Status Report

NASA Spaceline Current Awareness List #712 25 August 2016 (Space Life Science Research Results)

By SpaceRef Editor

August 25, 2016

Filed under Extrasolar, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

White O, Clément G, Fortrat J-O, Pavy-LeTraon A, Thonnard J-L, Blanc S, Wuyts FL, Paloski WH.

Towards human exploration of space: The THESEUS review series on neurophysiology research priorities.

npj Microgravity. 2016 Aug 18;2:16023. Review.

http://www.nature.com/articles/npjmgrav201623

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This review is a product of the Theseus Project: Towards Human Exploration of Space: A European Strategy of the European Science Foundation and was supported by European Community’s seventh Framework Programme (FP7/2007-2013) under grant agreement #242482. We also thank the French (CNES), the German (DLR), the Italian (ASI) and the American (NASA) space agencies for their support.” “Published in cooperation with the Biodesign Institute at Arizona State University, with the support of NASA.” W. H. Paloski is affiliated with NASA Johnson Space Center.

Bergouignan A, Stein TP, Habold C, Coxam V, O’Gorman D, Blanc S.

Towards human exploration of space: The THESEUS review series on nutrition and metabolism research priorities.

npj Microgravity. 2016 Aug 18;2:16029. Review.

http://www.nature.com/articles/npjmgrav201629

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “Published in cooperation with the Biodesign Institute at Arizona State University, with the support of NASA.”

Hord JM, Botchlett R, Lawler JM.

Age-related alterations in the sarcolemmal environment are attenuated by lifelong caloric restriction and voluntary exercise.

Exp Gerontol. 2016 Aug 14. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27534381

PI: J.M. Lawler

Journal Impact Factor: 3.350

Funding: “Research reported in this publication was supported by grants from NIH (AR054084) (J.M.L.), NASA (NNX12AR62G) (J.M.L.), the Sydney and J.L. Huffines Institute (J.M.H., J.M.L.) at Texas A&M University, and the Strategic Research Award (J.M.H.) from the College of Health and Education at Texas A&M University.”

Barr Y, Clément G, Norsk P.

Human health countermeasure – Partial-Gravity Analogs Workshop, February 17. 2015.

Houston, TX: NASA Johnson Space Center, 2016; 52 p. NASA/TM-2016-218605.

http://ston.jsc.nasa.gov/collections/TRS/listfiles.cgi?DOC=TM-2016-218605

Note: This article may be obtained online without charge.

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.

Rothschild LJ.

Synthetic biology meets bioprinting: Enabling technologies for humans on Mars (and Earth).

Biochem Soc Trans. 2016 Aug 15;44(4):1158-64.

http://www.ncbi.nlm.nih.gov/pubmed/27528764

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.679

Funding: “This work was supported by the NASA Ames Research Center Director’s Discretionary fund; NASA Headquarters; Brown University; the Stanford University; the Rhode Island Space [NASA Grant NNX10AI195H, NASA Grant NNX15AI06H]; the Center Innovation Fund; the NASA Innovative Advanced Concepts programs; and the NASA’s Advanced Exploration Systems program.” L.J. Rothschild is affiliated with NASA Ames Research Center.

Wong JY, Pfahnl AC.

3D printed surgical instruments evaluated by a simulated crew of a Mars mission.

Aerosp Med Hum Perform. 2016 Sep;87(9):806-10. Review.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000009/art00009

Note: The study was conducted as part of the Hawai’i Space Exploration Analog and Simulation (HI-SEAS) II mission. “This study seeks to determine whether Mars analog crewmembers with no prior surgical experience would be able to use FDM 3D printed ABS thermoplastic surgical instruments in four simulated surgical tasks.”

Journal Impact Factor: 0.755

Funding: No funding cited for this project. The HI-SEAS mission is funded by NASA.

Clément GR, Charles JB, Paloski WH.

Revisiting the needs for artificial gravity during deep space missions.

REACH. 2016 Mar;1:1-10. Review. Epub 2016 Jul 20.

http://www.sciencedirect.com/science/article/pii/S2352309315300079

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: No funding cited. J. B. Charles and W. H. Paloski are affiliated with NASA Johnson Space Center.

______________________________________________________

Other papers of interest:

Gambelli CN, Theisen D, Willems PA, Schepens B.

Human motor control of landing from a drop in simulated microgravity.

J Appl Physiol (1985). 2016 Aug 11:jap.00305.2016. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27516535

Note: Parabolic flight results.

Stenzel C.

Deployment of precise and robust sensors on board ISS – for scientific experiments and for operation of the station.

Anal Bioanal Chem. 2016 Aug 15. [Epub ahead of print] Review.

http://www.ncbi.nlm.nih.gov/pubmed/27526089

Note: ISS study. This article may be obtained online without charge.

Pletser V, Rouquette S, Friedrich U, Clervoy J-F, Gharib T, Gai F, Mora C.

The First European Parabolic Flight Campaign with the Airbus A310 ZERO-G.

Microgravity Sci Technol. 2016 Aug 20:1-15. [Article in Press]

http://link.springer.com/article/10.1007%2Fs12217-016-9515-8

Note: Parabolic flight results.

Goulard R, Vercher JL, Viollet S.

To crash or not to crash: How do hoverflies cope with free-fall situations and weightlessness?

J Exp Biol. 2016 Aug 15;219(Pt 16):2497-503.

http://www.ncbi.nlm.nih.gov/pubmed/27535987

Note: An electromagnetic field and free fall were used.

Cucinotta FA, Hamada N, Little MP.

Commentary — No evidence for an increase in circulatory disease mortality in astronauts following space radiation exposures.

Life Sci Space Res. 2016 Aug 20. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552416300566

Note: This article comments on: Delp MD, Charvat JM, Limoli CL, Globus RK, Ghosh P. Apollo lunar astronauts show higher cardiovascular disease mortality: Possible deep space radiation effects on the vascular endothelium. Sci Rep. 2016 Jul 28;6:29901. http://www.ncbi.nlm.nih.gov/pubmed/27467019. The article appeared in Current Awareness List #709 on August 5, 2016.

Huangfu J, Xu Y, Li C, Li J.

Overexpressing target helper genes enhances secretion and glycosylation of recombinant proteins in Pichia pastoris under simulated microgravity.

J Ind Microbiol Biotechnol. 2016 Aug 17. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27535143

Note: A Rotary Cell Culture System (RCCS) with a High Aspect Ratio Vessel (HARV) was used.

Liu R, Fan W, Krüger K, Xiao Y, Pilat C, Seimetz M, Ringseis R, Baumgart-Vogt E, Eder K, Weissmann N, Mooren FC.

Exercise affects T cell function via modifying intracellular calcium homeostasis.

Med Sci Sports Exerc. 2016 Aug 12. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27525377

van Helmond N, Johnson BD, Curry TB, Cap AP, Convertino VA, Joyner MJ.

White blood cell concentrations during lower body negative pressure and blood loss in humans.

Exp Physiol. 2016 Aug 13. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27520090

Bosutti A, Salanova M, Blottner D, Buehlmeier J, Mulder E, Rittweger J, Yap MH, Ganse B, Degens H.

Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days bed rest.

J Appl Physiol (1985). 2016 Aug 11:jap.00936.2015. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27516541

Note: Bed rest study.

Mirzoev T, Tyganov S, Vilchinskaya N, Lomonosova Y, Shenkman B.

Key markers of mTORC1-dependent and mTORC1-independent signaling pathways regulating protein synthesis in rat soleus muscle during early stages of hindlimb unloading.

Cell Physiol Biochem. 2016 Aug 19;39(3):1011-20.

http://www.ncbi.nlm.nih.gov/pubmed/27536969

Note: Hindlimb unloading study. This article may be obtained online without charge.

Zhu Y, Song K, Jiang S, Chen J, Tang L, Li S, Fan J, Wang Y, Zhao J, Liu T.

Numerical simulation of mass transfer and three-dimensional fabrication of tissue-engineered cartilages based on chitosan/gelatin hybrid hydrogel scaffold in a rotating bioreactor.

Appl Biochem Biotechnol. 2016 Aug 15. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27526111

Note: A rotating wall vessel bioreactor was used.

Acharya MM, Green KN, Allen BD, Najafi AR, Syage A, Minasyan H, Le MT, Kawashita T, Giedzinski E, Parihar VK, West BL, Baulch JE, Limoli CL.

Elimination of microglia improves cognitive function following cranial irradiation.

Sci Rep. 2016 Aug 12;6:31545.

http://www.ncbi.nlm.nih.gov/pubmed/27516055

Note: This article may be obtained online without charge.

Pan D, Zhang Y, Li Z, Tian Z.

Association of individual characteristics with teleoperation performance.

Aerosp Med Hum Perform. 2016 Sep;87(9):772-80.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000009/art00004

Nicolas M, Bishop SL, Weiss K, Gaudino M.

Social, occupational, and cultural adaptation during a 12-month wintering in Antarctica.

Aerosp Med Hum Perform. 2016 Sep;87(9):781-9.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000009/art00005

Zhou Y, Hu Z.

Epigenetic DNA demethylation causes inner ear stem cell differentiation into hair cell-like cells.

Front Cell Neurosci. 2016 Aug 3;10:185.

http://www.ncbi.nlm.nih.gov/pubmed/27536218

Note: This article may be obtained online without charge.

Krieger G, Shkolnik D, Miller G, Fromm H.

Reactive oxygen species tune root tropic responses.

Plant Physiol. 2016 Aug 17. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27535793

Note: This article may be obtained online without charge.

Stephan AB, Kunz HH, Yang E, Schroeder JI.

Rapid hyperosmotic-induced Ca2+ responses in Arabidopsis thaliana exhibit sensory potentiation and involvement of plastidial KEA transporters.

Proc Natl Acad Sci U S A. 2016 Aug 15. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27528686

http://www.sciencedirect.com/science/journal/23523093/1/supp/C

Pletser V.

European aircraft parabolic flights for microgravity research, applications and exploration: A review.

REACH. 2016 Mar;1:11-9. Review. Epub 2016 Jul 20.

http://www.sciencedirect.com/science/article/pii/S2352309316300049

Note: Parabolic flight. This article may be obtained online without charge.

García A, Lamb A, Sleptsov A, Moreno C, Victorova M, Glazkova N, Shteyngardt V.

Post-ISS plans: What should be done?

REACH. 2016 Mar;1:63-73. Review. Epub 2016 Jul 20.

http://www.sciencedirect.com/science/article/pii/S2352309316300074

Note: This article may be obtained online without charge.

Gushin VI, Yusupova AK, Shved DM, Shueva LV, Vinokhodova AG, Bubeev YA.

The evolution of methodological approaches to the psychological analysis of the crew communications with Mission Control Center.

REACH. 2016 Mar;1:74-83. Review. Epub 2016 Jul 20.

http://www.sciencedirect.com/science/article/pii/S2352309316300037

Note: This article may be obtained online without charge.

Ruyters G, Stang K.

Space medicine 2025 – A vision: Space medicine driving terrestrial medicine for the benefit of people on Earth

REACH. 2016 Mar;1:55-62. Epub 2016 Jul 20.

http://www.sciencedirect.com/science/article/pii/S2352309316300025

Note: This article may be obtained online without charge.

SpaceRef Editor

SpaceRef staff editor.

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