NASA Spaceline Current Awareness List #658 24 July 2015

Editor’s note: NASA’s various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website – nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&page=1

Papers deriving from NASA support:

1
Carman JG, Hole P, Salisbury FB, Bingham GE.
Developmental, nutritional and hormonal anomalies of weightlessness-grown wheat.
Life Sci Space Res. 2015. Epub 2015 Jul 15.
http://www.sciencedirect.com/science/article/pii/S221455241500067X
PIs: F.B. Salisbury, G.E. Bingham
Note: Mir results.
Journal Impact Factor: 1.183
Funding: “This research was supported by NASA Grant NCC 2-831 and by the Utah Agricultural Experiment Station, Utah State University, Logan UT 84322-4810 (approved as UAES journal paper number 8749).”

2
Bretschger O, Carpenter K, Phan T, Suzuki S, Ishii S, Grossi-Soyster E, Flynn M, Hogan J.
Functional and taxonomic dynamics of an electricity-consuming methane-producing microbial community.
Bioresour Technol. 2015 Jul 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/26178785
Journal Impact Factor: 4.494
Funding: “This work was supported by NASA ARC (Contract Nos. NNX12AG92A and NNX13AI31A) and the Roddenberry Foundation.” J. Hogan is at NASA Ames Research Center.

3
Mao CP, Macias BR, Hargens AR.
Shoulder skin and muscle hemodynamics during backpack carriage.
Appl Ergon. 2015 Nov;51:80-4. Epub 2015 May 19.
http://www.ncbi.nlm.nih.gov/pubmed/26154207
PIs: A.R. Hargens, B.R. Macias
Journal Impact Factor: 2.023
Funding: “This work is supported by the National Space Biomedical Research Institute through NCC 9-58 (to BRM). This study was funded by NASA grant # NNX10AM18G (to ARH).”

4
Durocher JJ, Carter JR, Cooke WH, Young AH, Harwood MH.
Cerebral blood flow velocity during combined lower body negative pressure and cognitive stress.
Aerosp Med Hum Perform. 2015 Aug;86(8):688-92.
http://www.ingentaconnect.com/content/asma/amhp/2015/00000086/00000008/art00003
Journal Impact Factor: 0.875
Funding: “This project was supported by a grant from the National Aeronautics and Space Administration through the Michigan Space Grant Consortium to John J. Durocher.”

5
Oestreich AK, Carleton SM, Yao X, Gentry BA, Raw CE, Brown M, Pfeiffer FM, Wang Y, Phillips CL.
Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice.
Osteoporos Int. 2015 Jul 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/26179666
PI: S.M. Carleton, NSBRI Postdoctoral Fellowship Program
Journal Impact Factor: 4.169
Funding: “We would also like to thank the following funding sources: National Institutes of Health Grants AR055907 (SMC, BAG, AKO, CER, CLP) and T32RR007004 (BAG), National Space and Biomedical Research Institute Postdoctoral Fellowship NCC 9–58 (SMC), Leda J. Sears Trust Foundation Grant (SMC, BAG, CER, CLP), Phi Zeta Grant (BAG), University of Missouri Life Sciences Fellowship (AKO), University of Missouri Research Board Grant (MB, CLP), and University of Missouri Interdisciplinary Intercampus Research Program (CLP,YW,AKO).”

6
Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ Jr, Gerson S, Hlatky L, Kirsch DG, Lederer U, Shay J, Wang Y, Weil MM.
Concepts and challenges in cancer risk prediction for the space radiation environment.
Life Sci Space Res. 2015. Epub 2015 Jul 17.
http://www.sciencedirect.com/science/article/pii/S2214552415000681
PIs: M.H. Barcellos-Hoff; E.A. Blakely; S. Burma; U. Lederer; L. Hlatky; M.M. Weil; M.H. Barcellos-Hoff/A.J. Fornace, Jr./D.G. Kirsch/Y. Wang/R. Ullrich/M.M. Weil/NSCOR
Note: From the abstract: “This white paper reviews broad issues related to experimental models and concepts in space radiation carcinogenesis as well as the current state of the field to place into context recent findings and concepts derived from the NASA Space Radiation Program.”
Journal Impact Factor: 1.183
Funding: “This material is based upon discussion in the Cancer Biology Working Group under the auspices of supported by the National Aeronautics and Space Administration under Grant/Contract/Agreement No. NNX13AF06G and NNX09AM52G (MHBH); NNJ11HA94I (EAB); NNX13AI13G (SB); NNX15AI21G (AJF); NNX11AC60G (DGK); NNX14AC50G (UL); NNX11AK26G and NNX13AJ01G (LH); NNX11AC30G (YW); NNX09AM08G and NNX12AB54G (MMW).”

7
Lee SH, Ledri M, Tóth B, Marchionni I, Henstridge CM, Dudok B, Kenesei K, Barna L, Szabó SI, Renkecz T, Oberoi M, Watanabe M, Limoli CL, Horvai G, Soltesz I, Katona I.
Multiple forms of endocannabinoid and endovanilloid signaling regulate the tonic control of GABA release.
J Neurosci. 2015 Jul 8;35(27):10039-57.
http://www.ncbi.nlm.nih.gov/pubmed/26157003
PIs: G. Nelson/C.L. Limoli/I. Soltesz/NSCOR
Note: This article may be obtained online without charge.
Journal Impact Factor: 6.344
Funding: “This work was supported by Hungarian Academy of Sciences Momentum Program LP-54/2013, European Research Council Grant 243153 (I.K.), National Institute of Health Grant NS35915 (I.S.), and NASA Grants NNX10AD59G and NNX15AI22G (C.L.L., I.S.). Super-resolution microscopy was funded by Hungarian Academy of Sciences Equipment Grant IF-22/2012. I.K. is a recipient of a Wellcome Trust International Senior Research Fellowship. M.O. was funded by Minority Science Program National Institutes of Health/Maximizing Access to Research Careers Grant GM-69337.”

8
Mukherjee M, Eikema DJ, Chien JH, Myers SA, Scott-Pandorf M, Bloomberg JJ, Stergiou N.
Plantar tactile perturbations enhance transfer of split-belt locomotor adaptation.
Exp Brain Res. 2015 Jul 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/26169104
Journal Impact Factor: 2.036
Funding: “This study was supported by funds from the NASA Experimental Program to Stimulate Competitive Research (EPSCoR) award number NNX11AM06A, the National Institute of General Medical Sciences of the National Institutes of Health award number P20GM109090 and award number 1I01RX000604 from the Rehabilitation Research and Development Service of the VA Office of Research and Development.” J.J. Bloomberg is at NASA Johnson Space Center.

9
Su S-H, Gray WM, Masson PH.
Auxin: Shape matters.
Nature Plants. 2015 Jul 7;1:15097.
http://www.nature.com/articles/nplants201597
(You may need to copy the URL into your browser.)
PI: P.H. Masson
Journal Impact Factor: Not available for this journal
Funding: No funding cited. PI reports funding under NASA grant NNX14AT23G.

10
Neufeld MJ, Charles JB.
Practicing for space underwater: Inventing neutral buoyancy training, 1963–1968.
Endeavour. 2015 Jul 15. [Article in Press]
http://www.sciencedirect.com/science/article/pii/S0160932715200567
Journal Impact Factor: 0.217
Funding: No funding cited. J.B. Charles is at NASA Johnson Space Center.

11
Starr J, Castro E, Crosas M, Dumontier M, Downs RR, Duerr R, Haak LL, Haendel M, Herman I, Hodson S, Hourclé J, Kratz JE, Lin J, Nielsen LH, Nurnberger A, Proell S, Rauber A, Sacchi S, Smith A, Taylor M, Clark T.
Achieving human and machine accessibility of cited data in scholarly publications.
PeerJ Comput Sci. 2015;1.
http://www.ncbi.nlm.nih.gov/pubmed/26167542
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “The following grant information was disclosed by the authors: National Institutes of Health (NIH): # NIH 1U54AI117925-01. Alfred P. Sloan Foundation: #2012-3-23. European Union (FP7): #269977, #269940. National Aeronautics and Space Administration (NASA): NNG13HQ04C.”
_____________________________________________________

Other papers of interest:

1
Atomi Y.
Gravitational effects on human physiology.
Subcell Biochem. 2015;72:627-59. Review.
http://www.ncbi.nlm.nih.gov/pubmed/26174402
Note: Hindlimb unloading study results are discussed.

2
MacInnis MJ, Carter EA, Donnelly J, Koehle MS.
A meta-analysis of exhaled nitric oxide in acute normobaric hypoxia.
Aerosp Med Hum Perform. 2015 Aug;86(8):693-7.
http://www.ingentaconnect.com/content/asma/amhp/2015/00000086/00000008/art00004

3
Indo HP, Tomiyoshi T, Suenaga S, Tomita K, Suzuki H, Masuda D, Terada M, Ishioka N, Gusev O, Cornette R, Okuda T, Mukai C, Majima HJ.
MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1.
J Clin Biochem Nutr. 2015. [Article in Press]
https://www.jstage.jst.go.jp/article/jcbn/advpub/0/advpub_15-20/_article
Note: Clinorotation was used. This article may be obtained online without charge.

4
Behringer M, Schüren T, McCourt M, Mester J.
Efficacy of manual versus free-weight training to improve maximal strength and performance for microgravity conditions.
J Sports Sci. 2015:1-7. Epub 2015 Jul 15.
http://www.tandfonline.com/doi/full/10.1080/02640414.2015.1066025#.VbCzp_ngC00
Note: The Self-Powered Rope Trainer Duo (SPoRT Duo) system is presented as an alternate in-flight exercise device.

5
Fuentes TI, Appleby N, Raya M, Bailey L, Hasaniya N, Stodieck L, Kearns-Jonker M.
Simulated microgravity exerts an age-dependent effect on the differentiation of cardiovascular progenitors isolated from the human heart.
PLoS One. 2015 Jul 10;10(7):e0132378.
http://www.ncbi.nlm.nih.gov/pubmed/26161778
Note: 2D clinorotation was used. This article may be obtained online without charge.

6
Abou-Elnaga AF, Torigoe D, Fouda MM, Darwish RA, Abou-Ismail UA, Morimatsu M, Agui T.
Identification of multiple genetic loci in the mouse controlling immobility time in the tail suspension and forced swimming tests.
Jpn J Vet Res. 2015 May;63(2):53-62.
http://www.ncbi.nlm.nih.gov/pubmed/26164874
Note: Hindlimb unloading was used.

7
Tanner RE, Brunker LB, Agergaard J, Barrows KM, Briggs RA, Kwon OS, Young LM, Hopkins PN, Volpi E, Marcus RL, LaStayo PC, Drummond MJ.
Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation.
J Physiol. 2015 Jul 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/26173027
Note: Bed rest study.

8
Wu H, Xia Y, Jiang J, Du H, Guo X, Liu X, Li C, Huang G, Niu K.
Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: A systematic review and meta-analysis.
Arch Gerontol Geriatr. 2015 Jul 3. [Epub ahead of print] Review.
http://www.ncbi.nlm.nih.gov/pubmed/26169182

9
Sung B, Hwang SY, Kim MJ, Kim M, Jeong JW, Kim CM, Chung HY, Kim ND.
Loquat leaf extract enhances myogenic differentiation, improves muscle function and attenuates muscle loss in aged rats.
Int J Mol Med. 2015 Jul 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/26178971
Note: Muscle strength was measured by a grip strength meter using the forelimb.

10
Kang C, Goodman CA, Hornberger TA, Ji LL.
PGC-1alpha overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization.
FASEB J. 2015 Jul 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/26178167
Note: Hindlimb immobilization was attained by fixing the limb in knee extension and ankle plantarflexion.

11
McGee-Lawrence M, Buckendahl P, Carpenter C, Henriksen K, Vaughan M, Donahue S.
Suppressed bone remodeling in black bears conserves energy and bone mass during hibernation.
J Exp Biol. 2015 Jul 1;218(Pt 13):2067-74.
http://www.ncbi.nlm.nih.gov/pubmed/26157160
Note: This article may be obtained online without charge.

12
Vegger JB, Brüel A, Thomsen JS.
Vertical trabeculae are thinned more than horizontal trabeculae in skeletal-unloaded rats.
Calcif Tissue Int. 2015 Jul 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/26163234
Note: Hindlimbs were immobilized by botulinum toxin A injection.

13
Volpon JB, Silva AV, Falcai MJ, Louzada MJ, Zamarioli A, Kotake BG, Issa JP.
The osteogenic effects of swimming on bone mass, strength, and microarchitecture in rats with unloading-induced bone loss.
Microsc Res Tech. 2015 Jul 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/26179081
Note: Hindlimb unloading was used.

14
Chishti AA, Hellweg CE, Berger T, Baumstark-Khan C, Feles S, Kätzel T, Reitz G.
Constitutive expression of tdTomato protein as a cytotoxicity and proliferation marker for space radiation biology.
Life Sci Space Res. 2015 Jan;4:35-45. Epub 2015 Jan 6.
http://www.ncbi.nlm.nih.gov/pubmed/26177619
Note: This article may be obtained online without charge.

15
Fels M, Bauer R, Gharabaghi A.
Predicting workload profiles of brain-robot interface and electromygraphic neurofeedback with cortical resting-state networks: Personal trait or task-specific challenge?
J Neural Eng. 2015 Aug;12(4):046029. Epub 2015 Jul 14.
http://www.ncbi.nlm.nih.gov/pubmed/26170164
Note: The NASA Task Load Index was used.

16
Wilson GI, Holton MD, Walker J, Jones MW, Grundy E, Davies IM, Clarke D, Luckman A, Russill N, Wilson V, Plummer R, Wilson RP.
A new perspective on how humans assess their surroundings; derivation of head orientation and its role in ‘framing’ the environment.
PeerJ. 2015 Jun 18;3:e908.
http://www.ncbi.nlm.nih.gov/pubmed/26157643
Note: This article may be obtained online without charge.

17
Zheng Y, Lu Y, Wang Z, Huang D, Fu S.
Developing a measurement for task complexity in flight.
Aerosp Med Hum Perform. 2015 Aug;86(8):698-704.
http://www.ingentaconnect.com/content/asma/amhp/2015/00000086/00000008/art00005

18
Milleville-Pennel I, Charron C.
Driving for real or on a fixed-base simulator: Is it so different? An explorative study.
Presence-Teleop Virt. 2015 Winter;24(1):74-91.
http://www.mitpressjournals.org/doi/10.1162/PRES_a_00216#.VbDOEvngCzc
Note: The NASA Task Load Index was used. This article may be obtained online without charge.

19
Cohen TN, Wiegmann DA, Shappell SA.
Evaluating the reliability of the human factors analysis and classification system.
Aerosp Med Hum Perform. 2015 Aug;86(8):728-35. Review.
http://www.ingentaconnect.com/content/asma/amhp/2015/00000086/00000008/art00009

20
Kamal KY, Hemmersbach R, Medina FJ, Herranz R.
Proper selection of 1 g controls in simulated microgravity research as illustrated with clinorotated plant cell suspension cultures.
Life Sci Space Res. 2015 Apr;5:47-52. Epub 2015 Apr 18.
http://www.ncbi.nlm.nih.gov/pubmed/26177849
Note: Clinorotation was used.

21
Ache JM, Dürr V.
A computational model of a descending mechanosensory pathway involved in active tactile sensing.
PLoS Comput Biol. 2015 Jul;11(7):e1004263.
http://www.ncbi.nlm.nih.gov/pubmed/26158851
Note: This article may be obtained online without charge.

22
Sokabe M, Sawada Y, Kobayashi T.
Ion channels activated by mechanical forces in bacterial and eukaryotic cells.
Subcell Biochem. 2015;72:613-26. Review.
http://www.ncbi.nlm.nih.gov/pubmed/26174401