Status Report

NASA Spaceline Current Awareness List #709 4 August 2016 (Space Life Science Research Results)

By SpaceRef Editor

August 4, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

Fajardo-Cavazos P, Nicholson WL.

Cultivation of Staphylococcus epidermidis in the human spaceflight environment leads to alterations in the frequency and spectrum of spontaneous rifampicin-resistance mutations in the rpoB gene.

Front Microbiol. 2016 Jul 28.;7:999.

http://www.ncbi.nlm.nih.gov/pubmed/27446039

PI: W.L. Nicholson

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.165

Funding: “This work was supported by a grant from the NASA Research Opportunities in Space Biology Program (NNX12AN70G) to WN and PF-C.”

Singh NK, Blachowicz A, Checinska A, Wang C, Venkateswaran K.

Draft genome sequences of two Aspergillus fumigatus strains, isolated from the International Space Station.

Genome Announc. 2016 Jul 14;4(4).

http://www.ncbi.nlm.nih.gov/pubmed/27417828

PI: K. Venkateswaran

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This research was funded by 2012 Space Biology NNH12ZTT001N grant 19-12829-26 under task order NNN13D111T awarded to K.V., which also funded post-doctoral fellowships for N.K.S. and A.C., a graduate fellowship to A.B., and a JPL subcontract 1511581 to C.W.”

Delp MD, Charvat JM, Limoli CL, Globus RK, Ghosh P.

Apollo lunar astronauts show higher cardiovascular disease mortality: Possible deep space radiation effects on the vascular endothelium.

Sci Rep. 2016 Jul 28;6:29901.

http://www.ncbi.nlm.nih.gov/pubmed/27467019

PIs: M.D. Delp, R.K. Globus

Note: Apollo results. This paper has received significant national and international media interest. Coverage in The Washington Post can be found at https://www.washingtonpost.com/news/speaking-of-science/wp/2016/07/28/studying-heart-disease-in-astronauts-yields-clues-but-not-conclusive-evidence/. The article may be obtained online without charge.

Journal Impact Factor: 5.228

Funding: “This study was supported by grants from the National Space and Biomedical Research Institute (MA02501) under the NASA Cooperative Agreement NCC 9-58 and NASA Space Biology (NNX14AQ57G and NNX16AC28G).”

Massa GD, Wheeler RM, Morrow RC, Levine HG.

Growth chambers on the International Space Station for large plants.

Acta Hortic. 2016 May;1134:215-22.

http://www.actahort.org/books/1134/1134_29.htm

PI: G.D. Massa

Note: ISS results.

Journal Impact Factor: Not available for this journal

Funding: “The authors wish to thank NASA’s ISS research program for supporting development of the hardware and NASA’s Space Life and Physical Sciences Space Biology program for developing science needs and funding verification tests.”

Hammond TG, Stodieck L, Koenig P, Hammond JS, Gunter MA, Allen PL, Birdsall HH.

Effects of microgravity and clinorotation on the virulence of Klebsiella, Streptococcus, Proteus, and Pseudomonas.

Gravit Space Res. 2016 Jul;4(1):39-50.

http://gravitationalandspacebiology.org/index.php/journal/article/view/719

PI: T.G. Hammond

Note: STS-125, ISS results. Centrifugation was used for ground studies. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “These studies were supported by NASA Space Biology grants NNX12AM93G and NNX13AN32G, SpaceHab/Astrotech, and Astrogenetix Inc.”

Ramaswamy V, Goins A, Allen JB.

Altered functions of human blood-derived vascular endothelial cells by simulated microgravity.

Gravit Space Res. 2016 Jul;4(1):2-16.

http://gravitationalandspacebiology.org/index.php/journal/article/view/711

PI: J.B. Allen

Note: A rotating wall vessel bioreactor was used. The article is featured on the cover of this issue. “From the cover: Differentiated human blood derived endothelial cells expressing von Willebrand factor, a characteristic endothelial cell marker. Cells cultured under simulated microgravity using microcarrier beads and a rotating wall vessel bioreactor. The effect of simulated microgravity was studied to better understand vascular health following spaceflight.” This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work is funded by National Aeronautics and Space Administration, Space Biology Division, with Grant # NNX13AM03G to J. Allen.”

Birdsall HH, Allen PL, Hammond JS, Gunter MA, Hammond TG.

Establishing a low redox potential in giant yeast colonies: Effects of media and rotation.

Gravit Space Res. 2016 Jul;4(1):27-38.

http://gravitationalandspacebiology.org/index.php/journal/article/view/718

PI: T.G. Hammond

Note: A rotating cell culture system was used. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “These studies were supported by NASA Grants NNX13AN32G and NNX10AP01G.”

Saldanha JN, Pandey S, Powell-Coffman JA.

The effects of short-term hypergravity on Caenorhabditis elegans.

Life Sci Space Res. 2016 Jul 20. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552415300080

PI: S. Pandey

Note: Centrifugation was used.

Journal Impact Factor: 1.183

Funding: “This work was funded by a grant from The National Aeronautics and Space Administration (NNX12AO60G to S.P. and J.A.P.-C.).”

Benzekry S, Beheshti A, Hahnfeldt P, Hlatky L.

Capturing the driving role of tumor-host crosstalk in a dynamical model of tumor growth.

Bio Protoc. 2015 Nov 5;5(21). Epub 2016 Jul 28.

http://www.ncbi.nlm.nih.gov/pubmed/27453916

PIs: L. Hlatky; L. Hlatky/P. Hahnfeldt/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This project was supported, in part, by the National Aeronautics and Space Administration under NSCOR grants NNJ06HA28G and NNX11AK26G and by Award Number U54CA149233 from the National Cancer Institute, both to L. Hlatky. This study also received support within the frame of the LABEX TRAIL, ANR-10-LABX-0057 with financial support from the French State, managed by the French National Research Agency (ANR) in the frame of the “Investments for the future” Programme IdEx (ANR 10-IDEX-03-02).”

Moding EJ, Min HD, Castle KD, Ali M, Woodlief L, Williams N, Ma Y, Kim Y, Lee CL, Kirsch DG.

An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer.

JCI Insight. 2016 Jul 7;1(10).

http://www.ncbi.nlm.nih.gov/pubmed/27453951

PI: D.G. Kirsch/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “These studies were supported by NASA NSCOR NNX11AC60G (to D.G. Kirsch), NCI F30 CA177220 (to E.J. Moding), and MEST NRF 2013R1A2A2A01068237 (to Y. Kim).”

Hu G, Zhang Q, Ivkovic V, Strangman GE.

Ambulatory diffuse optical tomography and multimodality physiological monitoring system for muscle and exercise applications.

J Biomed Opt. 2016 Sep 1;21(9):91314. Epub 2016 Jul 29.

http://www.ncbi.nlm.nih.gov/pubmed/27467190

PI: G.E. Strangman

Journal Impact Factor: 2.556

Funding: “This work was supported by the National Space Biomedical Research Institute through NASA NCC 9-58.”

Heuskin AC, Osseiran AI, Tang J, Costes SV.

Simulating space radiation-induced breast tumor incidence using automata.

Radiat Res. 2016 Jul;186(1):27-38.

http://www.ncbi.nlm.nih.gov/pubmed/27333083

Journal Impact Factor: 3.022

Funding: “Support was provided by the Belgian American Education Foundation, the Fulbright Commission and the Walloon region of Belgium (ACH, postdoctoral fellow), as well as the National Aeronautics and Space Administration (grant no. NNL15AA08I awarded to SVC, JT and AO).”

Prior S, Miousse IR, Nzabarushimana E, Pathak R, Skinner C, Kutanzi KR, Allen AR, Raber J, Tackett AJ, Hauer-Jensen M, Nelson GA, Koturbash I.

Densely ionizing radiation affects DNA methylation of selective LINE-1 elements.

Environ Res. 2016 Oct;150:470-81. Epub 2016 Jul 14

http://www.ncbi.nlm.nih.gov/pubmed/27419368

PIs: G.A. Nelson/A.R. Allen/J. Raber/NSCOR; J. Raber; M. Boerma/M. Hauer-Jensen/G.A. Nelson/I. Koturbash/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 3.088

Funding: “The work was supported by National Institute of Health Center of Biological Research Excellence [grant number 1P20GM109005], National Institute of Health [grant number R21ES025268]; National Aeronautics and Space Administration [grant numbers NNX10AD59G, NNJ12ZSA001N]; Arkansas Space Grant Consortium through National Aeronautics and Space Administration [grant number NNX13AB29A]; National Space Biomedical Research Institute through the National Aeronautics and Space Administration NCC 9–58 [grant number RE03701]; NIH/UAMS Clinical and Translational Science Award [grant numbers UL1TR000039, KL2TR000063], and the Arkansas Biosciences Institute.”

Rithidech KN, Jangiam W, Tungjai M, Gordon C, Honikel L, Whorton EB.

Induction of chronic inflammation and altered levels of DNA hydroxymethylation in somatic and germinal tissues of CBA/CaJ mice exposed to (48)Ti ions.

Front Oncol. 2016 Jun 27;6:155.

http://www.ncbi.nlm.nih.gov/pubmed/27446801

PI: K.N. Rithidech

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This research was supported in part by the National Aeronautics and Space Administration (NASA) Grant # NNX11AK91G and the Department of Pathology, Stony Brook University, Stony Brook, NY, USA.”

Lourenco TF, Serra TS, Cordeiro AM, Swanson SJ, Gilroy S, Saibo N, Oliveira MM.

Rice root curling, a response to mechanosensing, is modulated by the rice E3-ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 (OsHOS1).

Plant Signal Behav. 2016 Jul 28:0. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27467198

PI: S. Gilroy

Journal Impact Factor: Not available for this journal

Funding: No funding cited in the preprint. The PI reports NASA funding under grant NNX13AM50G.

______________________________________________________

Other papers of interest:

Liu C.

The theory and application of space microbiology: China’s experiences in space experiments and beyond.

Environ Microbiol. 2016 Jul 26. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27459305

Note: Shenzhou results.

Parmar P, Perry R, Cesarz G, Roberts A, Hardman H, Caruso JF.

Physiological effects of spaceflight/unloading and the mitigating effects of flywheel-based resistive exercise.

Gravit Space Res. 2016 Jul;4(1):64-77. Review.

http://gravitationalandspacebiology.org/index.php/journal/article/view/697

Note: ISS results.This article may be obtained online without charge.

Camirand A, Goltzman D, Gupta A, Kaouass M, Panda D, Karaplis A.

The role of parathyroid hormone-related protein (PTHrP) in osteoblast response to microgravity: Mechanistic implications for osteoporosis development.

PLoS One. 2016 Jul 27;11(7):e0160034.

http://www.ncbi.nlm.nih.gov/pubmed/27463808

Note: Foton M3 results. A Rotary Cell Culture System was used for ground studies. This article may be obtained online without charge.

Clément G, Loureiro N, Sousa D, Zandvliet A.

Perception of egocentric distance during gravitational changes in parabolic flight.

PLoS One. 2016 Jul 27;11(7):e0159422.

http://www.ncbi.nlm.nih.gov/pubmed/27463106

Note: Parabolic flight results. This article may be obtained online without charge.

Zhong G, Li Y, Li H, Sun W, Cao D, Li J, Zhao D, Song J, Jin X, Song H, Yuan X, Wu X, Li Q, Xu Q, Kan G, Cao H, Ling S, Li Y.

Simulated microgravity and recovery-induced remodeling of the left and right ventricle.

Front Physiol. 2016 Jun 29;7:274.

http://www.ncbi.nlm.nih.gov/pubmed/27445861

Note: Hindlimb unloading study. This article may be obtained online without charge.

Zaitseva EN, Dubishchev AV, Yakovlev DS, Anisimova VA.

[Nephroprotective properties of 5-HT3 receptor blocker RU-63 in experimental acute renal failure under hypergravity conditions].

Eksp Klin Farmakol. 2016;79(3):18-26. Russian.

http://www.ncbi.nlm.nih.gov/pubmed/27455574

Note: Centrifugation was used.

Foresto CS, Paula-Gomes S, Silveira WA, Graça FA, Kettelhut ID, Gonçalves DA, Mattiello-Sverzut AC.

Morphological and molecular aspects of immobilization-induced muscle atrophy in rats at different stages of postnatal development: The role of autophagy.

J Appl Physiol (1985). 2016 Jul 21:jap.00687.2015. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27445301

Note: Hindlimb unloading study.

Jaafar H.

Maximal voluntary co-contraction task: Potential utility for individuals in microgravity.

Phys Sportsmed. 2016 Jul 21:1-2. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27426741

Note: This article may be obtained online without charge.

Mancinelli R, Di Filippo ES, Verratti V, Fulle S, Toniolo L, Reggiani C, Pietrangelo T.

The regenerative potential of female skeletal muscle upon hypobaric hypoxic exposure.

Front Physiol. 2016 Jul 14;7:303.

http://www.ncbi.nlm.nih.gov/pubmed/27471475

Note: This article may be obtained online without charge.

Neuhaus P, Jumonville C, Perry RA, Edwards R, Martin JL, Alarbi A, Potter WT, Caruso JF.

Comparative responses to squats completed with free weights and an exoskeleton.

Gravit Space Res. 2016 Jul;4(1):51-63.

http://gravitationalandspacebiology.org/index.php/journal/article/view/716

Note: This article may be obtained online without charge.

Rozo M, Li L, Fan CM.

Targeting beta1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice.

Nat Med. 2016 Jul 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27376575

Uchida K, Tanaka M, Kondo H, Ishihara A, Fujino H.

L-arginine supplementation attenuates capillary regression without increasing integrated succinate dehydrogenase activity and VEGF expression in skeletal muscle during hindlimb unloading.

Gen Physiol Biophys. 2016 Jul 22. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27447401

Note: Hindlimb unloading study.

Chen Z, Luo Q, Lin C, Kuang D, Song G.

Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation.

Sci Rep. 2016 Jul 22;6:30322.

http://www.ncbi.nlm.nih.gov/pubmed/27444891

Note: A 2D clinostat was used. This article may be obtained online without charge.

Dohke T, Iba K, Hanaka M, Kanaya K, Abe Y, Okazaki S, Yamashita T.

Regional osteoporosis due to osteoclast activation as a trigger for the pain-like behaviors in tail-suspended mice.

J Orthop Res. 2016 Jul 19. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27431941

Note: Hindlimb unloading study.

Mladenova V, Mladenov E, Iliakis G.

Novel biological approaches for testing the contributions of single DSBs and DSB clusters to the biological effects of high LET radiation.

Front Oncol. 2016 Jun 28;6:163.

http://www.ncbi.nlm.nih.gov/pubmed/27446809

Note: This article may be obtained online without charge.

Williams JP, Calvi L, Chakkalakal JV, Finkelstein JN, O’Banion MK, Puzas E.

Addressing the symptoms or fixing the problem? Developing countermeasures against normal tissue radiation injury.

Radiat Res. 2016 Jul;186(1):1-16. Review.

http://www.ncbi.nlm.nih.gov/pubmed/27332954

Mujoo K, Butler EB, Pandita RK, Hunt CR, Pandita TK.

Pluripotent stem cells and DNA damage response to ionizing radiations.

Radiat Res. 2016 Jul;186(1):17-26.

http://www.ncbi.nlm.nih.gov/pubmed/27332952

Port M, Herodin F, Valente M, Drouet M, Lamkowski A, Majewski M, Abend M.

First generation gene expression signature for early prediction of late occurring hematological acute radiation syndrome in baboons.

Radiat Res. 2016 Jul;186(1):39-54.

http://www.ncbi.nlm.nih.gov/pubmed/27333084

DeBo RJ, Lees CJ, Dugan GO, Caudell DL, Michalson KT, Hanbury DB, Kavanagh K, Cline JM, Register TC.

Late effects of total-body gamma irradiation on cardiac structure and function in male rhesus macaques.

Radiat Res. 2016 Jul;186(1):55-64.

http://www.ncbi.nlm.nih.gov/pubmed/27333082

Ojima M, Iwashita K, Kashino G, Kobashigawa S, Sasano N, Takeshita A, Ban N, Kai M.

Early and delayed induction of DSBs by nontargeted effects in ICR mouse lymphocytes after in vivo X irradiation.

Radiat Res. 2016 Jul;186(1):65-70.

http://www.ncbi.nlm.nih.gov/pubmed/27351761

Bujold K, Hauer-Jensen M, Donini O, Rumage A, Hartman D, Hendrickson HP, Stamatopoulos J, Naraghi H, Pouliot M, Ascah A, Sebastian M, Pugsley MK, Wong K, Authier S.

Citrulline as a biomarker for gastrointestinal-acute radiation syndrome: Species differences and experimental condition effects.

Radiat Res. 2016 Jul;186(1):71-8.

http://www.ncbi.nlm.nih.gov/pubmed/27351760

Laiakis EC, Strawn SJ, Brenner DJ, Fornace AJ Jr.

Assessment of saliva as a potential biofluid for biodosimetry: A pilot metabolomics study in mice.

Radiat Res. 2016 Jul;186(1):92-7.

http://www.ncbi.nlm.nih.gov/pubmed/27332953

Anson ER, Bigelow RT, Carey JP, Xue QL, Studenski S, Schubert MC, Agrawal Y.

VOR gain is related to compensatory saccades in healthy older adults.

Front Aging Neurosci. 2016 Jun 24;8:150.

http://www.ncbi.nlm.nih.gov/pubmed/27445793

Note: This article may be obtained online without charge.

Ishii K, Kazama Y, Morita R, Hirano T, Ikeda T, Usuda S, Hayashi Y, Ohbu S, Motoyama R, Nagamura Y, Abe T.

Linear energy transfer-dependent change in rice gene expression profile after heavy-ion beam irradiation.

PLoS One. 2016 Jul 27;11(7):e0160061.

http://www.ncbi.nlm.nih.gov/pubmed/27462908

Note: This article may be obtained online without charge.

Ko?ciarz-Grzesiok A, Siero?-Stoltny K, Polak M, Siero? A, Karcz W.

Effect of low frequency pulsed magnetic field on gravitropic response and cell elongation in coleoptiles of maize seedlings.

Gen Physiol Biophys. 2016 Jul 22. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27447398

Ju L, Chen Y, Xue L, Du X, Zhu C.

Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals.

Elife. 2016 Jul 19;5. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27434669

Note: This article may be obtained online without charge.

Kopylov AT, Ilgisonis EV, Tikhonova OV, Moysa AA, Zavialova MG, Novikova SE, Lisitsa AV, Ponomarenko EA, Moshkovskii SA, Markin AA, Grigoriev AI, Zgoda VG, Archakov AI.

Targeted quantitative screening of chromosome 18 encoded proteome in plasma samples of astronaut candidates.

J Proteome Res. 2016 Jul 26. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27457493