Status Report

NASA Spaceline Current Awareness 20 December 2013 (Recent Space Life Science Research Results)

By SpaceRef Editor

December 20, 2013

Filed under Spaceline, Spaceline Current Awareness, US

To list recipients: This will be the last NASA Current Awareness List, until further notice. After 14 years producing these lists, I am retiring. I apologize for the late announcement. If the lists resume, we will let you know. As the saying goes, it has been an honor and a privilege to have been able to produce these lists for you through the years. I hope it has contributed in some small way to increasing knowledge of the space life sciences.

Signing off –

Ron Dutcher

Papers deriving from NASA support:

Stenger MB, Lee SM, Ribeiro LC, Phillips TR, Ploutz-Snyder RJ, Willig MC, Westby CM, Platts SH.

Gradient compression garments protect against orthostatic intolerance during recovery from bed rest.

Eur J Appl Physiol. 2013 Dec 14. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24337701

(PIs: M.B. Stenger, S.H. Platts)

NOTE: Bed rest study.

Crucian B, Quiriarte H, Guess T, Ploutz-Snyder R, McMonigal K, Sams C.

A miniaturized analyzer capable of white-blood-cell and differential analyses during spaceflight.

Lab Med. 2013 Fall;44(4):304-12.

http://labmed.ascpjournals.org/content/44/4/304.full.pdf+html

NOTE: Parabolic flight results. The article reports tests of a device being considered for possible future use on ISS. The article, which may be obtained online without charge, is apparently featured on the cover of the journal: http://labmed.ascpjournals.org/content/44/4.toc

Buehlmeier J, Mulder E, Noppe A, Frings-Meuthen P, Angerer O, Rudwill F, Biolo G, Smith SM, Blanc S, Heer M.

A combination of whey protein and potassium bicarbonate supplements during head-down-tilt bed rest: Presentation of a multidisciplinary randomized controlled trial (MEP study).

Acta Astronaut. 2014 Feb-Mar;95:82-91.

http://www.sciencedirect.com/science/article/pii/S0094576513003937

NOTE: Bed rest study.

Scully RR, Lam CW, James JT.

Estimating safe human exposure levels for lunar dust using benchmark dose modeling of data from inhalation studies in rats.

Inhal Toxicol. 2013 Dec;25(14):785-93.

http://www.ncbi.nlm.nih.gov/pubmed/24304305

(PIs: C.W. Lam, J.T. James)

Crabbé A, Nielsen-Preiss SM, Woolley CM, Barrila J, Buchanan K, McCracken J, Inglis DO, Searles SC, Nelman-Gonzalez MA, Ott CM, Wilson JW, Pierson DL, Stefanyshyn-Piper HM, Hyman LE, Nickerson CA.

Spaceflight enhances cell aggregation and random budding in Candida albicans.

PLoS One. 2013 Dec 4;8(12):e80677.

http://www.ncbi.nlm.nih.gov/pubmed/24324620

(PI: C.A. Nickerson)

NOTE: STS-115 results. This article may be obtained online without charge.

Lang TF, Saeed IH, Streeper T, Carballido-Gamio J, Harnish RJ, Frassetto LA, Lee SM, Sibonga JD, Keyak JH, Spiering BA, Grodsinsky CM, Bloomberg JJ, Cavanagh PR.

Spatial heterogeneity in the response of the proximal femur to two lower-body resistance exercise regimens.

J Bone Miner Res. 2013 Nov 30. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24293094

(PI: T.F. Lang)

Hassler DM, Zeitlin C, Wimmer-Schweingruber RF, Ehresmann B, Rafkin S, Eigenbrode JL, Brinza DE, Weigle G, Böttcher S, Böhm E, Burmeister S, Guo J, Köhler J, Martin C, Reitz G, Cucinotta FA, Kim MH, Grinspoon D, Bullock MA, Posner A, Gómez-Elvira J, Vasavada A, Grotzinger JP, Team MS; the MSL Science Team.

Mars’ surface radiation environment measured with the Mars Science Laboratory’s Curiosity Rover.

http://www.ncbi.nlm.nih.gov/pubmed/24324275

NOTE: Mars Science Laboratory Curiosity results. Press release: http://www.swri.org/9what/releases/2013/mars-measurements.htm

Sanzari JK, Muehlmatt A, Savage A, Lin L, Kennedy AR.

Increased intracranial pressure in mini-pigs exposed to simulated solar particle event radiation.

Acta Astronaut. 2014 Feb;94(2):807-12.

http://www.sciencedirect.com/science/article/pii/S0094576513003767

(PI: A.R. Kennedy/Center of Acute Radiation Research)

Rivera PD, Shih HY, LeBlanc JA, Cole MG, Amaral WZ, Mukherjee S, Zhang S, Lucero MJ, DeCarolis NA, Chen BP, Eisch J.

Acute and fractionated exposure to high-LET (56)Fe HZE-particle radiation both result in similar long-term deficits in adult hippocampal neurogenesis.

Radiat Res. 2013 Dec 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24320054

(PIs: B.P. Chen, A.J. Eisch)

Mao XW, Pecaut MJ, Cao JD, Moldovan M, Gridley DS.

Low-dose radiation modifies skin response to acute gamma-rays and protons.

In Vivo. 2013 Nov-Dec;27(6):695-700.

http://www.ncbi.nlm.nih.gov/pubmed/24292570

(PI: D.S. Gridley)

Diffenderfer ES, Dolney D, Schaettler M, Sanzari JK, McDonough J, Cengel KA.

Monte Carlo modeling in CT-based geometries: Dosimetry for biological modeling experiments with particle beam radiation.

J Radiat Res. 2013 Dec 5. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24309720

(PIs: A.R. Kennedy/K.A. Cengel/Center of Acute Radiation Research)

NOTE: This article may be obtained online without charge.

Youngquist RC, Nurge MA, Starr SO, Koontz SL.

Thick galactic cosmic radiation shielding using atmospheric data.

Acta Astronaut. 2014 Jan-Feb;94(1):132-8.

http://www.sciencedirect.com/science/article/pii/S0094576513003196

Deshpande N, Tourtillott BM, Peters BT, Bloomberg JJ.

Dynamic visual acuity (DVA) during locomotion for targets at near and far distances: Effects of aging, walking speed and head-trunk coupling.

J Vestib Res. 2013 Jan 1;23(4):195-201.

http://www.ncbi.nlm.nih.gov/pubmed/24284599

Barger LK, Wright KP Jr., Burke TM, Chinoy ED, Ronda JM, Lockley SW, Czeisler CA.

Sleep and cognitive function of crewmembers and mission controllers working 24-h shifts during a simulated 105-day spaceflight mission.

Acta Astronaut. 2014 Jan;93:230-42.

http://www.sciencedirect.com/science/article/pii/S0094576513002348

(PI: C.A. Czeisler)

NOTE: This article and the other articles in this issue may be obtained online without charge if accessed via the Table of Contents.

McCauley P, Kalachev LV, Mollicone DJ, Banks S, Dinges DF, Van Dongen HP.

Dynamic circadian modulation in a biomathematical model for the effects of sleep and sleep loss on waking neurobehavioral performance.

http://www.ncbi.nlm.nih.gov/pubmed/24293775

(PI: D.F. Dinges)

Love SG, Harvey RP.

Crew autonomy for deep space exploration: Lessons from the Antarctic Search for Meteorites.

Acta Astronaut. 2014 Jan-Feb;94(1):83-92.

http://www.sciencedirect.com/science/article/pii/S0094576513002968

Willson D, Rask JC, George SC, de Leon P, Bonaccorsi R, Blank J, Slocombe J, Silburn K, Steele H, Gargarno M, McKay CP.

The performance of field scientists undertaking observations of early life fossils while in simulated space suit.

Acta Astronaut. 2014 Jan;93:193-206.

http://www.sciencedirect.com/science/article/pii/S0094576513002440

NOTE: This article and the other articles in this issue may be obtained online without charge if accessed via the Table of Contents.

Aliakbargolkar A, Crawley EF.

A Delphi-Based Framework for systems architecting of in-orbit exploration infrastructure for human exploration beyond Low Earth Orbit.

Acta Astronaut. 2014 Jan-Feb;94(1):17-33.

http://www.sciencedirect.com/science/article/pii/S0094576513003135

Alibay F, Desaraju VR, Duda JE, Hoffman JA.

Fractionated robotic architectures for planetary surface mobility systems.

Acta Astronaut. 2014 Feb-Mar;95:15-29.

http://www.sciencedirect.com/science/article/pii/S0094576513003846

Hu X, Raja WK, An B, Tokareva O, Cebe P, Kaplan DL.

Stability of silk and collagen protein materials in space.

Sci Rep. 2013 Dec 5;3:3428.

http://www.ncbi.nlm.nih.gov/pubmed/24305951

NOTE: ISS results. This article may be obtained online without charge.

Stefano G, Osterrieder A, Hawes C, Brandizzi F.

Endomembrane and Golgi traffic in plant cells.

Methods Cell Biol. 2013;118:69-83.

http://www.ncbi.nlm.nih.gov/pubmed/24295301

(PI: F. Brandizzi)

Surpin M.

Plant chemical genomics: Gravity sensing and response.

Methods Mol Biol. 2014;1056:115-24.

http://www.ncbi.nlm.nih.gov/pubmed/24306868

(PI: N.V. Raikhel)

Other papers of interest:

Dubeau-Laramée G, Rivière C, Jean I, Mermut O, Cohen LY.

Microflow1, a sheathless fiber-optic flow cytometry biomedical platform: Demonstration onboard the International Space Station.

Cytometry A. 2013 Dec 12. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24339248

NOTE: Parabolic flight and ISS results. The demonstration on ISS was performed by Canadian astronaut Chris Hadfield (the article has a photograph of him with the device).

Pastushkova LKh, Valeeva OA, Kononikhin AS, Nikolaev EN, Larina IM, Dobrokhotov IV, Popov IA, Pochuev VI, Kireev KS.

Changes of protein profile of human urine after long-term orbital flights.

Bull Exp Biol Med. 2013 Dec;156(2):201-4.

http://www.ncbi.nlm.nih.gov/pubmed/24319748

NOTE: ISS results. This paper is an English translation from Byulleten’ Eksperimental’noi Biologii i Meditsiny. 2013 Aug;156(8):166-70.

Tseilikman VE, Pankov NE, Pankova NA, Filimonova TA, Sinitskii AI, Kozochkin DA, Tseilikman OB.

Correlation between circulating corticosterone and protein carbonylation in the liver after short-term hypokinesia.

Bull Exp Biol Med. 2013 Dec;156(2):188-90.

http://www.ncbi.nlm.nih.gov/pubmed/24319745

NOTE: Hypokinesia consisted of placing rats in tight boxes. This paper is an English translation from Byulleten’ Eksperimental’noi Biologii i Meditsiny. 2013 Aug;156(8):153-5.

Tseilikman VE, Osikov MV, Strelnikova LA, Filimonova TA, Strelnikov IV, Tseilikman OB, Kozochkin DA, Sinitskiy AI, Pankov NE, Pankova NA.

Effects of preliminary hypokinetic stress on sensitivity of the bone marrow to the hypoplastic effect of exogenous glucocorticoid.

Bull Exp Biol Med. 2013 Sep;155(5):601-4.

http://www.ncbi.nlm.nih.gov/pubmed/24288718

NOTE: Hypokinetic stress was induced by immobilization in tight plastic cages. This paper is an English translation from Byulleten’ Eksperimental’noi Biologii i Meditsiny. 2013 May;155(5):547-50.

Iqbal J, Li W, Hasan M, Li YJ, Ullah K, Yun W, Awan U, Qing H, Deng Y.

Distortion of homeostatic signaling proteins by simulated microgravity in rat hypothalamus -(16) O/(18) O labeled comparative integrated proteomic approach.

http://www.ncbi.nlm.nih.gov/pubmed/24323493

Horn FC, Deppe MH, Marshall H, Parra-Robles J, Wild JM.

Quantification of regional fractional ventilation in human subjects by measurement of hyperpolarized 3He washout with 2D and 3D MRI.

J Appl Physiol (1985). 2013 Dec 5. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24311749

Oakes JM, Marsden AL, Grandmont C, Shadden SC, Darquenne C, Vignon-Clementel IE.

Airflow and particle deposition simulations in health and emphysema: From in vivo to in silico animal experiments.

Ann Biomed Eng. 2013 Dec 7. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24318192

Spieth P, Bluth T, Gama De Abreu M, Bacelis A, Goetz A, Kiefmann R.

Mechanotransduction in the lungs.

Minerva Anestesiol. 2013 Dec 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24299920

Nazer B, Gerstenfeld EP, Hata A, Crum LA, Matula TJ.

Cardiovascular applications of therapeutic ultrasound.

J Interv Card Electrophysiol. 2013 Dec 3. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24297498

Seref O, Brooks JP, Fong SS.

Decomposition of flux distributions into metabolic pathways.

IEEE/ACM Trans Comput Biol Bioinform. 2013 Jul-Aug;10(4):984-93.

http://www.ncbi.nlm.nih.gov/pubmed/24334391

Grigoriev AI, Potapov AN.

Approaches to the development of biomedical support systems for piloted exploration missions.

Acta Astronaut. 2014 Jan-Feb;94(1):14-6.

http://www.sciencedirect.com/science/article/pii/S0094576513002877

Kluge G, Stern C, Trammer M, Chaudhuri I, Tuschy P, Gerzer R.

Commercial suborbital space tourism-proposal on passenger’s medical selection.

Acta Astronaut. 2013 Dec;92(2):187-92.

NOTE: This article and the following article are in an issue on this topic: 2nd IAA Symposium on Private Human Access to Space.

http://www.sciencedirect.com/science/article/pii/S0094576512003037

Carminati MV, Griffith D, Campbell MR.

Sub-orbital commercial Human space flight and informed consent in the United States.

Acta Astronaut. 2013 Dec;92(2):263-5.

http://www.sciencedirect.com/science/article/pii/S0094576512002706

Reilly BD, Hickey AJ, Cramp RL, Franklin CE.

Decreased hydrogen peroxide production and mitochondrial respiration in skeletal muscle but not cardiac muscle of the green-striped burrowing frog, a natural model of muscle disuse.

J Exp Biol. 2013 Dec 5. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24311816

NOTE: An interesting feature of this aestivation model is that as the animals burrow underground and create a waterproof cocoon, skeletal muscle movement stops since the hindlimbs are completely immobilized.

Guerra B, Ponce-González JG, Morales-Alamo D, Guadalupe-Grau A, Kiilerich K, Fuentes T, Ringholm S, Biensø RS, Santana A, Lundby C, Pilegaard H, Calbet JA.

Leptin signaling in skeletal muscle after bed rest in healthy humans.

Eur J Appl Physiol. 2013 Nov 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24292882

NOTE: Bed rest study.

Alway SE, Bennett BT, Wilson JC, Edens NK, Pereira SL.

Epigallocatechin-3-gallate improves plantaris muscle recovery after disuse in aged rats.

Exp Gerontol. 2014 Feb;50:82-94.

http://www.ncbi.nlm.nih.gov/pubmed/24316035

Goto A, Ohno Y, Ikuta A, Suzuki M, Ohira T, Egawa T, Sugiura T, Yoshioka T, Ohira Y, Goto K.

Up-regulation of adiponectin expression in antigravitational soleus muscle in response to unloading followed by reloading, and functional overloading in mice.

PLoS One. 2013 Dec 6;8(12):e81929.

http://www.ncbi.nlm.nih.gov/pubmed/24324732

NOTE: This article may be obtained online without charge.

Weber T, Ducos M, Yang P, Jos D, Frings-Meuthen P, Brüggemann GP, Bloch W, Rittweger J.

The HEPHAISTOS study: Compliance and adherence with a novel orthotic device for calf muscle unloading.

J Musculoskelet Neuronal Interact. 2013 Dec;13(4):487-95.

http://www.ncbi.nlm.nih.gov/pubmed/24292619

NOTE: This article may be obtained online without charge.

Savary-Auzeloux I, Magne H, Migné C, Oberli M, Breuillé D, Faure M, Vidal K, Perrot M, Rémond D, Combaret L, Dardevet D.

A dietary supplementation with leucine and antioxidants is capable to accelerate muscle mass recovery after immobilization in adult rats.

PLoS One. 2013 Nov 29;8(11):e81495.

http://www.ncbi.nlm.nih.gov/pubmed/24312309

NOTE: This article may be obtained online without charge.

Hindi SM, Mishra V, Bhatnagar S, Tajrishi MM, Ogura Y, Yan Z, Burkly LC, Zheng TS, Kumar A.

Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program.

FASEB J. 2013 Dec 10. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24327607

Luxa N, Salanova M, Schiffl G, Gutsmann M, Besnard S, Denise P, Clarke A, Blottner D.

Increased myofiber remodelling and NFATc1-myonuclear translocation in rat postural skeletal muscle after experimental vestibular deafferentation.

J Vestib Res. 2013 Jan 1;23(4):187-93.

http://www.ncbi.nlm.nih.gov/pubmed/24284598

NOTE: This article may be obtained online without charge.

Benedini-Elias PC, Morgan MC, Cornachione AS, Martinez EZ, Mattiello-Sverzut AC.

Post-immobilization eccentric training promotes greater hypertrophic and angiogenic responses than passive stretching in muscles of weanling rats.

Acta Histochem. 2013 Dec 2. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24304683

Kos O, Hughson RL, Hart DA, Clément G, Frings-Meuthen P, Linarsson D, Paloski WH, Rittweger J, Wuyts F, Zange J, Gorczynski RM.

Elevated serum soluble CD200 and CD200R as surrogate markers of bone loss under bed rest conditions.

http://www.ncbi.nlm.nih.gov/pubmed/24333170

NOTE: Bed rest and centrifugation study.

Niehoff A, Lechner P, Ratiu O, Reuter S, Hamann N, Brüggemann GP, Schönau E, Bloch W, Beccard R.

Effect of whole-body vibration and insulin-like growth factor-I on muscle paralysis-induced bone degeneration after botulinum toxin injection in mice.

Calcif Tissue Int. 2013 Nov 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24292598

Ciani C, Sharma D, Doty SB, Fritton SP.

Ovariectomy enhances mechanical load-induced solute transport around osteocytes in rat cancellous bone.

http://www.ncbi.nlm.nih.gov/pubmed/24316418

Thi MM, Suadicani SO, Schaffler MB, Weinbaum S, Spray DC.

Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require αVβ3 integrin.

Proc Natl Acad Sci U S A. 2013 Dec 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24324138

Klein-Nulend J, van Oers RF, Bakker AD, Bacabac RG.

Nitric oxide signaling in mechanical adaptation of bone.

Osteoporos Int. 2013 Dec 10. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24322479

Gridley DS, Pecaut MJ, Mao XW, Wroe AJ, Luo-Owen X.

Biological effects of passive versus active scanning proton beams on human lung epithelial cells.

Technol Cancer Res Treat. 2013 Dec 6. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24325134

Costantino L, Sotiriou SK, Rantala JK, Magin S, Mladenov E, Helleday T, Haber JE, Iliakis G, Kallioniemi O, Halazonetis TD.

Break-induced replication repair of damaged forks induces genomic duplications in human cells.

http://www.ncbi.nlm.nih.gov/pubmed/24310611

Fakir H, Hlatky L, Li H, Sachs R.

Repopulation of interacting tumor cells during fractionated radiotherapy: Stochastic modeling of the tumor control probability.

Med Phys. 2013 Dec;40(12):121716.

http://www.ncbi.nlm.nih.gov/pubmed/24320502

Liu G, Stevens JB, Horne SD, Abdallah BY, Ye KJ, Bremer SW, Ye CJ, Chen DJ, Heng HH.

Genome chaos: Survival strategy during crisis.

Cell Cycle. 2013 Dec 3;13(4). [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24299711

NOTE: The web version of the article may be obtained online without charge by clicking on Full Text Viewer at the publisher’s site.

Ling AP, Ung YC, Hussein S, Harun AR, Tanaka A, Yoshihiro H.

Morphological and biochemical responses of Oryza sativa L. (cultivar MR219) to ion beam irradiation.

J Zhejiang Univ Sci B. 2013 Dec;14(12):1132-43.

http://www.ncbi.nlm.nih.gov/pubmed/24302713

Bakshi A, Ventura J, DiZio P, Lackner JR.

Adaptation to Coriolis perturbations of voluntary body sway transfers to pre-programmed fall-recovery behavior.

J Neurophysiol. 2013 Dec 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24304863

Paillard AC, Quarck G, Paolino F, Denise P, Paolino M, Golding JF, Ghulyan-Bedikian V.

Motion sickness susceptibility in healthy subjects and vestibular patients: Effects of gender, age and trait-anxiety.

J Vestib Res. 2013 Jan 1;23(4):203-9.

http://www.ncbi.nlm.nih.gov/pubmed/24284600

Rosenberg A, Cowan NJ, Angelaki DE.

The visual representation of 3D object orientation in parietal cortex.

J Neurosci. 2013 Dec 4;33(49):19352-61.

http://www.ncbi.nlm.nih.gov/pubmed/24305830

Barnett-Cowan M.

Vestibular perception is slow: A review.

Multisens Res. 2013;26(4):387-403.

http://www.ncbi.nlm.nih.gov/pubmed/24319930

Smith PF, Zheng Y.

From ear to uncertainty: Vestibular contributions to cognitive function.

Front Integr Neurosci. 2013 Nov 26;7:84.

http://www.ncbi.nlm.nih.gov/pubmed/24324413

NOTE: This article may be obtained online without charge.

Keshavarz B, Hettinger LJ, Vena D, Campos JL.

Combined effects of auditory and visual cues on the perception of vection.

Exp Brain Res. 2013 Dec 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24306440

Colagiorgio P, Colnaghi S, Versino M, Ramat S.

A new tool for investigating the functional testing of the VOR.

Front Neurol. 2013 Oct 25;4:165.

http://www.ncbi.nlm.nih.gov/pubmed/24298265

NOTE: This article may be obtained online without charge.

Lucas RJ, Peirson SN, Berson DM, Brown TM, Cooper HM, Czeisler CA, Figueiro MG, Gamlin PD, Lockley SW, O’Hagan JB, Price LL, Provencio I, Skene DJ, Brainard GC.

Measuring and using light in the melanopsin age.

Trends Neurosci. 2013 Nov 25. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24287308

Menzies AK, Timonin ME, McGuire LP, Willis CK.

Personality variation in little brown bats.

PLoS One. 2013 Nov 27;8(11):e80230.

http://www.ncbi.nlm.nih.gov/pubmed/24312205

NOTE: Perhaps “batty” can be an accurate word. This article may be obtained online without charge.

Vinokhodova AG, Gushin VI.

Study of values and interpersonal perception in cosmonauts on board of International Space Station.

Acta Astronaut. 2014 Jan;93:359-65.

http://www.sciencedirect.com/science/article/pii/S0094576513002580

NOTE: ISS results. This article and the other articles in this issue may be obtained online without charge if accessed via the Table of Contents.

Urbina DA, Charles R.

Symposium keynote: Enduring the isolation of interplanetary travel: A personal account of the Mars500 mission.

Acta Astronaut. 2014 Jan;93:374-83.

http://www.sciencedirect.com/science/article/pii/S0094576513002609

NOTE: This article and the other articles in this issue may be obtained online without charge if accessed via the Table of Contents.

Peldszus R, Dalke H, Pretlove S, Welch C.

The perfect boring situation—Addressing the experience of monotony during crewed deep space missions through habitability design.

Acta Astronaut. 2014 Jan-Feb;94(1):262-76.

http://www.sciencedirect.com/science/article/pii/S0094576513001471

Orgel C, Kereszturi A, Váczi T, Groemer G, Sattler B.

Scientific results and lessons learned from an integrated crewed Mars exploration simulation at the Rio Tinto Mars analogue site.

Acta Astronaut. 2014 Feb;94(2):736-48.

http://www.sciencedirect.com/science/article/pii/S0094576513003688

Paulsen K, Tauber S, Goelz N, Simmet DM, Engeli S, Birlem M, Dumrese C, Karer A, Hunziker S, Biskup J, Konopasek S, Suh D, Hürlimann E, Signer C, Wang A, Sang C, Grote KH, Zhuang F, Ullrich O.

Severe disruption of the cytoskeleton and immunologically relevant surface molecules in a human macrophageal cell line in microgravity—Results of an in vitro experiment on board of the Shenzhou-8 space mission.

Acta Astronaut. 2014 Jan-Feb;94(1):277-92.

http://www.sciencedirect.com/science/article/pii/S0094576513001975

NOTE: Shenzhou 8 results. This article may be obtained online without charge.

Preu P, Braun M.

German SIMBOX on Chinese mission Shenzhou-8: Europe’s first bilateral cooperation utilizing China’s Shenzhou programme.

Acta Astronaut. 2014 Feb;94(2):584-91.

http://www.sciencedirect.com/science/article/pii/S0094576513003421

Espinosa-Jeffrey A, Paez PM, Cheli VT, Spreuer V, Wanner I, de Vellis J.

Impact of simulated microgravity on oligodendrocyte development: Implications for central nervous system repair.

PLoS One. 2013 Dec 4;8(12):e76963.

http://www.ncbi.nlm.nih.gov/pubmed/24324574

NOTE: This article may be obtained online without charge.

Huyan T, Li Q, Yang H, Jin ML, Zhang MJ, Ye LJ, Li J, Huang QS, Yin DC.

Protective effect of polysaccharides on simulated microgravity-induced functional inhibition of human NK cells.

Carbohydr Polym. 2014 Jan 30;101:819-27. Epub 2013 Oct 12.

http://www.ncbi.nlm.nih.gov/pubmed/24299844

NOTE: Microgravity was simulated with the use of a 2-D RWV, developed by the China Astronaut Research and Training Center.

Zhang S, Zhang Y, Chen L, Liu T, Li Y, Wang Y, Geng Y.

Efficient large-scale generation of functional hepatocytes from mouse embryonic stem cells grown in a rotating bioreactor with exogenous growth factors and hormones.

Stem Cell Res Ther. 2013 Dec 2;4:145. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24294908

NOTE: This article may be obtained online without charge.

Mierke CT.

Invasive cancer cells and metastasis.

Phys Biol. 2013 Dec 4;10(6):060301. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24304690

NOTE: This short article introduces a special section on the topic of invasive cancer cells and metastasis, emphasizing the role of the mechanical properties of cancer cells in metastasis. The following article is part of this special section. All of the articles in the special section are available online without charge.

Mierke CT.

The role of focal adhesion kinase in the regulation of cellular mechanical properties.

Phys Biol. 2013 Dec 4;10(6):065005. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24304934

Campàs O, Mammoto T, Hasso S, Sperling RA, O’Connell D, Bischof AG, Maas R, Weitz DA, Mahadevan L, Ingber DE.

Quantifying cell-generated mechanical forces within living embryonic tissues.

Nat Methods. 2013 Dec 8. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24317254

Salmi ML, Clark G, Roux SJ.

Current status and proposed roles for nitric oxide as a key mediator of the effects of extracellular nucleotides on plant growth.

Front Plant Sci. 2013 Oct 25;4:427.

http://www.ncbi.nlm.nih.gov/pubmed/24298275