings construct an internal model of gravity leading to a sense of verticality and relate ‘‘up” and ‘‘down” directions in order to spatially orient themselves and the world. This internal model represents a general neural process used by the brain to integrate information from disparate sensory modalities, combine efferent and afferent information but also to resolve sensory ambiguity. . . To test this . . . we dissociated the orientations of body and visual gravity so that body orientation could be inverted while visual gravity remained congruent with actual gravity.”

Sarris A.

Antarctic station life: The first 15 years of mixed expeditions to the Antarctic.

Acta Astronaut. 2016 Nov 17. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0094576516307639

Note: From the Introduction: “The aim of this study was to examine the attitudes and experiences of returned women expeditioners toward Antarctic station life and culture using a longitudinal processual retrospective approach with purposeful sampling to provide a historical ‘snap shot’ of women’s experiences in mixed expeditions.”

Tohge T, Fernie AR.

Specialized metabolites of the flavonol class mediate root phototropism and growth.

Mol Plant. 2016 Nov 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27845216