Status Report

NASA Spaceline Current Awareness List #723 14 November 2016 (Space Life Science Research Results)

By SpaceRef Editor

November 14, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

Stoffle N, Keller J, Semones E.

Initial report on International Space Station radiation environment monitor performance.

Houston, TX: NASA Johnson Space Center, 2016 Sep. 44 p. NASA/TM-2016-219278.

https://ston.jsc.nasa.gov/collections/TRS/listfiles.cgi?DOC=TM-2016-219278

Note: ISS results. This report may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: “This work was supported by the NASA Advanced Exploration Systems Program and NASA Bioastronautics Contract NAS9-02078.”

Nandi S, Chandramohan D, Fioriti L, Melnick AM, Hebert JM, Mason CE, Rajasethupathy P, Kandel ER.

Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain.

Proc Natl Acad Sci U S A. 2016 Oct 24. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27791114

PI: C.E. Mason

Journal Impact Factor: 9.674

Funding: “This work was supported by the Howard Hughes Medical Institute (HHMI) (E.R.K., senior investigator of HHMI); NIH Grant NS076465 and Foundation Grant STARR I9-A9-071, the Bert L. and N. Kuggie Vallee Foundation, the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, the Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, 15-15Omni2-0063), and the WorldQuant Foundation (to C.E.M.); NIH Grants MH083804 and MH070596 (to J.M.H.); and NIH Grants CA155226, CA104348, and CA143032 (to A.M.M.). D.C. was supported by NIH Training Grant 1T32GM083937.”

Metzger CE, Narayanan A, Zawieja DC, Bloomfield SA.

Inflammatory bowel disease in a rodent model alters osteocyte protein levels controlling bone turnover.

J Bone Miner Res. 2016 Oct 31. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27796050

Journal Impact Factor: 5.622

Funding: “AN was supported via the NASA-National Space Biomedical Research Institute Predoctoral Fellowship by NASA Cooperative Agreement NCC 9-58.”

Hu S.

Linking doses with clinical scores of hematopoietic acute radiation syndrome.

Health Phys. 2016 Oct;111(4):337-47.

https://www.ncbi.nlm.nih.gov/pubmed/27575346

PI: S. Blattnig

Journal Impact Factor: 1.193

Funding: “This study was supported by the NASA Space Radiation Risk Assessment Project.”

Hu S, Zeitlin C, Atwell W, Fry D, Barzilla JE, Semones E.

Segmental interpolating spectra for solar particle events and in situ validation.

Space Weather. 2016 Sep 21;14.

http://onlinelibrary.wiley.com/doi/10.1002/2016SW001476/abstract

Journal Impact Factor: 2.398

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.

Bruce EN, Bruce MC.

Prediction of the consequences of endogenous carbon monoxide production during extravehicular activity in microgravity.

Houston, TX: NASA Johnson Space Center, 2016 Oct. 24 p. NASA/TM-2016-219279.

https://ston.jsc.nasa.gov/collections/TRS/listfiles.cgi?DOC=TM-2016-219279

Note: This report may be obtained online without charge.

Journal Impact Factor: Not applicable to this publication

Funding: “Work completed for NASA under a subcontract through Universities Space Research Association: NNJ11HE31A, PN 02.106.001.”

______________________________________________________

Other papers of interest:

Gaveau J, Berret B, Angelaki DE, Papaxanthis C.

Direction-dependent arm kinematics reveal optimal integration of gravity cues.

Elife. 2016 Nov 2;5. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27805566

Note: Parabolic flight results. This article may be obtained online without charge.

Mora M, Mahnert A, Koskinen K, Pausan MR, Oberauner-Wappis L, Krause R, Perras AK, Gorkiewicz G, Berg G, Moissl-Eichinger C.

Microorganisms in confined habitats: Microbial monitoring and control of intensive care units, operating rooms, cleanrooms and the International Space Station.

Front Microbiol. 2016 Oct;7:1573.

https://www.ncbi.nlm.nih.gov/pubmed/27790191

Note: ISS studies are reported. This article may be obtained online without charge.

Zea L, Prasad N, Levy SE, Stodieck L, Jones A, Shrestha S, Klaus D.

A molecular genetic basis explaining altered bacterial behavior in space.

PLoS One. 2016 Nov 2;11(11):e0164359.

https://www.ncbi.nlm.nih.gov/pubmed/27806055

Note: ISS results. The study was funded in part by the Center for the Advancement of Science in Space (CASIS). This article may be obtained online without charge.

de Maistre S, Vallee N, Gempp E, Louge P, Duchamp C, Blatteau JE.

Gut fermentation seems to promote decompression sickness in humans.

J Appl Physiol (1985). 2016 Oct 1;121(4):973-9.

https://www.ncbi.nlm.nih.gov/pubmed/27633737

Buckner SL, Dankel SJ, Mattocks KT, Jessee MB, Mouser JG, Counts BR, Loenneke JP.

The problem of muscle hypertrophy: Revisited.

Muscle Nerve. 2016 Oct 7. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27717161

Chacon-Cabrera A, Lund-Palau H, Gea J, Barreiro E.

Time-course of muscle mass loss, damage, and proteolysis in gastrocnemius following unloading and reloading: Implications in chronic diseases.

PLoS One. 2016 Oct 28;11(10):e0164951.

https://www.ncbi.nlm.nih.gov/pubmed/27792730

Note: Hindlimbs were immobilized via splinting. This article may be obtained online without charge.

Fusi L, Brunello E, Yan Z, Irving M.

Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle.

Nat Commun. 2016 Oct 31;7:13281.

https://www.ncbi.nlm.nih.gov/pubmed/27796302

Note: This article may be obtained online without charge.

Hvid LG, Brocca L, Ørtenblad N, Suetta C, Aagaard P, Kjaer M, Bottinelli R, Pellegrino MA.

Myosin content of single muscle fibers following short-term disuse and active recovery in young and old healthy men.

Exp Gerontol. 2016 Oct 26. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27794458

Note: Whole leg casting was used.

Badilatti SD, Christen P, Parkinson I, Muller R.

Load-adaptive bone remodeling simulations reveal osteoporotic microstructural and mechanical changes in whole human vertebrae.

J Biomech. 2016 Oct 13. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27793404

Liu PC, Liu K, Liu JF, Xia K, Chen LY, Wu X.

Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging.

Oncotarget. 2016 Sep 6;7(39):62873-85.

https://www.ncbi.nlm.nih.gov/pubmed/27802423

Note: A rotary cell culture system was used. This article may be obtained online without charge.

Raber J, Davis MJ, Pfankuch T, Rosenthal R, Doctrow SR, Moulder JE.

Mitigating effect of EUK-207 on radiation-induced cognitive impairments.

Behav Brain Res. 2016 Oct 24. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27789343

Tilton SC, Markillie LM, Hays S, Taylor RC, Stenoien DL.

Identification of differential gene expression patterns after acute exposure to high and low doses of low-let ionizing radiation in a reconstituted human skin tissue.

Radiat Res. 2016 Nov 1. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27802111

Boucheron-Dubuisson E, Manzano AI, Le Disquet I, Matía I, Sáez-Vasquez J, van Loon JJ, Herranz R, Carnero-Diaz E, Medina FJ.

Functional alterations of root meristematic cells of Arabidopsis thaliana induced by a simulated microgravity environment.

J Plant Physiol. 2016 Oct 19;207:30-41. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27792899

Note: A clinostat was used.

Kamiya M, Higashio SY, Isomoto A, Kim JM, Seki M, Miyashima S, Nakajima K.

Control of root cap maturation and cell detachment by BEARSKIN transcription factors in Arabidopsis.

Development. 2016 Nov 1;143(21):4063-72.

https://www.ncbi.nlm.nih.gov/pubmed/27803060

Lee HJ, Ha JH, Kim SG, Choi HK, Kim ZH, Han YJ, Kim JI, Oh Y, Fragoso V, Shin K, Hyeon T, Choi HG, Oh KH, Baldwin IT, Park CM.