Status Report

NASA Spaceline Current Awareness List #700 27 May 2016 (Space Life Science Research Results)

By SpaceRef Editor

May 27, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

Papers deriving from NASA support:

Spielmann G, Bollard CM, Kunz H, Hanley PJ, Simpson RJ.

A single exercise bout enhances the manufacture of viral-specific T-cells from healthy donors: implications for allogeneic adoptive transfer immunotherapy.

Sci Rep. 2016 May 16;6:25852.

http://www.ncbi.nlm.nih.gov/pubmed/27181409

PI: R.J. Simpson

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.578

Funding: “This work was supported by NASA grants NNJ10ZSA003N and NNJ14ZSA001N-FLAGSHIP to R.J. Simpson and NCI P01 CA148600-01A1 to C.M. Bollard.” The cited NASA grants are solicitation numbers; corresponding grant numbers are NNX12AB48G and NNX16AB29G, respectively.

Boothby TC, Goldstein B.

Reply to Bemm et al. and Arakawa: Identifying foreign genes in independent Hypsibius dujardini genome assemblies.

Proc Natl Acad Sci U S A. 2016 May 12. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27173900

PI: T.C. Boothby

Note: This letter replies to comments on the article “Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade” by Boothby TC, Tenlen JR, Smith FW, Wang JR, Patanella KA, Osborne Nishimura E, Tintori SC, Li Q, Jones CD, Yandell M, Messina DN, Glasscock J, Goldstein B. Proc Natl Acad Sci USA, 2015 Dec 29;112(52):15976–81. The original article, with funding acknowledgements, appeared in SPACELINE Current Awareness List #676, 4 Dec 2015, http://www.ncbi.nlm.nih.gov/pubmed/26598659.

Journal Impact Factor: 9.674

Funding: No funding was cited in the Letter. The original article was supported by NASA “Grant 14-14SF_Step2-0019 [NNX15AB44G] (to T.C.B.).”

Feola AJ, Myers JG, Raykin J, Mulugeta L, Nelson ES, Samuels BC, Ethier CR.

Finite element modeling of factors influencing optic nerve head deformation due to intracranial pressure.

Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):1901-11.

http://www.ncbi.nlm.nih.gov/pubmed/27088762

PI: C.R. Ethier

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.404

Funding: “Supported by NASA grant NNX13AP91G and the Georgia Research Alliance.”

Mendoza ML, Anderson EM, Kourrich S, Eisch AJ.

A NAc for spinal adjustments after cocaine or stress.

Biol Psychiatry. 2016 Jun 1;79(11):872-4.

http://www.ncbi.nlm.nih.gov/pubmed/27198520

PI: A.J. Eisch

Journal Impact Factor: 10.255

Funding: “This work was supported by the National Institutes of Health Grant Nos. DA023555, DA023555, and MH107945 (to AJE), Brain and Behavior Research Foundation NARSAD Young Investigator Award (to SK), and National Aeronautics and Space Administration Grant No. NNX15AE09G (to AJE). MLM and EMA are supported by the National Institutes of Health Institutional T32 Grant No. DA007290 (PI AJE).”

Hammond T, Allen P, Birdsall H.

Is there a space-based technology solution to problems with preclinical drug toxicity testing?

Pharm Res. 2016 May 16. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27183841

PI: T. Hammond

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.420

Funding: “This material is the result of work supported with NASA grants NNX13AN32G, NNX12AM93G, and NNX10AP01G, and resources at the Durham Veterans Affairs Medical Center and the Veterans Health Administration’s Office of Research and Development, U.S. Department of Veterans Affairs.”

Iwaniec UT, Philbrick KA, Wong CP, Gordon JL, Kahler-Quesada AM, Olson DA, Branscum AJ, Sargent JL, DeMambro VE, Rosen CJ, Turner RT.

Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss.

Osteoporos Int. 2016 May 17. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27189604

PI: R.T. Turner

Journal Impact Factor: 4.169

Funding: “This study received financial support from NIH AR060913, NASA NNX12AL24, and USDA 38420–17804.”

Sridharan DM, Asaithamby A, Blattnig SR, Costes SV, Doetsch PW, Dynan WS, Hahnfeldt P, Hlatky L, Kidane Y, Kronenberg A, Naidu MD, Peterson LE, Plante I, Ponomarev AL, Saha J, Snijders AM, Srinivasan K, Tang J, Werner E, Pluth JM.

Evaluating biomarkers to model cancer risk post cosmic ray exposure.

Life Sci Space Res. 2016 May 21. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552416300165

PIs: A. Asaithamby; H. Sadek; W. Dynan; L. Hlatky; S. Blattnig; A. Kronenberg; M.D. Naidu; J.M. Pluth; M.H. Barcellos-Hoff/A. Kronenberg/S.V. Costes/NSCOR; L. Hlatky/Y. Wang/ P.W. Doetsch/W.S. Dynan/NSCOR; L. Hlatky/P. Hahnfeldt/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.183

Funding: “This work was supported by National Aeronautics and Space Administration NNX13AD57G, and NNX15AE06G (to A. Asaithamby); National Aeronautics and Space Administration NNJ09HC64I and the Low Dose Scientific Focus Area, United States Department of Energy DE-AC02-05CH11231 (to S.V. Costes); National Aeronautics and Space Administration NNX15AD63G (to W. Dynan), NASA Specialized Center of Research (NSCOR) NNX11AC30G (to Emory University -W.Dynan, P.Doetsch, and E.Werner); National Aeronautics and Space Administration grants NNX13AJ01G, NNX11AK26G, and NSCOR NNJ06HA28G (to L. Hlatky); National Aeronautics and Space Administration NAS9-02078 (to Y. Kidane, I. Plante, and A. Ponomarev); National Aeronautics and Space Administration NNJ12HB88I (to A. Kronenberg); National Aeronautics and Space Administration NNX11AO89G and NNX13AD74G (to M. Naidu); National Aeronautics and Space Administration NNX12AO52A (to Tatiana Kovyrshina, M.S. who performed QC, normalization, and batch-effect removal of expression arrays used for pathway activation for analysis by L. Peterson). National Aeronautics and Space Administration NNJ12HD071 and NNJ13HA96I (to J.Pluth); Dose Scientific Focus Area, US Department of Energy DE-AI02-10ER64969- J.Saha (to F. Cucinotta); Low Dose Scientific Focus Area, US Department of Energy DE-AC02-05CH11231 (to A.Snijders).”

Miller J, Zeitlin C.

Twenty years of space radiation physics at the BNL AGS and NASA Space Radiation Laboratory.

Life Sci Space Res. 2016 May 18. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552416300244

Note: From the Abstract: “The NASA Space Radiation Laboratory at BNL was constructed specifically for space radiation research. Here we review some of the space-related physics results obtained over the first 20 years of NASA-sponsored research at Brookhaven.”

Journal Impact Factor: 1.183

Funding: No funding cited.

______________________________________________________

Other papers of interest:

Mukhopadhyay S, Saha R, Palanisamy A, Ghosh M, Biswas A, Roy S, Pal A, Sarkar K, Bagh S.

A systems biology pipeline identifies new immune and disease related molecular signatures and networks in human cells during microgravity exposure.

Sci Rep. 2016 May 17;6:25975.

http://www.ncbi.nlm.nih.gov/pubmed/27185415

Note: Results from ISS, Progress 40P (ESA-SPHINX), STS-135, and ground based studies. The method used for microgravity simulation is not identified. This article may be obtained online without charge.

Johannes B, Salnitski V, Dudukin A, Shevchenko L, Bronnikov S.

Performance assessment in the PILOT experiment on board space stations Mir and ISS.

Aerosp Med Hum Perform. 2016 Jun;87(6):534-44.

http://www.ncbi.nlm.nih.gov/pubmed/27208676

Note: Mir and ISS results.

Bae JE, Bang S, Min S, Lee SH, Kwon SH, Lee Y, Lee YH, Chung J, Chae KS.

Positive geotactic behaviors induced by geomagnetic field in Drosophila.

Mol Brain. 2016 May 18;9(1):55.

http://www.ncbi.nlm.nih.gov/pubmed/27192976

Note: This article may be obtained online without charge.

Salvadego D, Keramidas ME, Brocca L, Domenis R, Mavelli I, Rittweger J, Eiken O, Mekjavic IB, Grassi B.

Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans.

J Appl Physiol (1985). 2016 May 19:jap.00832.2015. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27197861

Note: Bed rest study. The title on the Epub is: LunHab: Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans. LunHab stands for Lunar Habitat Simulation

Yoon G, Oh CS, Kim HS.

Hypergravity upregulates renal inducible nitric oxide synthase expression and nitric oxide production.

Oncotarget. 2016 May 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27174912

Note: Centrifugation was used. This article may be obtained online without charge.

Yoon G, Sik Oh C, Kim HS.

Distinctive expression patterns of hypoxia-inducible factor-1alpha and endothelial nitric oxide synthase following hypergravity exposure.

Oncotarget. 2016 May 14. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27191892

Note: Centrifugation was used. This article may be obtained online without charge.

Zhuravlyova OA, Markin AA, Kuzichkin DS, Loginov VI, Zabolotskaya IV, Vostrikova LV.

[Oxidation stress markers dynamics in the experiment of long-term antiorthostatic hypokinesia (Retrospective study)].

Fiziol Cheloveka. 2016 Jan-Feb;42(1):94-9. Russian.

http://www.ncbi.nlm.nih.gov/pubmed/27188151

Note: The method used for antiorthostatic hypokinesia is not specified in the English abstract.

Xu X, Wang B, Jin Z, Zhang Y.

A dynamic rabbit model of sinus barotrauma and its related pathology.

Aerosp Med Hum Perform. 2016 Jun;87(6):521-7.

http://www.ncbi.nlm.nih.gov/pubmed/27208674

Eftedal I.

Diving int006F the rat plasma proteome to get to the bottom of decompression sickness.

Proteomics Clin Appl. 2016 May 16. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27196271

Note: This is a Commentary on the article: “Effect of simulated air dive and decompression sickness on the plasma proteome of rats.” by Lautridou J, Pichereau V, Artigaud S, Buzzacott P, Wang Q, Bernay B, Driad S, Mazur A, Lambrechts K, Théron M, Guerrero F. Proteomics Clin Appl. 2016 May;10(5):614-20. http://www.ncbi.nlm.nih.gov/pubmed/27068327, which appeared in SPACELINE Current Awareness List #695, 22 Apr 2016.

Webb JT, Morgan TR, Sarsfield SD.

Altitude decompression sickness risk and physical activity during exposure.

Aerosp Med Hum Perform. 2016 Jun;87(6):516-20.

http://www.ncbi.nlm.nih.gov/pubmed/27208673

Wang H, Yan Y, Rong D, Wang J, Wang H, Liu Z, Wang J, Yang R, Han Y.

Increased biofilm formation ability in Klebsiella pneumoniae after short-term exposure to a simulated microgravity environment.

Microbiologyopen. 2016 May 16. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27185296

Note: A high-aspect ratio rotating-wall vessel (HARV) was used. This article may be obtained online without charge.

Quinones QJ, Zhang Z, Ma Q, Smith MP, Soderblom E, Moseley MA, Bain J, Newgard CB, Muehlbauer MJ, Hirschey M, Drew KL, Barnes BM, Podgoreanu MV.

Proteomic profiling reveals adaptive responses to surgical myocardial ischemia-reperfusion in hibernating Arctic ground squirrels compared to rats.

Anesthesiology. 2016 Jun;124(6):1296-310.

http://www.ncbi.nlm.nih.gov/pubmed/27187119

Wilson MH.

Monro-Kellie 2.0: The dynamic vascular and venous pathophysiological components of intracranial pressure.

J Cereb Blood Flow Metab. 2016 May 12. [Epub ahead of print] Review.

http://www.ncbi.nlm.nih.gov/pubmed/27174995

Note: This article may be obtained online without charge.

Terada M, Seki M, Takahashi R, Yamada S, Higashibata A, Majima HJ, Sudoh M, Mukai C, Ishioka N.

Correction: Effects of a closed space environment on gene expression in hair follicles of astronauts in the international Space Station.

PLoS One. 2016 May 18;11(5):e0156190.

http://www.ncbi.nlm.nih.gov/pubmed/27192056

Note: ISS results. From the article: “There is an error in the fifth sentence of the last paragraph of the introduction. The correct sentence is: Recently, analysis of skin from space-flown mice showed that prolonged exposure to space conditions might induce skin atrophy and dysregulate the hair follicle cycle. There are errors in the last two sentences of the first paragraph of the discussion. The correct sentence is: Neutelings et al. investigated skin from space-flown mice and suggested that prolonged exposure to space environment might induce skin atrophy and deregulate hair follicle cycle, although they reported that the number of hair follicle in anagen increased in the space environment. Considering the FGF18 function on hair cycle, our results are not inconsistent with their findings.” The original article appeared in SPACELINE Current Awareness List #693, 4 Apr 2016, http://www.ncbi.nlm.nih.gov/pubmed/27029003. This Correction and the original article may be obtained online without charge.

Murata M, Kosaka R, Kurihara K, Yamashita S, Tachibana H.

Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression.

Biosci Biotechnol Biochem. 2016 May 16:1-5. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27180787

Note: Hindlimb unloading study.

Gnyubkin V, Guignandon A, Laroche N, Vanden-Bossche A, Malaval L, Vico L.

High-acceleration whole body vibration stimulates cortical bone accrual and increases bone mineral content in growing mice.

J Biomech. 2016 May 3. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27178020

Note: An accelerometer was used to achieve 2g peak acceleration.

Verbruggen SW, Vaughan TJ, McNamara LM.

Mechanisms of osteocyte stimulation in osteoporosis.

J Mech Behav Biomed Mater. 2016 May 10;62:158-68. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27203269

Wang J, Wang CD, Zhang N, Tong WX, Zhang YF, Shan SZ, Zhang XL, Li QF.

Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1.

Cell Death Dis. 2016 May 12;7:e2221.

http://www.ncbi.nlm.nih.gov/pubmed/27171263

Note: This article may be obtained online without charge.

Retraction: “Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts,” by Suzanne R.L. Young, Rita Gerard-O’Riley, Jae-Beom Kim and Fredrick M Pavalko.

J Bone Miner Res. 2016 May 13. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27177386

Note: From the text: “The . . . article from the Journal of Bone and Mineral Research, published online on 3 November 2008 in Wiley Online Library (wileyonlinelibrary.com) and in JBMR Volume 24, Issue 3, pages 411-424, together with its accompanying Erratum, published online on 18 October 2013, has been retracted by agreement between the journal’s editor-in-chief, Juliet E. Compston, the authors’ institution, Indiana University, and Wiley Periodicals, Inc. The authors have requested the retraction based on their acknowledgement of concerns regarding the images used within the publication which could not be verified due to a subsequent loss of raw research data. The original article appeared in SPACELINE Current Awareness List #419, 12 December 2008, http://www.ncbi.nlm.nih.gov/pubmed/19016591. The Retraction notice may be obtained online without charge.

Pani G, Verslegers M, Quintens R, Samari N, de Saint-Georges L, van Oostveldt P, Baatout S, Benotmane MA.

Combined exposure to simulated microgravity and acute or chronic radiation reduces neuronal network integrity and survival.

PLoS One. 2016 May 20;11(5):e0155260.

http://www.ncbi.nlm.nih.gov/pubmed/27203085

Note: A random positioning machine was used. This article may be obtained online without charge.

Zhang X, Ye C, Sun F, Wei W, Hu B, Wang J.

Both complexity and location of DNA damage contribute to cellular senescence induced by ionizing radiation.

PLoS One. 2016 May 17;11(5):e0155725.

http://www.ncbi.nlm.nih.gov/pubmed/27187621

Note: This article may be obtained online without charge.

Bringoux L, Scotto Di Cesare C, Borel L, Macaluso T, Sarlegna FR.

Do visual and vestibular inputs compensate for somatosensory loss in the perception of spatial orientation? Insights from a deafferented patient.