Status Report

NASA Spaceline Current Awareness List #683 29 January 2016

By SpaceRef Editor

January 29, 2016

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Papers deriving from NASA support:

Flynn-Evans EE, Barger LK, Kubey AA, Sullivan JP, Czeisler CA.

Circadian misalignment affects sleep and medication use before and during spaceflight.

npj Microgravity. 2016 Jan 7;2:15019.

http://www.nature.com/articles/npjmgrav201519

PI: C.A. Czeisler

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “The study was supported by NASA cooperative agreement NCC 9-119. Barger and Flynn-Evans were the recipients of National Heart, Lung and Blood Institute fellowships in the program of training in Sleep, Circadian and Respiratory Neurobiology at Brigham and Women’s Hospital (NHLBI; T32 HL079010).”

Ferl RJ, Paul A-L.

The effect of spaceflight on the gravity-sensing auxin gradient of roots: GFP reporter gene microscopy on orbit.

npj Microgravity. 2016 Jan 21;2:15023.

http://www.nature.com/articles/npjmgrav201523

PI: R.J. Ferl

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This research was supported by grants NASA NNX12AN69G and CASIS GA-2013-104 to RJF and A-LP.”

Florian JP, Baisch FJ, Heer M, Pawelczyk JA.

Caloric restriction diminishes the pressor response to static exercise.

Extrem Physiol Med. 2016 Jan 20;5:2.

http://www.ncbi.nlm.nih.gov/pubmed/26793301

PI: J.A. Pawelcyzk

Note: Bed rest study. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This research was supported by National Space Biomedical Research Institute Contract TD00206.”

Wickens CD, Gutzwiller RS, Vieane A, Clegg BA, Sebok A, Janes J.

Time sharing between robotics and process control: Validating a model of attention switching.

Hum Factors. 2016 Jan 15. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/26772605

PI: A. Sebok

Journal Impact Factor: 1.694

Funding: “This material is based upon work supported by NASA under Grant NNX12AE69G.”

Morris CJ, Purvis TE, Mistretta J, Scheer FA.

Effects of the internal circadian system and circadian misalignment on glucose tolerance in chronic shift workers.

J Clin Endocrinol Metab. 2016 Jan 15:jc20153924. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/26771705

PI: C.J. Morris

Journal Impact Factor: 6.209

Funding: “This study was supported by National Heart, Lung, and Blood Institute (NHLBI) Grant R01 HL094806 (to F.A.J.L.S.). C.J.M. was partly supported by the National Space Biomedical Research Institute through National Aeronautics and Space Administration Grant NCC 958. F.A.J.L.S. was supported in part by NHLBI Grant R01 HL094806, the Fund to Sustain Research Excellence by the Brigham and Women’s Hospital Biomedical Research Institute, National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK099512, and NHLBI Grant R01 HL118601. This project was supported by Clinical Translational Science Award UL1RR025758 to Harvard University and Brigham and Women’s Hospital from the National Center for Research Resources.”

Raber J, Allen AR, Sharma S, Allen B, Rosi S, Olsen RH, Davis MJ, Eiwaz M, Fike JR, Nelson GA.

Effects of proton and combined proton and (56)Fe radiation on the hippocampus.

Radiat Res. 2016 Jan;185(1):20-30.

http://www.ncbi.nlm.nih.gov/pubmed/26720797

PIs: G.A. Nelson/J. Raber/A. Allen/S. Rosi/J. Fike/NSCOR

Journal Impact Factor: 2.911

Funding: “This work was supported by National Aeronautics and Space Administration (NASA) grant no. NNX10AD59G.”

Schmidt MA, Goodwin TJ, Pelligra R.

Incorporation of omics analyses into artificial gravity research for space exploration countermeasure development.

Metabolomics. 2016 Jan 20;12:36. Review.

http://link.springer.com/article/10.1007/s11306-015-0942-0/fulltext.html

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.85

Funding: No funding cited. T.J. Goodwin is at NASA Johnson Space Center, R. Pelligra is at NASA Ames Research Center.

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Other papers of interest:

Higashibata A, Hashizume T, Nemoto K, Higashitani N, Etheridge T, Mori C, Harada S, Sugimoto T, Szewczyk NJ, Baba SA, Mogami Y, Fukui K, Higashitani A.

Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans.

npj Microgravity. 2016 Jan 21;2:15022.

http://www.nature.com/articles/npjmgrav201522

Note: ISS results. This article may be obtained online without charge.

Sugita T, Yamazaki T, Makimura K, Cho O, Yamada S, Ohshima H, Mukai C.

Comprehensive analysis of the skin fungal microbiota of astronauts during a half-year stay at the International Space Station.

Med Mycol. 2016 Jan 14. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/26773135

Note: ISS results.

Nowacki D, Klinger FG, Mazur G, Felici MD.

Effect of culture in simulated microgravity on the development of mouse embryonic testes.

Adv Clin Exp Med. 2015 Sep-Oct;24(5):769-74. Epub 2016 Jan 16.

http://www.ncbi.nlm.nih.gov/pubmed/26768626

Note: A Rotary Cell Culture System bioreactor was used. This article may be obtained online without charge.

Longland TM, Oikawa SY, Mitchell CJ, Devries MC, Phillips SM.

Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: A randomized trial.

Am J Clin Nutr. 2016 Jan 27. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/26817506

Mazur A, Lambrechts K, Wang Q, Belhomme M, Theron M, Buzzacott P, Guerrero F.

Influence of decompression sickness on vasocontraction of isolated rat vessels.

J Appl Physiol (1985). 2016 Jan 14:jap.00139.2015. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/26769950

Zueco J, Lpez-Gonzlez LM.

Network model to study physiological processes of hypobaric decompression sickness: New numerical results.

Acta Astronaut. 2016 Apr;121:256-70.

http://www.sciencedirect.com/science/article/pii/S0094576515301235

Simpson EJ, Debevec T, Eiken O, Mekjavic IB, Macdonald IA.

The combined and separate effects of 16 days bed rest and normobaric hypoxic confinement on circulating lipids and indices of insulin sensitivity in healthy men.

J Appl Physiol (1985). 2016 Jan 14:jap.00897.2015. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/26769956

Note: Bed rest study. This is part of the Planetary Habitat Simulation Study supported by the European Space Agency.

Greene CS, Foster JA, Stanton BA, Hogan DA, Bromberg Y.

Computational approaches to study microbes and microbiomes.

Pac Symp Biocomput. 2016;21:557-67.

http://www.ncbi.nlm.nih.gov/pubmed/26776218

Note: This article may be obtained online without charge.

Deschenes MR, Leathrum CM.

Gender-specific neuromuscular adaptations to unloading in isolated rat soleus muscles.

Muscle Nerve. 2016 Jan 16. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/26773754

Note: Hindlimb unloading study.

Moreira JB, Wohlwend M, Amellem I, Jannig PR.

Age-dependent effects of bed rest in human skeletal muscle: Exercise to the rescue.

J Physiol. 2016 Jan 15;594(2):265-6.

http://www.ncbi.nlm.nih.gov/pubmed/26767889

Note: This article is a Journal Club discussion of the article “Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation” by RE Tanner, et al. in 2015 Sep 15;593(18):4259-73. (http://www.ncbi.nlm.nih.gov/pubmed/26173027) The original article appeared in Current Awareness List #658, 24 July 2015.

Samsa WE, Vasanji A, Midura RJ, Kondratov RV.

Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype.

Bone. 2016 Jan 14;84:194-203. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/26789548

Stadelmann VA, Brun J, Bonnet N.

Preclinical mouse models for assessing axial compression of long bones during exercise.

Bonekey Rep. 2015 Dec 23;4:768.

http://www.ncbi.nlm.nih.gov/pubmed/26788286

Papali A.

Providing health care in rural and remote areas: Lessons from the International Space Station.

Bull World Health Organ. 2016 Jan 1;94(1):73-4.

http://www.ncbi.nlm.nih.gov/pubmed/26770000

Note: NASA’s use of task-shifting by training non-medical ISS crew members in the use of diagnostic ultrasound, telemedicine for point-of-care treatment, and virtual remote guidance are used as models for providing health care in remote areas on Earth. This article may be obtained online without charge.

Wardman P.

Time as a variable in radiation biology: The oxygen effect.

Radiat Res. 2016 Jan;185(1):1-3. Epub 2016 Jan 5.

http://www.ncbi.nlm.nih.gov/pubmed/26731298

Xi W, Gong X, Yang Q, Yu H, Liou Y-C.

Pin1At regulates PIN1 polar localization and root gravitropism.

Nat Commun. 2016 Jan 21;7.

http://www.nature.com/ncomms/2016/160121/ncomms10430/full/ncomms10430.html

Note: This article may be obtained online without charge.

Boccaccio A, Uva AE, Fiorentino M, Mori G, Monno G.

Geometry design optimization of functionally graded scaffolds for bone tissue engineering: A mechanobiological approach.

PLoS One. 2016 Jan 15;11(1):e0146935.