NASA Spaceline Current Awareness List #649 – 22 May 2015
Of interest this week:
GeneLab Data System 1.0, the first version of NASA’s open-access, online searchable data repository for Space Biology experiments, has been released. This initial 1.0 release of the GeneLab Data System is part of a larger four-phased development approach to the GeneLab project. The iterative development approach is to enable community feedback and tailored updates to the system. See http://genelab.nasa.gov/data.
A recent paper by NASA-funded researcher Karen Plaut has been chosen for the May 2015 APSselect list (http://apsselect.physiology.org/) of “the very best original research papers published by the American Physiological Society.” The paper, “Transcriptomes reveal alterations in gravity impact circadian clocks and activate mechanotransduction pathways with adaptation through epigenetic change” by Theresa Casey, Osman V. Patel, and Karen Plaut appears in Physiological Genomics, volume 47, 2015, and was cited ahead of print in SPACELINE Current Awareness List #635, February 13, 2015.
Papers deriving from NASA support:
1
Beaton KH, Huffman WC, Schubert MC.
Binocular misalignments elicited by altered gravity provide evidence for nonlinear central compensation.
Front Syst Neurosci. 2015 May 9;9:81.
http://journal.frontiersin.org/article/10.3389/fnsys.2015.00081
PI: M.C. Schubert
Note: Parabolic flight results. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal.
Funding: “This work was funded by NASA through the Human Research Program grant NNX10AO19G and the Flight Opportunities Program.”
2
Hwang SA, Crucian B, Sams C, Actor JK.
Post-spaceflight (STS-135) mouse splenocytes demonstrate altered activation properties and surface molecule expression.
PLoS One. 2015 May 13;10(5):e0124380.
http://www.ncbi.nlm.nih.gov/pubmed/25970640
Note: STS-135 results. This article may be obtained online without charge.
Journal Impact Factor: 3.534
Funding: B. Crucian and C. Sams are at NASA Johnson Space Center.
3
Guo J, Zeitlin C, Wimmer-Schweingruber RF, Hassler DM, Ehresmann B, Köhler J, Böhm E, Böttcher S, Brinza D, Burmeister S, Cucinotta F, Martin C, Posner A, Rafkin S, Reitz G.
MSL-RAD radiation environment measurements.
Radiat Prot Dosimetry. 2015 May 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25969529
Note: Mars Science Laboratory results.
Journal Impact Factor: 0.861
Funding: “RAD is supported by the National Aeronautics and Space Administration (NASA) under JPL subcontract 1273039 to the Southwest Research Institute and by DLR and DLR’s Space Administration, grant numbers 50QM0501 and 50QM1201, to the Christian Albrechts University in Kiel, Germany. Part of this research was carried out at JPL under a contact with NASA.” A. Posner is at NASA Headquarters and D. Brinza is at the Jet Propulsion Laboratory, California Institute of Technology.
4
Wallace WT, Gazda DB, Limero TF, Minton JM, Macatangay AV, Dwivedi P, Fernandez FM.
Electrothermal vaporization sample introduction for spaceflight water quality monitoring via gas chromatography-differential mobility spectrometry.
Anal Chem. 2015 May 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25971650
Note: ISS results.
Journal Impact Factor: 5.825
Funding: “WTW, DBG, and TFL acknowledge funding under NASA contract # NAS 9-02078. The work of JMM was supported through the Arkansas Space Grant Consortium. . .FMF thanks NASA for award number NNX13AF51G S02.” A. V. Macatangay is at NASA Johnson Space Center.
5
Crabbé A, Liu Y, Sarker SF, Bonenfant NR, Barrila J, Borg ZD, Lee JJ, Weiss DJ, Nickerson CA.
Recellularization of decellularized lung scaffolds is enhanced by dynamic suspension culture.
PLoS One. 2015 May 11;10(5):e0126846.
http://www.ncbi.nlm.nih.gov/pubmed/25962111
PI: C.A. Nickerson
Note: A rotating wall vessel was used. This article may be obtained online without charge.
Journal Impact Factor: 3.545
Funding: “This work was funded by the National Institutes of Health (National Institutes of Health grants RC4HL106625 [DJW and CAN], NHLBI R21HL108689 [DJW], NHLBI R21HL094611 [DJW], NIGMS COBRE P30 GM103532 [C Irvin PI]), the National Aeronautics and Space Administration (NASA grants NNX10AO52G [CAN] and NNX13AM01G [CAN]) and by a Mayo Clinic-ASU Seed grant (AC, CAN, JJL).”
6
Clark TK, Newman MC, Oman CM, Merfeld DM, Young LR.
Modeling human perception of orientation in altered gravity.
Front Syst Neurosci. 2015 May 5;9:68.
http://journal.frontiersin.org/article/10.3389/fnsys.2015.00068
PIs: C.M. Oman; L.R. Young; T.K. Clark, NSBRI Postdoctoral Fellowship Program
Note: From the abstract: “Here we evaluate our modified utricular shear and modified observer models in four altered gravity motion paradigms: (a) static roll tilt in hyper-gravity, (b) static pitch tilt in hyper-gravity, (c) static roll tilt in hypo-gravity, and (d) static pitch tilt in hypo-gravity.” This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work was supported by the National Space Biomedical Research Institute (NSBRI) through NASA NCC9-58 (TC, CO, LY) and via NIDCD/NIH R01 DC04158 (DM).”
7
Meredith FL, Kirk ME, Rennie KJ.
Kv1 channels and neural processing in vestibular calyx afferents.
Front Syst Neurosci. 2015 May 18;9:86.
http://journal.frontiersin.org/article/10.3389/fnsys.2015.00085
PI: F.L. Meredith, NSBRI Postdoctoral Fellowship Program
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this publication.
Funding: “This work was supported by the National Space Biomedical Research Institute through NCC 9-58 to FLM and an American Hearing Research Foundation Grant to KJR.”
8
Oddsson LI, Finkelstein MJ, Meissner S.
Feasibility of early functional rehabilitation in acute stroke survivors using the balance-bed–A technology that emulates microgravity.
Front Syst Neurosci. 2015 May 12;9:83.
http://journal.frontiersin.org/article/10.3389/fnsys.2015.00083
PIs: J.J. Bloomberg, A. Mulavera
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal.
Funding: “This study was supported by a grant from the Sister Kenny Foundation (now Courage Kenny Foundation), part of Allina Health and in part by a grant from the National Space Biomedical Research Institute through NASA NCC 9-58, SA03801 to Dr. Ajitkumar Mulavara and 02801 to Dr. Jacob Bloomberg.”
9
Weerts A, Putcha L, Hoag SW, Hallgren E, Van Ombergen A, Van de Heyning PH, Wuyts FL.
Intranasal scopolamine affects the semicircular canals centrally and peripherally.
J Appl Physiol (1985). 2015 May 7:jap.00149.2015. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25953832
Journal Impact Factor: 3.434
Funding: “This research was made possible by the Belgian Science Policy program PRODEX-9 project SPIN-D in support of the European Space Agency AO-2004-093 corresponding project. Angelique Van Ombergen is a research fellow for the Research Foundation Flanders (FWO Vlaanderen; grant 11N6414N).” L. Putcha is at NASA Johnson Space Center.
10
Casner SM, Schooler JW.
Vigilance impossible: Diligence, distraction, and daydreaming all lead to failures in a practical monitoring task.
Conscious Cogn. 2015 May 9;35:33-41. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25966369
Journal Impact Factor: 2.235
Funding: “This work was internally funded by the National Aeronautics and Space Administration under the agency’s Aviation Safety Program.” S.M. Casner is at NASA Ames Research Center.
______________________________________________________
Other papers of interest:
1
Gao Y, Xu D, Zhao L, Zhang M, Sun Y.
Effects of microgravity on DNA damage response in Caenorhabditis elegans during Shenzhou-8 spaceflight.
Int J Radiat Biol. 2015 May 12:1-9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25965668
Note: Shenzhou-8 results.
2
Gawthrope IC, Summers M, Macey DJ, Playford DA.
An observation of venous gas emboli in divers and susceptibility to decompression sickness.
Diving Hyperb Med. 2015 Mar;45(1):25-9.
http://www.ncbi.nlm.nih.gov/pubmed/25964035
3
Yuan M, Alameddine A, Coupe M, Navasiolava NM, Li Y, Gauquelin-Koch G, Bai Y, Jiang S, Wan Y, Wang J, Li Y, Custaud MA.
Effect of Chinese herbal medicine on vascular functions during 60-day head-down bed rest.
Eur J Appl Physiol. 2015 May 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25957107
Note: Bed rest study.
4
Cervantes JL, Hong BY.
Dysbiosis and immune dysregulation in outer space.
Int Rev Immunol. 2015 May 13. [Epub ahead of print] Review.
http://www.ncbi.nlm.nih.gov/pubmed/25970037
Note: From the abstract: “This review focuses on the current knowledge/understanding of how spaceflight affects human immunity and microbiome.”
5
Kwon OS, Tanner RE, Barrows KM, Runtsch M, Symons JD, Jalili T, Bikman BT, McClain DA, O’Connell RM, Drummond MJ.
MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling and glucose intolerance.
Am J Physiol Endocrinol Metab. 2015 May 12:ajpendo.00124.2015. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25968578
Note: Hindlimb unloading study.
6
Goodman CA, Dietz JM, Jacobs BL, McNally RM, You JS, Hornberger TA.
Yes-Associated Protein is up-regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy.
FEBS Lett. 2015 May 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25959868
7
Xin M, Yang Y, Zhang D, Wang J, Chen S, Zhou D.
Attenuation of hind-limb suspension-induced bone loss by curcumin is associated with reduced oxidative stress and increased vitamin D receptor expression.
Osteoporos Int. 2015 May 12. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25963235
Note: Hindlimb unloading study.
8
Sakata R, Iwakura T, Reddi AH.
Articular cartilage regeneration: Challenges and opportunities.
Tissue Eng Part B Rev. 2015 May 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25951707
Note: Alternate title from provisional PDF: “Regeneration of articular cartilage surface: Morphogens, cells and extracellular matrix scaffolds.” This article may be obtained online without charge.
9
Mora-Macias J, Reina-Romo E, López-Pliego M, Giráldez-Sánchez MA, Domínguez J.
In vivo mechanical characterization of the distraction callus during bone consolidation.
Ann Biomed Eng. 2015 May 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25956927
10
Galea GL, Hannuna S, Meakin LB, Delisser PJ, Lanyon LE, Price JS.
Quantification of alterations in cortical bone geometry using site specificity software in mouse models of aging and the responses to ovariectomy and altered loading.
Front Endocrinol (Lausanne). 2015 Apr 23;6:52.
http://www.ncbi.nlm.nih.gov/pubmed/25954246
Note: Mice were subjected to tibial loading or unilateral sciatic neurectomy. This article may be obtained online without charge.
11
Bourne DA, Moo EK, Herzog W.
Cartilage and chondrocyte response to extreme muscular loading and impact loading: Can in vivo pre-load decrease impact-induced cell death?
Clin Biomech (Bristol, Avon). 2015 Apr 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25957254
Note: Loading conditions were a short-duration maximal-intensity protocol and a long-duration low-intensity protocol.
12
Schmitt E, Friedland W, Kundrat P, Dingfelder M, Ottolenghi A.
Cross-section scaling for track structure simulations of low-energy ions in liquid water.
Radiat Prot Dosimetry. 2015 May 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25969528
13
Moscariello M, Wieloch R, Kurosawa A, Li F, Adachi N, Mladenov E, Iliakis G.
Role for Artemis nuclease in the repair of radiation-induced DNA double strand breaks by alternative end joining.
DNA Repair (Amst). 2015 Apr 25;31:29-40. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25973742
14
Edmondson EF, Hunter NR, Weil MM, Mason KA.
Tumor induction in mice after localized single- or fractionated-dose irradiation: Differences in tumor histotype and genetic susceptibility based on dose scheduling.
Int J Radiat Oncol Biol Phys. 2015 Mar 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25956832
15
Demertzi A, Van Ombergen A, Tomilovskaya E, Jeurissen B, Pechenkova E, Di Perri C, Litvinova L, Amico E, Rumshiskaya A, Rukavishnikov I, Sijbers J, Sinitsyn V, Kozlovskaya IB, Sunaert S, Parizel PM, Van de Heyning PH, Laureys SS, Wuyts FL.
Cortical reorganization in an astronaut’s brain after long-duration spaceflight.
Brain Struct Funct. 2015 May 12. Epub [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25963710
Note: The study assessed a cosmonaut who completed a 169-day ISS mission. This article may be obtained online without charge.
16
Carriot J, Jamali M, Cullen KE.
Rapid adaptation of multisensory integration in vestibular pathways.
Front Syst Neurosci. 2015 May 2;9:59. Review.
http://www.ncbi.nlm.nih.gov/pubmed/25932009
Note: This article may be obtained online without charge.
17
Bock O, Schott N, Papaxanthis C.
Motor imagery: Lessons learned in movement science might be applicable for spaceflight.
Front Syst Neurosci. 2015 Apr 24;9:75.
http://journal.frontiersin.org/article/10.3389/fnsys.2015.00075
Note: This article may be obtained online without charge.
Something to think about while grilling your hamburgers on Memorial Day:
18
Pandurangan M, Kim DH.
A novel approach for in vitro meat production.
Appl Microbiol Biotechnol. 2015 May 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25971200
Note: From the abstract: “Originally, the research on in vitro meat production was initiated by the National Aeronautics and Space Administration (NASA) for space voyages.”
