NASA Spaceline Current Awareness List #612 25 August 2014
Papers deriving from NASA support:
1
Zhang Q, Ivkovic V, Hu G, Strangman GE.
Twenty-four-hour ambulatory recording of cerebral hemodynamics, systemic hemodynamics, electrocardiography, and actigraphy during people’s daily activities.
J Biomed Opt. 2014 Apr;19(4):47003.
(PI: G.E. Strangman)
Journal Impact Factor: 2.752
Funding: “This work was supported by the National Space Biomedical Research Institute through NASA NCC 9-58.”
2
Crucian B, Simpson RJ, Mehta S, Stowe R, Chouker A, Hwang SA, Actor JK, Salam AP, Pierson D, Sams C.
Terrestrial stress analogs for spaceflight associated immune system dysregulation.
Brain Behav Immun. 2014 Jul;39:23-32. Epub 2014 Jan 24. Review.
(PIs: R.J. Simpson; R.P. Stowe; C. Sams; B. Crucian, NASA Flight Analogs Project)
Note: From the abstract: “Terrestrial space analogs generally replicate some of the physiological or psychological stress responses associated with spaceflight. These include the use of human test subjects in a laboratory setting (i.e. exercise, bed rest, confinement, circadian misalignment) and human remote deployment analogs (Antarctica winterover, undersea, etc.) that incorporate confinement, isolation, extreme environment, physiological mission stress and disrupted circadian rhythms…This article will characterize the array of terrestrial analogs for spaceflight immune dysregulation, the current evidence base for each, and interpret the analog catalog in the context of acute and chronic stress.”
Journal Impact Factor: 6.128
Funding: “Part of this work was supported by National Institutes of Health, National Center for Advancing Translational Sciences, grant 1UL1RR029876-01 and the NASA Flight Analogs Project (B. Crucian); by NASA grant NNX12AB48G to RJ Simpson and by NASA grant NNJ04HD75G to RP Stowe. A. Chouker was supported by the European Space Agency (ESA) ELIPS 3 and 4 programs and the German National Space Program (DLR, #50WB0719 and #WB0919).”
3
Dunmire B, Lee FC, Hsi RS, Cunitz BW, Paun M, Bailey MR, Sorensen MD, Harper JD.
Tools to improve the accuracy of kidney stone sizing with ultrasound.
J Endourol. 2014 Aug 8. [Epub ahead of print]
(PI: M.R. Bailey)
Journal Impact Factor: 2.095
Funding: “Funding was provided through the NIH DK43881 and DK092197, and NSBRI through NASA NCC 9-58. This material is the result of work supported by the resources from the VA Puget Sound Health Care System, Seattle, Washington. Funds and resources have also been provided by the University of Washington C4C, Institute of Translational Health Sciences, Coulter Institute, Washington Biotechnology & Biomedical Association (WBBA), and Washington Research Foundation.”
4
Maxwell AD, Cunitz BW, Kreider W, Sapozhnikov OA, Hsi RS, Harper JD, Bailey MR, Sorensen MD.
Fragmentation of urinary calculi in vitro by burst wave lithotripsy.
J Urol. 2014 Aug 8. pii: S0022-5347(14)04179-2. [Epub ahead of print]
(PI: M.R. Bailey)
Journal Impact Factor: 3.753
Funding: “This work was supported by the National Institute of Health through 2T32 DK007779-11A1, 2R01 EB007643-05, P01 DK043881, and R01 DK092197, and by NSBRI through NASA NCC 9-58.”
5
Boudreaux RD, Swift JM, Gasier HG, Wiggs MP, Hogan HA, Fluckey JD, Bloomfield SA.
Increased resistance during jump exercise does not enhance cortical bone formation.
Med Sci Sports Exerc. 2014 May;46(5):982-9.
(PIs: S.A. Bloomfield; R.D. Boudreaux and J.M. Swift, NSBRI Bioastronautics Graduate Education Program Summer Institute)
Journal Impact Factor: 4.459
Funding: “This study was funded by the Sydney and JL Huffines Institute for Sports Medicine and Human Performance (HGG), through the NASA Cooperative Agreement NCC 9-58 with the National Space Biomedical Research Institute (SAB), and by the National Institutes of Health (grant no. AG01025; JDF). RDB and JMS were supported by a National Space Biomedical Research Institute Graduate Fellowship (grant no. NSBRI-RFP-05-02).”
6
Morgan JL, Heer M, Hargens AR, Macias BR, Hudson EK, Shackelford LC, Zwart SR, Smith SM.
Sex-specific responses of bone metabolism and renal stone risk during bed rest.
Physiol Rep. 2014 Aug 7;2(8). pii: e12119. Print 2014 Aug 1.
(PI: A.R. Hargens)
Note: Bed rest study. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal.
Funding: “This project was funded by the National Aeronautics and Space Administration’s Human Research Program, and by a grant from the German Federal Ministry for Economics and Technology/DLR Forschung unter Weltraumbedingungen (50WB0931) to the University of Bonn (M.H.). It was also funded by National Aeronautics and Space Administration grants NAG 9-1425, 199-80-025-05, and NCC-2-1133 to A.R.H.”
7
Suman S, Moon BH, Thakor H, Fornace AJ Jr, Datta K.
Wip1 abrogation decreases intestinal tumor frequency in APC(Min/+) mice irrespective of radiation quality.
Radiat Res. 2014 Aug 12. [Epub ahead of print]
(PIs: K. Datta; A.J. Fornace, Jr./NSCOR)
Journal Impact Factor: 2.445
Funding: “This study is supported in part by NASA grants NNX13AD58G and NNX09AU95G. We acknowledge the Histopathology and Tissue Shared Resources supported by Award Number P30CA051008 from the National Cancer Institute.”
8
Weil MM, Ray FA, Genik PC, Yu Y, McCarthy M, Fallgren CM, Ullrich RL.
Effects of 28Si ions, 56Fe ions, and protons on the induction of murine acute myeloid leukemia and hepatocellular carcinoma.
PLoS One. 2014 Aug 15;9(7):e104819.
(PI: R.L. Ullrich/NSCOR)
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.534
Funding: “This work was supported by grant NNX09AM08G from the National Aeronautics and Space Administration (www.nasa.gov/exploration/humanresearch/) to RLU.”
9
Davis JA, Guatelli S, Petasecca M, Lerch MLF, Reinhard MI, Zaider M, Ziegler J, Rosenfeld AB.
Tissue equivalence study of a novel diamond-based microdosimeter for galactic cosmic rays and solar particle events.
IEEE Trans Nucl Sci. 2014 Aug;61(4):1544-51.
(PI: J. Ziegler)
Journal Impact Factor: 1.455
Funding: “…the authors recognize and thank NSBRI for their support in this project.”
10
Liu J, Liu B, Zhang S, Yang F, Yang P, Metaxas DM, Neidle C.
Non-manual grammatical marker recognition based on multi-scale, spatio-temporal analysis of head pose and facial expressions.
Image Vis Comput. 2014 Mar 11. [In Press]
(PI: D.F. Dinges)
Journal Impact Factor: 1.581
Funding: “This project was partially supported by grants from National Science Foundation (IIS-1064965, IIS-1065013, CNS-1059281, CNS-1059218, IIS-0964597, IIS-0964385), National Space Biomedical Research Institute through NASA NCC 9-58, the Center for Identification Technology Research, a National Science Foundation (NSF) Industry/University Cooperative Research Center, and funds provided by the University of North Carolina at Charlotte.”
11
Mitchell LA, Tovar TM, LeVan MD.
High pressure excess isotherms for adsorption of oxygen and argon in a carbon molecular sieve.
(PI: J.A. Ritter)
Journal Impact Factor: 6.160
Funding: “Financial support for this research was provided by NASA Cooperative Agreement NNX09AW24A and NSBRI funded project SMST02002 under NASA Cooperative Agreement NCC9-58.”
________________________________________________________________________
Other papers of interest:
1
Chakraborty N, Gautam A, Muhie S, Miller SA, Jett M, Hammamieh R.
An integrated omics analysis: Impact of microgravity on host response to lipopolysaccharide in vitro.
BMC Genomics. 2014 Aug 7;15(1):659. [Epub ahead of print]
Note: STS-135 results. This article may be obtained online without charge.
2
Girardi C, De Pittà C, Casara S, Calura E, Romualdi C, Celotti L, Mognato M.
Integration analysis of microRNA and mRNA expression profiles in human peripheral blood lymphocytes cultured in modeled microgravity.
Biomed Res Int. 2014;2014:296747. Epub 2014 Jun 23.
Note: A rotating wall vessel bioreactor was used. This article may be obtained online without charge.
3
Zhang R, Ran HH, Cai LL, Zhu L, Sun JF, Peng L, Liu XJ, Zhang LN, Fang Z, Fan YY, Cui G.
Simulated microgravity-induced mitochondrial dysfunction in rat cerebral arteries.
FASEB J. 2014 Jun;28(6):2715-24. Epub 2014 Mar 6.
Note: Hindlimb unloading study.
4
Režen T, Kovanda A, Eiken O, Mekjavic IB, Rogelj B.
Expression changes in human skeletal muscle miRNAs following 10 days of bed rest in young healthy males.
Acta Physiol (Oxf). 2014 Mar;210(3):655-66.
Note: Bed rest study.
5
Salanova M, Gelfi C, Moriggi M, Vasso M, Viganò A, Minafra L, Bonifacio G, Schiffl G, Gutsmann M, Felsenberg D, Cerretelli P, Blottner D.
Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: Evidence from structural and proteomic analysis.
FASEB J. 2014 Aug 13. pii: fj.14-252825. [Epub ahead of print]
Note: Bed rest study.
6
Coker RH, Hays NP, Williams RH, Wolfe RR, Evans WJ.
Bed rest promotes reductions in walking speed, functional parameters, and aerobic fitness in older, healthy adults.
J Gerontol A Biol Sci Med Sci. 2014 Aug 13. pii: glu123. [Epub ahead of print]
Note: Bed rest study.
7
Ye GJ, Nesmith AP, Parker KK.
The role of mechanotransduction on vascular smooth muscle myocytes cytoskeleton and contractile function.
Anat Rec (Hoboken). 2014 Sep;297(9):1758-69. Review.
8
Ulbrich C, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Magnusson N, Infanger M, Grosse J, Eilles C, Sundaresan A, Grimm D.
The impact of simulated and real microgravity on bone cells and mesenchymal stem cells.
Biomed Res Int. 2014;2014:928507. Epub 2014 Jul 10. Review.
Note: This article may be obtained online without charge.
9
Rucci N, Capulli M, Piperni SG, Cappariello A, Lau P, Frings-Meuthen P, Heer M, Teti A.
Lipocalin 2: A new mechanoresponding gene regulating bone homeostasis.
J Bone Miner Res. 2014 Aug 12. [Epub ahead of print]
Note: Bed rest study.
10
de Castro LF, Maycas M, Bravo B, Esbrit P, Gortazar A.
VEGF receptor 2 (VEGFR2) activation is essential for osteocyte survival induced by mechanotransduction.
J Cell Physiol. 2014 Aug 7. [Epub ahead of print]
11
Beck M, Rombouts C, Moreels M, Aerts A, Quintens R, Tabury K, Michaux A, Janssen A, Neefs M, Ernst E, Dieriks B, Lee R, De Vos WH, Lambert C, Van Oostveldt P, Baatout S.
Modulation of gene expression in endothelial cells in response to high LET nickel ion irradiation.
Int J Mol Med. 2014 Aug 11. [Epub ahead of print]
12
Laiakis EC, Strassburg K, Bogumil R, Lai S, Vreeken RJ, Hankemeier T, Langridge J, Plumb RS, Fornace AJ Jr, Astarita G.
Metabolic phenotyping reveals a lipid mediator response to ionizing radiation.
J Proteome Res. 2014 Aug 15. [Epub ahead of print]
13
Puchalska M, Bilski P, Berger T, Hajek M, Horwacik T, Körner C, Olko P, Shurshakov V, Reitz G.
NUNDO: A numerical model of a human torso phantom and its application to effective dose equivalent calculations for astronauts at the ISS.
Radiat Environ Biophys. 2014 Aug 15. [Epub ahead of print]
Note: From the abstract: “The present work reports the first successful attempt of the experimental determination of the effective dose equivalent in space, both for extra-vehicular activity (EVA) and intravehicular activity (IVA).” This article may be obtained online without charge.
14
Chung EJ, Hudak K, Horton JA, White A, Scroggins BT, Vaswani S, Citrin D.
Transforming growth factor alpha is a critical mediator of radiation lung injury.
Radiat Res. 2014 Aug 12. [Epub ahead of print]
15
Stevens DL, Bradley S, Goodhead DT, Hill MA.
The influence of dose rate on the induction of chromosome aberrations and gene mutation after exposure of plateau phase V79-4 cells with high-LET alpha particles.
Radiat Res. 2014 Aug 12. [Epub ahead of print]
16
Takahashi A, Kubo M, Ma H, Nakagawa A, Yoshida Y, Isono M, Kanai T, Ohno T, Furusawa Y, Funayama T, Kobayashi Y, Nakano T.
NHEJ repair plays a more important role than homologous recombination repair in defining radiosensitivity after exposure to high-LET radiation.
Radiat Res. 2014 Aug 12. [Epub ahead of print]
17
Migliaccio AA, Schubert MC.
Pilot study of a new rehabilitation tool: Improved unilateral short-term adaptation of the human angular vestibulo-ocular reflex.
Otol Neurotol. 2014 Aug 13. [Epub ahead of print]
18
Barbosa IC, Zourelidou M, Willige BC, Weller B, Schwechheimer C.
D6 protein kinase activates auxin transport-dependent growth and PIN-formed phosphorylation at the plasma membrane.
Dev Cell. 2014 Jun 23;29(6):674-85. Epub 2014 Jun 12.
19
Deng Q, Huo Y, Luo J.
Endothelial mechanosensors: The gatekeepers of vascular homeostasis and adaptation under mechanical stress.
Sci China Life Sci. 2014 Aug;57(8):755-62. Epub 2014 Aug 8.
Note: This article may be obtained online without charge.
20
Chubinskiy-Nadezhdin VI, Negulyaev YA, Morachevskaya EA.
Functional coupling of ion channels in cellular mechanotransduction.
Biochem Biophys Res Commun. 2014 Aug 7. pii: S0006-291X(14)01394-1. [Epub ahead of print]
The most recent issue of Progress in Molecular Biology and Translational Science is focused on mechanotransduction. From the Preface: “The chapters in this edition of the Progress in Molecular Biology and Translational Science series highlight a range of topics leading from the development and use of tools in molecular biology to commonly studied cellular structures, including focal adhesions and the nucleus…[and] various aspects of mechanotransduction in these uncommitted cells: in cardiac cells during their maturation, in the malignant behavior of tumor-initiating cells, and in stem cells…our final chapters focus on mechanotransduction in tissues.”
21
Hoffman BD.
The detection and role of molecular tension in focal adhesion dynamics.
Prog Mol Biol Transl Sci. 2014;126:3-24.
22
Lu S, Wang Y.
Single-cell imaging of mechanotransduction in endothelial cells.
Prog Mol Biol Transl Sci. 2014;126:25-51.
23
Kuo JC.
Focal adhesions function as a mechanosensor.
Prog Mol Biol Transl Sci. 2014;126:55-73.
24
Goldmann WH.
Mechanosensation: A basic cellular process.
Prog Mol Biol Transl Sci. 2014;126:75-102.
25
Haase K, Al-Rekabi Z, Pelling AE.
Mechanical cues direct focal adhesion dynamics.
Prog Mol Biol Transl Sci. 2014;126:103-34.
26
Hirata H, Sokabe M, Lim CT.
Molecular mechanisms underlying the force-dependent regulation of actin-to-ECM linkage at the focal adhesions.
Prog Mol Biol Transl Sci. 2014;126:135-54.
27
Kaminski A, Fedorchak GR, Lammerding J.
The cellular mastermind(?)—Mechanotransduction and the nucleus.
Prog Mol Biol Transl Sci. 2014;126:157-203.
28
Alam S, Lovett DB, Dickinson RB, Roux KJ, Lele TP.
Nuclear forces and cell mechanosensing.
Prog Mol Biol Transl Sci. 2014;126:205-15.
29
Kaushik G, Engler AJ.
From stem cells to cardiomyocytes: The role of forces in cardiac maturation, aging, and disease.
Prog Mol Biol Transl Sci. 2014;126:219-42.
30
Wong SY, Kumar S.
Matrix regulation of tumor-initiating cells.
Prog Mol Biol Transl Sci. 2014;126:243-56.
31
Gjorevski N, Lutolf M.
Biomaterials approaches in stem cell mechanobiology.
Prog Mol Biol Transl Sci. 2014;126:257-78.
32
Cram EJ.
Mechanotransduction in C. elegans morphogenesis and tissue function.
Prog Mol Biol Transl Sci. 2014;126:281-316.
33
Chanet S, Martin AC.
Mechanical force sensing in tissues.
Prog Mol Biol Transl Sci. 2014;126:317-52.
